R. Sanders Williams, MD

President Emeritus

Publications

  1. Williams RS, Desmond-Hellmann S. Making translation work. Science (New York, N.Y.) 2011. PMID: 21680815


  2. R. Sanders Williams, P. Darrell Neufer. Regulation of Gene Expression in Skeletal Muscle by Contractile Activity. Comprehensive Physiology 2011. PMID:


  3. R. Sanders Williams. Sputnik, Slime Molds, and Botticelli in the Making of a Physician-Scientist. Medicine Science and Dreams 2011. PMID:


  4. Dzau VJ, Ackerly DC, Sutton-Wallace P, Merson MH, Williams RS, Krishnan KR, Taber RC, Califf RM. The role of academic health science systems in the transformation of medicine. Lancet (London, England) 2009. PMID: 19800111


  5. Yang J, Williams RS, Kelly DP. Bcl3 interacts cooperatively with peroxisome proliferator-activated receptor gamma (PPARgamma) coactivator 1alpha to coactivate nuclear receptors estrogen-related receptor alpha and PPARalpha. Molecular and cellular biology 2009. PMID: 19451226


  6. Jensen EB, Zheng D, Russell RA, Bassel-Duby R, Williams RS, Olson AL, Dohm GL. Regulation of GLUT4 expression in denervated skeletal muscle. American journal of physiology. Regulatory, integrative and comparative physiology 2009. PMID: 19321702


  7. Williams RS. Involvement of academic health centers abroad. Academic medicine : journal of the Association of American Medical Colleges 2008. PMID: 19202475


  8. R. Sanders Williams, Rhonda Bassel-Duby, Beverly Rothermel. Rcan1-4. AfCS-Nature Molecule Pages 2008. PMID:


  9. Stiber J, Hawkins A, Zhang ZS, Wang S, Burch J, Graham V, Ward CC, Seth M, Finch E, Malouf N, Williams RS, Eu JP, Rosenberg P. STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. Nature cell biology 2008. PMID: 18488020


  10. Michener JL, Yaggy S, Lyn M, Warburton S, Champagne M, Black M, Cuffe M, Califf R, Gilliss C, Williams RS, Dzau VJ. Improving the health of the community: Duke's experience with community engagement. Academic medicine : journal of the Association of American Medical Colleges 2008. PMID: 18367904


  11. Stiber JA, Zhang ZS, Burch J, Eu JP, Zhang S, Truskey GA, Seth M, Yamaguchi N, Meissner G, Shah R, Worley PF, Williams RS, Rosenberg PB. Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. Molecular and cellular biology 2008. PMID: 18268005


  12. Williams RS, Casey PJ, Kamei RK, Buckley EG, Soo KC, Merson MH, Krishnan RK, Dzau VJ. A global partnership in medical education between Duke University and the National University of Singapore. Academic medicine : journal of the Association of American Medical Colleges 2008. PMID: 18303355


  13. Davies KJ, Ermak G, Rothermel BA, Pritchard M, Heitman J, Ahnn J, Henrique-Silva F, Crawford D, Canaider S, Strippoli P, Carinci P, Min KT, Fox DS, Cunningham KW, Bassel-Duby R, Olson EN, Zhang Z, Williams RS, Gerber HP, Pérez-Riba M, Seo H, Cao X, Klee CB, Redondo JM, Maltais LJ, Bruford EA, Povey S, Molkentin JD, McKeon FD, Duh EJ, Crabtree GR, Cyert MS, de la Luna S, Estivill X. Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2007. PMID: 17595344


  14. Meeson AP, Shi X, Alexander MS, Williams RS, Allen RE, Jiang N, Adham IM, Goetsch SC, Hammer RE, Garry DJ. Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells. The EMBO journal 2007. PMID: 17363903


  15. Ellis B Jensen, R Sanders Williams, Rhonda Susan Bassel-Duby, G. Lynis Dohm. Calcium/Calmodulin-Activated Protein Kinase may be Important for Regulating GLUT4 Expression in Response to Exercise Training. The FASEB Journal 2006. PMID:


  16. Li P, Akimoto T, Zhang M, Williams RS, Yan Z. Resident stem cells are not required for exercise-induced fiber-type switching and angiogenesis but are necessary for activity-dependent muscle growth. American journal of physiology. Cell physiology 2006. PMID: 16407413


  17. Zhen Yan, R. Sanders Williams. Skeletal Muscle Hypertrophy and Response to Training. Principles of Molecular Medicine 2006. PMID:


  18. Stiber JA, Tabatabaei N, Hawkins AF, Hawke T, Worley PF, Williams RS, Rosenberg P. Homer modulates NFAT-dependent signaling during muscle differentiation. Developmental biology 2005. PMID: 16226241


  19. Akimoto T, Ushida T, Miyaki S, Akaogi H, Tsuchiya K, Yan Z, Williams RS, Tateishi T. Mechanical stretch inhibits myoblast-to-adipocyte differentiation through Wnt signaling. Biochemical and biophysical research communications 2005. PMID: 15721317


  20. Williams RS, Kraus WE. Exercise and health: can biotechnology confer similar benefits? PLoS medicine 2005. PMID: 15783257


  21. Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, Williams RS, Yan Z. Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. The Journal of biological chemistry 2005. PMID: 15767263


  22. Williams RS, Annex BH. Plasticity of myocytes and capillaries: a possible coordinating role for VEGF. Circulation research 2004. PMID: 15242980


  23. Masino AM, Gallardo TD, Wilcox CA, Olson EN, Williams RS, Garry DJ. Transcriptional regulation of cardiac progenitor cell populations. Circulation research 2004. PMID: 15242968


  24. Akimoto T, Ribar TJ, Williams RS, Yan Z. Skeletal muscle adaptation in response to voluntary running in Ca2+/calmodulin-dependent protein kinase IV-deficient mice. American journal of physiology. Cell physiology 2004. PMID: 15229108


  25. Rosenberg P, Hawkins A, Stiber J, Shelton JM, Hutcheson K, Bassel-Duby R, Shin DM, Yan Z, Williams RS. TRPC3 channels confer cellular memory of recent neuromuscular activity. Proceedings of the National Academy of Sciences of the United States of America 2004. PMID: 15199180


  26. Cronin EM, Thurmond FA, Bassel-Duby R, Williams RS, Wright WE, Nelson KD, Garner HR. Protein-coated poly(L-lactic acid) fibers provide a substrate for differentiation of human skeletal muscle cells. Journal of biomedical materials research. Part A 2004. PMID: 15127383


  27. van Rooij E, Doevendans PA, Crijns HJ, Heeneman S, Lips DJ, van Bilsen M, Williams RS, Olson EN, Bassel-Duby R, Rothermel BA, De Windt LJ. MCIP1 overexpression suppresses left ventricular remodeling and sustains cardiac function after myocardial infarction. Circulation research 2004. PMID: 14739160


  28. Rybkin II, Markham DW, Yan Z, Bassel-Duby R, Williams RS, Olson EN. Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. The Journal of biological chemistry 2003. PMID: 12590133


  29. Chin ER, Grange RW, Viau F, Simard AR, Humphries C, Shelton J, Bassel-Duby R, Williams RS, Michel RN. Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin. The Journal of physiology 2003. PMID: 12562945


  30. Vega RB, Rothermel BA, Weinheimer CJ, Kovacs A, Naseem RH, Bassel-Duby R, Williams RS, Olson EN. Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. Proceedings of the National Academy of Sciences of the United States of America 2003. PMID: 12515860


  31. Wu H, Gallardo T, Olson EN, Williams RS, Shohet RV. Transcriptional analysis of mouse skeletal myofiber diversity and adaptation to endurance exercise. Journal of muscle research and cell motility 2003. PMID: 14870974


  32. Yan Z, Choi S, Liu X, Zhang M, Schageman JJ, Lee SY, Hart R, Lin L, Thurmond FA, Williams RS. Highly coordinated gene regulation in mouse skeletal muscle regeneration. The Journal of biological chemistry 2002. PMID: 12477723


  33. Vega RB, Yang J, Rothermel BA, Bassel-Duby R, Williams RS. Multiple domains of MCIP1 contribute to inhibition of calcineurin activity. The Journal of biological chemistry 2002. PMID: 12063245


  34. Wu H, Kanatous SB, Thurmond FA, Gallardo T, Isotani E, Bassel-Duby R, Williams RS. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science (New York, N.Y.) 2002. PMID: 11951046


  35. Hill JA, Rothermel B, Yoo KD, Cabuay B, Demetroulis E, Weiss RM, Kutschke W, Bassel-Duby R, Williams RS. Targeted inhibition of calcineurin in pressure-overload cardiac hypertrophy. Preservation of systolic function. The Journal of biological chemistry 2002. PMID: 11786544


  36. Wu H, Rothermel B, Kanatous S, Rosenberg P, Naya FJ, Shelton JM, Hutcheson KA, DiMaio JM, Olson EN, Bassel-Duby R, Williams RS. Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. The EMBO journal 2001. PMID: 11707412


  37. Grange RW, Meeson A, Chin E, Lau KS, Stull JT, Shelton JM, Williams RS, Garry DJ. Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice. American journal of physiology. Cell physiology 2001. PMID: 11600411


  38. Dunn SE, Simard AR, Bassel-Duby R, Williams RS, Michel RN. Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. The Journal of biological chemistry 2001. PMID: 11555650


  39. Kong Y, Shelton JM, Rothermel B, Li X, Richardson JA, Bassel-Duby R, Williams RS. Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. Circulation 2001. PMID: 11390345


  40. Meeson AP, Radford N, Shelton JM, Mammen PP, DiMaio JM, Hutcheson K, Kong Y, Elterman J, Williams RS, Garry DJ. Adaptive mechanisms that preserve cardiac function in mice without myoglobin. Circulation research 2001. PMID: 11304494


  41. Rothermel BA, McKinsey TA, Vega RB, Nicol RL, Mammen P, Yang J, Antos CL, Shelton JM, Bassel-Duby R, Olson EN, Williams RS. Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America 2001. PMID: 11248078


  42. Yan Z, Serrano AL, Schiaffino S, Bassel-Duby R, Williams RS. Regulatory elements governing transcription in specialized myofiber subtypes. The Journal of biological chemistry 2001. PMID: 11279187


  43. Yang J, Rothermel B, Vega RB, Frey N, McKinsey TA, Olson EN, Bassel-Duby R, Williams RS. Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Circulation research 2000. PMID: 11110780


  44. Zhu W, Williams RS, Kodadek T. A CDC6 protein-binding peptide selected using a bacterial two-hybrid-like system is a cell cycle inhibitor. The Journal of biological chemistry 2000. PMID: 10896933


  45. Wren JD, Forgacs E, Fondon JW, Pertsemlidis A, Cheng SY, Gallardo T, Williams RS, Shohet RV, Minna JD, Garner HR. Repeat polymorphisms within gene regions: phenotypic and evolutionary implications. American journal of human genetics 2000. PMID: 10889045


  46. Li K, Li Y, Shelton JM, Richardson JA, Spencer E, Chen ZJ, Wang X, Williams RS. Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell 2000. PMID: 10830166


  47. Garry DJ, Meeson A, Elterman J, Zhao Y, Yang P, Bassel-Duby R, Williams RS. Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF. Proceedings of the National Academy of Sciences of the United States of America 2000. PMID: 10792059


  48. Wu H, Naya FJ, McKinsey TA, Mercer B, Shelton JM, Chin ER, Simard AR, Michel RN, Bassel-Duby R, Olson EN, Williams RS. MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. The EMBO journal 2000. PMID: 10790363


  49. Rothermel B, Vega RB, Yang J, Wu H, Bassel-Duby R, Williams RS. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. The Journal of biological chemistry 2000. PMID: 10722714


  50. Naya FJ, Mercer B, Shelton J, Richardson JA, Williams RS, Olson EN. Stimulation of slow skeletal muscle fiber gene expression by calcineurin in vivo. The Journal of biological chemistry 2000. PMID: 10671477


  51. Yan Z, Fedorov SA, Mumby MC, Williams RS. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Molecular and cellular biology 2000. PMID: 10629059


  52. Xia Y, McMillin JB, Lewis A, Moore M, Zhu WG, Williams RS, Kellems RE. Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. The Journal of biological chemistry 2000. PMID: 10636885


  53. Yang Q, Kong Y, Rothermel B, Garry DJ, Bassel-Duby R, Williams RS. The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B. The Biochemical journal 2000. PMID: 10620510


  54. YANG Quan, KONG Yanfeng, Beverly ROTHERMEL, Daniel J. GARRY, Rhonda BASSEL-DUBY, R. Sanders WILLIAMS. The winged-helix/forkhead protein myocyte nuclear factor ß (MNF-ß) forms a co-repressor complex with mammalian Sin3B. Biochemical Journal 2000. PMID:


  55. E. R. Chin, R. W. Grange, M. Maier, R. S. Bassel-Duby, R. S. Williams. ALTERED CONTRACTILE FUNCTION IN SLOW-TWITCH MUSCLE FROM TRANSGENIC MICE OVEREXPRESSING PARVALBUMIN. Medicine & Science in Sports & Exercise 1999. PMID:


  56. Garry DJ, Ordway GA, Lorenz JN, Radford NB, Chin ER, Grange RW, Bassel-Duby R, Williams RS. Mice without myoglobin. Nature 1998. PMID: 9804424


  57. Grayson J, Bassel-Duby R, Williams RS. Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. Journal of cellular biochemistry 1998. PMID: 9706874


  58. Chin ER, Olson EN, Richardson JA, Yang Q, Humphries C, Shelton JM, Wu H, Zhu W, Bassel-Duby R, Williams RS. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes & development 1998. PMID: 9716403


  59. Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, Nevins JR. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes & development 1998. PMID: 9679057


  60. Z. Yan, Bassel-Duby R., K. H. Graves, R. S. Williams. DEVELOPMENTAL REGULATION OF MYOGLOBIN GENE EXPRESSION IN TRANSGENIC MICE. Medicine & Science in Sports & Exercise 1998. PMID:


  61. Yan Z, DeGregori J, Shohet R, Leone G, Stillman B, Nevins JR, Williams RS. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 1998. PMID: 9520412


  62. Schultz RA, Swoap SJ, McDaniel LD, Zhang B, Koon EC, Garry DJ, Li K, Williams RS. Differential expression of mitochondrial DNA replication factors in mammalian tissues. The Journal of biological chemistry 1998. PMID: 9452467


  63. Neufer PD, Ordway GA, Williams RS. Transient regulation of c-fos, alpha B-crystallin, and hsp70 in muscle during recovery from contractile activity. The American journal of physiology 1998. PMID: 9486122


  64. Yang Q, Bassel-Duby R, Williams RS. Transient expression of a winged-helix protein, MNF-beta, during myogenesis. Molecular and cellular biology 1997. PMID: 9271401


  65. Garry DJ, Yang Q, Bassel-Duby R, Williams RS. Persistent expression of MNF identifies myogenic stem cells in postnatal muscles. Developmental biology 1997. PMID: 9268575


  66. Li K, Williams RS. Tetramerization and single-stranded DNA binding properties of native and mutated forms of murine mitochondrial single-stranded DNA-binding proteins. The Journal of biological chemistry 1997. PMID: 9079701


  67. Williams RS, Shohet RV, Stillman B. A human protein related to yeast Cdc6p. Proceedings of the National Academy of Sciences of the United States of America 1997. PMID: 8990175


  68. Neufer PD, Ordway GA, Hand GA, Shelton JM, Richardson JA, Benjamin IJ, Williams RS. Continuous contractile activity induces fiber type specific expression of HSP70 in skeletal muscle. The American journal of physiology 1996. PMID: 8997182


  69. Radford NB, Fina M, Benjamin IJ, Moreadith RW, Graves KH, Zhao P, Gavva S, Wiethoff A, Sherry AD, Malloy CR, Williams RS. Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America 1996. PMID: 8637874


  70. Parsons WJ, Williams RS, Shelton JM, Luo Y, Kessler DJ, Richardson JA. Developmental regulation of cytochrome oxidase subunit VIa isoforms in cardiac and skeletal muscle. The American journal of physiology 1996. PMID: 8779832


  71. Garry DJ, Bassel-Duby RS, Richardson JA, Grayson J, Neufer PD, Williams RS. Postnatal development and plasticity of specialized muscle fiber characteristics in the hindlimb. Developmental genetics 1996. PMID: 8900047


  72. Wilson LB, Dyke CK, Parsons D, Wall PT, Pawelczyk JA, Williams RS, Mitchell JH. Effect of skeletal muscle fiber type on the pressor response evoked by static contraction in rabbits. Journal of applied physiology (Bethesda, Md. : 1985) 1995. PMID: 8594037


  73. Li K, Neufer PD, Williams RS. Nuclear responses to depletion of mitochondrial DNA in human cells. The American journal of physiology 1995. PMID: 7491917


  74. Li K, Williams RS. Cloning and characterization of three new murine genes encoding short homologues of RNase P RNA. The Journal of biological chemistry 1995. PMID: 7559668


  75. Grayson J, Williams RS, Yu YT, Bassel-Duby R. Synergistic interactions between heterologous upstream activation elements and specific TATA sequences in a muscle-specific promoter. Molecular and cellular biology 1995. PMID: 7891680


  76. Michel JB, Ordway GA, Richardson JA, Williams RS. Biphasic induction of immediate early gene expression accompanies activity-dependent angiogenesis and myofiber remodeling of rabbit skeletal muscle. The Journal of clinical investigation 1994. PMID: 7518831


  77. Bassel-Duby R, Hernandez MD, Yang Q, Rochelle JM, Seldin MF, Williams RS. Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Molecular and cellular biology 1994. PMID: 8007964


  78. R Bassel-Duby, M D Hernandez, Q Yang, J M Rochelle, M F Seldin, R S Williams. Myocyte nuclear factor, a novel winged-helix transcription factor under both developmental and neural regulation in striated myocytes. Molecular and cellular biology 1994. PMID:


  79. Gregory A. Hand, R. Sanders Williams, Jeffrey B. Michel, George A. Ordway. 752 CHRONIC MOTOR NERVE STIMULATION INDUCES EXPRESSION OF CYTOSOLIC AND MITOCHONDRIAL HEAT SHOCK RNAS. Medicine & Science in Sports & Exercise 1994. PMID:


  80. Li K, Smagula CS, Parsons WJ, Richardson JA, Gonzalez M, Hagler HK, Williams RS. Subcellular partitioning of MRP RNA assessed by ultrastructural and biochemical analysis. The Journal of cell biology 1994. PMID: 7510714


  81. G. Grohé, R. H. Karas, Ludwig Neyses, Hans Vetter, R. S. Williams. 77 Genetic control of muscle growth by the growth-suppressor gene, p53. Journal of hypertension 1993. PMID:


  82. Ordway GA, Li K, Hand GA, Williams RS. RNA subunit of mitochondrial RNA-processing enzyme is induced by contractile activity in striated muscle. The American journal of physiology 1993. PMID: 7506487


  83. Neyses L, Nouskas J, Luyken J, Fronhoffs S, Oberdorf S, Pfeifer U, Williams RS, Sukhatme VP, Vetter H. Induction of immediate-early genes by angiotensin II and endothelin-1 in adult rat cardiomyocytes. Journal of hypertension 1993. PMID: 7504706


  84. Bassel-Duby R, Grohe CM, Jessen ME, Parsons WJ, Richardson JA, Chao R, Grayson J, Ring WS, Williams RS. Sequence elements required for transcriptional activity of the human myoglobin promoter in intact myocardium. Circulation research 1993. PMID: 8330378


  85. Williams RS, Thomas JA, Fina M, German Z, Benjamin IJ. Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress. The Journal of clinical investigation 1993. PMID: 8326014


  86. Parsons WJ, Richardson JA, Graves KH, Williams RS, Moreadith RW. Gradients of transgene expression directed by the human myoglobin promoter in the developing mouse heart. Proceedings of the National Academy of Sciences of the United States of America 1993. PMID: 8446585


  87. Bassel-Duby R, Hernandez MD, Gonzalez MA, Krueger JK, Williams RS. A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter. Molecular and cellular biology 1992. PMID: 1406677


  88. R Bassel-Duby, M D Hernandez, M A Gonzalez, J K Krueger, R S Williams. A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter. Molecular and cellular biology 1992. PMID:


  89. Mao ZF. [Surgical treatment of abnormal myocardial bundle in the right ventricle]. Zhonghua xin xue guan bing za zhi 1992. PMID: 1304494


  90. Benjamin IJ, Horie S, Greenberg ML, Alpern RJ, Williams RS. Induction of stress proteins in cultured myogenic cells. Molecular signals for the activation of heat shock transcription factor during ischemia. The Journal of clinical investigation 1992. PMID: 1569208


  91. D. B. Friedman, R. D. Adamick, T. I. Musch, G. A. Ordway, R. S. Williams. Exercise function and biochemical properties of ß-adrenergic receptors of canine heart. Scandinavian Journal of Medicine and Science in Sports 1991. PMID:


  92. Williams RS, Johnston SA, Riedy M, DeVit MJ, McElligott SG, Sanford JC. Introduction of foreign genes into tissues of living mice by DNA-coated microprojectiles. Proceedings of the National Academy of Sciences of the United States of America 1991. PMID: 2011582


  93. Ludwig Neyses, Janis Nouskas, Joachim Luyken, Stefan Fronhoffs, R.Sanders Williams, Vikas P. Sukhatme, Hans Vetter. Induction of the early growth response gene-1, c-fos, and protein synthesis in adult cardiomyocytes by angiotensin II and endothelin. Journal of the American College of Cardiology 1991. PMID:


  94. Annex BH, Kraus WE, Dohm GL, Williams RS. Mitochondrial biogenesis in striated muscles: rapid induction of citrate synthase mRNA by nerve stimulation. The American journal of physiology 1991. PMID: 1996609


  95. Stephen A. Johnston, Mark Riedy, Michael J. De Vit, J. C. Sanford, Sandra McElligott, R. Sanders Williams. Biolistic transformation of animal tissue. In Vitro Cellular & Developmental Biology - Plant 1991. PMID:


  96. Annex BH, Williams RS. Mitochondrial DNA structure and expression in specialized subtypes of mammalian striated muscle. Molecular and cellular biology 1990. PMID: 1700273


  97. B H Annex, R S Williams. Mitochondrial DNA structure and expression in specialized subtypes of mammalian striated muscle. Molecular and cellular biology 1990. PMID:


  98. Benjamin IJ, Kröger B, Williams RS. Activation of the heat shock transcription factor by hypoxia in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America 1990. PMID: 1696723


  99. Williams RS. Genetic mechanisms that determine oxidative capacity of striated muscles. Control of gene transcription. Circulation 1990. PMID: 2197016


  100. Morrow NG, Kraus WE, Moore JW, Williams RS, Swain JL. Increased expression of fibroblast growth factors in a rabbit skeletal muscle model of exercise conditioning. The Journal of clinical investigation 1990. PMID: 2347914


  101. Wefald FC, Devlin BH, Williams RS. Functional heterogeneity of mammalian TATA-box sequences revealed by interaction with a cell-specific enhancer. Nature 1990. PMID: 2156167


  102. Devlin BH, Wefald FC, Kraus WE, Bernard TS, Williams RS. Identification of a muscle-specific enhancer within the 5'-flanking region of the human myoglobin gene. The Journal of biological chemistry 1989. PMID: 2760049


  103. Kraus WE, Bernard TS, Williams RS. Interactions between sustained contractile activity and beta-adrenergic receptors in regulation of gene expression in skeletal muscles. The American journal of physiology 1989. PMID: 2538062


  104. Schachat F, Williams RS, Schnurr CA. Coordinate changes in fast thin filament and Z-line protein expression in the early response to chronic stimulation. The Journal of biological chemistry 1988. PMID: 3170534


  105. Harlan WR, Williams RS. Activity-induced adaptations in skeletal muscles of iron-deficient rabbits. Journal of applied physiology (Bethesda, Md. : 1985) 1988. PMID: 2844718


  106. Blumenthal JA, Emery CF, Walsh MA, Cox DR, Kuhn CM, Williams RB, Williams RS. Exercise training in healthy type A middle-aged men: effects on behavioral and cardiovascular responses. Psychosomatic medicine 1988. PMID: 3413273


  107. Blumenthal JA, Rejeski WJ, Walsh-Riddle M, Emery CF, Miller H, Roark S, Ribisl PM, Morris PB, Brubaker P, Williams RS. Comparison of high- and low-intensity exercise training early after acute myocardial infarction. The American journal of cardiology 1988. PMID: 3337013


  108. Williams RS, Harlan W. Effects of inhibition of mitochondrial protein synthesis in skeletal muscle. The American journal of physiology 1987. PMID: 2892413


  109. Friedman DB, Ordway GA, Williams RS. Exercise-induced functional desensitization of canine cardiac beta-adrenergic receptors. Journal of applied physiology (Bethesda, Md. : 1985) 1987. PMID: 3036756


  110. Underwood LE, Williams RS. Pretranslational regulation of myoglobin gene expression. The American journal of physiology 1987. PMID: 3565559


  111. Williams RS, Garcia-Moll M, Mellor J, Salmons S, Harlan W. Adaptation of skeletal muscle to increased contractile activity. Expression nuclear genes encoding mitochondrial proteins. The Journal of biological chemistry 1987. PMID: 2880844


  112. Friedman DB, Musch TI, Williams RS, Ordway GA. Beta adrenergic blockade with propranolol and atenolol in the exercising dog: evidence for beta 2 adrenoceptors in the sinoatrial node. Cardiovascular research 1987. PMID: 2822246


  113. William E. Kraus, Maria Garcia-Moll, R. Sanders Williams. Identification of tissue-specific and developmental stage-specific nuclear proteins that bind to two elements in the 5'-flanking region of the human myoglobin gene. Journal of molecular and cellular cardiology 1987. PMID:


  114. Williams RS. Mitochondrial gene expression in mammalian striated muscle. Evidence that variation in gene dosage is the major regulatory event. The Journal of biological chemistry 1986. PMID: 3745193


  115. Schaffer W, Williams RS. Age-dependent changes in expression of alpha 1-adrenergic receptors in rat myocardium. Biochemical and biophysical research communications 1986. PMID: 3017323


  116. Higginbotham MB, Morris KG, Williams RS, Coleman RE, Cobb FR. Physiologic basis for the age-related decline in aerobic work capacity. The American journal of cardiology 1986. PMID: 3717040


  117. Higginbotham MB, Morris KG, Williams RS, McHale PA, Coleman RE, Cobb FR. Regulation of stroke volume during submaximal and maximal upright exercise in normal man. Circulation research 1986. PMID: 3948345


  118. Williams RS, Salmons S, Newsholme EA, Kaufman RE, Mellor J. Regulation of nuclear and mitochondrial gene expression by contractile activity in skeletal muscle. The Journal of biological chemistry 1986. PMID: 3941082


  119. McLeod AA, Knopes KD, Shand DG, Williams RS. Beta 1-selective and non-selective beta-adrenoceptor blockade, anaerobic threshold and respiratory gas exchange during exercise. British journal of clinical pharmacology 1985. PMID: 2858214


  120. Adragna NC, Chang JL, Morey MC, Williams RS. Effect of exercise on cation transport in human red cells. Hypertension (Dallas, Tex. : 1979) 1985. PMID: 2579902


  121. Williams RS, McKinnis RA, Cobb FR, Higginbotham MB, Wallace AG, Coleman RE, Califf RM. Effects of physical conditioning on left ventricular ejection fraction in patients with coronary artery disease. Circulation 1984. PMID: 6723012


  122. McLeod AA, Kraus WE, Williams RS. Effects of beta 1-selective and nonselective beta-adrenoceptor blockade during exercise conditioning in healthy adults. The American journal of cardiology 1984. PMID: 6375340


  123. Shalom R, Blumenthal JA, Williams RS, McMurray RG, Dennis VW. Feasibility and benefits of exercise training in patients on maintenance dialysis. Kidney international 1984. PMID: 6471676


  124. Williams RS, Schaible TF, Bishop T, Morey M. Effects of endurance training on cholinergic and adrenergic receptors of rat heart. Journal of molecular and cellular cardiology 1984. PMID: 6330370


  125. McLeod AA, Brown JE, Kitchell BB, Sedor FA, Kuhn DC, Williams RS, Shand DG. Hemodynamic and metabolic responses to exercise after alpha 1-, beta 1-, and nonselective beta-adrenoceptor blockade in man. The American journal of medicine 1984. PMID: 6702866


  126. Williams RS, Caron MG, Daniel K. Skeletal muscle beta-adrenergic receptors: variations due to fiber type and training. The American journal of physiology 1984. PMID: 6320672


  127. Williams RS, Schaible TF, Scheuer J, Kennedy R. Effects of experimental diabetes on adrenergic and cholinergic receptors of rat myocardium. Diabetes 1983. PMID: 6311651


  128. McLeod AA, Brown JE, Kuhn C, Kitchell BB, Sedor FA, Williams RS, Shand DG. Differentiation of hemodynamic, humoral and metabolic responses to beta 1- and beta 2-adrenergic stimulation in man using atenolol and propranolol. Circulation 1983. PMID: 6299612


  129. Williams RS. Selectivity of prenalterol for adrenergic receptor subtypes: a potential mechanism of inotropic selectivity. Journal of cardiovascular pharmacology 1983. PMID: 6188901


  130. Kopitsky RG, Switzer ME, Williams RS, McKee PA. The basis for the increase in factor VIII procoagulant activity during exercise. Thrombosis and haemostasis 1983. PMID: 6405498


  131. R. SANDERS WILLIAMS, ROBERT J. LEFKOWITZ. 11 The Effects of Thyroid Hormone on Adrenergic Receptors. 1983. PMID:


  132. Blumenthal JA, Williams RS, Wallace AG, Williams RB, Needles TL. Physiological and psychological variables predict compliance to prescribed exercise therapy in patients recovering from myocardial infarction. Psychosomatic medicine 1982. PMID: 7163455


  133. Blumenthal JA, Williams RS, Needels TL, Wallace AG. Psychological changes accompany aerobic exercise in healthy middle-aged adults. Psychosomatic medicine 1982. PMID: 7163456


  134. Williams RS, Bishop T. Enhanced receptor-cyclase coupling and augmented catecholamine-stimulated lipolysis in exercising rats. The American journal of physiology 1982. PMID: 6291402


  135. Cobb FR, Williams RS, McEwan P, Jones RH, Coleman RE, Wallace AG. Effects of exercise training on ventricular function in patients with recent myocardial infarction. Circulation 1982. PMID: 7083497


  136. Conn EH, Williams RS, Wallace AG. Exercise responses before and after physical conditioning in patients with severely depressed left ventricular function. The American journal of cardiology 1982. PMID: 7058745


  137. Williams RS, Eden RS, Moll ME, Lester RM, Wallace AG. Autonomic mechanisms of training bradycardia: beta-adrenergic receptors in humans. Journal of applied physiology: respiratory, environmental and exercise physiology 1981. PMID: 6271713


  138. Williams RS, Bishop T. Selectivity of dobutamine for adrenergic receptor subtypes: in vitro analysis by radioligand binding. The Journal of clinical investigation 1981. PMID: 6263950


  139. Williams RS, Dukes DF, Lefkowitz RJ. Subtype specificity of alpha-adrenergic receptors in rat heart. Journal of cardiovascular pharmacology 1981. PMID: 6168833


  140. Williams RS, Bashore TM. Paroxysmal hypotension associated with sympathetic withdrawal. A new disorder of autonomic vasomotor regulation. Circulation 1980. PMID: 7408163


  141. Williams RS, Logue EE, Lewis JG, Barton T, Stead NW, Wallace AG, Pizzo SV. Physical conditioning augments the fibrinolytic response to venous occlusion in healthy adults. The New England journal of medicine 1980. PMID: 7189244


  142. Blumenthal JA, Williams RS, Williams RB, Wallace AG. Effects of exercise on the Type A (coronary prone) behavior pattern. Psychosomatic medicine 1980. PMID: 7192871


  143. Williams RS. Physical conditioning and membrane receptors for cardioregulatory hormones. Cardiovascular research 1980. PMID: 6249497


  144. Eric H. Conn, R.Sanders Williams, Andrew G. Wallace. Physical conditioning in patients with severely depressed left ventricular function. The American journal of cardiology 1980. PMID:


  145. Williams RS, Behar VS, Peter RH. Left bundle branch block: angiographic segmental wall motion abnormalities. The American journal of cardiology 1979. PMID: 495497


  146. Moll ME, Williams RS, Lester RM, Quarfordt SH, Wallace AG. Cholesterol metabolism in non-obese women--Failure of physical conditioning to alter levels of high density lipoprotein cholesterol. Atherosclerosis 1979. PMID: 229871


  147. Williams RS, Guthrow CE, Lefkowitz RJ. Beta-Adrenergic receptors of human lymphocytes are unaltered by hyperthyroidism. The Journal of clinical endocrinology and metabolism 1979. PMID: 218998


  148. Williams RS, Lefkowitz RJ. Thyroid hormone regulation of alpha-adrenergic receptors: studies in rat myocardium. Journal of cardiovascular pharmacology 1979. PMID: 94388


  149. Jarboe CH, Lipson SF, Bannon MJ, Dunnigan DA. 2,5-Bis(3,4-dimethoxybenzyl)cyclopentylamine, a peripheral dopamine blocking agent. Journal of medicinal chemistry 1978. PMID: 569208


  150. Williams RS, Lefkowitz RJ. Alpha-adrenergic receptors in rat myocardium. Identification by binding of [3H]dihydroergocryptine. Circulation research 1978. PMID: 213201