V Courtney Broaddus, MD

Professor

Pulmonary, Critical Care, Allergy and Sleep Medicine

Education
Post-Doc Fellow/Scholar, 1986 - Medicine, University of California, San Francisco
Residency, 1982 - School of Medicine, University of Pennsylvania
Medical Degree, 1979 - Medicine, University of Pennsylvania
BS, 1975 - Zoology, Duke University
Honors and Awards
  • Elizabeth Rich Award, American Thoracic Society, 2018
  • Wagner Medal, International Mesothelioma Interest Group, 2016
  • John F. Murray Distinguished Professorship, UCSF, 2012
  • Pioneer Award, The Mesothelioma Applied Research Foundation, 2010
Publications
  1. Lee HK, Noh MH, Hong SW, Kim SM, Kim SH, Kim YS, Broaddus VC, Hur DY. Erlotinib Activates Different Cell Death Pathways in EGFR-mutant Lung Cancer Cells Grown in 3D Versus 2D Culture Systems. 2021. PMID: 33788717


  2. Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cantí C, Cao B, Caraglia M, Caramés B, Carchman EH, Cardenal-Muñoz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmona-Gutierrez D, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1. 2021. PMID: 33634751


  3. Richard Horuk, V Courtney Broaddus, Caroline A Hébert. The Role of Interleukin-8 in Inflammatory Diseases. 2020. PMID:


  4. Broaddus VC. Clearing the Air - A Conservative Option for Spontaneous Pneumothorax. The New England journal of medicine 2020. PMID: 31995695


  5. Follo C, Cheng Y, Richards WG, Bueno R, Broaddus VC. Autophagy facilitates the release of immunogenic signals following chemotherapy in 3D models of mesothelioma. Molecular carcinogenesis 2019. PMID: 31215708


  6. Follo C, Cheng Y, Richards WG, Bueno R, Broaddus VC. Inhibition of autophagy initiation potentiates chemosensitivity in mesothelioma. Molecular carcinogenesis 2017. PMID: 29073722


  7. V. Courtney Broaddus, Carlo Follo, Dario Barbone. 3D Models of Mesothelioma in the Study of Mechanisms of Cell Survival. Asbestos and Mesothelioma 2017. PMID:


