Saptarsi Haldar, MD, BS

Clinical Professor

Clinical: I am a cardiologist specializing in general adult cardiology.

Primary Appointment: In 2018, I was recruited to be a Vice President of Research at Amgen, based in South San Francisco. I am the head of Cardiometabolic Research at Amgen, where I lead multidisciplinary efforts in drug discovery and development for a wide range of cardiovascular and metabolic diseases. I have maintained visiting faculty appointments at UCSF and Gladstone Institutes, where I continue to participate in mentorship, original research, volunteer clinical service and other academic activities.

Research: I am a Visiting Investigator at the Gladstone Institute of Cardiovascular Disease and a Visiting Professor the University of California, San Francisco. My scientific focus is to understand gene-regulatory and epigenetic mechanisms governing cell state transitions in the cardiovascular system and in skeletal muscle with an ultimate goal of finding novel therapeutic strategies to prevent and treat heart failure, cardiometabolic, and myopathic diseases.

A major focus of our team is in the pathobiology of heart failure, a devastating disease for which morbidity and mortality remain extremely high despite current standards of medical care. As a practicing physician-scientist that recognizes this major unmet need, one of my laboratory’s central goals is to discover novel mechanisms underlying heart failure pathogenesis and to develop new therapeutic strategies for this extremely common and lethal condition. We have a deep interest in the very nascent area of cardiovascular epigenetics and seek to unravel how chromatin-dependent signal transduction drives cardiovascular plasticity during physiological and pathophysiological states. As epigenetic regulators and chromatin-associated proteins are often tractable drug targets, we actively seek to translate our findings into novel transcriptionally-active cardiovascular therapeutics.

Education
Fellowship in Cardiovascular Medicine, 2006 - , Brigham and Women's Hospital, Harvard Medical School
Olser Medical Residency, 2003 - Internal Medicine, Johns Hopkins University
M.D., 2000 - , Johns Hopkins University
B.S., 1995 - , Cornell University
Honors and Awards
  • American Society for Clinical Investigation (ASCI), 2018
  • Fellow of the American Heart Association, AHA Council on Basic Cardiovascular Science (BCVS), 2018
  • Science Translational Medicine, Associate Scientific Advisory Board, 2014
  • Hartwell Foundation Biomedical Research Award, 2013
  • ASCI Best Research Poster Award, 2012
  • Jeremiah Stamler Distinguished Young Investigator Award, Northwestern Univ. YI Competition, 2009
  • Sarnoff Fellowship, 1998
Publications

  1. Berger JH, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP. SGLT2 Inhibitors Act Independently of SGLT2 to Confer Benefit for HFrEF in Mice. Circulation research 2024. PMID: 39041214


  2. Berger JH, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP. Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice. bioRxiv : the preprint server for biology 2024. PMID: 38746425


  3. Padmanabhan A, de Soysa TY, Pelonero A, Sapp V, Shah PP, Wang Q, Li L, Lee CY, Sadagopan N, Nishino T, Ye L, Yang R, Karnay A, Poleshko A, Bolar N, Linares-Saldana R, Ranade SS, Alexanian M, Morton SU, Jain M, Haldar SM, Srivastava D, Jain R. A genome-wide CRISPR screen identifies BRD4 as a regulator of cardiomyocyte differentiation. Nature cardiovascular research 2024. PMID: 39196112


  4. Haldar SM. Keeping translational research grounded in human biology. The Journal of clinical investigation 2024. PMID: 38226617


  5. El Abdellaoui Soussi F, Durumutla HB, Latimer H, Prabakaran AD, McFarland K, Miz K, Piczer K, Werbrich C, Jain MK, Haldar SM, Quattrocelli M. Light-phase prednisone promotes glucose oxidation in heart through novel transactivation targets of cardiomyocyte-specific GR and KLF15. bioRxiv : the preprint server for biology 2023. PMID: 38187555


  6. Kim HJ, Cheng P, Travisano S, Weldy C, Monteiro JP, Kundu R, Nguyen T, Sharma D, Shi H, Lin Y, Liu B, Haldar S, Jackson S, Quertermous T. Molecular mechanisms of coronary artery disease risk at the PDGFD locus. Nature communications 2023. PMID: 36792607


  7. Kim HJ, Cheng P, Travisano S, Weldy C, Monteiro JOP, Kundu R, Nguyen T, Sharma D, Shi H, Lin Y, Liu B, Haldar S, Jackson S, Quertermous T. Molecular mechanisms of coronary artery disease risk at the PDGFD locus. bioRxiv : the preprint server for biology 2023. PMID: 36747745


  8. Alexanian M, Padmanabhan A, Nishino T, Travers JG, Ye L, Lee CY, Sadagopan N, Huang Y, Pelonero A, Auclair K, Zhu A, Gonzalez Teran B, Flanigan W, Kim CK, Lumbao-Conradson K, Costa M, Jain R, Charo I, Haldar SM, Pollard KS, Vagnozzi RJ, McKinsey TA, Przytycki PF, Srivastava D. Chromatin Remodeling Drives Immune-Fibroblast Crosstalk in Heart Failure Pathogenesis. bioRxiv : the preprint server for biology 2023. PMID: 36711864


  9. Hsu A, Duan Q, Day DS, Luo X, McMahon S, Huang Y, Feldman ZB, Jiang Z, Zhang T, Liang Y, Alexanian M, Padmanabhan A, Brown JD, Lin CY, Gray NS, Young RA, Bruneau BG, Haldar SM. Targeting transcription in heart failure via CDK7/12/13 inhibition. Nature communications 2022. PMID: 35896549


  10. Fan L, Sweet DR, Fan EK, Prosdocimo DA, Madera A, Jiang Z, Padmanabhan R, Haldar SM, Vinayachandran V, Jain MK. Transcription factors KLF15 and PPARδ cooperatively orchestrate genome-wide regulation of lipid metabolism in skeletal muscle. 2022. PMID: 35413288


  11. Jiang Z, Elsarrag SZ, Duan Q, LaGory EL, Wang Z, Alexanian M, McMahon S, Rulifson IC, Winchester S, Wang Y, Vaisse C, Brown JD, Quattrocelli M, Lin CY, Haldar SM. KLF15 cistromes reveal a hepatocyte pathway governing plasma corticosteroid transport and systemic inflammation. 2022. PMID: 35263131


  12. Koren MJ, Moriarty PM, Baum SJ, Neutel J, Hernandez-Illas M, Weintraub HS, Florio M, Kassahun H, Melquist S, Varrieur T, Haldar SM, Sohn W, Wang H, Elliott-Davey M, Rock BM, Pei T, Homann O, Hellawell J, Watts GF. Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a). 2022. PMID: 35027752


  13. Massopust R, Juros D, Shapiro D, Lopes M, Haldar SM, Taetzsch T, Valdez G. KLF15 overexpression in myocytes fails to ameliorate ALS-related pathology or extend the lifespan of SOD1G93A mice. 2021. PMID: 34902552


  14. Alexanian M, Przytycki PF, Micheletti R, Padmanabhan A, Ye L, Travers JG, Gonzalez-Teran B, Silva AC, Duan Q, Ranade SS, Felix F, Linares-Saldana R, Li L, Lee CY, Sadagopan N, Pelonero A, Huang Y, Andreoletti G, Jain R, McKinsey TA, Rosenfeld MG, Gifford CA, Pollard KS, Haldar SM, Srivastava D. A transcriptional switch governs fibroblast activation in heart disease. Nature 2021. PMID: 34163071


  15. Virginia S Hahn, Hildur Knutsdottir, Kenneth C Bedi, Kenneth B Margulies, Saptarsi M Haldar, Marina Stolina, Joel S Bader, David A Kass, Kavita Sharma. Abstract 17168: Myocardial Natriuretic Peptide Expression in Heart Failure With Preserved Ejection Fraction. Circulation 2020. PMID:


  16. Hahn VS, Knutsdottir H, Luo X, Bedi K, Margulies KB, Haldar SM, Stolina M, Yin J, Khakoo AY, Vaishnav J, Bader JS, Kass DA, Sharma K. Myocardial Gene Expression Signatures in Human Heart Failure with Preserved Ejection Fraction. Circulation 2020. PMID: 33118835


