Kathleen Liu, MD, PhD

Zarbock A, Forni LG, Koyner JL, Bell S, Reis T, Meersch M, Bagshaw SM, Fuhmann DY, Liu KD, Pannu N, Arikan AA, Angus DC, Duquette D, Goldstein SL, Hoste E, Joannidis M, Jongs N, Legrand M, Mehta RL, Murray PT, Nadim MK, Ostermann M, Prowle J, See EJ, Selby NM, Shaw AD, Srisawat N, Ronco C, Kellum JA. Recommendations for clinical trial design in acute kidney injury from the 31st acute disease quality initiative consensus conference. A consensus statement. Intensive care medicine 2024. PMID: 39115567

Ware LB, Files DC, Fowler A, Aboodi MS, Aggarwal NR, Brower RG, Chang SY, Douglas IS, Fields S, Foulkes AS, Ginde AA, Harris ES, Hendey GW, Hite RD, Huang W, Lai P, Liu KD, Thompson BT, Matthay MA, National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinic. Acetaminophen for Prevention and Treatment of Organ Dysfunction in Critically Ill Patients With Sepsis: The ASTER Randomized Clinical Trial. JAMA 2024. PMID: 38762798

Antonucci E, Garcia B, Chen D, Matthay MA, Liu KD, Legrand M. Incidence of acute kidney injury and attributive mortality in acute respiratory distress syndrome randomized trials. Intensive care medicine 2024. PMID: 38864911

Chan MJ, Liu KD. Acute Kidney Injury and Subsequent Cardiovascular Disease: Epidemiology, Pathophysiology, and Treatment. Seminars in nephrology 2024. PMID: 38849258

Evrard B, Sinha P, Delucchi K, Hendrickson CM, Kangelaris KN, Liu KD, Willmore A, Wu N, Neyton L, Schmiege E, Gomez A, Kerchberger VE, Zalucky A, Matthay MA, Ware LB, Calfee CS. Causes and attributable fraction of death from ARDS in inflammatory phenotypes of sepsis. Critical care (London, England) 2024. PMID: 38745253

Valda Toro PL, Willmore A, Wu NE, Delucchi KL, Jauregui A, Sinha P, Liu KD, Hendrickson CM, Sarma A, Neyton LPA, Leligdowicz A, Langelier CR, Zhuo H, Jones C, Kangelaris KN, Gomez AD, Matthay MA, Calfee CS. Rapidly improving ARDS differs clinically and biologically from persistent ARDS. Critical care (London, England) 2024. PMID: 38649920

Prasad PA, Esmaili AM, Oreper S, Beagle AJ, Hubbard C, Raffel KE, Abe-Jones Y, Fang MC, Liu KD, Matthay MA, Kangelaris KN. Timing of antibiotic treatment identifies distinct clinical presentations among patients presenting with suspected septic shock. Journal of the American College of Emergency Physicians open 2024. PMID: 38596320

Pickkers P, Angus DC, Bass K, Bellomo R, van den Berg E, Bernholz J, Bestle MH, Doi K, Doig CJ, Ferrer R, Francois B, Gammelager H, Pedersen UG, Hoste E, Iversen S, Joannidis M, Kellum JA, Liu K, Meersch M, Mehta R, Millington S, Murray PT, Nichol A, Ostermann M, Pettilä V, Solling C, Winkel M, Young PJ, Zarbock A, REVIVAL investigators. Correction: Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL). Intensive care medicine 2024. PMID: 38436728

Neyton LPA, Sinha P, Sarma A, Mick E, Kalantar K, Chen S, Wu N, Delucchi K, Zhuo H, Bos LDJ, Jauregui A, Gomez A, Hendrickson CM, Kangelaris KN, Leligdowicz A, Liu KD, Matthay MA, Langelier CR, Calfee CS. Host and Microbe Blood Metagenomics Reveals Key Pathways Characterizing Critical Illness Phenotypes. American journal of respiratory and critical care medicine 2024. PMID: 38190719

Sinha P, Neyton L, Sarma A, Wu N, Jones C, Zhuo H, Liu KD, Sanchez Guerrero E, Ghale R, Love C, Mick E, Delucchi KL, Langelier CR, Thompson BT, Matthay MA, Calfee CS, NHLBI PETAL Network. Molecular Phenotypes of ARDS in the ROSE Trial have Differential Outcomes and Gene Expression Patterns That Differ at Baseline and Longitudinally Over Time. American journal of respiratory and critical care medicine 2024. PMID: 38345571

Legrand M, Bagshaw SM, Bhatraju PK, Bihorac A, Caniglia E, Khanna AK, Kellum JA, Koyner J, Harhay MO, Zampieri FG, Zarbock A, Chung K, Liu K, Mehta R, Pickkers P, Ryan A, Bernholz J, Dember L, Gallagher M, Rossignol P, Ostermann M. Sepsis-associated acute kidney injury: recent advances in enrichment strategies, sub-phenotyping and clinical trials. Critical care (London, England) 2024. PMID: 38515121

Alipanah-Lechner N, Hurst-Hopf J, Delucchi K, Swigart L, Willmore A, LaCombe B, Dewar R, Lane HC, Lallemand P, Liu KD, Esserman L, Matthay MA, Calfee CS, I-SPY COVID Consortium. Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial. Critical care (London, England) 2024. PMID: 38383504

Pickkers P, Angus DC, Bass K, Bellomo R, van den Berg E, Bernholz J, Bestle MH, Doi K, Doig CJ, Ferrer R, Francois B, Gammelager H, Pedersen UG, Hoste E, Iversen S, Joannidis M, Kellum JA, Liu K, Meersch M, Mehta R, Millington S, Murray PT, Nichol A, Ostermann M, Pettilä V, Solling C, Winkel M, Young PJ, Zarbock A, REVIVAL investigators. Phase-3 trial of recombinant human alkaline phosphatase for patients with sepsis-associated acute kidney injury (REVIVAL). Intensive care medicine 2024. PMID: 38172296

Matthay MA, Arabi Y, Arroliga AC, Bernard G, Bersten AD, Brochard LJ, Calfee CS, Combes A, Daniel BM, Ferguson ND, Gong MN, Gotts JE, Herridge MS, Laffey JG, Liu KD, Machado FR, Martin TR, McAuley DF, Mercat A, Moss M, Mularski RA, Pesenti A, Qiu H, Ramakrishnan N, Ranieri M, Riviello ED, Rubin E, Slutsky A, Thompson BT, Twagirumugabe T, Ware LB, Wick KD. A New Global Definition of Acute Respiratory Distress Syndrome. American journal of respiratory and critical care medicine 2023. PMID: 37487152

Wald R, Gaudry S, da Costa BR, Adhikari NKJ, Bellomo R, Du B, Gallagher MP, Hoste EA, Lamontagne F, Joannidis M, Liu KD, McAuley DF, McGuinness SP, Nichol AD, Ostermann M, Palevsky PM, Qiu H, Pettilä V, Schneider AG, Smith OM, Vaara ST, Weir M, Dreyfuss D, Bagshaw SM, STARRT-AKI Investigators. Initiation of continuous renal replacement therapy versus intermittent hemodialysis in critically ill patients with severe acute kidney injury: a secondary analysis of STARRT-AKI trial. Intensive care medicine 2023. PMID: 37815560

Menez S, Wen Y, Xu L, Moledina DG, Thiessen-Philbrook H, Hu D, Obeid W, Bhatraju PK, Ikizler TA, Siew ED, Chinchilli VM, Garg AX, Go AS, Liu KD, Kaufman JS, Kimmel PL, Himmelfarb J, Coca SG, Cantley LG, Parikh CR. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events. Kidney international 2023. PMID: 37652206

Sinha P, Kerchberger VE, Willmore A, Chambers J, Zhuo H, Abbott J, Jones C, Wickersham N, Wu N, Neyton L, Langelier CR, Mick E, He J, Jauregui A, Churpek MM, Gomez AD, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Delucchi KL, Liu KD, Russell JA, Matthay MA, Walley KR, Ware LB, Calfee CS. Identifying molecular phenotypes in sepsis: an analysis of two prospective observational cohorts and secondary analysis of two randomised controlled trials. The Lancet. Respiratory medicine 2023. PMID: 37633303

Muiru AN, Hsu JY, Zhang X, Appel LJ, Chen J, Cohen DL, Drawz PE, Freedman BI, Go AS, He J, Horwitz EJ, Hsu RK, Lash JP, Liu KD, McCoy IE, Porter A, Rao P, Ricardo AC, Rincon-Choles H, Sondheimer J, Taliercio J, Unruh M, Hsu CY, and the CRIC Study Investigators*. Risk for Chronic Kidney Disease Progression After Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort Study. Annals of internal medicine 2023. PMID: 37429030

Kwong YD, Liu KD, Hsu CY, Cooper B, Palevsky PM, Kellum JA, Johansen KL, Miaskowski C. Subgroups of patients with distinct health utility profiles following acute kidney injury. Kidney360 2023. PMID: 37357351

Rosenberger CM, Wick KD, Zhuo H, Wu N, Chen Y, Kapadia SB, Guimaraes A, Chang D, Choy DF, Chen H, Peck M, Sullivan KM, Ke S, Jauregui A, Leligdowicz A, Sinha P, Gomez AD, Kangelaris KN, Delucchi K, Liu KD, Calfee CS, Matthay MA, Hendrickson CM. Early plasma angiopoietin-2 is prognostic for ARDS and mortality among critically ill patients with sepsis. Critical care (London, England) 2023. PMID: 37312169

Wen Y, Xu L, Melchinger IA, Thiessen-Philbrook H, Moledina DG, Coca SG, Hsu CY, Go AS, Liu KD, Siew ED, Ikizler TA, Chinchilli VM, Kaufman JS, Kimmel PL, Himmelfarb J, Cantley LG, Parikh CR. Longitudinal biomarkers and kidney disease progression after acute kidney injury. JCI insight 2023. PMID: 36951957

McCoy IE, Hsu JY, Zhang X, Diamantidis CJ, Taliercio J, Go AS, Liu KD, Drawz P, Srivastava A, Horwitz EJ, He J, Chen J, Lash JP, Weir MR, Hsu CY, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Probing the association between AKI and cardiovascular outcomes. Clinical journal of the American Society of Nephrology : CJASN 2023. PMID: 37116457

Pickkers P, Angus DC, Arend J, Bellomo R, van den Berg E, Bernholz J, Bestle M, Broglio K, Carlsen J, Doig CJ, Ferrer R, Joannidis M, Francois B, Doi K, Kellum JA, Laterre PF, Liu K, Mehta RL, Murray PT, Ostermann M, Pettil? V, Richards S, Young P, Zarbock A, Kj?lbye AL. Study protocol of a randomised, double-blind, placebo-controlled, two-arm parallel-group, multi-centre phase 3 pivotal trial to investigate the efficacy and safety of recombinant human alkaline phosphatase for treatment of patients with sepsis-associated BMJ open 2023. PMID: 37012016

Vasquez-Rios G, Oh W, Lee S, Bhatraju P, Mansour SG, Moledina DG, Gulamali FF, Siew ED, Garg AX, Sarder P, Chinchilli VM, Kaufman JS, Hsu CY, Liu KD, Kimmel PL, Go AS, Wurfel MM, Himmelfarb J, Parikh CR, Coca SG, Nadkarni GN. Joint Modeling of Clinical and Biomarker Data in Acute Kidney Injury Defines Unique Subphenotypes with Differing Outcomes: The ASSESS-AKI Study. Clinical journal of the American Society of Nephrology : CJASN 2023. PMID: 36975209

Liu K, Koyner JL, Heung M, Vijayan A. Care of the Hospitalized Patients with Kidney Failure during COVID-19 Pandemic: Lessons Learned. Clinical journal of the American Society of Nephrology : CJASN 2023. PMID: 36795034

National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinic, Shapiro NI, Douglas IS, Brower RG, Brown SM, Exline MC, Ginde AA, Gong MN, Grissom CK, Hayden D, Hough CL, Huang W, Iwashyna TJ, Jones AE, Khan A, Lai P, Liu KD, Miller CD, Oldmixon K, Park PK, Rice TW, Ringwood N, Semler MW, Steingrub JS, Talmor D, Thompson BT, Yealy DM, Self WH. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. The New England journal of medicine 2023. PMID: 36688507

Alipanah-Lechner N, Neyton L, Mick E, Willmore A, Leligdowicz A, Contrepois K, Jauregui A, Zhuo H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Matthay MA, Rogers AJ, Calfee CS. Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS. American journal of physiology. Lung cellular and molecular physiology 2023. PMID: 36648136

Lazzareschi DV, Fong N, Mavrothalassitis O, Whitlock EL, Chen CL, Chiu C, Adelmann D, Bokoch MP, Chen LL, Liu KD, Pirracchio R, Mathis MR, Legrand M, MPOG Collaborators. Intraoperative Use of Albumin in Major non-cardiac surgery: Incidence, Variability, and Association with Outcomes. Annals of surgery 2022. PMID: 36521076

