Publications

Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.

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Volume 145 of Issue 2 | The Journal of cell biology

The integrin alpha9beta1 mediates adhesion to activated endothelial cells and transendothelial neutrophil migration through interaction with vascular cell adhesion molecule-1.

1999

Authors: Taooka Y, Chen J, Yednock T, Sheppard D

The integrin alpha9beta1 has been shown to be widely expressed on smooth muscle and epithelial cells, and to mediate adhesion to the extracellular matrix proteins osteopontin and tenascin-C. We have found that the peptide sequence this integrin recognizes in tenascin-C is highly homologous to the sequence recognized by the closely related integrin alpha4beta1, in the inducible endothelial ligand, vascular cell adhesion mole-cule-1 (VCAM-1). We therefore sought to determine whether alpha9beta1 also recognizes VCAM-1, and whether any such interaction would be biologically significant. In this report, we demonstrate that alpha9beta1 mediates stable cell adhesion to recombinant VCAM-1 and to VCAM-1 induced on human umbilical vein endothelial cells by tumor necrosis factor-alpha. Furthermore, we show that alpha9beta1 is highly and selectively expressed on neutrophils and is critical for neutrophil migration on VCAM-1 and tenascin-C. Finally, alpha9beta1 and alpha4 integrins contribute to neutrophil chemotaxis across activated endothelial monolayers. These observations suggest a possible role for alpha9beta1/VCAM-1 interactions in extravasation of neutrophils at sites of acute inflammation.

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Lancet (London, England)

Hip fractures attributable to corticosteroid use. Study of Osteoporotic Fractures Group.

1999

Authors: Baltzan MA, Suissa S, Bauer DC, Cummings SR

AIDS (London, England)

HIV RNA and CD4 cell count response to protease inhibitor therapy in an urban AIDS clinic: response to both initial and salvage therapy.

1999

Authors: Deeks SG, Hecht FM, Swanson M, Elbeik T, Loftus R, Cohen PT, Grant RM

TO REMOVE

A re-examination of adult mouse nicotinic acetylcholine receptor channel activation kinetics.

1999

Authors: Salamone FN, Zhou M, Auerbach A

Transplantation

Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment.

1999

Authors: Hausen B, Boeke K, Berry GJ, Segarra I, Benet LZ, Christians U, Morris RE

Biochimica et biophysica acta

Isoforms of the human PDZ-73 protein exhibit differential tissue expression.

1999

Authors: Scanlan MJ, Williamson B, Jungbluth A, Stockert E, Arden KC, Viars CS, Gure AO, Gordan JD, Chen YT, Old LJ

JAMA

Anabolic effects of nandrolone decanoate in patients receiving dialysis: a randomized controlled trial.

1999

Authors: Johansen KL, Mulligan K, Schambelan M

Volume 159 of Issue 7 | Archives of internal medicine

Advance directives are more likely among seniors asked about end-of-life care preferences.

1999

Authors: Gordon NP, Shade SB

View Abstract

OBJECTIVES

To estimate the proportion of seniors in a large health maintenance organization (HMO) who had been asked about their end-of-life care preferences (EOLCPs) by a clinician and who had completed an advance directive (AD). To examine the association of having had an EOLCP discussion and AD completion.

SUBJECTS AND METHODS

A random sample of HMO members aged 65 years or older were asked to complete a mailed survey about health and health-related issues in 1996. Data provided by 5117 seniors (80% response rate) were used to estimate the prevalence of EOLCP and AD among seniors overall and in specific risk groups. Bivariate and multiple logistic regression models were used to identify predictors of AD completion, especially having been asked about EOLCP.

RESULTS

One third of seniors reported having an AD on file with the HMO, but only 15% had talked with a clinician about EOLCP. Both having been asked about EOLCP and having an AD were positively associated with age, but not significantly associated with sex, race/ethnicity, marital status, or self-rated health status. Having been asked by a clinician about EOLCP was significantly associated with completion of an AD.