Cathy Smith lab

From bench to bedside, the Department of Medicine focuses on generating knowledge from research that will alleviate human suffering through the prevention and treatment of disease.Over the last decade, the Department has ranked at or near the top among all departments of medicine in research dollars granted by the National Institutes of Health (NIH).

Including all sources, we currently receive more than 1,100 grants, fellowships and contracts totaling more than $200 million. Our continued accomplishments in this highly competitive arena attest to the quality and significance of the research performed by our basic and clinical scientists. Important for this success is the research environment at UCSF, which, along with its collaborative culture, affords virtually unlimited opportunities for interdisciplinary research and education.

Research Grants

In calendar 2018, Department of Medicine investigators received 231 new peer-review grants and fellowships, as well as a combined total of 279 new sub-awards, joint personnel agreements, and contracts for a combined dollar amount of $412.9million. These 15 grants were the largest.

1.  Alan Ashworth, PhD; Eric Small, MD; Emily Bergsland, MD; Robert A. Hiatt, MD, PhD; Ben Braun, MD, PhD; and Kate Shumate, MPA, received a five-year, $41.2 million grant from the National Cancer Institute for the Helen Diller Family Comprehensive Cancer Center. 

2.  Stanton Glantz, PhD; Pamela Ling, MD, MPH; Carolyn Calfee, MD, MAS; Jeffrey Gotts, MD, PhD; Michael Matthay, MD; Matthew Springer, PhD; Gideon St. Helen, PhD; and Neal Benowitz, MD, received a five-year, $20 million grant from the National Heart, Lung and Blood Institute for a project titled “Integrated Health, Behavioral and Economic Research on Current and Emerging Tobacco Products.”

3.  David Erle, MD; Prescott Woodruff, MD, MPH; Nirav Bhakta, MD; Walter Eckalbar, PhD; John Fahy, MD; and Feroz Papa, MD, PhD, received a five-year, $7 million grant from the National Institute of Allergy and Infectious Diseases for a project titled “Understanding Asthma Endotypes.”

4.  Carolyn Calfee, MD, MAS; Michael Matthay, MD; Kevin Delucchi, PhD; Lorraine Ware, MD; and B. Taylor Thompson, MD, received a six-year, $6.8 million grant from the National Heart, Lung and Blood Institute for a project titled “Precision Medicine in the Acute Respiratory Distress Syndrome.”

5.  Kenneth Covinsky, MD, MPH, BS; Mike Steinman, MD; John Boscardin, PhD; Rebecca Sudore, MD; Brie Williams, MD, MS; Alex Smith, MD, MPH, MS; Sei Lee, MD, MAS; Louise Walter, MD; and Kristine Yaffe, MD, received a five-year, $6.2 million grant from the National Institute on Aging for the UCSF Older Americans Independence Center.

6.  Jacquelyn Maher, MD; Holger Willenbring, MD, PhD; Sandy Feng, MD, PhD; Jody Baron, MD, PhD; and James P. Grenert, MD, PhD, received a five-year, $6 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases for the UCSF Liver Center.

7.  Steve Schroeder, MD; Jason Satterfield, PhD; Catherine Saucedo; Christine Cheng; Jennifer Matekuare; Brian Clark; Jennifer Lucero; Maria Pamatmat; and Tony Wu received a five-year, $5 million grant from the SAMHSA Center for Mental Health Services for the National Center of Excellence for Tobacco-Free Recovery.

8.  John Metcalfe, MD, PhD, MPH; and David Engelthaler, PhD, a key collaborator from Translational Genomics Research Institue, received a 5-year, $3.8 million grant from the National Institute of Health (NIH)/National Institute of Allergy and Infectious Disease (NIAID) for Multidrug-resistant tuberculosis (MDR-TB), a worsening global public health crisis [Novel next-generation sequencing assay for monitoring multidrug-resistant tuberculosis treatment in the setting of HIV infection].

9.  Veronica Ann Yank, MD; Leah Karliner, MD; Kenneth Covinsky, MD, MPH, BS; Catherine (Kit) Chesla, RN, PhD, FAAN; Jing Cheng, MD, MS, PhD; and key collaborators from Stanford University and Texas A&M University received a five-year, $3.8 million grant from the National Institute on Aging for a project titled “Evaluating the Effectiveness of an Online Small-Group Self-Management Workshop for Rural Caregivers of Individuals with Alzheimer's Disease and Related.”

10.  Ralph Gonzales, MD, MSPH; Urmimala Sarkar, MD, MPH; Madeline Mann; James Harrison, PhD; Tasce Bongiovanni, MD; William Brown, PhD; and Mathew Pantell, MD, received a five-year, $3.6 million grant from PHS Agency for Healthcare Research and Quality for the UCSF Learning Health System K12 Career Development Program.

11.  Philip J. Rosenthal, MD; Sam Nsobya, BBLT, MSC, PhD; Jean Bosco Ouedraogo, MD, PhD; Roland Cooper, PhD; and Jeffrey Bailey, MD, PhD, received a five-year, $3.5 million grant from the National Institute of Allergy & Infectious Diseases for a project titled “Mechanisms of varied sensitivity of P. falciparum field isolates to the antimalarial drug pipeline.”

12.  Monica Gandhi, MD, MPH; David Glidden, PhD; Hideaki Okochi, PhD; Leslie Z. Benet, PhD; Rivet Amico, PhD; Jared Baeten, MD, PhD; Kenneth Ngure, MPH, MSc, PhD; and Nelly Mugo, MBChB, MMed, MPH, received a five-year, $3.5 million grant from National Institute of Allergy and Infectious Diseases for a project titled “Point-of-care Urine Monitoring of Adherence (PUMA): Testing a Real-Time Urine Assay of Tenofovir in PrEP.”

13.  Alison Huang, MD, MAS; Margaret Chesney, PhD; Eric Vittinghoff, PhD; Wendy Mendes, PhD; Sarah Pawlowsky, DPT; and Leslee Subak, MD, received a five-year, $3.4 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases for a project titled “A Randomized Controlled Trial of a Group-Based Therapeutic Yoga Intervention for Urinary Incontinence in Ambulatory Older Women.”

14.  Diane Havlir, MD; Edwin Charlebois, PhD, MPH; Ted Ruel, MD; and key collaborators from Makerere University, Uganda and the Kenya Medical Research Institute received a 2-year, $3.4 million grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development for the Strategic antiretroviral therapy and HIV testing for youth in rural Africa (SATURN) study.

15.  Adithya Cattamanchi, MD; Payam Nahid, MD, MPH; Patrick Phillips, PhD, MS, MA; Amanda Sammann, MD, MPH; and key collaborators at the Infectious Diseases Research Collaboration, the Uganda Tuberculosis Implementation Research Consortium, and John Hopkins Bloomberg School of Public Health received a $3.3 million grant from the National Heart, Lung and Blood Institute for a project titled “Options for Delivery of Short-Course Tuberculosis Preventive Therapy: The 3HP Options Trial.”