BMJ (Clinical research ed.)
Authors: Majeed A, Gray J, Ambler G, Carroll K, Bindman AB
Volume 170 of Issue 4 | Journal of immunology (Baltimore, Md. : 1950)
Authors: Mohrs M, Lacy DA, Locksley RM
Activation of naive Th lymphocytes by the TCR and the costimulatory molecule, CD28, is believed to provide competent signals for differentiation to effector cells. Such activated cells proliferated and expressed IL-2, but arrested in an immature state maintained by CTLA-4. Although unresponsive to restimulation by TCR/CD28 alone, restimulation with TCR/CD28 and either Stat4- or Stat6-mediated cytokine signals rescued cells to proliferate and differentiate to the appropriately matched canonical Th subsets. Addition of IL-4 at defined periods revealed that naive T cells were receptive to IL-4-mediated differentiation for up to 3 days after their initial priming. A Stat-dependent anergic checkpoint between clonal expansion and effector cell differentiation may defer the cytokine profile to be instructed at the site of infection, thus preventing the unregulated development of potentially damaging effector cells.
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Volume 114 of Issue 3 | The American journal of medicine
Authors: Ziv E, Kahn A, Cauley J, Morin P, Saiz R, Browner W
AIDS (London, England)
Authors: Deeks SG, Grant RM, Wrin T, Paxinos EE, Liegler T, Hoh R, Martin JN, Petropoulos CJ
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Authors: Chapurlat RD, Bauer DC, Nevitt M, Stone K, Cummings SR
JAMA
Authors: Steinman MA, Landefeld CS, Gonzales R
JAMA
Authors: Bradley DJ, Bradley EA, Baughman KL, Berger RD, Calkins H, Goodman SN, Kass DA, Powe NR
Neurology
Authors: Du AT, Schuff N, Zhu XP, Jagust WJ, Miller BL, Reed BR, Kramer JH, Mungas D, Yaffe K, Chui HC, Weiner MW
Volume 107 of Issue 5 | Circulation
Authors: Angeja BG, Grossman W
Bioorganic & medicinal chemistry letters
Authors: Dhar TG, Watterson SH, Chen P, Shen Z, Gu HH, Norris D, Carlsen M, Haslow KD, Pitts WJ, Guo J, Chorba J, Fleener CA, Rouleau KA, Townsend R, Hollenbaugh D, Iwanowicz EJ