  8. asey Ager, Matthew Reilley, Courtney Nicholas, Todd Bartkowiak, Ashvin Jaiswal, Michael Curran, Tina C. Albershardt, Anshika Bajaj, Jacob F. Archer, Rebecca S. Reeves, Lisa Y. Ngo, Peter Berglund, Jan ter Meulen, Caroline Denis, Hormas Ghadially, Thomas Arnoux, Fabien Chanuc, Nicolas Fuseri, Robert W. Wilkinson, Nicolai Wagtmann, Yannis Morel, Pascale Andre, Michael B. Atkins, Matteo S. Carlino, Antoni Ribas, John A. Thompson, Toni K. Choueiri, F. Stephen Hodi, Wen-Jen Hwu, David F. McDermott, Victoria Atkinson, Jonathan S. Cebon, Bernie Fitzharris, Michael B. Jameson, Catriona McNeil, Andrew G. Hill, Eric Mangin, Malidi Ahamadi, Marianne van Vugt, Mariëlle van Zutphen, Nageatte Ibrahim, Georgina V. Long, Robyn Gartrell, Zoe Blake, Ines Simoes, Yichun Fu, Takuro Saito, Yingzhi Qian, Yan Lu, Yvonne M. Saenger, Sadna Budhu, Olivier De Henau, Roberta Zappasodi, Kyle Schlunegger, Bruce Freimark, Jeff Hutchins, Christopher A. Barker, Jedd D. Wolchok, Taha Merghoub, Elena Burova, Omaira Allbritton, Peter Hong, Jie Dai, Jerry Pei, Matt Liu, Joel Kantrowitz, Venus Lai, William Poueymirou, Douglas MacDonald, Ella Ioffe, Markus Mohrs, William Olson, Gavin Thurston, Cristian Capasso, Federica Frascaro, Sara Carpi, Siri Tähtinen, Sara Feola, Manlio Fusciello, Karita Peltonen, Beatriz Martins, Madeleine Sjöberg, Sari Pesonen, Tuuli Ranki, Lukasz Kyruk, Erkko Ylösmäki, Vincenzo Cerullo, Fabio Cerignoli, Biao Xi, Garret Guenther, Naichen Yu, Lincoln Muir, Leyna Zhao, Yama Abassi, Víctor Cervera-Carrascón, Mikko Siurala, João Santos, Riikka Havunen, Suvi Parviainen, Akseli Hemminki, Angus Dalgleish, Satvinder Mudan, Mark DeBenedette, Ana Plachco, Alicia Gamble, Elizabeth W. Grogan, John Krisko, Irina Tcherepanova, Charles Nicolette, Pooja Dhupkar, Ling Yu, Eugenie S. Kleinerman, Nancy Gordon, Italia Grenga, Lauren Lepone, Sofia Gameiro, Karin M. Knudson, Massimo Fantini, Kwong Tsang, James Hodge, Renee Donahue, Jeffrey Schlom, Elizabeth Evans, Holm Bussler, Crystal Mallow, Christine Reilly, Sebold Torno, Maria Scrivens, Cathie Foster, Alan Howell, Leslie Balch, Alyssa Knapp, John E. Leonard, Mark Paris, Terry Fisher, Siwen Hu-Lieskovan, Antoni Ribas, Ernest Smith, Maurice Zauderer, William Fogler, Marilyn Franklin, Matt Thayer, Dan Saims, John L. Magnani, Jian Gong, Michael Gray, Jeff Hutchins, Bruce Freimark, George Fromm, Suresh de Silva, Louise Giffin, Xin Xu, Jason Rose, Taylor H. Schreiber, Massimo Fantini, Sofia R. Gameiro, Karin M. Knudson, Paul E. Clavijo, Clint T. Allen, Renee Donahue, Lauren Lepone, Italia Grenga, James W. Hodge, Kwong Y. Tsang, Jeffrey Schlom, Michael Gray, Jian Gong, Jeff Hutchins, Bruce Freimark, Jane Grogan, Nicholas Manieri, Eugene Chiang, Patrick Caplazi, Mahesh Yadav, Patrick Hagner, Hsiling Chiu, Michelle Waldman, Anke Klippel, Anjan Thakurta, Michael Pourdehnad, Anita Gandhi, Ian Henrich, Laura Quick, Rob Young, Margaret Chou, Andrew Hotson, Stephen Willingham, Po Ho, Carmen Choy, Ginna Laport, Ian McCaffery, Richard Miller, Kimberly A. Tipton, Kenneth R. Wong, Victoria Singson, Chihunt Wong, Chanty Chan, Yuanhiu Huang, Shouchun Liu, Jennifer H. Richardson, W. Michael Kavanaugh, James West, Bryan A. Irving, Kimberly A. Tipton, Kenneth R. Wong, Victoria Singson, Chihunt Wong, Chanty Chan, Yuanhiu Huang, Shouchun Liu, Jennifer H. Richardson, W. Michael Kavanaugh, James West, Bryan A. Irving, Ritika Jaini, Matthew Loya, Charis Eng, Melissa L. Johnson, Alex A. Adjei, Mateusz Opyrchal, Suresh Ramalingam, Pasi A. Janne, George Dominguez, Dmitry Gabrilovich, Laura de Leon, Jeannette Hasapidis, Scott J. Diede, Peter Ordentlich, Scott Cruickshank, Michael L. Meyers, Matthew D. Hellmann, Pawel Kalinski, Amer Zureikat, Robert Edwards, Ravi Muthuswamy, Nataša Obermajer, Julie Urban, Lisa H. Butterfield, William Gooding, Herbert Zeh, David Bartlett, Olga Zubkova, Larissa Agapova, Marina Kapralova, Liudmila Krasovskaia, Armen Ovsepyan, Maxim Lykov, Artem Eremeev, Vladimir Bokovanov, Olga Grigoryeva, Andrey Karpov, Sergey. 31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two. Journal for immunotherapy of cancer 2016. PMID:


  9. Follo C, Barbone D, Richards WG, Bueno R, Broaddus VC. Autophagy initiation correlates with the autophagic flux in 3D models of mesothelioma and with patient outcome. Autophagy 2016. PMID: 27097020


  10. Barbone D, Van Dam L, Follo C, Jithesh PV, Zhang SD, Richards WG, Bueno R, Fennell DA, Broaddus VC. Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma. PloS one 2016. PMID: 26982031


  11. Weinstock T, Kidambi P, Channick CL, Michaud GC, Broaddus C, Makani SS, Wiener RS, Wilson KC, Thomson CC. Implementation of Lung Cancer Screening Programs with Low-Dose Computed Tomography in Clinical Practice. Annals of the American Thoracic Society 2016. PMID: 26963353


  12. V. Courtney Broaddus, Richard W. Light. 79 Pleural Effusion. Murray and Nadel\u0027s Textbook of Respiratory Medicine 2016. PMID:


  13. V. Courtney Broaddus, Bruce W.S. Robinson. 82 Pleural Tumors. Murray and Nadel\u0027s Textbook of Respiratory Medicine 2016. PMID:


  14. John F. Murray, Jay A. Nadel, V. Courtney Broaddus, Robert J. Mason, Joel D. Ernst, Talmadge E. King, Stephen C. Lazarus, Arthur S. Slutsky, Michael B. Gotway. Preface to the Sixth Edition. Murray and Nadel\u0027s Textbook of Respiratory Medicine 2016. PMID:


  15. Barbone D, Follo C, Echeverry N, Gerbaudo VH, Klabatsa A, Bueno R, Felley-Bosco E, Broaddus VC. Autophagy Correlates with the Therapeutic Responsiveness of Malignant Pleural Mesothelioma in 3D Models. PloS one 2015. PMID: 26284517


  16. Broaddus VC, Grippi MA. Medical Subspecialty Textbooks in the 21st Century. Essential or Headed for Extinction? Annals of the American Thoracic Society 2015. PMID: 26177458


  17. Acencio MM, Soares B, Marchi E, Silva CS, Teixeira LR, Broaddus VC. Inflammatory Cytokines Contribute to Asbestos-Induced Injury of Mesothelial Cells. Lung 2015. PMID: 26059286


  18. Echeverry N, Ziltener G, Barbone D, Weder W, Stahel RA, Broaddus VC, Felley-Bosco E. Inhibition of autophagy sensitizes malignant pleural mesothelioma cells to dual PI3K/mTOR inhibitors. Cell death & disease 2015. PMID: 25950487


  19. Busacca S, Chacko AD, Klabatsa A, Arthur K, Sheaff M, Barbone D, Mutti L, Gunasekharan VK, Gorski JJ, El-Tanani M, Broaddus VC, Gaudino G, Fennell DA. BAK and NOXA are critical determinants of mitochondrial apoptosis induced by bortezomib in mesothelioma. PloS one 2013. PMID: 23762382


  20. Collin Blakely, Tina Bose, Melissa Wheeler, Raphael Bueno, David Sugarbaker, David Jablons, V. Courtney Broaddus, Lisa Coussens. Abstract 4723: Macrophages foster neoplastic progression of malignant mesothelioma and limit response to chemotherapy. Immunology 2013. PMID:


  21. Barbone D, Cheung P, Battula S, Busacca S, Gray SG, Longley DB, Bueno R, Sugarbaker DJ, Fennell DA, Broaddus VC. Vorinostat eliminates multicellular resistance of mesothelioma 3D spheroids via restoration of Noxa expression. PloS one 2012. PMID: 23300762


  22. Lee HK, Park GB, Kim YS, Song H, Broaddus VC, Hur DY. Ligation of CM1 enhances apoptosis of lung cancer cells through different mechanisms in conformity with EGFR mutation. International journal of oncology 2012. PMID: 23232551


  23. I. Stasik, J.L. Hurwitz, D. Barbone, V.C. Broaddus, S.G. Gray, K.J. O'Byrne, D.A. Fennell, D.B. Longley. 842 FLIP as a Critical Target for Vorinostat in Mesothelioma. European Journal of Cancer 2012. PMID:


  24. V. Courtney Broaddus, Sailaja Battula, Dario Barbone, Collin Blakely, David J. Sugarbaker, Raphael Bueno, Lisa M. Coussens. Abstract LB-251: Manipulation of macrophage phenotype enhances the apoptotic response to chemotherapy in mesothelioma. Experimental and Molecular Therapeutics 2012. PMID:


  25. Hurwitz JL, Stasik I, Kerr EM, Holohan C, Redmond KM, McLaughlin KM, Busacca S, Barbone D, Broaddus VC, Gray SG, O'Byrne KJ, Johnston PG, Fennell DA, Longley DB. Vorinostat/SAHA-induced apoptosis in malignant mesothelioma is FLIP/caspase 8-dependent and HR23B-independent. European journal of cancer (Oxford, England : 1990) 2011. PMID: 22154545


  26. Collin M. Blakely, Nikita Kolhatkar, Magnus Johansson, Cornelia M. Hainer, Melissa Wheeler, Adam Yagui-Beltran, Raphael Bueno, David J. Sugarbaker, Thierry M. Jahan, Brian L. West, David M. Jablons, V. Courtney Broaddus, Lisa M. Coussens. Abstract C231: Colony-stimulating factor-1 receptor blockade reprograms malignant mesothelioma tumor microenvironments and decreases tumor growth. Tumor Microenvironment 2011. PMID:


  27. Phung YT, Barbone D, Broaddus VC, Ho M. Rapid generation of in vitro multicellular spheroids for the study of monoclonal antibody therapy. Journal of Cancer 2011. PMID: 22043235


  28. Barbone D, Ryan JA, Kolhatkar N, Chacko AD, Jablons DM, Sugarbaker DJ, Bueno R, Letai AG, Coussens LM, Fennell DA, Broaddus VC. The Bcl-2 repertoire of mesothelioma spheroids underlies acquired apoptotic multicellular resistance. Cell death & disease 2011. PMID: 21697949


  29. Collin M. Blakely, Nikita Kolhatkar, Magnus Johansson, Adam Beltran, Dario Barbone, Raphael Bueno, David Sugarbaker, Thierry Jahan, David Jablons, V. Courtney Broaddus, Lisa M. Coussens. Abstract 454: Targeting macrophages in a preclinical model of malignant mesothelioma. Tumor Biology 2011. PMID:


  30. Iyer AK, Lan X, Zhu X, Su Y, Feng J, Zhang X, Gao D, Seo Y, Vanbrocklin HF, Broaddus VC, Liu B, He J. Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas. Cancer research 2011. PMID: 21447742


  31. Xiang X, Phung Y, Feng M, Nagashima K, Zhang J, Broaddus VC, Hassan R, Fitzgerald D, Ho M. The development and characterization of a human mesothelioma in vitro 3D model to investigate immunotoxin therapy. PloS one 2011. PMID: 21305058


  32. Broaddus VC, Everitt JI, Black B, Kane AB. Non-neoplastic and neoplastic pleural endpoints following fiber exposure. Journal of toxicology and environmental health. Part B, Critical reviews 2011. PMID: 21534088


  33. Nikita S. Kolhatkar, Magnus Johansson, Dario Barbone, Adam Yagui-Beltran, Raphael Bueno, David J. Sugarbaker, David M. Jablons, V. Courtney Broaddus, Lisa M. Coussens. Abstract 3844: Targeting macrophages as a novel therapeutic approach for malignant pleural mesothelioma. Tumor Biology 2010. PMID:


  34. V. Courtney Broaddus, Richard W. Light. Chapter 73 Pleural Effusion. Murray and Nadel\u0027s Textbook of Respiratory Medicine 2010. PMID:


  35. V. Courtney Broaddus, Bruce W.S. Robinson. Chapter 75 Tumors of the Pleura. Murray and Nadel\u0027s Textbook of Respiratory Medicine 2010. PMID:


  36. John F. Murray, Jay A. Nadel, Robert J. Mason, V. Courtney Broaddus, Thomas R. Martin, Talmadge E. King, Dean E. Schraufnagel. Preface to the Fifth Edition. Murray and Nadel\u0027s Textbook of Respiratory Medicine 2010. PMID:


  37. Dario Barbone, Dean A. Fennell, V. Courtney Broaddus. Abstract B31: Multicellular resistance to bortezomib acquired by mesothelioma spheroids can be reversed by modulation of the Bcl-2 repertoire. Apoptosis, Necrosis, and Autophagy 2009. PMID:


  38. Bidlingmaier S, He J, Wang Y, An F, Feng J, Barbone D, Gao D, Franc B, Broaddus VC, Liu B. Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma. Cancer research 2009. PMID: 19221091


  39. Yang TM, Barbone D, Fennell DA, Broaddus VC. Bcl-2 family proteins contribute to apoptotic resistance in lung cancer multicellular spheroids. American journal of respiratory cell and molecular biology 2008. PMID: 19097992


  40. Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus VC. mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids. American journal of respiratory cell and molecular biology 2008. PMID: 18511708


  41. V Courtney Broaddus. Physiology: fluid and solute exchange in normal physiological states. Textbook of Pleural Diseases 2008. PMID:


  42. Barbone D, Yang TM, Morgan JR, Gaudino G, Broaddus VC. Mammalian target of rapamycin contributes to the acquired apoptotic resistance of human mesothelioma multicellular spheroids. The Journal of biological chemistry 2008. PMID: 18339627


  43. An F, Drummond DC, Wilson S, Kirpotin DB, Nishimura SL, Broaddus VC, Liu B. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies. Molecular cancer therapeutics 2008. PMID: 18319332


  44. Hassan R, Broaddus VC, Wilson S, Liewehr DJ, Zhang J. Anti-mesothelin immunotoxin SS1P in combination with gemcitabine results in increased activity against mesothelin-expressing tumor xenografts. Clinical cancer research : an official journal of the American Association for Cancer Research 2007. PMID: 18056197


  45. Araya J, Cambier S, Markovics JA, Wolters P, Jablons D, Hill A, Finkbeiner W, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. Volume 117 of Issue 11. The Journal of clinical investigation 2007. PMID: 17965775


  46. Acencio MM, Vargas FS, Marchi E, Carnevale GG, Teixeira LR, Antonangelo L, Broaddus VC. Pleural mesothelial cells mediate inflammatory and profibrotic responses in talc-induced pleurodesis. Lung 2007. PMID: 17932716


  47. Abayasiriwardana KS, Barbone D, Kim KU, Vivo C, Lee KK, Dansen TB, Hunt AE, Evan GI, Broaddus VC. Malignant mesothelioma cells are rapidly sensitized to TRAIL-induced apoptosis by low-dose anisomycin via Bim. Molecular cancer therapeutics 2007. PMID: 17938269


  48. Carbone M, Albelda SM, Broaddus VC, Flores RM, Hillerdal G, Jaurand MC, Kjaerheim K, Pass HI, Robinson B, Tsao A. Eighth international mesothelioma interest group. Oncogene 2007. PMID: 17496929


  49. V.C. Broaddus, K. Abayasiriwardana, S. Wilson, D. Barbone, G. Evan. 165 TRAIL and damage pathways converge to induce synergistic apoptosis. Lung Cancer 2006. PMID:


  50. D. Barbone, K. Abayasiriwardana, S. Wilson, G. Gaudino, V.C. Broaddus. 166 Three-dimensional models of mesothelioma and multi-cellular apoptotic resistance. Lung Cancer 2006. PMID:


  51. B. Liu, F. An, S. Bidlingmaier, S. Wilson, V.C. Broaddus, S.L. Nishimura, D.C. Drummond. 53 Identifying and targeting a spectrum of internalizing cell surface antigens expressed by mesothelioma. Lung Cancer 2006. PMID:


  52. Shannon Michelle Wilson, Ki-Up Kim, Keith S. Abayasiriwardana, Lars Fjellbirkland, Zhidong Xu, David M. Jablons, Stephen L. Nishimura, V. Courtney Broaddus. Inhibition of the PI3K and mTOR survival pathways enhances apoptosis in human mesothelioma tumor fragment spheroids. 2006. PMID:


  53. Dario Barbone, Keith Abayasiriwardana, Ramir Arcega, Shannon Wilson, V. Courtney Broaddus. Malignant Mesothelioma multicellular spheroids: mechanism of multicellular resistance. 2006. PMID:


  54. K Abayasiriwardana, K Kim, K Lee, C Vivo, T Dansen, A Hunt, G Evan, V C Broaddus. Selective apoptosis of mesothelioma cells is mediated in part by the BH3-only protein Bim. 2006. PMID:


  55. Kim KU, Wilson SM, Abayasiriwardana KS, Collins R, Fjellbirkeland L, Xu Z, Jablons DM, Nishimura SL, Broaddus VC. A novel in vitro model of human mesothelioma for studying tumor biology and apoptotic resistance. American journal of respiratory cell and molecular biology 2005. PMID: 16123394


  56. Broaddus VC, Dansen TB, Abayasiriwardana KS, Wilson SM, Finch AJ, Swigart LB, Hunt AE, Evan GI. Bid mediates apoptotic synergy between tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and DNA damage. The Journal of biological chemistry 2004. PMID: 15615731


  57. Mutti L, Broaddus VC. Malignant mesothelioma as both a challenge and an opportunity. Oncogene 2004. PMID: 15516978


  58. Evaldo Marchi, Francisco S. Vargas, Milena M. Acencio, Mauro Canzian, Orlando G. Ribeiro, Olga M. Ibanez, V. Courtney Broaddus. Asbestos-Induced Pleural Inflammation in Mice Genetically Selected for Maximum or Minimum Inflammatory Response. CHEST Journal 2004. PMID:


  59. Leard LE, Broaddus VC. Mesothelial cell proliferation and apoptosis. Respirology (Carlton, Vic.) 2004. PMID: 15362999


  60. Geiser T, Ishigaki M, van Leer C, Matthay MA, Broaddus VC. H(2)O(2) inhibits alveolar epithelial wound repair in vitro by induction of apoptosis. American journal of physiology. Lung cellular and molecular physiology 2004. PMID: 15121637


  61. Fjellbirkeland L, Cambier S, Broaddus VC, Hill A, Brunetta P, Dolganov G, Jablons D, Nishimura SL. Integrin alphavbeta8-mediated activation of transforming growth factor-beta inhibits human airway epithelial proliferation in intact bronchial tissue. The American journal of pathology 2003. PMID: 12875973


  62. Crapo JD, Broaddus VC, Brody AR, Malindzak G, Samet J, Wright JR. Workshop on lung disease and the environment: where do we go from here? American journal of respiratory and critical care medicine 2003. PMID: 12851246


  63. Mu D, Cambier S, Fjellbirkeland L, Baron JL, Munger JS, Kawakatsu H, Sheppard D, Broaddus VC, Nishimura SL. The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. Volume 157 of Issue 3. The Journal of cell biology 2002. PMID: 11970960


  64. Broaddus VC. Apoptosis and asbestos-induced disease: Is there a connection? The Journal of laboratory and clinical medicine 2001. PMID: 11329527


  65. Cambier S, Mu DZ, O'Connell D, Boylen K, Travis W, Liu WH, Broaddus VC, Nishimura SL. A role for the integrin alphavbeta8 in the negative regulation of epithelial cell growth. Cancer research 2000. PMID: 11156415


  66. Wu J, Liu W, Koenig K, Idell S, Broaddus VC. Vitronectin adsorption to chrysotile asbestos increases fiber phagocytosis and toxicity for mesothelial cells. American journal of physiology. Lung cellular and molecular physiology 2000. PMID: 11053028


  67. Liu W, Ernst JD, Broaddus VC. Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage, and apoptosis in mesothelial cells. American journal of respiratory cell and molecular biology 2000. PMID: 10970829


  68. Levresse V, Renier A, Levy F, Broaddus VC, Jaurand M. DNA breakage in asbestos-treated normal and transformed (TSV40) rat pleural mesothelial cells. Mutagenesis 2000. PMID: 10792017


  69. Marchi E, Liu W, Broaddus VC. Mesothelial cell apoptosis is confirmed in vivo by morphological change in cytokeratin distribution. American journal of physiology. Lung cellular and molecular physiology 2000. PMID: 10710525


  70. Perkins RC, Broaddus VC, Shetty S, Hamilton S, Idell S. Asbestos upregulates expression of the urokinase-type plasminogen activator receptor on mesothelial cells. American journal of respiratory cell and molecular biology 1999. PMID: 10536123


  71. Miyazaki H, Broaddus VC, Wiener-Kronish JP, Sawa T, Pittet JF, Kravchenko V, Mathison JC, Nishizawa H, Hattori S, Yamakawa T, Yamada H, Kudoh I. The effects of two antiinflammatory pretreatments on bacterial-induced lung injury. Anesthesiology 1999. PMID: 10360864


  72. Narasimhan SR, Yang L, Gerwin BI, Broaddus VC. Resistance of pleural mesothelioma cell lines to apoptosis: relation to expression of Bcl-2 and Bax. The American journal of physiology 1998. PMID: 9688948


  73. Ernst JD, Yang L, Rosales JL, Broaddus VC. Preparation and characterization of an endogenously fluorescent annexin for detection of apoptotic cells. Analytical biochemistry 1998. PMID: 9648647


  74. Nishimura SL, Broaddus VC. Asbestos-induced pleural disease. Clinics in chest medicine 1998. PMID: 9646983


  75. Broaddus VC. Asbestos, the mesothelial cell and malignancy: a matter of life or death. American journal of respiratory cell and molecular biology 1997. PMID: 9409552


  76. V. Courtney Broaddus, Lin Yang, Louis M. Scavo, Joel D. Ernst, Alice M. Boylan. Crocidolite Asbestos Induces Apoptosis of Pleural Mesothelial Cells: Role of Reactive Oxygen Species and Poly(ADP-Ribosyl) Polymerase. Environmental health perspectives 1997. PMID:


  77. Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Crocidolite asbestos induces apoptosis of pleural mesothelial cells: role of reactive oxygen species and poly(ADP-ribosyl) polymerase. Environmental health perspectives 1997. PMID: 9400715


  78. Marchi E, Broaddus VC. Mechanisms of pleural liquid formation in pleural inflammation. Current opinion in pulmonary medicine 1997. PMID: 9262118


  79. Broaddus VC, Hébert CA. Neutralization of interleukin-8 in in vivo models of lung and pleural injury. Methods in enzymology 1997. PMID: 9356994


  80. Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. The Journal of clinical investigation 1996. PMID: 8903324


  81. Boylan AM, Sanan DA, Sheppard D, Broaddus VC. Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5. Volume 96 of Issue 4. The Journal of clinical investigation 1995. PMID: 7560092


  82. Folkesson HG, Matthay MA, Hébert CA, Broaddus VC. Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. The Journal of clinical investigation 1995. PMID: 7615779


  83. V. Broaddus. Infections in the Pleural Space: An Update on Pathogenesis and Management. Seminars in respiratory and critical care medicine 1995. PMID:


  84. Boylan AM, Hébert CA, Sadick M, Wong WL, Chuntharapai A, Hoeffel JM, Hartiala KT, Broaddus VC. Interleukin-8 is a major component of pleural liquid chemotactic activity in a rabbit model of endotoxin pleurisy. The American journal of physiology 1994. PMID: 8074236


  85. Michael Matthay, V.C. Broaddus. Fluid and Hemodynamic Management in Acute Lung Injury. 1994. PMID:


  86. Broaddus VC, Feigal DW. Starting an academic career. A survey of junior academic pulmonary physicians. Chest 1994. PMID: 8205889


  87. Broaddus VC, Boylan AM, Hoeffel JM, Kim KJ, Sadick M, Chuntharapai A, Hébert CA. Neutralization of IL-8 inhibits neutrophil influx in a rabbit model of endotoxin-induced pleurisy. Journal of immunology (Baltimore, Md. : 1950) 1994. PMID: 8144895


  88. Wiener-Kronish JP, Broaddus VC. Interrelationship of pleural and pulmonary interstitial liquid. Annual review of physiology 1993. PMID: 8466174


  89. Broaddus VC, Hébert CA, Vitangcol RV, Hoeffel JM, Bernstein MS, Boylan AM. Interleukin-8 is a major neutrophil chemotactic factor in pleural liquid of patients with empyema. The American review of respiratory disease 1992. PMID: 1416405


  90. Broaddus VC, Light RW. What is the origin of pleural transudates and exudates? Chest 1992. PMID: 1516384


  91. Boylan AM, Rüegg C, Kim KJ, Hébert CA, Hoeffel JM, Pytela R, Sheppard D, Goldstein IM, Broaddus VC. Evidence of a role for mesothelial cell-derived interleukin 8 in the pathogenesis of asbestos-induced pleurisy in rabbits. The Journal of clinical investigation 1992. PMID: 1556187


  92. Broaddus VC, Araya M. Liquid and protein dynamics using a new minimally invasive pleural catheter in rabbits. Journal of applied physiology (Bethesda, Md. : 1985) 1992. PMID: 1568980


  93. Broaddus VC, Araya M, Carlton DP, Bland RD. Developmental changes in pleural liquid protein concentration in sheep. The American review of respiratory disease 1991. PMID: 1986682


  94. Broaddus VC, Wiener-Kronish JP, Staub NC. Clearance of lung edema into the pleural space of volume-loaded anesthetized sheep. Journal of applied physiology (Bethesda, Md. : 1985) 1990. PMID: 2384440


  95. J.P. Wiener-Kronish, V.C. Broaddus, K.H. Albertine. Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep. Journal of critical care 1989. PMID:


  96. Wiener-Kronish JP, Broaddus VC, Albertine KH, Gropper MA, Matthay MA, Staub NC. Relationship of pleural effusions to increased permeability pulmonary edema in anesthetized sheep. The Journal of clinical investigation 1988. PMID: 3170750


  97. Berthiaume Y, Broaddus VC, Gropper MA, Tanita T, Matthay MA. Alveolar liquid and protein clearance from normal dog lungs. Journal of applied physiology (Bethesda, Md. : 1985) 1988. PMID: 3170409


  98. Broaddus VC, Wiener-Kronish JP, Berthiaume Y, Staub NC. Removal of pleural liquid and protein by lymphatics in awake sheep. Journal of applied physiology (Bethesda, Md. : 1985) 1988. PMID: 3356657


  99. Wiener-Kronish JP, Goldstein R, Matthay RA, Biondi JW, Broaddus VC, Chatterjee K, Matthay MA. Lack of association of pleural effusion with chronic pulmonary arterial and right atrial hypertension. Chest 1987. PMID: 3677841


  100. V. Courtney Broaddus, Yves Berthiaume, James W. Biondi, Michael A. Matthay. Analytic Reviews : Hemodynamic Management of the Adult Respiratory Distress Syndrome. Journal of intensive care medicine 1987. PMID:


  101. Seltzer J, Broaddus VC, Jacobs R, Golden JA. Reactivation of coccidioides infection. The Western journal of medicine 1986. PMID: 3529635