Rohit Bose, MD, PhD

Assistant Professor

I'm a physician-scientist who sees prostate cancer patients, and runs a prostate cancer-focused research lab. Our focus is in understanding hormone-related tumor evolution and dynamics. Understanding how tumors shift their dependencies and identity during therapy is critical to improving patients' clinical care.

Education
Instructor, 2018 - Dept. of Medicine, Genitourinary Service, Memorial Sloan Kettering Cancer Center
Fellowship, 2016 - Advanced Oncology, Memorial Sloan Kettering Cancer Center
Fellowship, Medical Research Track, 2014 - Medical Oncology, Memorial Sloan Kettering Cancer Center
Residency, Medical Research Track, 2010 - Internal Medicine, Weill Cornell Medicine
MD/PhD, 2008 - Medicine & Molecular Genetics, University of Toronto
Honors and Awards
  • Idea Development Award, Department of Defense, Prostate Cancer Program, 2023-2026
  • Research Scholar Grant, American Cancer Society, 2022-2026
  • Bakar Aging Research Institute Investigator Award, UCSF, 2021
  • Pilot Award for Junior Investigators in Basic and Clinical/Translational Sciences, UCSF, 2020
  • Research Funding Pilot Award, UCSF, 2019
  • K08 Mentored Clinical Scientist Research Career Development Award, NIH NCI, 2018-2023
  • (Declined) Recruitment of First-Time Tenure-Track Faculty Members Award, CPRIT, 2018
  • Physician Research Training Award, Department of Defense, Prostate Cancer Research Program, 2016-2020
  • Young Investigator Award, Prostate Cancer Foundation, 2016-2019
  • Postdoctoral Research Training Award, Department of Defense, Prostate Cancer Research Program, 2013-2015
  • Young Investigator Award, ASCO / Conquer Cancer Foundation, 2013-2014
  • Dana Fellow in Biomedical Research, Clinical Scholars Training Program, Dana Foundation, Memorial Sloan Kettering Cancer Center, Dana Foundation, 2011-2013
  • John Mendelsohn Housestaff Teaching Award, Memorial Sloan Kettering Cancer Center, 2011
  • John Ruffo Graduate Fellowship for Outstanding Achievement during M.D./Ph.D., University of Toronto, 2007
  • (Declined) Jean Alloul Entrance Scholarship for M.D./Ph.D. Program, McGill University, 1999
  • Biochemistry Scholarship for Highest Academic Achievement in Dept of Biochemistry, University of Saskatchewan, 1999
  • Earl of Bessborough Prize for Most Distinguished Graduate Receiving a B.Sc., University of Saskatchewan, 1999
  • Haslam Medal for Most Distinguished Graduate of the College of Arts and Sciences, University of Saskatchewan, 1999
  • J.F. Morgan Memorial Award for Highest Academic Achievement in Dept of Microbiology & Immunology, University of Saskatchewan, 1999
  • Entrance Scholarship for Full Tuition, University of Saskatchewan, 1995
Websites
Publications

  1. Aggarwal R, Starzinski S, de Kouchkovsky I, Koshkin V, Bose R, Chou J, Desai A, Kwon D, Kaushal S, Trihy L, Rastogi M, Ippisch R, Aslam M, Friedlander T, Feng F, Oh D, Cheung A, Small E, Evans M, Fong L, Hope TA. Single-dose 177Lu-PSMA-617 followed by maintenance pembrolizumab in patients with metastatic castration-resistant prostate cancer: an open-label, dose-expansion, phase 1 trial. The Lancet. Oncology 2023. PMID: 37922930


  2. Jindal T, Zhang L, Deshmukh P, Reyes K, Chan E, Kumar V, Zhu X, Maldonado E, Feng S, Johnson M, Angelidakis A, Kwon D, Desai A, Borno HT, Bose R, Wong A, Hong J, Carroll P, Meng M, Porten S, Aggarwal R, Small EJ, Fong L, Chou J, Friedlander T, de Kouchkovsky I, Koshkin VS. Impact of Squamous Histology on Clinical Outcomes and Molecular Profiling in Metastatic Urothelial Carcinoma PatientsTreated With Immune Checkpoint Inhibitors or Enfortumab Vedotin. Clinical genitourinary cancer 2023. PMID: 37316414


  3. Jindal T, Zhu X, Bose R, Kumar V, Maldonado E, Deshmukh P, Shipp C, Feng S, Johnson MS, Angelidakis A, Kwon D, Borno HT, de Kouchkovsky I, Desai A, Aggarwal R, Fong L, Small EJ, Wong A, Porten S, Chou J, Friedlander T, Koshkin VS. Somatic alterations of TP53 and MDM2 associated with response to enfortumab vedotin in patients with advanced urothelial cancer. Frontiers in oncology 2023. PMID: 37091148


  4. Kwon DH, Shakhnazaryan N, Shui D, Hong JC, Mohamad O, de Kouchkovsky I, Borno HT, Bose R, Chou J, Desai A, Fong L, Friedlander TW, Koshkin VS, Aggarwal RR, Feng FY, Hope TA, Small EJ. Serial stereotactic body radiation therapy for oligometastatic prostate cancer detected by novel PET-based radiotracers. Urologic oncology 2022. PMID: 36435709


  5. Sjöström M, Zhao SG, Levy S, Zhang M, Ning Y, Shrestha R, Lundberg A, Herberts C, Foye A, Aggarwal R, Hua JT, Li H, Bergamaschi A, Maurice-Dror C, Maheshwari A, Chen S, Ng SWS, Ye W, Petricca J, Fraser M, Chesner L, Perry MD, Moreno-Rodriguez T, Chen WS, Alumkal JJ, Chou J, Morgans AK, Beer TM, Thomas GV, Gleave M, Lloyd P, Phillips T, McCarthy E, Haffner MC, Zoubeidi A, Annala M, Reiter RE, Rettig MB, Witte ON, Fong L, Bose R, Huang FW, Luo J, Bjartell A, Lang JM, Mahajan NP, Lara PN, Evans CP, Tran PT, Posadas EM, He C, Cui XL, Huang J, Zwart W, Gilbert LA, Maher CA, Boutros PC, Chi KN, Ashworth A, Small EJ, He HH, Wyatt AW, Quigley DA, Feng FY. The 5-Hydroxymethylcytosine Landscape of Prostate Cancer. Cancer research 2022. PMID: 36251389


  6. Ogura K, Elkrief A, Bowman AS, Koche RP, de Stanchina E, Benayed R, Mauguen A, Mattar MS, Khodos I, Meyers PA, Healey JH, Tap WD, Hameed M, Zehir A, Shukla N, Sawyers C, Bose R, Slotkin E, Ladanyi M. Prospective Clinical Genomic Profiling of Ewing Sarcoma: ERF and FGFR1 Mutations as Recurrent Secondary Alterations of Potential Biologic and Therapeutic Relevance. JCO precision oncology 2022. PMID: 35952322


  7. Kwon DH, Karthikeyan S, Chang A, Borno HT, Koshkin VS, Desai A, Bose R, Friedlander T, Rodvelt T, Li P, Small EJ, Aggarwal RR, Belkora J. Mobile Audio Recording Technology to Promote Informed Decision Making in Advanced Prostate Cancer. 2021. PMID: 34932386


  8. Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY. The DNA methylation landscape of advanced prostate cancer. Nature genetics 2020. PMID: 32661416


  9. Ryan MJ, Bose R. Genomic Alteration Burden in Advanced Prostate Cancer and Therapeutic Implications. Frontiers in oncology 2019. PMID: 31824860


  10. Adams EJ, Karthaus WR, Hoover E, Liu D, Gruet A, Zhang Z, Cho H, DiLoreto R, Chhangawala S, Liu Y, Watson PA, Davicioni E, Sboner A, Barbieri CE, Bose R, Leslie CS, Sawyers CL. FOXA1 mutations alter pioneering activity, differentiation and prostate cancer phenotypes. Nature 2019. PMID: 31243370


  11. Bose R, Karthaus WR, Armenia J, Abida W, Iaquinta PJ, Zhang Z, Wongvipat J, Wasmuth EV, Shah N, Sullivan PS, Doran MG, Wang P, Patruno A, Zhao Y, Zheng D, Schultz N, Sawyers CL. ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis. Volume 546 of Issue 7660. Nature 2017. PMID: 28614298


  12. Viloria-Petit AM, David L, Jia JY, Erdemir T, Bane AL, Pinnaduwage D, Roncari L, Narimatsu M, Bose R, Moffat J, Wong JW, Kerbel RS, O'Malley FP, Andrulis IL, Wrana JL. A role for the TGFbeta-Par6 polarity pathway in breast cancer progression. Volume 106 of Issue 33. Proceedings of the National Academy of Sciences of the United States of America 2009. PMID: 19667198


  13. Narimatsu M, Bose R, Pye M, Zhang L, Miller B, Ching P, Sakuma R, Luga V, Roncari L, Attisano L, Wrana JL. Regulation of planar cell polarity by Smurf ubiquitin ligases. Volume 137 of Issue 2. Cell 2009. PMID: 19379695


  14. Bose R, Wrana JL. Regulation of Par6 by extracellular signals. Volume 18 of Issue 2. Current opinion in cell biology 2006. PMID: 16490351


  15. Wang HR, Ogunjimi AA, Zhang Y, Ozdamar B, Bose R, Wrana JL. Degradation of RhoA by Smurf1 ubiquitin ligase. Volume 406. Methods in enzymology 2006. PMID: 16472676


  16. Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL. High-throughput mapping of a dynamic signaling network in mammalian cells. Volume 307 of Issue 5715. Science (New York, N.Y.) 2005. PMID: 15761153


  17. Ozdamar B, Bose R, Barrios-Rodiles M, Wang HR, Zhang Y, Wrana JL. Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Volume 307 of Issue 5715. Science (New York, N.Y.) 2005. PMID: 15761148


  18. Bose R, Hwang SW. Income and spending patterns among panhandlers. Volume 167 of Issue 5. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 2002. PMID: 12240813


  19. Bose R, Ahmad A, Dicks A, Novak M, Kayser K, McClelland R. Spectroscopic characterization by laser flash photolysis of electrophilic intermediates derived from 4-aminostilbenes. Stilbene "nitrenium" ions and quinone methide imines Journal of the Chemical Society, Perkin Transactions 2 1999. PMID: