Thiennu Vu, MD

Clinical Professor Recall

Pulmonary, Critical Care, Allergy and Sleep Medicine

Dr. Vu received her M.D. and Ph.D. from the University of California, San Francisco in 1991 after completion of the Medical Scientist Training Program. She completed a Residency in Internal Medicine at the University of California, San Diego and a Fellowship in Pulmonary and Critical Care Medicine at UCSF. She was the principal investigator of a research program focusing on the molecular mechanisms of lung development and the biology of lung progenitor and stem cells from 2000 to 2016. She currently practices pulmonary medicine at the UCSF Mt Zion Pulmonary clinic.

Education
Post-Doc Fellow/Scholar, 1996 - Medicine, University of California, San Francisco
M.D., 1991 - Medicine, University of California, San Francisco
Ph.D., 1990 - Graduate Division (Cell Biology), University of California, San Francisco
Publications

  1. Zhu W, Shen F, Mao L, Zhan L, Kang S, Sun Z, Nelson J, Zhang R, Zou D, McDougall CM, Lawton MT, Vu TH, Wu Z, Scaria A, Colosi P, Forsayeth J, Su H. Soluble FLT1 Gene Therapy Alleviates Brain Arteriovenous Malformation Severity. Volume 48 of Issue 5. Stroke 2017. PMID: 28325846


  2. Yun EJ, Lorizio W, Seedorf G, Abman SH, Vu TH. VEGF and endothelium-derived retinoic acid regulate lung vascular and alveolar development. Volume 310 of Issue 4. American journal of physiology. Lung cellular and molecular physiology 2015. PMID: 26566904


  3. Hogan BL, Barkauskas CE, Chapman HA, Epstein JA, Jain R, Hsia CC, Niklason L, Calle E, Le A, Randell SH, Rock J, Snitow M, Krummel M, Stripp BR, Vu T, White ES, Whitsett JA, Morrisey EE. Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Volume 15 of Issue 2. Cell stem cell 2014. PMID: 25105578


  4. Yun EJ, Vu TH. mSmile is necessary for bronchial smooth muscle and alveolar myofibroblast development. Volume 295 of Issue 1. Anatomical record (Hoboken, N.J. : 2007) 2011. PMID: 21956870


  5. . Integrin a6ß4 identifies an adult distal lung epithelial population with regenerative potential in mice. TO REMOVE 2011. PMID:


  6. Chapman HA, Li X, Alexander JP, Brumwell A, Lorizio W, Tan K, Sonnenberg A, Wei Y, Vu TH. Integrin a6ß4 identifies an adult distal lung epithelial population with regenerative potential in mice. Volume 121 of Issue 7. The Journal of clinical investigation 2011. PMID: 21701069


  7. Ortega N, Wang K, Ferrara N, Werb Z, Vu TH. Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation. Volume 3 of Issue 3-4. Disease models & mechanisms 2010. PMID: 20142327


  8. Kim N, Yamamoto H, Pauling MH, Lorizio W, Vu TH. Ablation of lung epithelial cells deregulates FGF-10 expression and impairs lung branching morphogenesis. Volume 292 of Issue 1. Anatomical record (Hoboken, N.J. : 2007) 2009. PMID: 19115389


  9. Leung JK, Cases S, Vu TH. P311 functions in an alternative pathway of lipid accumulation that is induced by retinoic acid. Volume 121 of Issue Pt 16. Journal of cell science 2008. PMID: 18664493


  10. Yamamoto H, Yun EJ, Gerber HP, Ferrara N, Whitsett JA, Vu TH. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Volume 308 of Issue 1. Developmental biology 2007. PMID: 17583691


  11. Kim N, Vu TH. Parabronchial smooth muscle cells and alveolar myofibroblasts in lung development. Volume 78 of Issue 1. Birth defects research. Part C, Embryo today : reviews 2006. PMID: 16622850


  12. Zhao L, Leung JK, Yamamoto H, Goswami S, Kheradmand F, Vu TH. Identification of P311 as a potential gene regulating alveolar generation. Volume 35 of Issue 1. American journal of respiratory cell and molecular biology 2006. PMID: 16484684


  13. Hartenstein B, Dittrich BT, Stickens D, Heyer B, Vu TH, Teurich S, Schorpp-Kistner M, Werb Z, Angel P. Epidermal development and wound healing in matrix metalloproteinase 13-deficient mice. Volume 126 of Issue 2. The Journal of investigative dermatology 2006. PMID: 16374453


  14. Zhao L, Wang K, Ferrara N, Vu TH. Vascular endothelial growth factor co-ordinates proper development of lung epithelium and vasculature. Volume 122 of Issue 7-8. Mechanisms of development 2005. PMID: 15927453


  15. Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH. Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment. Volume 279 of Issue 51. The Journal of biological chemistry 2004. PMID: 15456762


  16. Pauling MH, Vu TH. Mechanisms and regulation of lung vascular development. Volume 64. Current topics in developmental biology 2004. PMID: 15563945


  17. Vu TH, Alemayehu Y, Werb Z. New insights into saccular development and vascular formation in lung allografts under the renal capsule. Volume 120 of Issue 3. Mechanisms of development 2003. PMID: 12591600


  18. Vu TH. Don't mess with the matrix. Volume 28 of Issue 3. Nature genetics 2001. PMID: 11431682


  19. Engsig MT, Chen QJ, Vu TH, Pedersen AC, Therkidsen B, Lund LR, Henriksen K, Lenhard T, Foged NT, Werb Z, Delaissé JM. Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones. Volume 151 of Issue 4. The Journal of cell biology 2000. PMID: 11076971


  20. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Volume 2 of Issue 10. Nature cell biology 2000. PMID: 11025665


  21. . Biology and Regulation of the Matrix Metalloproteinases. TO REMOVE 2000. PMID:


  22. Vu TH, Werb Z. Matrix metalloproteinases: effectors of development and normal physiology. Volume 14 of Issue 17. Genes & development 2000. PMID: 10970876


  23. Delaissé JM, Engsig MT, Everts V, del Carmen Ovejero M, Ferreras M, Lund L, Vu TH, Werb Z, Winding B, Lochter A, Karsdal MA, Troen T, Kirkegaard T, Lenhard T, Heegaard AM, Neff L, Baron R, Foged NT. Proteinases in bone resorption: obvious and less obvious roles. Volume 291 of Issue 2. Clinica chimica acta; international journal of clinical chemistry 2000. PMID: 10675725


  24. Gerber HP, Vu TH, Ryan AM, Kowalski J, Werb Z, Ferrara N. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Volume 5 of Issue 6. Nature medicine 1999. PMID: 10371499


  25. Werb Z, Vu TH, Rinkenberger JL, Coussens LM. Matrix-degrading proteases and angiogenesis during development and tumor formation. Volume 107 of Issue 1. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 1999. PMID: 10190275


  26. Liu Z, Shipley JM, Vu TH, Zhou X, Diaz LA, Werb Z, Senior RM. Gelatinase B-deficient mice are resistant to experimental bullous pemphigoid. Volume 188 of Issue 3. The Journal of experimental medicine 1998. PMID: 9687525


  27. Vu TH, Shipley JM, Bergers G, Berger JE, Helms JA, Hanahan D, Shapiro SD, Senior RM, Werb Z. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Volume 93 of Issue 3. Cell 1998. PMID: 9590175


  28. . Gelatinase B: Structure, Regulation, and Function. TO REMOVE 1998. PMID: