Roselle Abraham, MD

Assoc. Professor in Residence

Cardiology UCSF Health

CLINICAL INTERESTS: Dr. Roselle Abraham is a cardiologist with expertise in the treatment of patients with hypertrophic cardiomyopathy.

RESEARCH INTERESTS: Dr. Roselle Abraham is a physician scientist with a background in electrophysiology, imaging and stem cell research. She is using multi-modality imaging for risk stratification of atrial and ventricular arrhythmias. The overall goal of her research program is to use a combination of multi-modality clinical imaging and studies in model systems to tailor therapies for patients with hypertrophic cardiomyopathy.

Publications
  1. Gordon JW, Autry AW, Tang S, Graham JY, Bok RA, Zhu X, Villanueva-Meyer JE, Li Y, Ohilger MA, Abraham MR, Xu D, Vigneron DB, Larson PEZ. A variable resolution approach for improved acquisition of hyperpolarized 13 C metabolic MRI. Magnetic resonance in medicine 2020. PMID: 32697867


  2. Yalcin H, Valenta I, Zhao M, Tahari A, Lu DY, Higuchi T, Yalcin F, Kucukler N, Soleimanifard Y, Zhou Y, Pomper MG, Abraham TP, Tsui B, Lodge MA, Schindler TH, Abraham MR. Correction to: Comparison of two software systems for quantification of myocardial blood flow in patients with hypertrophic cardiomyopathy. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2018. PMID: 29423907


  3. Bhattacharya M, Lu DY, Kudchadkar SM, Greenland GV, Lingamaneni P, Corona-Villalobos CP, Guan Y, Marine JE, Olgin JE, Zimmerman S, Abraham TP, Shatkay H, Abraham MR. Identifying Ventricular Arrhythmias and Their Predictors by Applying Machine Learning Methods to Electronic Health Records in Patients With Hypertrophic Cardiomyopathy (HCM-VAr-Risk Model). The American journal of cardiology 2019. PMID: 30952382


  4. Vakrou S, Fukunaga R, Foster DB, Sorensen L, Liu Y, Guan Y, Woldemichael K, Pineda-Reyes R, Liu T, Tardiff JC, Leinwand LA, Tocchetti CG, Abraham TP, O'Rourke B, Aon MA, Abraham MR. Allele-specific differences in transcriptome, miRNome, and mitochondrial function in two hypertrophic cardiomyopathy mouse models. JCI insight 2018. PMID: 29563334


  5. Lu DY, Pozios I, Haileselassie B, Ventoulis I, Liu H, Sorensen LL, Canepa M, Phillip S, Abraham MR, Abraham TP. Clinical Outcomes in Patients With Nonobstructive, Labile, and Obstructive Hypertrophic Cardiomyopathy. Journal of the American Heart Association 2018. PMID: 29478967


  6. Pozios I, Pinheiro A, Corona-Villalobos C, Sorensen LL, Dardari Z, Liu HY, Cresswell K, Phillip S, Bluemke DA, Zimmerman SL, Abraham MR, Abraham TP. Rest and Stress Longitudinal Systolic Left Ventricular Mechanics in Hypertrophic Cardiomyopathy: Implications for Prognostication. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2018. PMID: 29426649


  7. Lu DY, Yalçin H, Yalçin F, Zhao M, Sivalokanathan S, Valenta I, Tahari A, Pomper MG, Abraham TP, Schindler TH, Abraham MR. Stress Myocardial Blood Flow Heterogeneity Is a Positron Emission Tomography Biomarker of Ventricular Arrhythmias in Patients With Hypertrophic Cardiomyopathy. The American journal of cardiology 2018. PMID: 29678336


  8. Yalcin H, Valenta I, Zhao M, Tahari A, Lu DY, Higuchi T, Yalcin F, Kucukler N, Soleimanifard Y, Zhou Y, Pomper MG, Abraham TP, Tsui B, Lodge MA, Schindler TH, Roselle Abraham M. Comparison of two software systems for quantification of myocardial blood flow in patients with hypertrophic cardiomyopathy. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2018. PMID: 29359273


  9. Lu DY, Haileselassie B, Ventoulis I, Liu HY, Liang HY, Pozios I, Canepa M, Phillip S, Abraham MR, Abraham T. E/e' ratio and outcome prediction in hypertrophic cardiomyopathy: the influence of outflow tract obstruction. European heart journal cardiovascular Imaging 2018. PMID: 28977350


  10. Lu DY, Hailesealassie B, Ventoulis I, Liu H, Liang HY, Nowbar A, Pozios I, Canepa M, Cresswell K, Luo HC, Abraham MR, Abraham TP. Impact of peak provoked left ventricular outflow tract gradients on clinical outcomes in hypertrophic cardiomyopathy. International journal of cardiology 2017. PMID: 28747034


  11. Li Z, Guo X, Sun G, Zheng L, Sun Y, Liu Y, Abraham MR. Plasma homocysteine levels associated with a corrected QT interval. BMC cardiovascular disorders 2017. PMID: 28693429


  12. Chu LC, Corona-Villalobos CP, Halushka MK, Zhang Y, Pozzessere C, Kamel IR, Pozios I, Van Der Geest RJ, Gai N, Abraham RM, Abraham TP, Bluemke DA, Zimmerman SL. Structural and Functional Correlates of Myocardial T1 Mapping in 321 Patients With Hypertrophic Cardiomyopathy. Journal of computer assisted tomography 2017. PMID: 27997439


  13. Liu H, Pozios I, Haileselassie B, Nowbar A, Sorensen LL, Phillip S, Lu DY, Ventoulis I, Luo H, Abraham MR, Abraham TP. Role of Global Longitudinal Strain in Predicting Outcomes in Hypertrophic Cardiomyopathy. The American journal of cardiology 2017. PMID: 28687124


  14. Corona-Villalobos CP, Saha S, Pozios I, Hurtado-de-Mendoza Paz D, Sorensen L, Gonzalez Cordoba J, Dolores-Cerna K, Kamel IR, Mormontoy Laurel W, Bluemke DA, Abraham TP, Zimmerman SL, Abraham MR. Exercise-QTc is associated with diffuse interstitial fibrosis reflected by lower approximated T1 relaxation time in hypertrophic cardiomyopathy patients. Journal of electrocardiology 2017. PMID: 28292523


  15. Hurtado-de-Mendoza D, Corona-Villalobos CP, Pozios I, Gonzales J, Soleimanifard Y, Sivalokanathan S, Montoya-Cerrillo D, Vakrou S, Kamel I, Mormontoy-Laurel W, Dolores-Cerna K, Suarez J, Perez-Melo S, Bluemke DA, Abraham TP, Zimmerman SL, Abraham MR. Diffuse interstitial fibrosis assessed by cardiac magnetic resonance is associated with dispersion of ventricular repolarization in patients with hypertrophic cardiomyopathy. Journal of arrhythmia 2016. PMID: 28607615


  16. Sorensen LL, Liang HY, Pinheiro A, Hilser A, Dimaano V, Olsen NT, Hansen TF, Sogaard P, Nowbar A, Pisanello C, Pozios I, Phillip S, Zhou X, Abraham R, Abraham TP. Safety profile and utility of treadmill exercise in patients with high-gradient hypertrophic cardiomyopathy. American heart journal 2016. PMID: 27892886


  17. Yalçin H, Valenta I, Yalçin F, Corona-Villalobos C, Vasquez N, Ra J, Kucukler N, Tahari A, Pozios I, Zhou Y, Pomper M, Abraham TP, Schindler TH, Abraham MR. Effect of Diffuse Subendocardial Hypoperfusion on Left Ventricular Cavity Size by 13N-Ammonia Perfusion PET in Patients With Hypertrophic Cardiomyopathy. The American journal of cardiology 2016. PMID: 27771003


  18. Li Z, Guo X, Liu Y, Zhang N, Chang Y, Chen Y, Sun Y, Abraham MR. Metabolism rather than obesity is associated with ischemic stroke: a cross-sectional study in rural Northeastern China. SpringerPlus 2016. PMID: 27625973


  19. Li Z, Guo X, Liu Y, Chang Y, Sun Y, Zhu G, Abraham MR. The Relation of Moderate Alcohol Consumption to Hyperuricemia in a Rural General Population. International journal of environmental research and public health 2016. PMID: 27447659


  20. Lin X, Steinberg S, Kandasamy SK, Afzal J, Mbiyangandu B, Liao SE, Guan Y, Corona-Villalobos CP, Matkovich SJ, Epstein N, Tripodi D, Huo Z, Cutting G, Abraham TP, Fukunaga R, Abraham MR. Common miR-590 Variant rs6971711 Present Only in African Americans Reduces miR-590 Biogenesis. PloS one 2016. PMID: 27196440


  21. Corona-Villalobos CP, Sorensen LL, Pozios I, Chu L, Eng J, Abraham MR, Abraham TP, Kamel IR, Zimmerman SL. Left ventricular wall thickness in patients with hypertrophic cardiomyopathy: a comparison between cardiac magnetic resonance imaging and echocardiography. The international journal of cardiovascular imaging 2016. PMID: 26896038


  22. Sørensen LL, Bedja D, Sysa-Shah P, Liu H, Maxwell A, Yi X, Pozios I, Olsen NT, Abraham TP, Abraham R, Gabrielson K. Echocardiographic Characterization of a Murine Model of Hypertrophic Obstructive Cardiomyopathy Induced by Cardiac-specific Overexpression of Epidermal Growth Factor Receptor 2. Comparative medicine 2016. PMID: 27538857


  23. Ardekani S, Jain S, Sanzi A, Corona-Villalobos CP, Abraham TP, Abraham MR, Zimmerman SL, Wu KC, Winslow RL, Miller MI, Younes L. Shape analysis of hypertrophic and hypertensive heart disease using MRI-based 3D surface models of left ventricular geometry. Medical image analysis 2015. PMID: 26766206


  24. Pozios I, Corona-Villalobos C, Sorensen LL, Bravo PE, Canepa M, Pisanello C, Pinheiro A, Dimaano VL, Luo H, Dardari Z, Zhou X, Kamel I, Zimmerman SL, Bluemke DA, Abraham MR, Abraham TP. Comparison of Outcomes in Patients With Nonobstructive, Labile-Obstructive, and Chronically Obstructive Hypertrophic Cardiomyopathy. The American journal of cardiology 2015. PMID: 26239580


  25. Bravo PE, Luo HC, Pozios I, Zimmerman SL, Corona-Villalobos CP, Sorensen L, Kamel IR, Bluemke DA, Wahl RL, Abraham MR, Abraham TP. Late gadolinium enhancement confined to the right ventricular insertion points in hypertrophic cardiomyopathy: an intermediate stage phenotype? European heart journal cardiovascular Imaging 2015. PMID: 26077330


  26. Bravo PE, Tahari A, Pozios I, Luo HC, Bengel FM, Wahl RL, Abraham MR, Abraham TP. Apparent left ventricular cavity dilatation during PET/CT in hypertrophic cardiomyopathy: Clinical predictors and potential mechanisms. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2015. PMID: 25989730


  27. Rahman QA, Tereshchenko LG, Kongkatong M, Abraham T, Abraham MR, Shatkay H. Utilizing ECG-Based Heartbeat Classification for Hypertrophic Cardiomyopathy Identification. IEEE transactions on nanobioscience 2015. PMID: 25915962


  28. Luo HC, Dimaano VL, Kembro JM, Hilser A, Hurtado-de-Mendoza D, Pozios I, Tomas MS, Yalcin H, Dolores-Cerna K, Mormontoy W, Aon MA, Cameron D, Bluemke DA, Stewart KJ, Russell SD, Cordova JG, Abraham TP, Abraham MR. Exercise heart rates in patients with hypertrophic cardiomyopathy. The American journal of cardiology 2015. PMID: 25746289


  29. Rahman QA, Tereshchenko LG, Kongkatong M, Abraham T, Abraham MR, Shatkay H. Identifying Hypertrophic Cardiomyopathy Patients by Classifying Individual Heartbeats from 12-lead ECG Signals. Proceedings. IEEE International Conference on Bioinformatics and Biomedicine 2014. PMID: 25737801


  30. Luo HC, Pozios I, Vakrou S, Sorensen L, Abraham RM, Abraham T. Age-related changes in familial hypertrophic cardiomyopathy phenotype in transgenic mice and humans. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 2014. PMID: 25318870


  31. Vakrou S, Abraham MR. Hypertrophic cardiomyopathy: a heart in need of an energy bar? Frontiers in physiology 2014. PMID: 25191275


  32. Canepa M, Sorensen LL, Pozios I, Dimaano VL, Luo HC, Pinheiro AC, Strait JB, Brunelli C, Abraham MR, Ferrucci L, Abraham TP. Comparison of clinical presentation, left ventricular morphology, hemodynamics, and exercise tolerance in obese versus nonobese patients with hypertrophic cardiomyopathy. The American journal of cardiology 2013. PMID: 24079444


  33. Lin X, Liang HY, Pinheiro A, Dimaano V, Sorensen L, Aon M, Tereshchenko LG, Chen Y, Xiang M, Abraham TP, Abraham MR. Electromechanical relationship in hypertrophic cardiomyopathy. Journal of cardiovascular translational research 2013. PMID: 23771430


  34. Abraham MR, Bottomley PA, Dimaano VL, Pinheiro A, Steinberg A, Traill TA, Abraham TP, Weiss RG. Creatine kinase adenosine triphosphate and phosphocreatine energy supply in a single kindred of patients with hypertrophic cardiomyopathy. The American journal of cardiology 2013. PMID: 23751935


  35. Bravo PE, Zimmerman SL, Luo HC, Pozios I, Rajaram M, Pinheiro A, Steenbergen C, Kamel IR, Wahl RL, Bluemke DA, Bengel FM, Abraham MR, Abraham TP. Relationship of delayed enhancement by magnetic resonance to myocardial perfusion by positron emission tomography in hypertrophic cardiomyopathy. Circulation. Cardiovascular imaging 2013. PMID: 23418294


  36. Hueper K, Zapf A, Skrok J, Pinheiro A, Goldstein TA, Zheng J, Zimmerman SL, Kamel IR, Abraham R, Wacker F, Bluemke DA, Abraham T, Vogel-Claussen J. In hypertrophic cardiomyopathy reduction of relative resting myocardial blood flow is related to late enhancement, T2-signal and LV wall thickness. PloS one 2012. PMID: 22860042


  37. Bravo PE, Pozios I, Pinheiro A, Merrill J, Tsui BM, Wahl RL, Bengel FM, Abraham MR, Abraham TP. Comparison and effectiveness of regadenoson versus dipyridamole on stress electrocardiographic changes during positron emission tomography evaluation of patients with hypertrophic cardiomyopathy. The American journal of cardiology 2012. PMID: 22748357


  38. Vogel-Claussen J, Santaularia Tomas M, Newatia A, Boyce D, Pinheiro A, Abraham R, Abraham T, Bluemke DA. Cardiac MRI evaluation of hypertrophic cardiomyopathy: left ventricular outflow tract/aortic valve diameter ratio predicts severity of LVOT obstruction. Journal of magnetic resonance imaging : JMRI 2012. PMID: 22549972


  39. Bravo PE, Pinheiro A, Higuchi T, Rischpler C, Merrill J, Santaularia-Tomas M, Abraham MR, Wahl RL, Abraham TP, Bengel FM. PET/CT assessment of symptomatic individuals with obstructive and nonobstructive hypertrophic cardiomyopathy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2012. PMID: 22315440


  40. Bonios M, Chang CY, Terrovitis J, Pinheiro A, Barth A, Dong P, Santaularia M, Foster DB, Raman V, Abraham TP, Abraham MR. Constitutive HIF-1a expression blunts the beneficial effects of cardiosphere-derived cell therapy in the heart by altering paracrine factor balance. Journal of cardiovascular translational research 2011. PMID: 21538185


  41. Wafae N, Ruiz CR, Abraham M, Freire CH, Demarchi GT, Wafae GC. Anatomy of the tendinous cords of the interventricular septum of the human heart. Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 2008. PMID: 19507468


  42. Bonios MJ, Terrovitis JV, Abraham MR. Stem cell: "KANT" you see it? Journal of cardiovascular translational research 2008. PMID: 20559903


  43. Abraham MR, Olson LJ, Joyner MJ, Turner ST, Beck KC, Johnson BD. Angiotensin-converting enzyme genotype modulates pulmonary function and exercise capacity in treated patients with congestive stable heart failure. Circulation 2002. PMID: 12356632