  17. Padmanabhan A, Alexanian M, Linares-Saldana R, González-Terán B, Andreoletti G, Huang Y, Connolly AJ, Kim W, Hsu A, Duan Q, Winchester SAB, Felix F, Perez-Bermejo JA, Wang Q, Li L, Shah PP, Haldar SM, Jain R, Srivastava D. BRD4 Interacts with GATA4 to Govern Mitochondrial Homeostasis in Adult Cardiomyocytes. Circulation 2020. PMID: 33094644


  18. Virginia S. Hahn, Hildur Knutsdottir, Aditi Madan, Xin Luo, Kenneth Bedi, Kenneth B. Margulies, Saptarsi M. Haldar, Marina Stolina, Jun Yin, Aarif Y. Khahoo, Joban Vaishnav, Anthony Cammarato, Joel S. Bader, David A. Kass, Kavita Sharma. Distinct Myocardial Gene Expression Signatures in Heart Failure with Preserved Ejection Fraction. Journal of cardiac failure 2020. PMID:


  19. Alexanian M, Haldar SM. BETs that cover the spread from acquired to heritable heart failure. The Journal of clinical investigation 2020. PMID: 32773407


  20. Antolic A, Wakimoto H, Jiao Z, Gorham JM, DePalma SR, Lemieux ME, Conner DA, Lee DY, Qi J, Seidman JG, Bradner JE, Brown JD, Haldar SM, Seidman CE, Burke MA. BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy. JCI insight 2020. PMID: 32603312


  21. Ang YS, Rajamani S, Haldar SM, Hüser J. A New Therapeutic Framework for Atrial Fibrillation Drug Development. Circulation research 2020. PMID: 32717173


  22. Hsu A, Duan Q, McMahon S, Huang Y, Wood SA, Gray NS, Wang B, Bruneau BG, Haldar SM. Salt-inducible kinase 1 maintains HDAC7 stability to promote pathologic cardiac remodeling. The Journal of clinical investigation 2020. PMID: 32106109


  23. Quattrocelli M, Zelikovich AS, Jiang Z, Peek CB, Demonbreun AR, Kuntz NL, Barish GD, Haldar SM, Bass J, McNally EM. Pulsed glucocorticoids enhance dystrophic muscle performance through epigenetic-metabolic reprogramming. JCI insight 2019. PMID: 31852847


  24. George MR, Duan Q, Nagle A, Kathiriya IS, Huang Y, Rao K, Haldar SM, Bruneau BG. Minimal in vivo requirements for developmentally regulated cardiac long intergenic non-coding RNAs. Development (Cambridge, England) 2019. PMID: 31784461


  25. Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MP, Haldar SM, Lin CY, McKinsey TA. Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation. Circulation research 2019. PMID: 31409188


  26. Padmanabhan A, Haldar SM. Drugging transcription in heart failure. The Journal of physiology 2019. PMID: 30927446


  27. Alexanian M, Padmanabhan A, McKinsey TA, Haldar SM. Epigenetic therapies in heart failure. Journal of molecular and cellular cardiology 2019. PMID: 30991033


  28. Padmanabhan A, Haldar SM. Unusual transcription factor protects against heart failure. Science (New York, N.Y.) 2018. PMID: 30573617


  29. Alexanian M, Haldar SM. The Cardiac Myofibroblast. Circulation research 2018. PMID: 30566054


  30. Michael A. Burke, Hiroko Wakimoto, Zhe Jiao, Joshua M. Gorham, Steven R. DePalma, David A. Conner, Jun Qi, Jonathan G. Seidman, James E. Bradner, Jonathan D. Brown, Saptarsi M. Haldar, Christine E. Seidman. Epigenomic Control of Cardiac Fibrosis by Bet Bromodomain Proteins in Dilated Cardiomyopathy. Journal of cardiac failure 2018. PMID:


