Lynda Frassetto, MD

Professor

Lynda Frassetto, MD, is a Professor Emeritus of Medicine in the Division of Nephrology at the University of California, San Francisco (USCF). She grew up in the greater New York metropolitan area and attended college and medical school in Connecticut.

She trained as a nephrologist at UCSF and was in private practice in San Francisco before returning to UCSF to start her research career with Drs. Anthony Sebastian and R. Curtis Morris Jr. Over approximately 20 years, the group published papers on regulation of acid base balance in healthy and aging people and dietary influences on acid-base balance in healthy people and those with diabetes.

Dr. Frassetto also collaborates with Dr. Leslie Z Benet, past chair of the Department of Biopharmaceutical Sciences at UCSF. Dr. Benet has pioneered a novel model predicting drug interactions in vivo, depending on the degree of in vitro membrane transporter and intracellular metabolizing enzyme interactions with a specific drug, xenobiotic or toxin. These predictions are then tested in clinical trials in healthy people and those with kidney disease, diabetes or HIV before and after transplantation.

In addition to research, Dr. Frassetto was the director of the adult Clinical Research Center at the Parnassus Campus in UCSF’s Clinical and Translational Science Institute, and still supervises inpatient and outpatient care at three of the University’s hospital campuses. For the last several years, she has also been participating in and teaching programs that teach UC students and faculty better communication and behavioral stress modification techniques.

Publications

  1. Frassetto LA, Masharani U. Effects of Alterations in Acid-Base Effects on Insulin Signaling. International journal of molecular sciences 2024. PMID: 38473990


  2. Derakhshandeh-Rishehri SM, Franco LP, Hua Y, Herder C, Kalhoff H, Frassetto LA, Wudy SA, Remer T. Higher Renal Net Acid Excretion, but Not Higher Phosphate Excretion, during Childhood and Adolescence Associates with the Circulating Renal Tubular Injury Marker Interleukin-18 in Adulthood. International journal of molecular sciences 2024. PMID: 38338685


  3. Wilson L, Gress AF, Frassetto L, Sarathy H, Gress EA, Fissell WH, Roy S. Patient Preference Trade-offs for Next-Generation Kidney Replacement Therapies. Clinical journal of the American Society of Nephrology : CJASN 2023. PMID: 37874941


  4. Moyer J, Wilson MW, Sorrentino TA, Santandreu A, Chen C, Hu D, Kerdok A, Porock E, Wright N, Ly J, Blaha C, Frassetto LA, Fissell WH, Vartanian SM, Roy S. Renal Embolization-Induced Uremic Swine Model for Assessment of Next-Generation Implantable Hemodialyzers. Toxins 2023. PMID: 37755973


  5. Frassetto LA, Goas A, Gannon R, Lanham-New SA, Lambert H. Potassium. Advances in nutrition (Bethesda, Md.) 2023. PMID: 37308080


  6. Banerjee T, Sebastian A, Frassetto L. Association of diet-dependent systemic acid load, renal function, and serum albumin concentration. Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 2023. PMID: 36736469


  7. Frassetto L, Remer T, Banerjee T. Dietary Contributions to Metabolic Acidosis. Advances in chronic kidney disease 2022. PMID: 36175075


  8. Sirch C, Khanna N, Frassetto L, Bianco F, Artero ML. Diagnosis of acute intermittent porphyria in a renal transplant patient: A case report. 2022. PMID: 35096552


  9. Banerjee T, Sebastian A, Frassetto LA. Diet-dependent acid load associates with mean arterial pressure in a cohort of non-obese, non-black, post-menopausal women. 2021. PMID: 34614363


  10. Xiang Y, Okochi H, Kozachenko I, Sodhi JK, Frassetto LA, Benet LZ. Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers. Clinical pharmacology and therapeutics 2021. PMID: 33880760


  11. Angeloco LRN, Arces de Souza GC, Romão EA, Frassetto L, Chiarello PG. Association of dietary acid load with serum bicarbonate in chronic kidney disease (CKD) patients. European journal of clinical nutrition 2020. PMID: 32873960


  12. Frassetto LA, Sebastian A, DuBose TD. How metabolic acidosis and kidney disease may accelerate the aging process. European journal of clinical nutrition 2020. PMID: 32873954


  13. Parmenter BH, Dymock M, Banerjee T, Sebastian A, Slater GJ, Frassetto LA. Performance of Predictive Equations and Biochemical Measures Quantifying Net Endogenous Acid Production and the Potential Renal Acid Load. Kidney international reports 2020. PMID: 33102966


  14. Surofchy DD, Frassetto LA, Benet LZ. Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. Pharmaceutical research 2019. PMID: 31485804


  15. Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. Corrigendum to "Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base" [Nutrition 31 (2015) 1-13]. Nutrition (Burbank, Los Angeles County, Calif.) 2019. PMID: 30935711


  16. Frassetto LA, Sebastian A. Aging, metabolic acidosis and renal failure: Interactive accelerating processes. Medical hypotheses 2019. PMID: 30798927


  17. Frassetto LA, Sebastian A. .. Med Hypotheses Aging, metabolic acidosis and renal failure: Interactive accelerating processes 2019. PMID:


  18. Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clinical pharmacology and therapeutics 2019. PMID: 30652304


  19. Sebastian A, Cordain L, Frassetto L, Banerjee T, Morris RC. Postulating the major environmental condition resulting in the expression of essential hypertension and its associated cardiovascular diseases: Dietary imprudence in daily selection of foods in respect of their potassium and sodium content resulting in ox Medical hypotheses 2018. PMID: 30122481


  20. Frassetto L. Another strategy to help counter the effects of low gravity? The American journal of clinical nutrition 2018. PMID: 29722853


  21. Frassetto L, Banerjee T, Powe N, Sebastian A. Acid Balance, Dietary Acid Load, and Bone Effects-A Controversial Subject. Nutrients 2018. PMID: 29690515


  22. Hietavala EM, Ihalainen JK, Frassetto LA, Schumann M, Eklund D, Pitkänen H, Häkkinen K, Mero AA. Effects of 12-Week Low or Moderate Dietary Acid Intake on Acid-Base Status and Kidney Function at Rest and during Submaximal Cycling. Nutrients 2018. PMID: 29517990


  23. Hietavala EM, Stout JR, Frassetto LA, Puurtinen R, Pitkänen H, Selänne H, Suominen H, Mero AA. Dietary acid load and renal function have varying effects on blood acid-base status and exercise performance across age and sex. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2017. PMID: 28825967


  24. Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. Volume 106 of Issue 9. Journal of pharmaceutical sciences 2017. PMID: 28385543


  25. Arentson-Lantz EJ, Saeed IH, Frassetto LA, Masharani U, Harnish RJ, Seo Y, VanBrocklin HF, Hawkins RA, Mari-Aparici C, Pampaloni MH, Slater J, Paddon-Jones D, Lang TF. 11C-L-methyl methionine dynamic PET/CT of skeletal muscle: response to protein supplementation compared to L-[ring 13C6] phenylalanine infusion with serial muscle biopsy. Annals of nuclear medicine 2017. PMID: 28260185


  26. Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Volume 34 of Issue 3. Pharmaceutical research 2016. PMID: 28028768


  27. Parmenter BH, Slater GJ, Frassetto LA. Accuracy and precision of estimation equations to predict net endogenous acid excretion using the Australian food database. Nutrition & dietetics: the journal of the Dietitians Association of Australia 2016. PMID: 28731602


  28. Parmenter BH, Slater GJ, Frassetto LA. Spot-testing urine pH, a novel dietary biomarker? A randomised cross-over trial. Nutrition & dietetics: the journal of the Dietitians Association of Australia 2016. PMID: 28731600


  29. Frassetto LA, Gibson S. Febuxostat and Increased Dialysis as a Treatment for Severe Tophaceous Gout in a Hemodialysis Patient. Case reports in nephrology 2016. PMID: 27200198


  30. Sebastian A, Frassetto LA. A neglected requirement for optimizing treatment of age-related osteoporosis: Replenishing the skeleton's base reservoir with net base-producing diets. Medical hypotheses 2016. PMID: 27142156


  31. Frassetto LA, Schloetter M, Mietus-Synder M, Morris RC, Sebastian A. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. European journal of clinical nutrition 2015. PMID: 26626156


  32. Moassesfar S, Masharani U, Frassetto LA, Szot GL, Tavakol M, Stock PG, Posselt AM. A Comparative Analysis of the Safety, Efficacy, and Cost of Islet Versus Pancreas Transplantation in Nonuremic Patients With Type 1 Diabetes. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2015. PMID: 26595767


  33. Masharani U, Sherchan P, Schloetter M, Stratford S, Xiao A, Sebastian A, Nolte Kennedy M, Frassetto L. Metabolic and physiologic effects from consuming a hunter-gatherer (Paleolithic)-type diet in type 2 diabetes. European journal of clinical nutrition 2015. PMID: 25828624


  34. Lambert H, Frassetto L, Moore JB, Torgerson D, Gannon R, Burckhardt P, Lanham-New S. The effect of supplementation with alkaline potassium salts on bone metabolism: a meta-analysis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2015. PMID: 25572045


  35. Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014. PMID: 25342129


  36. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. Volume 16 of Issue 6. The AAPS journal 2014. PMID: 25274610


  37. Feinman RD, Pogozelski WK, Astrup A, Bernstein RK, Fine EJ, Westman EC, Accurso A, Frassetto L, Gower BA, McFarlane SI, Nielsen JV, Krarup T, Saslow L, Roth KS, Vernon MC, Volek JS, Wilshire GB, Dahlqvist A, Sundberg R, Childers A, Morrison K, Manninen AH, Dashti HM, Wood RJ, Wortman J, Worm N. Dietary carbohydrate restriction as the first approach in diabetes management: critical review and evidence base. Nutrition (Burbank, Los Angeles County, Calif.) 2014. PMID: 25287761


  38. Lang TF, Saeed IH, Streeper T, Carballido-Gamio J, Harnish RJ, Frassetto LA, Lee SM, Sibonga JD, Keyak JH, Spiering BA, Grodsinsky CM, Bloomberg JJ, Cavanagh PR. Spatial heterogeneity in the response of the proximal femur to two lower-body resistance exercise regimens. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2014. PMID: 24293094


  39. Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Volume 97 of Issue 6. Transplantation 2014. PMID: 24389906


  40. Fontes-Villalba M, Jönsson T, Granfeldt Y, Frassetto LA, Sundquist J, Sundquist K, Carrera-Bastos P, Fika-Hernándo M, Picazo Ó, Lindeberg S. A healthy diet with and without cereal grains and dairy products in patients with type 2 diabetes: study protocol for a random-order cross-over pilot study--Alimentation and Diabetes in Lanzarote--ADILAN. Trials 2014. PMID: 24383431


  41. Delgado C, Frassetto L. Hip fractures in hemodialysis patients. American journal of kidney diseases : the official journal of the National Kidney Foundation 2013. PMID: 24054940


  42. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Volume 34 of Issue 8. Biopharmaceutics & drug disposition 2013. PMID: 24030928


  43. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Volume 10 of Issue 11. Molecular pharmaceutics 2013. PMID: 23980906


  44. Frassetto LA, Shi L, Schloetter M, Sebastian A, Remer T. Established dietary estimates of net acid production do not predict measured net acid excretion in patients with Type 2 diabetes on Paleolithic-Hunter-Gatherer-type diets. European journal of clinical nutrition 2013. PMID: 23859996


  45. Frassetto LA, Sebastian A. Commentary to accompany the paper entitled 'nutritional disturbance in acid-base balance and osteoporosis: a hypothesis that disregards the essential homeostatic role of the kidney', by Jean-Philippe Bonjour. The British journal of nutrition 2013. PMID: 23769203


  46. Chakkera HA, Chang YH, Bodner JK, Behmen S, Heilman RL, Reddy KS, Mulligan DC, Moss AA, Khamash H, Katariya N, Hewitt WR, Pitta TL, Frassetto LA. Genetic differences in Native Americans and tacrolimus dosing after kidney transplantation. Transplantation proceedings 2013. PMID: 23375287


  47. Lanham-New SA, Lambert H, Frassetto L. Potassium. Advances in nutrition (Bethesda, Md.) 2012. PMID: 23153736


  48. Frassetto LA, Hardcastle AC, Sebastian A, Aucott L, Fraser WD, Reid DM, Macdonald HM. No evidence that the skeletal non-response to potassium alkali supplements in healthy postmenopausal women depends on blood pressure or sodium chloride intake. European journal of clinical nutrition 2012. PMID: 23093337


  49. Frassetto LA, Sebastian A. How metabolic acidosis and oxidative stress alone and interacting may increase the risk of fracture in diabetic subjects. Medical hypotheses 2012. PMID: 22583559


  50. Painter P, Krasnoff JB, Kuskowski M, Frassetto L, Johansen K. Effects of modality change on health-related quality of life. Hemodialysis international. International Symposium on Home Hemodialysis 2012. PMID: 22413899


  51. Shi L, Libuda L, Schönau E, Frassetto L, Remer T. Long term higher urinary calcium excretion within the normal physiologic range predicts impaired bone status of the proximal radius in healthy children with higher potential renal acid load. Bone 2012. PMID: 22342797


  52. Frassetto L, Kohlstadt I. Treatment and prevention of kidney stones: an update. American family physician 2011. PMID: 22150656


  53. Grover A, Frassetto LA, Benet LZ, Chakkera HA. Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients. Volume 39 of Issue 11. Drug metabolism and disposition: the biological fate of chemicals 2011. PMID: 21849516


  54. Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG. Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade. Transplantation 2010. PMID: 20978464


  55. Pushkin R, Frassetto L, Tsourounis C, Segal ES, Kim S. Improving the reporting of adverse drug reactions in the hospital setting. Postgraduate medicine 2010. PMID: 21084792


  56. Painter P, Krasnoff JB, Kuskowski M, Frassetto L, Johansen KL. Effects of modality change and transplant on peak oxygen uptake in patients with kidney failure. American journal of kidney diseases : the official journal of the National Kidney Foundation 2010. PMID: 20870330


  57. Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ. Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers. Volume 88 of Issue 4. Clinical pharmacology and therapeutics 2010. PMID: 20703222


  58. Posselt AM, Bellin MD, Tavakol M, Szot GL, Frassetto LA, Masharani U, Kerlan RK, Fong L, Vincenti FG, Hering BJ, Bluestone JA, Stock PG. Islet transplantation in type 1 diabetics using an immunosuppressive protocol based on the anti-LFA-1 antibody efalizumab. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010. PMID: 20659093


  59. Gordon PL, Frassetto LA. Management of osteoporosis in CKD Stages 3 to 5. American journal of kidney diseases : the official journal of the National Kidney Foundation 2010. PMID: 20438987


  60. Sun H, Frassetto LA, Huang Y, Benet LZ. Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease. Volume 87 of Issue 4. Clinical pharmacology and therapeutics 2010. PMID: 20090676


  61. Posselt AM, Szot GL, Frassetto LA, Masharani U, Stock PG. Clinical islet transplantation at the University of California, San Francisco. Clinical transplants 2010. PMID: 21698834


  62. Pizzorno J, Frassetto LA, Katzinger J. Diet-induced acidosis: is it real and clinically relevant? The British journal of nutrition 2009. PMID: 20003625


  63. Tuot D, Gibson S, Caughey AB, Frassetto LA. Intradialytic hyperalimentation as adjuvant support in pregnant hemodialysis patients: case report and review of the literature. Volume 42 of Issue 1. International urology and nephrology 2009. PMID: 19911296


  64. Tan-Tam CC, Frassetto LA, Stock PG. Liver and kidney transplantation in HIV-infected patients. AIDS reviews 2009. PMID: 19940946


  65. Frassetto LA, Tan-Tam C, Stock PG. Renal transplantation in patients with HIV. Nature reviews. Nephrology 2009. PMID: 19776780


  66. Frassetto LA, Hsu CY. Metabolic acidosis and progression of chronic kidney disease. Journal of the American Society of Nephrology : JASN 2009. PMID: 19696222


  67. Frassetto LA, Schloetter M, Mietus-Synder M, Morris RC, Sebastian A. Metabolic and physiologic improvements from consuming a paleolithic, hunter-gatherer type diet. European journal of clinical nutrition 2009. PMID: 19209185


  68. Zheng HX, Huang Y, Frassetto LA, Benet LZ. Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite. Volume 85 of Issue 1. Clinical pharmacology and therapeutics 2008. PMID: 18843263


  69. Berkemeyer S, Vormann J, Günther AL, Rylander R, Frassetto LA, Remer T. Renal net acid excretion capacity is comparable in prepubescence, adolescence, and young adulthood but falls with aging. Journal of the American Geriatrics Society 2008. PMID: 18808599


  70. Padilla J, Krasnoff J, Da Silva M, Hsu CY, Frassetto L, Johansen KL, Painter P. Physical functioning in patients with chronic kidney disease. Journal of nephrology 2008. PMID: 18651545


  71. Gannon RH, Millward DJ, Brown JE, Macdonald HM, Lovell DP, Frassetto LA, Remer T, Lanham-New SA. Estimates of daily net endogenous acid production in the elderly UK population: analysis of the National Diet and Nutrition Survey (NDNS) of British adults aged 65 years and over. The British journal of nutrition 2008. PMID: 18394215


  72. Frassetto LA, Morris RC, Sellmeyer DE, Sebastian A. Adverse effects of sodium chloride on bone in the aging human population resulting from habitual consumption of typical American diets. The Journal of nutrition 2008. PMID: 18203914


  73. Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG. HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes. Volume 8 of Issue 2. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007. PMID: 18093266


  74. Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Volume 7 of Issue 12. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007. PMID: 17949460


  75. Frassetto LA, Lanham-New SA, Macdonald HM, Remer T, Sebastian A, Tucker KL, Tylavsky FA. Standardizing terminology for estimating the diet-dependent net acid load to the metabolic system. The Journal of nutrition 2007. PMID: 17513412


  76. Frassetto LA, Morris RC, Sebastian A. Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet. American journal of physiology. Renal physiology 2007. PMID: 17522265


  77. Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ. Effects of uptake and efflux transporter inhibition on erythromycin breath test results. Volume 81 of Issue 6. Clinical pharmacology and therapeutics 2007. PMID: 17361125


  78. Nicandro JP, Tsourounis C, Frassetto L, Guglielmo BJ. In vivo effect of I'm-Yunity on hepatic cytochrome P450 3A4. Journal of herbal pharmacotherapy 2007. PMID: 17594986


  79. Lau YY, Huang Y, Frassetto L, Benet LZ. effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Volume 81 of Issue 2. Clinical pharmacology and therapeutics 2006. PMID: 17192770


  80. Roland ME, Carlson LL, Frassetto LA, Stock PG. Solid organ transplantation: referral, management, and outcomes in HIV-infected patients. The AIDS reader 2006. PMID: 17195325


  81. Sebastian A, Frassetto LA, Sellmeyer DE, Morris RC. The evolution-informed optimal dietary potassium intake of human beings greatly exceeds current and recommended intakes. Seminars in nephrology 2006. PMID: 17275582


  82. Morris RC, Schmidlin O, Frassetto LA, Sebastian A. Relationship and interaction between sodium and potassium. Journal of the American College of Nutrition 2006. PMID: 16772638


  83. Frassetto LA, Morris RC, Sebastian A. A practical approach to the balance between acid production and renal acid excretion in humans. Journal of nephrology 2006. PMID: 16736439


  84. Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET. Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma. Volume 20 of Issue 10. Rapid communications in mass spectrometry : RCM 2006. PMID: 16628600


  85. Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Volume 109 of Issue 1-2. Pharmacology & therapeutics 2005. PMID: 16085315


  86. Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L. Effects of short-term alendronate on bone mineral density in haemodialysis patients. Volume 10 of Issue 4. Nephrology (Carlton, Vic.) 2005. PMID: 16109088


  87. Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Volume 80 of Issue 1. Transplantation 2005. PMID: 16003227


  88. Frassetto L, Morris RC, Sebastian A. Long-term persistence of the urine calcium-lowering effect of potassium bicarbonate in postmenopausal women. The Journal of clinical endocrinology and metabolism 2004. PMID: 15572425


  89. Sun H, Huang Y, Frassetto L, Benet LZ. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Volume 32 of Issue 11. Drug metabolism and disposition: the biological fate of chemicals 2004. PMID: 15286055


  90. Frassetto LA, Benet LZ. Pharmacogenomics and transplantation: where are we? Volume 4 of Issue 6. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004. PMID: 15147415


  91. Stock PG, Roland ME, Carlson L, Freise CE, Roberts JP, Hirose R, Terrault NA, Frassetto LA, Palefsky JM, Tomlanovich SJ, Ascher NL. Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study. Transplantation 2003. PMID: 12883195


  92. Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Volume 18 of Issue 2. Drug metabolism and pharmacokinetics 2003. PMID: 15618725


  93. Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC. Estimation of the net acid load of the diet of ancestral preagricultural Homo sapiens and their hominid ancestors. The American journal of clinical nutrition 2002. PMID: 12450898


  94. Sherman ME, Shepherd J, Frassetto L, Genant HK. Discrepancy in results between spine and hip scans of a woman with end stage renal disease. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 2002. PMID: 11940734


  95. Stock P, Roland M, Carlson L, Freise C, Hirose R, Terrault N, Frassetto L, Coates T, Roberts J, Ascher N. Solid organ transplantation in HIV-positive patients. Transplantation proceedings 2001. PMID: 11750549


  96. Frassetto L, Morris RC, Sellmeyer DE, Todd K, Sebastian A. Diet, evolution and aging--the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. European journal of nutrition 2001. PMID: 11842945


  97. Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U. The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. Clinical pharmacology and therapeutics 2001. PMID: 11180035


  98. Frassetto LA, Todd KM, Morris RC, Sebastian A. Worldwide incidence of hip fracture in elderly women: relation to consumption of animal and vegetable foods. The journals of gerontology. Series A, Biological sciences and medical sciences 2000. PMID: 11034231


  99. Frassetto LA, Nash E, Morris RC, Sebastian A. Comparative effects of potassium chloride and bicarbonate on thiazide-induced reduction in urinary calcium excretion. Kidney international 2000. PMID: 10916098


  100. Morris RC, Schmidlin O, Tanaka M, Forman A, Frassetto L, Sebastian A. Differing effects of supplemental KCl and KHCO3: pathophysiological and clinical implications. Seminars in nephrology 1999. PMID: 10511388


  101. Frassetto LA, Todd KM, Morris RC, Sebastian A. Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein contents. The American journal of clinical nutrition 1998. PMID: 9734733


  102. Frassetto L, Morris RC, Sebastian A. Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women. The Journal of clinical endocrinology and metabolism 1997. PMID: 8989270


  103. Frassetto LA, Morris RC, Sebastian A. Effect of age on blood acid-base composition in adult humans: role of age-related renal functional decline. The American journal of physiology 1996. PMID: 8997384


  104. Frassetto L, Sebastian A. Age and systemic acid-base equilibrium: analysis of published data. The journals of gerontology. Series A, Biological sciences and medical sciences 1996. PMID: 8548506


  105. Yankowitz J, Piraino B, Laifer SA, Frassetto L, Gavin L, Kitzmiller JL, Crombleholme W. Erythropoietin in pregnancies complicated by severe anemia of renal failure. Obstetrics and gynecology 1992. PMID: 1495715


  106. Frassetto L, Schoenfeld PY, Humphreys MH. Increasing incidence of human immunodeficiency virus-associated nephropathy at San Francisco General Hospital. American journal of kidney diseases : the official journal of the National Kidney Foundation 1991. PMID: 1962649