Wald R, Kirkham B, daCosta BR, Ghamarian E, Adhikari NKJ, Beaubien-Souligny W, Bellomo R, Gallagher MP, Goldstein S, Hoste EAJ, Liu KD, Neyra JA, Ostermann M, Palevsky PM, Schneider A, Vaara ST, Bagshaw SM. Fluid balance and renal replacement therapy initiation strategy: a secondary analysis of the STARRT-AKI trial. Critical care (London, England) 2022. PMID: 36424662

Martinez RH, Liu KD, Aldrich JM. Overview of the Medical Management of the Critically Ill Patient. Clinical journal of the American Society of Nephrology : CJASN 2022. PMID: 36400435

Kalantar KL, Neyton L, Abdelghany M, Mick E, Jauregui A, Caldera S, Serpa PH, Ghale R, Albright J, Sarma A, Tsitsiklis A, Leligdowicz A, Christenson SA, Liu K, Kangelaris KN, Hendrickson C, Sinha P, Gomez A, Neff N, Pisco A, Doernberg SB, Derisi JL, Matthay MA, Calfee CS, Langelier CR. Integrated host-microbe plasma metagenomics for sepsis diagnosis in a prospective cohort of critically ill adults. Nature microbiology 2022. PMID: 36266337

Files DC, Esserman L, Liu KD, Calfee CS. Informed consent process in the ISPY COVID trial is ethically acceptable. European journal of internal medicine 2022. PMID: 36184277

Monteiro ACC, Vangala S, Wick KD, Delucchi KL, Siegel ER, Thompson BT, Liu KD, Sapru A, Sinha P, Matthay MA, NHLBI PETAL Network. The prognostic value of early measures of the ventilatory ratio in the ARDS ROSE trial. Critical care (London, England) 2022. PMID: 36175982

Parikh NI, Arowolo F, Durstenfeld MS, Nah G, Njoroge J, Vittinghoff E, Long CS, Ganz P, Pearce D, Hsue P, Wu AHS, Hajizadeh N, Liu KD, Lynch KL. Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls. Journal of the Endocrine Society 2022. PMID: 36338506

Wick KD, Leligdowicz A, Willmore A, Carrillo SA, Ghale R, Jauregui A, Chak SS, Nguyen V, Lee D, Jones C, Dewar R, Lane HC, Kangelaris KN, Hendrickson CM, Liu KD, Sinha P, Erle DJ, Langelier CR, Krummell MF, Woodruff PG, Calfee CS, Matthay MA, COMET Consortium. Plasma SARS-CoV-2 nucleocapsid antigen levels are associated with progression to severe disease in hospitalized COVID-19. Critical care (London, England) 2022. PMID: 36104754

McCoy IE, Hsu JY, Bonventre JV, Parikh CR, Go AS, Liu KD, Ricardo AC, Srivastava A, Cohen DL, He J, Chen J, Rao PS, Muiru AN, Hsu CY. Absence of long-term changes in urine biomarkers after AKI: findings from the CRIC study. BMC nephrology 2022. PMID: 36100915

Coca SG, Vasquez-Rios G, Mansour SG, Moledina DG, Thiessen-Philbrook H, Wurfel MM, Bhatraju P, Himmelfarb J, Siew E, Garg AX, Hsu CY, Liu KD, Kimmel PL, Chinchilli VM, Kaufman JS, Wilson M, Banks RE, Packington R, McCole E, Kurth MJ, Richardson C, Go AS, Selby NM, Parikh CR. Plasma Soluble Tumor Necrosis Factor Receptor Concentrations and Clinical Events After Hospitalization: Findings From the ASSESS-AKI and ARID Studies. American journal of kidney diseases : the official journal of the National Kidney Foundation 2022. PMID: 36108888

Vaara ST, Bhatraju PK, Stanski NL, McMahon BA, Liu K, Joannidis M, Bagshaw SM. Subphenotypes in acute kidney injury: a narrative review. Critical care (London, England) 2022. PMID: 35986336

Legrand M, Bagshaw SM, Koyner JL, Schulman IH, Mathis MR, Bernholz J, Coca S, Gallagher M, Gaudry S, Liu KD, Mehta RL, Pirracchio R, Ryan A, Steubl D, Stockbridge N, Erlandsson F, Turan A, Wilson FP, Zarbock A, Bokoch MP, Casey JD, Rossignol P, Harhay MO. Optimizing the Design and Analysis of Future AKI Trials. Journal of the American Society of Nephrology : JASN 2022. PMID: 35831022

Files DC, Matthay MA, Calfee CS, Aggarwal NR, Asare AL, Beitler JR, Berger PA, Burnham EL, Cimino G, Coleman MH, Crippa A, Discacciati A, Gandotra S, Gibbs KW, Henderson PT, Ittner CAG, Jauregui A, Khan KT, Koff JL, Lang J, LaRose M, Levitt J, Lu R, McKeehan JD, Meyer NJ, Russell DW, Thomas KW, Eklund M, Esserman LJ, Liu KD, ISPY COVID Adaptive Platform Trial Network, undefined. I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations. 2022. PMID: 35667714

Maeng CV, Christiansen CF, Liu KD, Kamper P, Christensen S, Medeiros BC, ?stg?rd LSG. Factors associated with risk and prognosis of intensive care unit admission in patients with acute leukemia: a Danish nationwide cohort study. Leukemia & lymphoma 2022. PMID: 35583300

Thompson Bastin ML, Stromberg AJ, Nerusu SN, Liu LJ, Mayer KP, Liu KD, Bagshaw SM, Wald R, Morris PE, Neyra JA. Association of Phosphate-Containing versus Phosphate-Free Solutions on Ventilator Days in Patients Requiring Continuous Kidney Replacement Therapy. Clinical journal of the American Society of Nephrology : CJASN 2022. PMID: 35477673

Moazed F, Hendrickson C, Jauregui A, Gotts J, Conroy A, Delucchi K, Zhuo H, Arambulo M, Vessel K, Ke S, Deiss T, Ni A, Leligdowicz A, Abbott J, Cohen MJ, Sinha P, Gomez A, Kangelaris K, Kornblith L, Matthay M, Benowitz N, Liu K, Calfee CS. Cigarette Smoke Exposure and ARDS in Sepsis: Epidemiology, Clinical Features, and Biologic Markers. 2022. PMID: 35050845

Muiru AN, Yang J, Derebail VK, Liu KD, Feldman HI, Srivastava A, Bhat Z, Saraf SL, Chen TK, He J, Estrella MM, Go AS, Hsu CY, CRIC Study Investigators. Black and White Adults With CKD Hospitalized With Acute Kidney Injury: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study. 2022. PMID: 35405207

Wen Y, Thiessen-Philbrook H, Moledina DG, Kaufman JS, Reeves WB, Ghahramani N, Ikizler TA, Go AS, Liu KD, Siew ED, Himmelfarb J, Kimmel PL, Hsu CY, Parikh CR. Considerations in Controlling for Urine Concentration for Biomarkers of Kidney Disease Progression After Acute Kidney Injury. Kidney international reports 2022. PMID: 35812275

McCoy IE, Hsu JY, Bonventre JV, Parikh CR, Go AS, Liu KD, Ricardo AC, Srivastava A, Cohen DL, He J, Chen J, Rao PS, Hsu CY, Chronic Renal Insufficiency Cohort (CRIC) Study Investigators. Acute Kidney Injury Associates with Long-Term Increases in Plasma TNFR1, TNFR2, and KIM-1: Findings from the CRIC Study. 2022. PMID: 35296554

Liu KD, Palevsky PM. Introduction to Critical Care Nephrology and Acute Kidney Injury. Clinical journal of the American Society of Nephrology : CJASN 2022. PMID: 35273007

Leligdowicz A, Kamm J, Kalantar K, Jauregui A, Vessel K, Caldera S, Serpa PH, Abbott J, Fang X, Tian X, Prakash A, Kangelaris KN, Liu KD, Calfee CS, Langelier C, Matthay MA. Functional Transcriptomic Studies of Immune Responses and Endotoxin Tolerance In early Human Sepsis. 2022. PMID: 35066510

Mansour S, Bhatraju P, Coca S, Obeid W, Wilson F, Stanaway I, Jia Y, Thiessen Philbrook H, Go A, Ikizler TA, Siew E, Chinchilli V, Hsu CY, Garg A, Reeves WB, Liu K, Kimmel P, Kaufman J, Wurfel M, Himmelfarb J, Parikh S, Parikh C. Angiopoietins as Prognostic Markers for Future Kidney Disease and Heart Failure Events After Acute Kidney Injury. 2022. PMID: 35017169

Maddali MV, Churpek M, Pham T, Rezoagli E, Zhuo H, Zhao W, He J, Delucchi KL, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Laffey JG, Bellani G, Calfee CS, Sinha P, LUNG SAFE Investigators and the ESICM Trials Group. Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data: an observational, multicohort, retrospective analysis. 2022. PMID: 35026177

Kwong YD, Liu KD, Hsu RK. Kidney Dysfunction After Acute Heart Failure: Is Acute Kidney Disease the New Acute Kidney Injury? 2021. PMID: 35257051

Rolandsson Enes S, Hampton TH, Barua J, McKenna DH, Dos Santos CC, Amiel E, Ashare A, Liu KD, Krasnodembskaya AD, English K, Stanton BA, Rocco PRM, Matthay MA, Weiss DJ. Healthy versus inflamed lung environments differentially effect MSCs. The European respiratory journal 2021. PMID: 33795318

Matthay MA, Liu KD. Preface. Critical care clinics 2021. PMID: 34548141

Vijayan A, Abdel-Rahman EM, Liu KD, Goldstein SL, Agarwal A, Okusa MD, Cerda J, AKI!NOW Steering Committee. Recovery after Critical Illness and Acute Kidney Injury. Clinical journal of the American Society of Nephrology : CJASN 2021. PMID: 34462285

Prasad PA, Fang MC, Martinez SP, Liu KD, Kangelaris KN. Identifying the Sickest During Triage: Using Point-of-Care Severity Scores to Predict Prognosis in Emergency Department Patients With Suspected Sepsis. Journal of hospital medicine 2021. PMID: 34328843

McCoy I, Brar S, Liu KD, Go AS, Hsu RK, Chinchilli VM, Coca SG, Garg AX, Himmelfarb J, Ikizler TA, Kaufman J, Kimmel PL, Lewis JB, Parikh CR, Siew ED, Ware LB, Zeng H, Hsu CY, Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) study inv. Achieved blood pressure post-acute kidney injury and risk of adverse outcomes after AKI: A prospective parallel cohort study. BMC nephrology 2021. PMID: 34325668

Rogers AJ, Leligdowicz A, Contrepois K, Jauregui A, Vessel K, Deiss TJ, Belzer A, Liu T, Lippi M, Ke S, Ross E, Zhou H, Hendrickson C, Gomez A, Sinha P, Kangelaris KN, Liu KD, Calfee CS, Matthay MA. Plasma Metabolites in Early Sepsis Identify Distinct Clusters Defined by Plasma Lipids. Critical Care Explorations 2021. PMID: 34345827

Cullaro G, Rubin JB, Fortune BE, Crawford CV, Verna EC, Hsu CY, Liu KD, Brown RS, Lai JC, Rosenblatt R. Association Between Kidney Dysfunction Types and Mortality Among Hospitalized Patients with Cirrhosis. Digestive diseases and sciences 2021. PMID: 34292470

Sinha P, Delucchi KL, Chen Y, Zhuo H, Abbott J, Wang C, Wickersham N, McNeil JB, Jauregui A, Ke S, Vessel K, Gomez A, Hendrickson CM, Kangelaris KN, Sarma A, Leligdowicz A, Liu KD, Matthay MA, Ware LB, Calfee CS. Latent class analysis-derived subphenotypes are generalisable to observational cohorts of acute respiratory distress syndrome: a prospective study. Thorax 2021. PMID: 34253679

Legrand M, Liu KD. Kidney Replacement Therapy in the ICU: Less Is More (Death)? American journal of kidney diseases : the official journal of the National Kidney Foundation 2021. PMID: 34245820

Legrand M, Bell S, Forni L, Joannidis M, Koyner JL, Liu K, Cantaluppi V. Pathophysiology of COVID-19-associated acute kidney injury. Nature reviews. Nephrology 2021. PMID: 34226718

Schmidt IM, Srivastava A, Sabbisetti V, McMahon GM, He J, Chen J, Kusek J, Taliercio J, Ricardo AC, Hsu CY, Kimmel PL, Liu KD, Mifflin TE, Nelson RG, Ramachandran VS, Xie D, Zhang X, Palsson R, Stillman IE, Rennke HG, Feldman HI, Bonventre JV, Waikar SS, Chronic Kidney Disease Biomarkers Consortium and the CRIC Study Investigators. Plasma Kidney Injury Molecule 1 in CKD: Findings From the Boston Kidney Biopsy Cohort and CRIC Studies. American journal of kidney diseases : the official journal of the National Kidney Foundation 2021. PMID: 34175376

Maeng CV, Østgård LSG, Christiansen CF, Liu KD. Changes in intensive care unit admission rates, organ support, and mortality in patients with acute myeloid leukaemia over a 12-year period: a Danish nationwide cohort study. British journal of haematology 2021. PMID: 34101163

Prowle JR, Forni LG, Bell M, Chew MS, Edwards M, Grams ME, Grocott MPW, Liu KD, McIlroy D, Murray PT, Ostermann M, Zarbock A, Bagshaw SM, Bartz R, Bell S, Bihorac A, Gan TJ, Hobson CE, Joannidis M, Koyner JL, Levett DZH, Mehta RL, Miller TE, Mythen MG, Nadim MK, Pearse RM, Rimmele T, Ronco C, Shaw AD, Kellum JA. Postoperative acute kidney injury in adult non-cardiac surgery: joint consensus report of the Acute Disease Quality Initiative and PeriOperative Quality Initiative. Nature reviews. Nephrology 2021. PMID: 33976395

Kwong YD, Liu KD, Lo LJ. Outpatient Dietary Management of Electrolyte Disorders During COVID-19: Food as Medicine. JAMA internal medicine 2021. PMID: 33555305

Ku E, Hsu RK, Johansen KL, McCulloch CE, Mitsnefes M, Grimes BA, Liu KD. Recovery of kidney function after dialysis initiation in children and adults in the US: A retrospective study of United States Renal Data System data. PLoS medicine 2021. PMID: 33606673

Puthumana J, Thiessen-Philbrook H, Xu L, Coca SG, Garg AX, Himmelfarb J, Bhatraju PK, Ikizler TA, Siew ED, Ware LB, Liu KD, Go AS, Kaufman JS, Kimmel PL, Chinchilli VM, Cantley LG, Parikh CR. Biomarkers of inflammation and repair in kidney disease progression. The Journal of clinical investigation 2021. PMID: 33290282

Ortiz-Soriano V, Butler CR, Levy M, Huen SC, Castaneda JL, Sakhuja A, Basu RK, Liu KD, Cerda J, Neyra JA. Survey of Current Practices of Outpatient Hemodialysis for AKI Patients. Kidney international reports 2021. PMID: 33912764

Kangelaris KN, Clemens R, Fang X, Jauregui A, Liu T, Vessel K, Deiss T, Sinha P, Leligdowicz A, Liu KD, Zhuo H, Alder MN, Wong HR, Calfee CS, Lowell CA, Matthay MA. A Neutrophil Subset Defined by Intracellular Olfactomedin 4 is Associated with Mortality in Sepsis. American journal of physiology. Lung cellular and molecular physiology 2020. PMID: 33355521

Brar S, Liu KD, Go AS, Hsu RK, Chinchilli VM, Coca SG, Garg AX, Himmelfarb J, Ikizler TA, Kaufman J, Kimmel PL, Parikh CR, Siew ED, Ware LB, Zeng H, Hsu CY, ASsessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) study inv , ASSESS-AKI Investigators. Prospective Cohort Study of Renin-Angiotensin System Blocker Usage after Hospitalized Acute Kidney Injury. Clinical journal of the American Society of Nephrology : CJASN 2020. PMID: 33272913

Legrand M, Liu K. Angiotensin-Converting Enzyme Inhibitors and or Receptor Blockers After Acute Kidney Injury: Rehabilitation of the Supervillains. Critical care medicine 2020. PMID: 33255118

Matthay MA, Leligdowicz A, Liu KD. Biological Mechanisms of COVID-19 ARDS. American journal of respiratory and critical care medicine 2020. PMID: 32997945

Self WH, Semler MW, Leither LM, Casey JD, Angus DC, Brower RG, Chang SY, Collins SP, Eppensteiner JC, Filbin MR, Files DC, Gibbs KW, Ginde AA, Gong MN, Harrell FE, Hayden DL, Hough CL, Johnson NJ, Khan A, Lindsell CJ, Matthay MA, Moss M, Park PK, Rice TW, Robinson BRH, Schoenfeld DA, Shapiro NI, Steingrub JS, Ulysse CA, Weissman A, Yealy DM, Thompson BT, Brown SM. Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial. JAMA 2020. PMID: 33165621

Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, Koyner JL, Legrand M, Lumlertgul N, Mohan S, Pannu N, Peng Z, Perez-Fernandez XL, Pickkers P, Prowle J, Reis T, Srisawat N, Tolwani A, Vijayan A, Villa G, Yang L, Ronco C, Kellum JA. Publisher Correction: COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nature reviews. Nephrology 2020. PMID: 33139940

Liu T, Deiss TJ, Lippi MW, Jauregui A, Vessel K, Ke S, Belzer A, Zhuo H, Kangelaris KN, Gomez AD, Matthay MA, Liu KD, Calfee CS. Alternative Tobacco Product Use in Critically Ill Patients. International journal of environmental research and public health 2020. PMID: 33255164

Hannon V, Kothari RP, Zhang L, Bokoch MP, Hill R, Roll GR, Mello A, Feiner JR, Liu KD, Niemann CU, Adelmann D. The Association Between Vena Cava Implantation Technique and Acute Kidney Injury After Liver Transplantation. Transplantation 2020. PMID: 32467477

Gupta S, Coca SG, Chan L, Melamed ML, Brenner SK, Hayek SS, Sutherland A, Puri S, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Schenck EJ, Goyal N, Hedayati SS, Dy R, Bansal A, Athavale A, Nguyen HB, Vijayan A, Charytan DM, Schulze CE, Joo MJ, Friedman AN, Zhang J, Sosa MA, Judd E, Velez JCQ, Mallappallil M, Redfern RE, Bansal AD, Neyra JA, Liu KD, Renaghan AD, Christov M, Molnar MZ, Sharma S, Kamal O, Boateng JO, Short SAP, Admon AJ, Sise ME, Wang W, Parikh CR, Leaf DE, STOP-COVID Investigators. AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19. Journal of the American Society of Nephrology : JASN 2020. PMID: 33067383

Nadim MK, Forni LG, Mehta RL, Connor MJ, Liu KD, Ostermann M, Rimmelé T, Zarbock A, Bell S, Bihorac A, Cantaluppi V, Hoste E, Husain-Syed F, Germain MJ, Goldstein SL, Gupta S, Joannidis M, Kashani K, Koyner JL, Legrand M, Lumlertgul N, Mohan S, Pannu N, Peng Z, Perez-Fernandez XL, Pickkers P, Prowle J, Reis T, Srisawat N, Tolwani A, Vijayan A, Villa G, Yang L, Ronco C, Kellum JA. COVID-19-associated acute kidney injury: consensus report of the 25th Acute Disease Quality Initiative (ADQI) Workgroup. Nature reviews. Nephrology 2020. PMID: 33060844

Kwong YD, Mehta K, Miaskowski C, Zhuo H, Yee K, Jauregui A, Ke S, Deiss T, Abbott J, Kangelaris KN, Sinha P, Hendrickson CM, Gomez A, Leligdowicz A, Matthay MA, Calfee CS, Liu KD. Using Best Subsets Regression to Identify Clinical Characteristics and Biomarkers Associated with Sepsis-Associated Acute Kidney Injury. American journal of physiology. Renal physiology 2020. PMID: 33044866

Baron RM, Christman JW, Liu KD, Matthay MA, Self WH, McVerry BJ, Hite RD, Paine R, Wurfel MM, Shapiro NI, Adams PW, Schmidt EP, Ringwood N. Monitoring Research Blood Sampling in Critically Ill Patients: Avoiding Iatrogenic Anemia. American journal of respiratory and critical care medicine 2020. PMID: 32357306

Siew ED, Liu KD, Bonn J, Chinchilli V, Dember LM, Girard TD, Greene T, Hernandez AF, Ikizler TA, James MT, Kampschroer K, Kopp JB, Levy M, Palevsky PM, Pannu N, Parikh CR, Rocco MV, Silver SA, Thiessen-Philbrook H, Wald R, Xie Y, Kimmel PL, Star RA. Improving Care for Patients after Hospitalization with AKI. Journal of the American Society of Nephrology : JASN 2020. PMID: 32912935

Abreu SC, Hampton TH, Hoffman E, Dearborn J, Ashare A, Singh Sidhu K, Matthews DE, McKenna DH, Amiel E, Barua J, Krasnodembskaya A, English K, Mahon BP, Santos CD, Cruz FF, Chambers DC, Liu KD, Matthay MA, Cramer RA, Stanton BA, Rocco PRM, Wargo MJ, Weiss DJ, Rolandsson Enes S. Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells. American journal of physiology. Lung cellular and molecular physiology 2020. PMID: 32901521

Dae MW, Liu KD, Solomon RJ, Gao DW, Stillson CA. Effect of Low-Frequency Therapeutic Ultrasound on Induction of Nitric Oxide in CKD: Potential to Prevent Acute Kidney Injury. Kidney diseases (Basel, Switzerland) 2020. PMID: 33313066

Files DC, Liu KD, Matthay M. Need for Additional Trials of Vitamin C for Sepsis. JAMA 2020. PMID: 32780134

Ward SL, Dahmer MK, Weeks HM, Sapru A, Quasney MW, Curley MAQ, Liu KD, Matthay MA, Flori HR. Association of patient weight status with plasma surfactant protein D, a biomarker of alveolar epithelial injury, in children with acute respiratory failure. Pediatric pulmonology 2020. PMID: 32725941

Kwong YD, Liu KD, Hsu RK, Johansen KL, McCulloch CE, Seth D, Fallahzadeh MK, Grimes BA, Ku E. Recovery of Kidney Function Among Patients With Glomerular Disease Starting Maintenance Dialysis. American journal of kidney diseases : the official journal of the National Kidney Foundation 2020. PMID: 32771649

Liu KD, Forni LG, Heung M, Wu VC, Kellum JA, Mehta RL, Ronco C, Kashani K, Rosner MH, Haase M, Koyner JL, Acute Disease Quality Initiative Investigators. Quality of Care for Acute Kidney Disease: Current Knowledge Gaps and Future Directions. Kidney international reports 2020. PMID: 33102955

Ikizler TA, Parikh CR, Himmelfarb J, Chinchilli VM, Liu KD, Coca SG, Garg AX, Hsu CY, Siew ED, Wurfel MM, Ware LB, Faulkner GB, Tan TC, Kaufman JS, Kimmel PL, Go AS. A prospective cohort study that examined acute kidney injury and kidney outcomes, cardiovascular events and death informs on long-term clinical outcomes. Kidney international 2020. PMID: 32707221

Bhatraju PK, Cohen M, Nagao RJ, Morrell ED, Kosamo S, Chai XY, Nance R, Dmyterko V, Delaney J, Christie JD, Liu KD, Mikacenic C, Gharib SA, Liles WC, Zheng Y, Christiani DC, Himmelfarb J, Wurfel MM. Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes. BMC nephrology 2020. PMID: 32680471

STARRT-AKI Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group, United Kingdom Critical Care Research Group, Canadian Nephrology Trials Network, Irish Critical Care Trials Group, Bagshaw SM, Wald R, Adhikari NKJ, Bellomo R, da Costa BR, Dreyfuss D, Du B, Gallagher MP, Gaudry S, Hoste EA, Lamontagne F, Joannidis M, Landoni G, Liu KD, McAuley DF, McGuinness SP, Neyra JA, Nichol AD, Ostermann M, Palevsky PM, Pettilä V, Quenot JP, Qiu H, Rochwerg B, Schneider AG, Smith OM, Thomé F, Thorpe KE, Vaara S, Weir M, Wang AY, Young P, Zarbock A. Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. The New England journal of medicine 2020. PMID: 32668114

Hendrickson CM, Kwong YD, Belzer AG, Shlipak MG, Matthay MA, Liu KD. Higher plasma cystatin C is associated with mortality after acute respiratory distress syndrome: findings from a Fluid and Catheter Treatment Trial (FACTT) substudy. Critical care (London, England) 2020. PMID: 32653023

Slagelse C, Gammelager H, Iversen LH, Liu KD, Sørensen HT, Christiansen CF. Renin-angiotensin system blockers and 1-year mortality in patients with post-operative acute kidney injury. Acta anaesthesiologica Scandinavica 2020. PMID: 32557539

Schwede M, Lee RY, Zhuo H, Kangelaris KN, Jauregui A, Vessel K, Belzer A, Deiss T, Matthay MA, Liu KD, Calfee CS. Clinician Recognition of the Acute Respiratory Distress Syndrome: Risk Factors for Under-Recognition and Trends Over Time. Critical care medicine 2020. PMID: 32317598

Auriemma CL, Delucchi K, Liu KD, Calfee CS. The attributable mortality of acute respiratory distress syndrome. Intensive care medicine 2020. PMID: 32451576

Ostermann M, Bellomo R, Burdmann EA, Doi K, Endre ZH, Goldstein SL, Kane-Gill SL, Liu KD, Prowle JR, Shaw AD, Srisawat N, Cheung M, Jadoul M, Winkelmayer WC, Kellum JA, Conference Participants. Controversies in acute kidney injury: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. Kidney international 2020. PMID: 32709292