  31. Walter LM, Deguise MO, Meijboom KE, Betts CA, Ahlskog N, van Westering TLE, Hazell G, McFall E, Kordala A, Hammond SM, Abendroth F, Murray LM, Shorrock HK, Prosdocimo DA, Haldar SM, Jain MK, Gillingwater TH, Claus P, Kothary R, Wood MJA, Bowerman M. Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice. EBioMedicine 2018. PMID: 29735415


  32. Brown JD, Feldman ZB, Doherty SP, Reyes JM, Rahl PB, Lin CY, Sheng Q, Duan Q, Federation AJ, Kung AL, Haldar SM, Young RA, Plutzky J, Bradner JE. BET bromodomain proteins regulate enhancer function during adipogenesis. Proceedings of the National Academy of Sciences of the United States of America 2018. PMID: 29444854


  33. Padmanabhan A, Haldar SM. Plasma MicroRNA Clusters in Human Left Ventricular Remodeling: A Biomarker and Discovery Platform. Volume 11 of Issue 2. Circulation. Heart failure 2018. PMID: 29438983


  34. Morrison-Nozik A, Haldar SM. Probing the Pathogenesis of Duchenne Muscular Dystrophy Using Mouse Models. Methods in molecular biology (Clifton, N.J.) 2018. PMID: 29067659


  35. Newman JC, Covarrubias AJ, Zhao M, Yu X, Gut P, Ng CP, Huang Y, Haldar S, Verdin E. Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice. Cell metabolism 2017. PMID: 28877458


  36. Stratton MS, Haldar SM, McKinsey TA. BRD4 inhibition for the treatment of pathological organ fibrosis. F1000Research 2017. PMID: 28721198


  37. Duan Q, McMahon S, Anand P, Shah H, Thomas S, Salunga HT, Huang Y, Zhang R, Sahadevan A, Lemieux ME, Brown JD, Srivastava D, Bradner JE, McKinsey TA, Haldar SM. BET bromodomain inhibition suppresses innate inflammatory and profibrotic transcriptional networks in heart failure. Science translational medicine 2017. PMID: 28515341


  38. Michael A Burke, Hiroko Wakimoto, Joshua M Gorham, David A Conner, Jonathan G Seidman, James E Bradner, Saptarsi M Haldar, Jonathan D Brown, Christine E Seidman. Abstract 417: BET Bromodomain Inhibition Blunts Heart Failure Progression and Fibrosis in Genetic Cardiomyopathy. Circulation research 2016. PMID:


  39. Stratton MS, Lin CY, Anand P, Tatman PD, Ferguson BS, Wickers ST, Ambardekar AV, Sucharov CC, Bradner JE, Haldar SM, McKinsey TA. Signal-Dependent Recruitment of BRD4 to Cardiomyocyte Super-Enhancers Is Suppressed by a MicroRNA. Cell reports 2016. PMID: 27425608


  40. Haldar SM, Srivastava D. Sarcomeres and Cardiac Growth: Tension in the Relationship. Trends in molecular medicine 2016. PMID: 27237981


  41. Priti Anand, Amir Munir, Saptarsi M. Haldar. BET Bromodomains and P-TEFb in Cardiac Transcription and Heart Failure Pathogenesis. Epigenetics in Cardiac Disease 2016. PMID:


  42. Morrison-Nozik A, Anand P, Zhu H, Duan Q, Sabeh M, Prosdocimo DA, Lemieux ME, Nordsborg N, Russell AP, MacRae CA, Gerber AN, Jain MK, Haldar SM. Glucocorticoids enhance muscle endurance and ameliorate Duchenne muscular dystrophy through a defined metabolic program. Proceedings of the National Academy of Sciences of the United States of America 2015. PMID: 26598680


  43. Matthew S Stratton, Bradley S Ferguson, Charles Y Lin, Priti Anand, Sean T Wickers, Philip D Tatman, James E Bradner, Saptarsi M Haldar, Timothy A McKinsey. Abstract 131: A microRNA Targets the Epigenetic Reader BRD4 to Suppress Transcription Elongation in the Heart. Circulation research 2015. PMID:


  44. Tandler B, Fujioka H, Hoppel CL, Haldar SM, Jain MK. Megamitochondria in Cardiomyocytes of a Knockout (Klf15-/-) Mouse. Ultrastructural pathology 2015. PMID: 26111268


  45. Milstone DS, Ilyama M, Chen M, O'Donnell P, Davis VM, Plutzky J, Brown JD, Haldar SM, Siu A, Lau AC, Zhu SN, Basheer MF, Collins T, Jongstra-Bilen J, Cybulsky MI. Differential role of an NF-?B transcriptional response element in endothelial versus intimal cell VCAM-1 expression. Circulation research 2015. PMID: 26034041


  46. Saptarsi M. Haldar. A change of heart for phosphodiesterase signaling. Science translational medicine 2015. PMID:


  47. Saptarsi M. Haldar. A mighty "MyD" guardian of heart function. Science translational medicine 2015. PMID:


  48. Saptarsi M. Haldar. HDL Cholesterol: Form Versus Function. 2015. PMID:


  49. Duan Q, Madan ND, Wu J, Kalisz J, Doshi KY, Haldar SM, Liu L, Pierre SV. Role of phosphoinositide 3-kinase IA (PI3K-IA) activation in cardioprotection induced by ouabain preconditioning. Journal of molecular and cellular cardiology 2015. PMID: 25575882


  50. Shuichi Yoneda, Saptarsi M Haldar, Jessica Jenkins, Yunmei Wang, Teruo Inoue, Mukesh K Jain, Can Shi, Daniel I Simon. Abstract 15863: Macrophage Foxp1 is a Regulator of Pathologic Cardiac Hypertrophy. Circulation 2014. PMID:


  51. Saptarsi M. Haldar. Monkeying Around with LDL Receptor Levels. 2014. PMID:


  52. Padmanabhan A, Haldar SM. Neuroprotection in ischemic stroke: AhR we making progress? Volume 130 of Issue 23. Circulation 2014. PMID: 25359167


  53. Saptarsi M. Haldar. A Bug in the System for Artificial Sweeteners. 2014. PMID:


  54. Di Salvo TG, Haldar SM. Epigenetic mechanisms in heart failure pathogenesis. Circulation. Heart failure 2014. PMID: 25228320


  55. Saptarsi M. Haldar. The Key to Myheart. 2014. PMID:


  56. Saptarsi M. Haldar. Fishing for Drugs That Mitigate Metabolic Syndrome. Science translational medicine 2014. PMID:


  57. Saptarsi M. Haldar. Metabolic Syndrome: A Family Affair. 2014. PMID:


  58. Haldar SM, McKinsey TA. BET-ting on chromatin-based therapeutics for heart failure. Journal of molecular and cellular cardiology 2014. PMID: 24838003


  59. Saptarsi M. Haldar. A Pregnant Pause in Pancreatic Function. 2014. PMID:


  60. Prosdocimo DA, Anand P, Liao X, Zhu H, Shelkay S, Artero-Calderon P, Zhang L, Kirsh J, Moore D, Rosca MG, Vazquez E, Kerner J, Akat KM, Williams Z, Zhao J, Fujioka H, Tuschl T, Bai X, Schulze PC, Hoppel CL, Jain MK, Haldar SM. Kruppel-like factor 15 is a critical regulator of cardiac lipid metabolism. The Journal of biological chemistry 2014. PMID: 24407292


  61. Anand P, Brown JD, Lin CY, Qi J, Zhang R, Artero PC, Alaiti MA, Bullard J, Alazem K, Margulies KB, Cappola TP, Lemieux M, Plutzky J, Bradner JE, Haldar SM. BET bromodomains mediate transcriptional pause release in heart failure. Cell 2013. PMID: 23911322


  62. Sasse SK, Mailloux CM, Barczak AJ, Wang Q, Altonsy MO, Jain MK, Haldar SM, Gerber AN. The glucocorticoid receptor and KLF15 regulate gene expression dynamics and integrate signals through feed-forward circuitry. Molecular and cellular biology 2013. PMID: 23508109


  63. Haldar SM, Stamler JS. S-nitrosylation: integrator of cardiovascular performance and oxygen delivery. The Journal of clinical investigation 2013. PMID: 23281416


  64. Fujioka H, Tandler B, Haldar SM, Jain MK, Hoppel CL. String mitochondria in mouse soleus muscle. Microscopy research and technique 2012. PMID: 23174930


  65. Haldar SM, Jeyaraj D, Anand P, Zhu H, Lu Y, Prosdocimo DA, Eapen B, Kawanami D, Okutsu M, Brotto L, Fujioka H, Kerner J, Rosca MG, McGuinness OP, Snow RJ, Russell AP, Gerber AN, Bai X, Yan Z, Nosek TM, Brotto M, Hoppel CL, Jain MK. Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation. Proceedings of the National Academy of Sciences of the United States of America 2012. PMID: 22493257


  66. Anthony Nicholas Gerber, Sarah Sasse, Saptarsi Haldar, Mukesh Jain. Induction of Klf15 by glucocorticoids in the lung regulates downstream transcriptional effects on mitochondrial function and metabolism. The FASEB Journal 2012. PMID:


  67. Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK. Klf15 orchestrates circadian nitrogen homeostasis. Cell metabolism 2012. PMID: 22405069


  68. Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK. Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature 2012. PMID: 22367544


  69. Haldar SM, Stamler JS. S-Nitrosylation at the interface of autophagy and disease. Molecular cell 2011. PMID: 21726803


  70. Ganapati H. Mahabeleshwar, Daiji Kawanami, Nikunj Sharma, Yoichi Takami, Guangjin Zhou, Hong Shi, Lalitha Nayak, Darwin Jeyaraj, Robert Grealy, Mary White, Ross McManus, Thomas Ryan, Patrick Leahy, Zhiyong Lin, Saptarsi M. Haldar, G. Brandon Atkins, Hector R. Wong, Jerry B. Lingrel, Mukesh K. Jain. The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock. Immunity 2011. PMID:


  71. Mahabeleshwar GH, Kawanami D, Sharma N, Takami Y, Zhou G, Shi H, Nayak L, Jeyaraj D, Grealy R, White M, McManus R, Ryan T, Leahy P, Lin Z, Haldar SM, Atkins GB, Wong HR, Lingrel JB, Jain MK. The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock. Immunity 2011. PMID: 21565532


  72. Masuno K, Haldar SM, Jeyaraj D, Mailloux CM, Huang X, Panettieri RA, Jain MK, Gerber AN. Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness. American journal of respiratory cell and molecular biology 2011. PMID: 21257922


  73. Lu Y, Haldar S, Croce K, Wang Y, Sakuma M, Morooka T, Wang B, Jeyaraj D, Gray SJ, Simon DI, Jain MK. Kruppel-like factor 15 regulates smooth muscle response to vascular injury--brief report. Arteriosclerosis, thrombosis, and vascular biology 2010. PMID: 20508206


  74. Liao X, Haldar SM, Lu Y, Jeyaraj D, Paruchuri K, Nahori M, Cui Y, Kaestner KH, Jain MK. Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy. Journal of molecular and cellular cardiology 2010. PMID: 20433848


  75. Haldar SM, Lu Y, Jeyaraj D, Kawanami D, Cui Y, Eapen SJ, Hao C, Li Y, Doughman YQ, Watanabe M, Shimizu K, Kuivaniemi H, Sadoshima J, Margulies KB, Cappola TP, Jain MK. Klf15 deficiency is a molecular link between heart failure and aortic aneurysm formation. Science translational medicine 2010. PMID: 20375365


  76. Daiji Kawanami, Saptarsi M. Haldar, Mukesh K. Jain. Role of Connective Tissue Growth Factor in Cardiac Fibrosis. CCN Proteins in Health and Disease 2010. PMID:


  77. Kawanami D, Mahabeleshwar GH, Lin Z, Atkins GB, Hamik A, Haldar SM, Maemura K, Lamanna JC, Jain MK. Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium. The Journal of biological chemistry 2009. PMID: 19491109


  78. Yuan Lu, Saptarsi Haldar, Caili Hao, Yingjie Cui, Yongqiu Doughman, Michiko Watanabe, Mukesh K Jain. Kruppel Like Factor 15 is a Critical Regulator of Angiotensin II Mediated Vascular Remodeling. The FASEB Journal 2009. PMID:


  79. Daiji Kawanami, Saptarsi M. Haldar, Mukesh K. Jain. Krüppel-like Factors in the Heart. The Biology of Krüppel-like Factors 2009. PMID:


  80. Saptarsi M Haldar, Yuan Lu, Yingjie Cui, Darwin Jeyaraj, Osama A Ibrahim, Manjusri Das, Caili Hao, Sam J Eapen, Daiji Kawanami, Yong Qiu Doughman, Michiko Watanabe, Junichi Sadoshima, Mukesh K Jain. Abstract 5275: Kruppel-Like Factor 15 Regulates the Cardiovascular Response to Angiotensin II. Circulation 2008. PMID:


  81. Daiji Kawanami, Zhiyong Lin, Ganapati Mahabaleshwar, G. B Atkins, Anne Hamik, Saptarsi Haldar, Koji Maemura, Jerry Lingrel, Mukesh Jain. Abstract 5440: Klf2 Inhibits Hif-1a Expression and Function in the Endothelium. Circulation 2008. PMID:


  82. Wang B, Haldar SM, Lu Y, Ibrahim OA, Fisch S, Gray S, Leask A, Jain MK. The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts. Journal of molecular and cellular cardiology 2008. PMID: 18586263


  83. Haldar SM, Ibrahim OA, Jain MK. Kruppel-like Factors (KLFs) in muscle biology. Journal of molecular and cellular cardiology 2007. PMID: 17531262


  84. Fisch S, Gray S, Heymans S, Haldar SM, Wang B, Pfister O, Cui L, Kumar A, Lin Z, Sen-Banerjee S, Das H, Petersen CA, Mende U, Burleigh BA, Zhu Y, Pinto YM, Pinto Y, Liao R, Jain MK. Kruppel-like factor 15 is a regulator of cardiomyocyte hypertrophy. Proceedings of the National Academy of Sciences of the United States of America 2007. PMID: 17438289


  85. Gray S, Wang B, Orihuela Y, Hong EG, Fisch S, Haldar S, Cline GW, Kim JK, Peroni OD, Kahn BB, Jain MK. Regulation of gluconeogenesis by Krüppel-like factor 15. Cell metabolism 2007. PMID: 17403374


  86. S. Fisch, S. Gray, S. Heymans, S. Haldar, B. Wang, Y. Zhu, R. Liao, Y. M. Pinto, M. K. Jain. 38 KRUPPEL-LIKE FACTOR 15 IS A NOVEL REGULATOR OF CARDIOMYOCYTE HYPERTROPHY. Journal of Investigative Medicine 2007. PMID:


  87. S. Fisch, S. Gray, S. Heymans, S. Haldar, B. Wang, Y. Zhu, R. Liao, Y. M. Pinto, M. K. Jain. KRUPPEL-LIKE FACTOR 15 IS A NOVEL REGULATOR OF CARDIOMYOCYTE HYPERTROPHY.: 38. Journal of Investigative Medicine 2007. PMID:


  88. S. Fisch, S. Gray, S. Heymans, S. Haldar, B. Wang, Y. Zhu, R. Liao, Y.M. Pinto, M.K. Jain. Kruppel-Like Factor 15 is a Novel Regulator of Cardiomyocyte Hypertrophy. Journal of Investigative Medicine 2007. PMID:


  89. Haldar SM, O'Gara PT. Infective endocarditis: diagnosis and management. Nature clinical practice. Cardiovascular medicine 2006. PMID: 16729009


  90. Champion HC, Georgakopoulos D, Haldar S, Wang L, Wang Y, Kass DA. Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart: application to study of phospholamban physiology. Circulation 2003. PMID: 14638552


  91. Peng X, Haldar S, Deshpande S, Irani K, Kass DA. Wall stiffness suppresses Akt/eNOS and cytoprotection in pulse-perfused endothelium. Hypertension (Dallas, Tex. : 1979) 2003. PMID: 12574111