Meghana Gadgil, MD
General Internal Medicine UCSF Health
My long-term goal is to prevent cardiometabolic disease in high-risk populations through a three-level approach: 1) clinical investigation of metabolomic processes at the individual level 2) improvements in chronic disease prevention inside the primary care office and 3) lifestyle changes with a focus on practical dietary interventions in the lived environment.
At the individual level:
My clinical research activities center on the metabolic processes connecting dietary intake and incident diabetes which are not yet well-characterized. I believe that further work with "omics" technologies can help to delineate the paths between diet and diabetes and identify targets for intervention.
Inside the PCP's office:
I am developing a program to improve postpartum transitions to primary care for women with gestational diabetes. In this program, we are identifying women with a pregnancy affected by GDM who are at high risk of transition to type 2 diabetes. We are then designing programs within our medical record system to track, improve postpartum follow-up and enroll patients into primary care.
In the lived environment:
A current research award from the Mount Zion Health Fund is supporting work improving the knowledge and uptake of prediabetes resources in the community.
I have completed a pilot intervention study enrolling participants with prediabetes to evaluate the impact evaluation walnut intake on dietary quality, measures of prediabetes and metabolite expression.
I am committed to work in the prevention of diabetes as it disproportionally impacts racial and ethnic minority populations. I also focus on research into the specific risk factors that women face in the development of diabetes, particularly those in the postpartum period. I feel strongly that each population should have appropriate and equitable guidance for a personalized care plan for the prevention of diabetes.
My future goals are to extend and individualize current knowledge about beneficial dietary and lifestyle interventions to prevent cardiometabolic disease, and to use digital tools and metabolomics to monitor responsiveness to these programs.
Cynthia Azam Ponir, Parag Anilkumar Chevli, Alka Kanaya, Meghana Gadgil, Luis A Rodriguez, Bharathi Upadhya, Morgana Mongraw-Chaffin. Association of Physical Activity and Dietary Quality with Weight, Ectopic Fat, and Insulin Resistance in South Asian Men and Women: The MASALA Study. Journal of clinical lipidology 2023. PMID:
Alexis Wood, Mackenzie Senn, Meghana Gadgil, Goncalo Graca, Matthew Allison, Ioanna Tzoulaki, Philip Greenland, Timothy Ebbels, Paul Elliott, Mark Goodarzi, Russell Tracy, Jerome Rotter, David Herrington. OR02-05-23 Untargeted Metabolomic Analysis Reveals Inverse Associations Between Red Meat Intake and Two Anti-Inflammatory Amino Acids. Current developments in nutrition 2023. PMID:
MEGHANA D. GADGIL, DAVID M. HERRINGTON, SUKHMANI SINGH, NAMRATHA R. KANDULA, ALKA M. KANAYA. 1399-P: Lipoprotein Subfractions and Type 2 Diabetes Incidence in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) and Multiethnic Study of Atherosclerosis (MESA) Cohorts. Diabetes 2023. PMID:
ALEXIS WOOD, MARK O. GOODARZI, MEGHANA D. GADGIL, MATTHEW ALLISON, GONÇALO GRAÇA, MICHAEL Y. MI, PHILIP GREENLAND, DAVID M. HERRINGTON, JEROME I. ROTTER. 205-LB: Using Metabolomic Biomarkers to Understand Relationships between Avocado Intake and Dysglycemia. Diabetes 2023. PMID:
MEGHANA D. GADGIL, RONALD M. KRAUSS. 603-P: Changes in Insulin Resistance by Protein Source and Level of Saturated Fat—An Analysis of the Animal and Plant Protein and Cardiovascular Health (APPROACH) Trial. Diabetes 2023. PMID:
Gadgil MD, Wood AC, Karaman I, Graça G, Tzoulaki I, Zhong VW, Greenland P, Kanaya AM, Herrington DM. Metabolomic Profile of the Healthy Eating Index-2015 in the Multiethnic Study of Atherosclerosis. The Journal of nutrition 2023. PMID: 37271414
Bridget M Hussain, Andrea L Deierlein, Sameera A Talegawkar, Joyce A O'Connor, Meghana Gadgil, Alka M Kanaya, Namratha Kandula, Yong Lin, Niyati Parekh. Abstract MP12: Dash Diet and Its Components is Associated With Visceral Fat Area and Hepatic Attenuation Among South Asian Adults in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study (2010-2013). Circulation 2023. PMID:
Kahn SE, Anderson CAM, Buse JB, Selvin E, Angell SY, Aroda VR, Castle JR, Cheng AYY, Danne T, Echouffo-Tcheugui JB, Florez JC, Gadgil MD, Gastaldelli A, Green JB, Jastreboff AM, Kanaya AM, Kandula NR, Kovesdy CP, Laiteerapong N, Nadeau KJ, Pop-Busui R, Powe CE, Rebholz CM, Rickels MR, Sattar N, Shaw JE, Sims EK, Utzschneider KM, Vella A, Zhang C. "The Times They Are A-Changin'" at Diabetes Care. Diabetes care 2023. PMID: 36548704
Gadgil MD, Ingram KH, Appiah D, Rudd J, Whitaker KM, Bennett WL, Shikany JM, Jacobs DR, Lewis CE, Gunderson EP. Prepregnancy Protein Source and BCAA Intake Are Associated with Gestational Diabetes Mellitus in the CARDIA Study. International journal of environmental research and public health 2022. PMID: 36361016
Gadgil MD, Kanaya AM, Sands C, Chekmeneva E, Lewis MR, Kandula NR, Herrington DM. Diet Patterns Are Associated With Circulating Metabolites and Lipid Profiles of South Asians in the United States. The Journal of nutrition 2022. PMID: 36040341
Gadgil MD, Kanaya AM, Sands C, Chekmeneva E, Lewis MR, Kandula NR, Herrington DM. Diet Patterns Are Associated with Circulating Metabolites and Lipid Profiles of South Asians in the United States. The Journal of nutrition 2022. PMID: 36774102
Gadgil MD, Sarkar M, Sands C, Lewis MR, Herrington DM, Kanaya AM. Associations of NAFLD with circulating ceramides and impaired glycemia. 2022. PMID: 35292328
Gadgil MD, Kanaya AM, Sands C, Lewis MR, Kandula NR, Herrington DM. Circulating metabolites and lipids are associated with glycaemic measures in South Asians. Diabetic medicine : a journal of the British Diabetic Association 2020. PMID: 33617033
Gadgil MD, Kandula NR, Kanaya AM. Acculturation is Associated with Dietary Patterns in South Asians in America. Journal of immigrant and minority health 2020. PMID: 32358772
Talegawkar SA, Lancki N, Jin Y, Siddique J, Gadgil M, Kanaya AM, Schneider JA, Van Horn L, De Koning L, Kandula NR. Social network characteristics are correlated with dietary patterns among middle aged and older South Asians living in the United States (U.S.). BMC nutrition 2020. PMID: 32944264
Gadgil MD, Ehrlich SF, Zhu Y, Brown SD, Hedderson MM, Crites Y, Ferrara A. Dietary Quality and Glycemic Control Among Women with Gestational Diabetes Mellitus. Journal of women's health (2002) 2018. PMID: 30376391
Bhupathiraju SN, Guasch-Ferré M, Gadgil MD, Newgard CB, Bain JR, Muehlbauer MJ, Ilkayeva OR, Scholtens DM, Hu FB, Kanaya AM, Kandula NR. Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk. The Journal of nutrition 2018. PMID: 29893901
Bharmal NH, McCarthy WJ, Gadgil MD, Kandula NR, Kanaya AM. The Association of Religious Affiliation with Overweight/Obesity Among South Asians: The Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study. Journal of religion and health 2018. PMID: 27460674
Gadgil MD, Oza-Frank R, Kandula NR, Kanaya AM. Type 2 diabetes after gestational diabetes mellitus in South Asian women in the United States. Diabetes/metabolism research and reviews 2017. PMID: 28224756
Shah BM, Shah S, Kandula NR, Gadgil MD, Kanaya AM. Psychosocial Factors Associated with Subclinical Atherosclerosis in South Asians: The MASALA Study. Journal of immigrant and minority health 2016. PMID: 26897179
Flowers E, Gadgil M, Aouizerat BE, Kanaya AM. Circulating micrornas associated with glycemic impairment and progression in Asian Indians. Biomarker research 2015. PMID: 26966540
Talegawkar SA, Kandula NR, Gadgil MD, Desai D, Kanaya AM. Dietary intakes among South Asian adults differ by length of residence in the USA. Public health nutrition 2015. PMID: 25990446
Gadgil MD, Anderson CA, Kandula NR, Kanaya AM. Dietary patterns are associated with metabolic risk factors in South Asians living in the United States. The Journal of nutrition 2015. PMID: 25904730
Sameera A Talegawkar, Namratha R Kandula, Meghana D Gadgil, Dipika Desai, Alka M Kanaya. Abstract P030: Traditional Cultural Beliefs and Length of Residence in the United States are Associated With Dietary Intakes Among South Asians. Circulation 2015. PMID:
Elena Flowers, Bradley E Aouizerat, Meghana Gadgil, Alka M Kanaya. Abstract P300: Circulating MicroRNAs Associated with Glycemic Impairment and Progression in Asian Indians. Circulation 2015. PMID:
Liu R, Christoffel KK, Brickman WJ, Liu X, Gadgil M, Wang G, Zimmerman D, Chen Q, Wang B, Li Z, Xing H, Xu X, Wang X. Do static and dynamic insulin resistance indices perform similarly in predicting pre-diabetes and type 2 diabetes? Diabetes research and clinical practice 2014. PMID: 24882014
Gadgil MD, Anderson CA, Kandula NR, Kanaya AM. Dietary patterns in Asian Indians in the United States: an analysis of the metabolic syndrome and atherosclerosis in South Asians Living in America study. Journal of the Academy of Nutrition and Dietetics 2013. PMID: 24295929
Gadgil MD, Chang HY, Richards TM, Gudzune KA, Huizinga MM, Clark JM, Bennett WL. Laboratory testing for and diagnosis of nutritional deficiencies in pregnancy before and after bariatric surgery. Journal of women's health (2002) 2013. PMID: 24102519
Gudzune KA, Huizinga MM, Chang HY, Asamoah V, Gadgil M, Clark JM. Screening and diagnosis of micronutrient deficiencies before and after bariatric surgery. Obesity surgery 2013. PMID: 23515975
Meghana D. Gadgil,Wendy L. Bennett. Caring for Women with Pregnancy after Bariatric Surgery. Bariatric Surgical Practice and Patient Care 2013. PMID:
Gadgil MD, Appel LJ, Yeung E, Anderson CA, Sacks FM, Miller ER. The effects of carbohydrate, unsaturated fat, and protein intake on measures of insulin sensitivity: results from the OmniHeart trial. Diabetes care 2012. PMID: 23223345
Perez K, Gadgil M, Dizon DS. Sexual ramifications of medical illness. Clinical obstetrics and gynecology 2009. PMID: 20393421