Liu KD, Goldstein SL, Vijayan A, Parikh CR, Kashani K, Okusa MD, Agarwal A, Cerdá J, AKI!Now Initiative of the American Society of Nephrology. AKI!Now Initiative: Recommendations for Awareness, Recognition, and Management of AKI. Clinical journal of the American Society of Nephrology : CJASN 2020. PMID: 32317329

Bhatraju PK, Zelnick LR, Chinchilli VM, Moledina DG, Coca SG, Parikh CR, Garg AX, Hsu CY, Go AS, Liu KD, Ikizler TA, Siew ED, Kaufman JS, Kimmel PL, Himmelfarb J, Wurfel MM. Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes. JAMA network open 2020. PMID: 32282046

Vranas KC, Ouyang D, Lin AL, Slatore CG, Sullivan DR, Prasad Kerlin M, Liu KD, Baron RM, Calfee CS, Ware LB, Halpern S, Matthay MA, Herridge M, Mehta S, Rogers AJ. Gender Differences in Authorship of Critical Care Literature. American journal of respiratory and critical care medicine 2020. PMID: 31968182

Auriemma CL, Zhuo H, Delucchi K, Deiss T, Liu T, Jauregui A, Ke S, Vessel K, Lippi M, Seeley E, Kangelaris KN, Gomez A, Hendrickson C, Liu KD, Matthay MA, Ware LB, Calfee CS. Acute respiratory distress syndrome-attributable mortality in critically ill patients with sepsis. Intensive care medicine 2020. PMID: 32206845

Liu KD. Clinical Trials for AKI: Lessons Learned From the ARDS Network. Seminars in nephrology 2020. PMID: 32303286

Hsu CY, Chinchilli VM, Coca S, Devarajan P, Ghahramani N, Go AS, Hsu RK, Ikizler TA, Kaufman J, Liu KD, Parikh CR, Reeves WB, Wurfel M, Zappitelli M, Kimmel PL, Siew ED. Post-Acute Kidney Injury Proteinuria and Subsequent Kidney Disease Progression: The Assessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study. JAMA internal medicine 2020. PMID: 31985750

Huang CT, Liu KD. Exciting developments in the field of acute kidney injury. Nature reviews. Nephrology 2020. PMID: 31848461

Griffin BR, Liu KD, Teixeira JP. Critical Care Nephrology: Core Curriculum 2020. American journal of kidney diseases : the official journal of the National Kidney Foundation 2020. PMID: 31982214

Liu S, Wang C, Green G, Zhuo H, Liu KD, Kangelaris KN, Gomez A, Jauregui A, Vessel K, Ke S, Hendrickson C, Matthay MA, Calfee CS, Ware LB, Wolters PJ. Peripheral Blood Leukocyte Telomere Length is Associated with Survival of Sepsis Patients. The European respiratory journal 2019. PMID: 31619475

Hsu CY, Liu KD, Yang J, Glidden DV, Tan TC, Pravoverov L, Zheng S, Go AS. Renin-Angiotensin System Blockade after Acute Kidney Injury (AKI) and Risk of Recurrent AKI. Clinical journal of the American Society of Nephrology : CJASN 2019. PMID: 31843974

Anderson BJ, Calfee CS, Liu KD, Reilly JP, Kangelaris KN, Shashaty MGS, Lazaar AL, Bayliffe AI, Gallop RJ, Miano TA, Dunn TG, Johansson E, Abbott J, Jauregui A, Deiss T, Vessel K, Belzer A, Zhuo H, Matthay MA, Meyer NJ, Christie JD. Plasma sTNFR1 and IL8 for prognostic enrichment in sepsis trials: a prospective cohort study. Critical care (London, England) 2019. PMID: 31818332

Kwong YD, Chen S, Bouajram R, Li F, Matthay MA, Mehta KM, Glidden DV, Liu KD. The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury. PloS one 2019. PMID: 31770424

Slagelse C, Gammelager H, Iversen LH, Liu KD, Sørensen HTT, Christiansen CF. Renin-angiotensin system blocker use and the risk of acute kidney injury after colorectal cancer surgery: a population-based cohort study. BMJ open 2019. PMID: 31753901

Abreu SC, Enes SR, Dearborn J, Goodwin M, Coffey A, Borg ZD, Dos Santos CC, Wargo MJ, Cruz FF, Loi R, DeSarno M, Ashikaga T, Antunes MA, Rocco PRM, Liu KD, Lee JW, Matthay MA, McKenna DH, Weiss DJ. Lung Inflammatory Environments Differentially Alter Mesenchymal Stromal Cell Behavior. American journal of physiology. Lung cellular and molecular physiology 2019. PMID: 31553626

Rogers AJ, Guan J, Trtchounian A, Hunninghake GM, Kaimal R, Desai M, Kozikowski LA, DeSouza L, Mogan S, Liu KD, Matthay MA, Steingrub J, Wheeler A, Yoon JH, Nakahira K, Choi AM, Baron RM. Association of Elevated Plasma Interleukin 18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome. Critical care medicine 2019. PMID: 31206358

Hsu CY, Hsu RK, Liu KD, Yang J, Anderson A, Chen J, Chinchilli VM, Feldman HI, Garg AX, Hamm L, Himmelfarb J, Kaufman JS, Kusek JW, Parikh CR, Ricardo AC, Rosas SE, Saab G, Sha D, Siew ED, Sondheimer J, Taliercio JJ, Yang W, Go AS. Impact of AKI on Urinary Protein Excretion: Analysis of Two Prospective Cohorts. Journal of the American Society of Nephrology : JASN 2019. PMID: 31235617

Hsu RK, Hsu CY, McCulloch CE, Yang J, Anderson AH, Chen J, Feldman HI, He J, Liu KD, Navaneethan SD, Porter AC, Rahman M, Tan TC, Wilson FP, Xie D, Zhang X, Go AS. Research-based versus clinical serum creatinine measurements and the association of acute kidney injury with subsequent kidney function: findings from the Chronic Renal Insufficiency Cohort study. Clinical kidney journal 2019. PMID: 32082553

National Heart, Lung, and Blood Institute PETAL Clinical Trials Network, Moss M, Huang DT, Brower RG, Ferguson ND, Ginde AA, Gong MN, Grissom CK, Gundel S, Hayden D, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Khan A, Liu KD, Talmor D, Thompson BT, Ulysse CA, Yealy DM, Angus DC. Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome. The New England journal of medicine 2019. PMID: 31112383

Kashani K, Rosner MH, Haase M, Lewington AJP, O'Donoghue DJ, Wilson FP, Nadim MK, Silver SA, Zarbock A, Ostermann M, Mehta RL, Kane-Gill SL, Ding X, Pickkers P, Bihorac A, Siew ED, Barreto EF, Macedo E, Kellum JA, Palevsky PM, Tolwani AJ, Ronco C, Juncos LA, Rewa OG, Bagshaw SM, Mottes TA, Koyner JL, Liu KD, Forni LG, Heung M, Wu VC. Quality Improvement Goals for Acute Kidney Injury. Clinical journal of the American Society of Nephrology : CJASN 2019. PMID: 31101671

Ostermann M, Liu K, Kashani K. Fluid Management in Acute Kidney Injury. Chest 2019. PMID: 31002784

Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM. Identification of Acute Kidney Injury Subphenotypes with Differing Molecular Signatures and Responses to Vasopressin Therapy. American journal of respiratory and critical care medicine 2019. PMID: 30334632

Zinter MS, Spicer AC, Liu KD, Orwoll BE, Alkhouli MF, Brakeman PR, Calfee CS, Matthay MA, Sapru A. Positive Cumulative Fluid Balance Is Associated With Mortality in Pediatric Acute Respiratory Distress Syndrome in the Setting of Acute Kidney Injury. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2019. PMID: 30672838

Matthay MA, Zhuo H, Gotts JE, Liu KD, Calfee CS. Precision medicine for cell therapy in acute respiratory distress syndrome - Authors' reply. The Lancet. Respiratory medicine 2019. PMID: 30926051

Kwong YD, Liu KD. Prediction Models for AKI: Will They Result in Improved Outcomes for AKI? Clinical journal of the American Society of Nephrology : CJASN 2019. PMID: 30917995

Dépret F, Peacock WF, Liu KD, Rafique Z, Rossignol P, Legrand M. Management of hyperkalemia in the acutely ill patient. Annals of intensive care 2019. PMID: 30820692

Lee BJ, Hsu CY, Parikh R, McCulloch CE, Tan TC, Liu KD, Hsu RK, Pravoverov L, Zheng S, Go AS. Predicting Renal Recovery After Dialysis-Requiring Acute Kidney Injury. Kidney international reports 2019. PMID: 30993232

Ward SL, Quinn CM, Steurer MA, Liu KD, Flori HR, Matthay MA. Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2018. PMID: 30277896

Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD. Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial. The Lancet. Respiratory medicine 2018. PMID: 30455077

Huppert LA, Liu KD, Matthay MA. Therapeutic potential of mesenchymal stromal cells in the treatment of ARDS. Transfusion 2018. PMID: 30383290

Liu KD, Yang J, Tan TC, Glidden DV, Zheng S, Pravoverov L, Hsu CY, Go AS. Risk Factors for Recurrent Acute Kidney Injury in a Large Population-Based Cohort. American journal of kidney diseases : the official journal of the National Kidney Foundation 2018. PMID: 30482577

Hsu RK, Truwit JD, Matthay MA, Levitt JE, Thompson BT, Liu KD. Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome. Canadian journal of kidney health and disease 2018. PMID: 30116543

Leligdowicz A, Chun LF, Jauregui A, Vessel K, Liu KD, Calfee CS, Matthay MA. Human pulmonary endothelial cell permeability after exposure to LPS-stimulated leukocyte supernatants derived from patients with early sepsis. American journal of physiology. Lung cellular and molecular physiology 2018. PMID: 30024307

Waikar SS, Rebholz CM, Zheng Z, Hurwitz S, Hsu CY, Feldman HI, Xie D, Liu KD, Mifflin TE, Eckfeldt JH, Kimmel PL, Vasan RS, Bonventre JV, Inker LA, Coresh J. Biological Variability of Estimated GFR and Albuminuria in CKD. American journal of kidney diseases : the official journal of the National Kidney Foundation 2018. PMID: 30031564

Pais FM, Sinha P, Liu KD, Matthay MA. Influence of Clinical Factors and Exclusion Criteria on Mortality in ARDS Observational Studies and Randomized Controlled Trials. Respiratory care 2018. PMID: 29991643

Kwong YD, Liu KD. Selection of Intravenous Fluids. American journal of kidney diseases : the official journal of the National Kidney Foundation 2018. PMID: 29980374

Lee BJ, Hsu CY, Parikh RV, Leong TK, Tan TC, Walia S, Liu KD, Hsu RK, Go AS. Non-recovery from dialysis-requiring acute kidney injury and short-term mortality and cardiovascular risk: a cohort study. BMC nephrology 2018. PMID: 29890946

Nadim MK, Forni LG, Bihorac A, Hobson C, Koyner JL, Shaw A, Arnaoutakis GJ, Ding X, Engelman DT, Gasparovic H, Gasparovic V, Herzog CA, Kashani K, Katz N, Liu KD, Mehta RL, Ostermann M, Pannu N, Pickkers P, Price S, Ricci Z, Rich JB, Sajja LR, Weaver FA, Zarbock A, Ronco C, Kellum JA. Cardiac and Vascular Surgery-Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group. Journal of the American Heart Association 2018. PMID: 29858368

Kao CC, Yang WS, Fang JT, Liu KD, Wu VC. Remote organ failure in acute kidney injury. Journal of the Formosan Medical Association = Taiwan yi zhi 2018. PMID: 29798818

Go AS, Hsu CY, Yang J, Tan TC, Zheng S, Ordonez JD, Liu KD. Acute Kidney Injury and Risk of Heart Failure and Atherosclerotic Events. Clinical journal of the American Society of Nephrology : CJASN 2018. PMID: 29773712

Self WH, Semler MW, Bellomo R, Brown SM, deBoisblanc BP, Exline MC, Ginde AA, Grissom CK, Janz DR, Jones AE, Liu KD, Macdonald SPJ, Miller CD, Park PK, Reineck LA, Rice TW, Steingrub JS, Talmor D, Yealy DM, Douglas IS, Shapiro NI, CLOVERS Protocol Committee and NHLBI Prevention and Early Treatment of Acute Lung Injury (PETAL) Net. Liberal Versus Restrictive Intravenous Fluid Therapy for Early Septic Shock: Rationale for a Randomized Trial. Annals of emergency medicine 2018. PMID: 29753517

Siew ED, Liu KD. Contrast-Induced Acute Kidney Injury in the PRESERVE Trial: Lessons Learned. Clinical journal of the American Society of Nephrology : CJASN 2018. PMID: 29674341

Zuk A, Palevsky PM, Fried L, Harrell FE, Khan S, McKay DB, Devey L, Chawla L, de Caestecker M, Kaufman JS, Thompson BT, Agarwal A, Greene T, Okusa MD, Bonventre JV, Dember LM, