The Journal of physiology
Authors: Lansdell KA, Cai Z, Kidd JF, Sheppard DN
The Journal of biological chemistry
Authors: Hanley K, Kömüves LG, Ng DC, Schoonjans K, He SS, Lau P, Bikle DD, Williams ML, Elias PM, Auwerx J, Feingold KR
The Journal of infectious diseases
Authors: Binley JM, Schiller DS, Ortiz GM, Hurley A, Nixon DF, Markowitz MM, Moore JP
Human molecular genetics
Authors: Dreyer SD, Morello R, German MS, Zabel B, Winterpacht A, Lunstrum GP, Horton WA, Oberg KC, Lee B
JAMA
Authors: Shlipak MG, Simon JA, Vittinghoff E, Lin F, Barrett-Connor E, Knopp RH, Levy RI, Hulley SB
Proceedings of the National Academy of Sciences of the United States of America
Authors: Ma T, Song Y, Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS
Archives of internal medicine
Authors: Simon JA, Hudes ES
Archives of internal medicine
Authors: Ernster VL, Barclay J, Kerlikowske K, Wilkie H, Ballard-Barbash R
The Journal of biological chemistry
Authors: Simon DI, Wei Y, Zhang L, Rao NK, Xu H, Chen Z, Liu Q, Rosenberg S, Chapman HA
Volume 288 of Issue 5463 | Science (New York, N.Y.)
Authors: Loots GG, Locksley RM, Blankespoor CM, Wang ZE, Miller W, Rubin EM, Frazer KA
Long-range regulatory elements are difficult to discover experimentally; however, they tend to be conserved among mammals, suggesting that cross-species sequence comparisons should identify them. To search for regulatory sequences, we examined about 1 megabase of orthologous human and mouse sequences for conserved noncoding elements with greater than or equal to 70% identity over at least 100 base pairs. Ninety noncoding sequences meeting these criteria were discovered, and the analysis of 15 of these elements found that about 70% were conserved across mammals. Characterization of the largest element in yeast artificial chromosome transgenic mice revealed it to be a coordinate regulator of three genes, interleukin-4, interleukin-13, and interleukin-5, spread over 120 kilobases.
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