Suzanne Noble, MD, PhD

Associate Professor

Education
M.D., 1997 - Medicine, University of California, San Francisco
Ph.D., 1995 - Graduate Division (Biochemistry), University of California, San Francisco
Postdoctoral Studies, - Graduate Division, University of California, San Francisco
Websites
Publications

  1. Xiong EH, Zhang X, Yan H, Ward HN, Lin ZY, Wong CJ, Fu C, Gingras AC, Noble SM, Robbins N, Myers CL, Cowen LE. Functional genomic analysis of genes important for Candida albicans fitness in diverse environmental conditions. Cell reports 2024. PMID: 39126650


  2. Pierre JF, Peters BM, La Torre D, Sidebottom AM, Tao Y, Zhu X, Cham CM, Wang L, Kambal A, Harris KG, Silva JF, Zaborina O, Alverdy JC, Herzog H, Witchley J, Noble SM, Leone VA, Chang EB. Peptide YY: A Paneth cell antimicrobial peptide that maintains Candida gut commensalism. Science (New York, N.Y.) 2023. PMID: 37535745


  3. Liu Z, Basso P, Hossain S, Liston SD, Robbins N, Whitesell L, Noble SM, Cowen LE. Multifactor transcriptional control of alternative oxidase induction integrates diverse environmental inputs to enable fungal virulence. Nature communications 2023. PMID: 37500616


  4. Lash E, Prudent V, Stogios PJ, Savchenko A, Noble SM, Robbins N, Cowen LE. Ent2 Governs Morphogenesis and Virulence in Part through Regulation of the Cdc42 Signaling Cascade in the Fungal Pathogen Candida albicans. mBio 2023. PMID: 36809010


  5. Basso P, Dang EV, Urisman A, Cowen LE, Madhani HD, Noble SM. Deep tissue infection by an invasive human fungal pathogen requires lipid-based suppression of the IL-17 response. Cell host & microbe 2022. PMID: 36323314


  6. Noble S, Burgess SM, Strauss E. Christine Guthrie (1945-2022). Science (New York, N.Y.) 2022. PMID: 36048934


  7. Shao TY, Kakade P, Witchley JN, Frazer C, Murray KL, Ene IV, Haslam DB, Hagan T, Noble SM, Bennett RJ, Way SS. Candida albicans oscillating UME6 expression during intestinal colonization primes systemic Th17 protective immunity. 2022. PMID: 35584674


  8. Fu C, Zhang X, Veri AO, Iyer KR, Lash E, Xue A, Yan H, Revie NM, Wong C, Lin ZY, Polvi EJ, Liston SD, VanderSluis B, Hou J, Yashiroda Y, Gingras AC, Boone C, O'Meara TR, O'Meara MJ, Noble S, Robbins N, Myers CL, Cowen LE. Leveraging machine learning essentiality predictions and chemogenomic interactions to identify antifungal targets. 2021. PMID: 34764269


  9. Ost KS, O'Meara TR, Stephens WZ, Chiaro T, Zhou H, Penman J, Bell R, Catanzaro JR, Song D, Singh S, Call DH, Hwang-Wong E, Hanson KE, Valentine JF, Christensen KA, O'Connell RM, Cormack B, Ibrahim AS, Palm NW, Noble SM, Round JL. Adaptive immunity induces mutualism between commensal eukaryotes. Nature 2021. PMID: 34262174


  10. Witchley JN, Basso P, Brimacombe CA, Abon NV, Noble SM. Recording of DNA-binding events reveals the importance of a repurposed Candida albicans regulatory network for gut commensalism. Cell host & microbe 2021. PMID: 33915113


  11. Witchley JN, Penumetcha PM, Noble SM. Visualization of Candida albicans in the Murine Gastrointestinal Tract Using Fluorescent In Situ Hybridization. Journal of visualized experiments : JoVE 2019. PMID: 31762460


  12. Brimacombe CA, Burke JE, Parsa JY, Catania S, O'Meara TR, Witchley JN, Burrack LS, Madhani HD, Noble SM. A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans. PLoS biology 2019. PMID: 31226107


  13. Witchley JN, Penumetcha P, Abon NV, Woolford CA, Mitchell AP, Noble SM. Candida albicans Morphogenesis Programs Control the Balance between Gut Commensalism and Invasive Infection. Cell host & microbe 2019. PMID: 30870623


  14. O'Meara TR, Duah K, Guo CX, Maxson ME, Gaudet RG, Koselny K, Wellington M, Powers ME, MacAlpine J, O'Meara MJ, Veri AO, Grinstein S, Noble SM, Krysan D, Gray-Owen SD, Cowen LE. High-Throughput Screening Identifies Genes Required for Candida albicans Induction of Macrophage Pyroptosis. mBio 2018. PMID: 30131363


  15. Tian C, Hromatka BS, Kiefer AK, Eriksson N, Noble SM, Tung JY, Hinds DA. Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections. Volume 8 of Issue 1. Nature communications 2017. PMID: 28928442


  16. Noble SM, Gianetti BA, Witchley JN. Candida albicans cell-type switching and functional plasticity in the mammalian host. Volume 15 of Issue 2. Nature reviews. Microbiology 2016. PMID: 27867199


  17. Phelan VV, Moree WJ, Aguilar J, Cornett DS, Koumoutsi A, Noble SM, Pogliano K, Guerrero CA, Dorrestein PC. Impact of a transposon insertion in phzF2 on the specialized metabolite production and interkingdom interactions of Pseudomonas aeruginosa. Volume 196 of Issue 9. Journal of bacteriology 2014. PMID: 24532776


  18. Noble SM. Candida albicans specializations for iron homeostasis: from commensalism to virulence. Volume 16 of Issue 6. Current opinion in microbiology 2013. PMID: 24121029


  19. Pande K, Chen C, Noble SM. Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism. Volume 45 of Issue 9. Nature genetics 2013. PMID: 23892606


  20. Chen C, Noble SM. Post-transcriptional regulation of the Sef1 transcription factor controls the virulence of Candida albicans in its mammalian host. Volume 8 of Issue 11. PLoS pathogens 2012. PMID: 23133381


  21. Chen C, Pande K, French SD, Tuch BB, Noble SM. An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis. Volume 10 of Issue 2. Cell host & microbe 2011. PMID: 21843869


  22. Noble SM, French S, Kohn LA, Chen V, Johnson AD. Systematic screens of a Candida albicans homozygous deletion library decouple morphogenetic switching and pathogenicity. Volume 42 of Issue 7. Nature genetics 2010. PMID: 20543849


  23. Hernday AD, Noble SM, Mitrovich QM, Johnson AD. Genetics and molecular biology in Candida albicans. Volume 470. Methods in enzymology 2010. PMID: 20946834


  24. Homann OR, Dea J, Noble SM, Johnson AD. A phenotypic profile of the Candida albicans regulatory network. Volume 5 of Issue 12. PLoS genetics 2009. PMID: 20041210


  25. Elson SL, Noble SM, Solis NV, Filler SG, Johnson AD. An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth. Volume 5 of Issue 9. PLoS genetics 2009. PMID: 19779551


  26. Liu OW, Chun CD, Chow ED, Chen C, Madhani HD, Noble SM. Systematic genetic analysis of virulence in the human fungal pathogen Cryptococcus neoformans. Volume 135 of Issue 1. Cell 2008. PMID: 18854164


  27. Noble SM, Johnson AD. Genetics of Candida albicans, a diploid human fungal pathogen. Volume 41. Annual review of genetics 2007. PMID: 17614788


  28. Hromatka BS, Noble SM, Johnson AD. Transcriptional response of Candida albicans to nitric oxide and the role of the YHB1 gene in nitrosative stress and virulence. Volume 16 of Issue 10. Molecular biology of the cell 2005. PMID: 16030247


  29. Noble SM, Johnson AD. Strains and strategies for large-scale gene deletion studies of the diploid human fungal pathogen Candida albicans. Volume 4 of Issue 2. Eukaryotic cell 2005. PMID: 15701792


  30. Chanfreau G, Noble SM, Guthrie C. Essential yeast protein with unexpected similarity to subunits of mammalian cleavage and polyadenylation specificity factor (CPSF). Science (New York, N.Y.) 1996. PMID: 8929408


  31. Noble SM, Guthrie C. Transcriptional pulse-chase analysis reveals a role for a novel snRNP-associated protein in the manufacture of spliceosomal snRNPs. The EMBO journal 1996. PMID: 8861964


  32. Noble SM, Guthrie C. Identification of novel genes required for yeast pre-mRNA splicing by means of cold-sensitive mutations. Genetics 1996. PMID: 8722763