Michael Kattah, MD, PhD

ASST PROF IN RES-HCOMP

Gastroenterology

As an Assistant Professor in the Division of GI at UCSF, I am interested in the molecular underpinnings of intestinal inflammation and Inflammatory Bowel Disease (IBD). We employ a variety of tools to study intestinal epithelial cells and death signaling pathways in mouse models, patient-derived biopsies, and organoids.

Education
Gastroenterology Fellowship, 2016 - Gastroenterology/Medicine, UCSF
Medicine Residency, 2012 - Medicine, Brigham and Women's Hospital
MD/PhD, 2010 - Medicine, Stanford University
Honors and Awards
  • Young Physician Scientist Award, American Society for Clinical Investigation, 2021
  • Recognition for Scientific Accomplishment as an Early Stage Investigator, DDW 2016, 2016
  • Resident Mentoring Award, Brigham and Women's Hospital, 2012
  • Hugh McDevitt Award, Stanford University, 2008
Websites
Publications
  1. Elvira Mennillo, Gyehyun Lee, Madison Lotstein, Jessica Tsui, Uma Mahadevan, Gabriela K. Fragiadakis, Alexis Combes, Michael Kattah. Tu1756 TWO SPATIAL TRANSCRIPTOMIC PLATFORMS IDENTIFIED POTENTIAL PATHWAYS LINKED TO VEDOLIZUMAB RESPONSIVENESS IN ULCERATIVE COLITIS. Gastroenterology 2024. PMID:


  2. Mennillo E, Kim YJ, Lee G, Rusu I, Patel RK, Dorman LC, Flynn E, Li S, Bain JL, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Lotstein ML, Rahim M, Naser M, Bernard-Vazquez F, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh DY, Fragiadakis GK, Pisco A, Combes AJ, Kattah MG. Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis. Nature communications 2024. PMID: 38374043


  3. Elvira Mennillo, Gyehyun Lee, Madison Lotstein, Jessica Tsui, Uma Mahadevan, Gabriela Fragiadakis, Alexis Combes, Michael Kattah. VEDOLIZUMAB RESPONSE AND NON-RESPONSE IN ULCERATIVE COLITIS: INSIGHTS FROM SPATIAL TRANSCRIPTOMICS. Gastroenterology 2024. PMID:


  4. Elvira Mennillo, Gyehyun Lee, Madison Lotstein, Jessica Tsui, Uma Mahadevan, Gabriela Fragiadakis, Alexis Combes, Michael Kattah. VEDOLIZUMAB RESPONSE AND NON-RESPONSE IN ULCERATIVE COLITIS: INSIGHTS FROM SPATIAL TRANSCRIPTOMICS. Inflammatory bowel diseases 2024. PMID:


  5. Mennillo E, Kim YJ, Rusu I, Lee G, Dorman LC, Bernard-Vazquez F, Bain JL, Patel R, Andersen C, Rao A, Tamaki S, Tsui J, Shen A, Naser M, Eckalbar W, Cho SJ, Beck K, El-Nachef N, Lewin S, Selvig DR, Terdiman JP, Mahadevan U, Oh DY, Fragiadakis GK, Pisco A, Combes AJ, Kattah MG. Single-cell and spatial multi-omics identify innate and stromal modules targeted by anti-integrin therapy in ulcerative colitis. bioRxiv : the preprint server for biology 2023. PMID: 36711576


  6. Elvira Mennillo, Yang Joon Kim, Iulia Rusu, Gyehyun Lee, Leah Dorman, Faviola Bernard-Vazquez, Jared Bain, Ravi K. Patel, Christopher Andersen, Stanley Tamaki, Jessica Tsui, Kendall Beck, Najwa El-Nachef, Sara M. Lewin, Daniel Selvig, Jonathan P. Terdiman, Uma Mahadevan, David Oh, Gabriela K. Fragiadakis, Angela O. Pisco, Alexis Combes, Michael Kattah. 630 SINGLE-CELL AND SPATIAL MULTI-OMICS IDENTIFY INNATE AND STROMAL MODULES TARGETED BY ANTI-INTEGRIN THERAPY IN ULCERATIVE COLITIS. Gastroenterology 2023. PMID:


  7. Basta DW, Vong M, Beshimova A, Nakamura BN, Rusu I, Kattah MG, Shao L. A20 Restricts NOS2 Expression and Intestinal Tumorigenesis in a Mouse Model of Colitis-Associated Cancer. Gastro Hep Advances 2022. PMID: 36636264


  8. Blaisdell A, Zhou Y, Kattah MG, Fisher SJ, Mahadevan U. Vedolizumab Antagonizes MAdCAM-1-Dependent Human Placental Cytotrophoblast Adhesion and Invasion In Vitro. 2022. PMID: 35349682


  9. Merana GR, Dwyer LR, Dhariwala MO, Weckel A, Gonzalez JR, Okoro JN, Cohen JN, Tamaki CM, Han J, Tasoff P, Palacios-Calderon Y, Ha CWY, Lynch SV, Segre JA, Kong HH, Kattah MG, Ma A, Scharschmidt TC. Intestinal inflammation alters the antigen-specific immune response to a skin commensal. 2022. PMID: 35649365


  10. Iulia Rusu, Elvira Mennillo, Jared L. Bain, Zhongmei Li, Xiaofei Sun, Kimberly Ly, Yenny Y. Rosli, Mohammad Naser, Zunqiu Wang, Rommel Advincula, Philip Achacoso, Ling Shao, Bahram Razani, Ophir D. Klein, Alexander Marson, Jessie A. Turnbaugh, Peter J. Turnbaugh, Barbara Malynn, Averil Ma, Michael Kattah. Tu1517: MICROBIAL SIGNALS, MYD88, AND LYMPHOTOXIN DRIVE TNFINDEPENDENT DEATH OF A20 AND ABIN-1 DEFICIENT EPITHELIUM. Gastroenterology 2022. PMID:


  11. Rusu I, Mennillo E, Bain JL, Li Z, Sun X, Ly KM, Rosli YY, Naser M, Wang Z, Advincula R, Achacoso P, Shao L, Razani B, Klein OD, Marson A, Turnbaugh JA, Turnbaugh PJ, Malynn BA, Ma A, Kattah MG. Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage. 2022. PMID: 35077396


  12. Regner EH, Green AJ, Bain JL, Kattah MG, Mahadevan U. Importance of Not MSing Cerebral White Matter Disease in Patients with Inflammatory Bowel Disease. Digestive diseases and sciences 2020. PMID: 32651742


  13. Talpin A, Kattah MG, Advincula R, Fadrosh D, Lynch K, LaMere B, Fujimura KE, Nagalingam NA, Malynn BA, Lynch SV, Ma A. A20 in dendritic cells restrains intestinal anti-bacterial peptide expression and preserves commensal homeostasis. PloS one 2019. PMID: 31295268


  14. Hammami MB, Gill R, Thiruvengadam N, Oh DY, Beck K, Mahadevan U, Kattah MG. Balancing the Checkpoint: Managing Colitis Associated with Dual Checkpoint Inhibitors and High-Dose Aspirin. Digestive diseases and sciences 2019. PMID: 30778872


  15. Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U. Correction: Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants. Clinical and translational gastroenterology 2018. PMID: 30065242


  16. Kattah MG, Shao L, Rosli YY, Shimizu H, Whang MI, Advincula R, Achacoso P, Shah S, Duong BH, Onizawa M, Tanbun P, Malynn BA, Ma A. A20 and ABIN-1 synergistically preserve intestinal epithelial cell survival. The Journal of experimental medicine 2018. PMID: 29930103


  17. Kidambi TD, Terdiman JP, El-Nachef N, Singh A, Kattah MG, Lee JK. Effect of I-scan Electronic Chromoendoscopy on Detection of Adenomas During Colonoscopy. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2018. PMID: 29935326


  18. Nakamura BN, Glazier A, Kattah MG, Duong B, Jia Y, Campo D, Shao L. A20 regulates canonical wnt-signaling through an interaction with RIPK4. PloS one 2018. PMID: 29718933


  19. Kattah MG, Milush JM, Burt T, McCabe RP, Whang MI, Ma A, Mahadevan U. Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants. Clinical and translational gastroenterology 2018. PMID: 29618720


  20. Chitre AS, Kattah MG, Rosli YY, Pao M, Deswal M, Deeks SG, Hunt PW, Abdel-Mohsen M, Montaner LJ, Kim CC, Ma A, Somsouk M, McCune JM. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS pathogens 2018. PMID: 29505600


  21. Kattah MG, Malynn BA, Ma A. Ubiquitin-Modifying Enzymes and Regulation of the Inflammasome. Journal of molecular biology 2017. PMID: 29031697


  22. Michael Kattah, Jeffrey Milush, Trevor Burt, Uma Mahadevan. 332e Multiparameter Flow Cytometry Reveals Differences in B Cells Subsets among Infants Born to Mothers being Treated for IBD. Gastroenterology 2017. PMID:


  23. Whang MI, Tavares RM, Benjamin DI, Kattah MG, Advincula R, Nomura DK, Debnath J, Malynn BA, Ma A. The Ubiquitin Binding Protein TAX1BP1 Mediates Autophagasome Induction and the Metabolic Transition of Activated T Cells. Immunity 2017. PMID: 28314591


  24. Michael Kattah, Ling Shao, Yenny Rosli, Michael Whang, Rommel Advincula, Barbara Malynn, Averil Ma. P-285 A20 and ABIN-1 Cooperate to Preserve Intestinal Epithelial Homeostasis. Inflammatory bowel diseases 2017. PMID:


  25. Benjamin Hassid, Brandon Lamere, Michael Kattah, Uma Mahadevan. Effect of Intense Exercise on Inflammatory Bowel Disease Activity. The American journal of gastroenterology 2016. PMID:


  26. Ling Shao, Michael G. Kattah, Michael Whang, Bao Duong, Michio Onizawa, Sadeea Abbasi, Yenny Rosli, Joseph Callahan, Mihir Pendse, Julio Barrera, Alison Glazier, Rommel Advincula, Barbara Malynn, Averil Ma. 245 A20 and ABIN-1 Cooperate to Restrict Intestinal Epithelial Cell Death and Maintain Mucosal Immune Homeostasis. Gastroenterology 2016. PMID:


  27. Kattah NH, Newell EW, Jarrell JA, Chu AD, Xie J, Kattah MG, Goldberger O, Ye J, Chakravarty EF, Davis MM, Utz PJ. Tetramers reveal IL-17-secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease. Proceedings of the National Academy of Sciences of the United States of America 2015. PMID: 25713364


  28. Haddon DJ, Jarrell JA, Hughes MR, Snyder K, McNagny KM, Kattah MG, Utz PJ. Measurement of mast cell surface molecules by high-throughput immunophenotyping using transcription (HIT). Methods in molecular biology (Clifton, N.J.) 2015. PMID: 25388264


  29. Nicole Kattah, Evan Newell, Alvina Chu, Michael Kattah, Mark Davis. Antigen Specific T Cells in Lupus Recognize U1-70 and Produce IL-17 by Tetramer Staining. Clinical Immunology 2010. PMID:


  30. Kattah NH, Kattah MG, Utz PJ. The U1-snRNP complex: structural properties relating to autoimmune pathogenesis in rheumatic diseases. Immunological reviews 2010. PMID: 20192997


  31. Lin JT, Lineberry NB, Kattah MG, Su LL, Utz PJ, Fathman CG, Wu L. Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression. Journal of immunology (Baltimore, Md. : 1950) 2009. PMID: 19414743


  32. Jack Lin, Neil Lineberry, Michael Kattah, Leon Su, Paul Utz, C. Garrison Fathman. OR.85. Regulation of GRAIL Expression by mTOR Controls Naive CD4 T Cell Proliferation. Clinical Immunology 2009. PMID:


  33. Lee JW, Wang P, Kattah MG, Youssef S, Steinman L, DeFea K, Straus DS. Differential regulation of chemokines by IL-17 in colonic epithelial cells. Journal of immunology (Baltimore, Md. : 1950) 2008. PMID: 18941244


  34. Chen Z, Tabakman SM, Goodwin AP, Kattah MG, Daranciang D, Wang X, Zhang G, Li X, Liu Z, Utz PJ, Jiang K, Fan S, Dai H. Protein microarrays with carbon nanotubes as multicolor Raman labels. Nature biotechnology 2008. PMID: 18953353


  35. Kattah MG, Coller J, Cheung RK, Oshidary N, Utz PJ. HIT: a versatile proteomics platform for multianalyte phenotyping of cytokines, intracellular proteins and surface molecules. Nature medicine 2008. PMID: 18849997


  36. Kattah MG, Wong MT, Yocum MD, Utz PJ. Cytokines secreted in response to Toll-like receptor ligand stimulation modulate differentiation of human Th17 cells. Arthritis and rheumatism 2008. PMID: 18512782


  37. Kattah MG, Utz PJ, Balboni I. Protein microarrays address the elephant in the room. Clinical chemistry 2008. PMID: 18509011


  38. Michael Kattah, Michael Wong, Matthew Yocum, Paul Utz. OR.40. Cytokines Secreted in Response to TLR-ligand Stimulation Modulate Human Th17 Differentiation. Clinical Immunology 2008. PMID:


  39. Chih Long Liu, Michael Kattah, Alex Kuo, Xiaobing Shi, Imelda Balboni, Paul Utz, Or Gozani. Sa.12. Profiling Epigenetic Biomarkers for the Study and Treatment of Lupus. Clinical Immunology 2008. PMID:


  40. Michael Kattah, John Coller, Regina Cheung, Neekaan Oshidary, Paul Utz. Sa.95. HIT: A Novel Protein Array Platform Identifies Down-regulation of CD26 on Regulatory T Cell Subsets. Clinical Immunology 2008. PMID:


  41. Pennathur S, Baldessari F, Santiago JG, Kattah MG, Steinman JB, Utz PJ. Free-solution oligonucleotide separation in nanoscale channels. Analytical chemistry 2007. PMID: 17883279


  42. Michael Kattah, John Coller, Golnaz Alemi, Neekaan Oshidary, Paul J. Utz. Antibody-oligo Arrays for Multiplex Surface Marker Profiling of Immune Cells Subsets. Clinical Immunology 2007. PMID:


  43. Kattah MG, Alemi GR, Thibault DL, Balboni I, Utz PJ. A new two-color Fab labeling method for autoantigen protein microarrays. Nature methods 2006. PMID: 16929321


  44. Busch R, Byrne B, Gandrud L, Sears D, Meyer E, Kattah M, Kurihara C, Haertel E, Parnes JR, Mellins ED. Medicine on a need-to-know basis. Nature immunology 2006. PMID: 16715061


  45. Balboni I, Chan SM, Kattah M, Tenenbaum JD, Butte AJ, Utz PJ. Multiplexed protein array platforms for analysis of autoimmune diseases. Annual review of immunology 2006. PMID: 16551254


  46. Michael Kattah, Golnaz Alemi, Donna Thibault, Paul Utz. Sa.127. A Novel Two-Color Fab Labeling Method for Autoantigen Protein Microarrays. Clinical Immunology 2006. PMID:


  47. Koehler NK, Yang CY, Varady J, Lu Y, Wu XW, Liu M, Yin D, Bartels M, Xu BY, Roller PP, Long YQ, Li P, Kattah M, Cohn ML, Moran K, Tilley E, Richert JR, Wang S. Structure-based discovery of nonpeptidic small organic compounds to block the T cell response to myelin basic protein. Journal of medicinal chemistry 2004. PMID: 15456243


  48. Radaev S, Kattah M, Rostro B, Colonna M, Sun PD. Crystal structure of the human myeloid cell activating receptor TREM-1. Structure (London, England : 1993) 2003. PMID: 14656437


  49. Sun PD, Radaev S, Kattah M. Generating isomorphous heavy-atom derivatives by a quick-soak method. Part I: test cases. Acta crystallographica. Section D, Biological crystallography 2002. PMID: 12077427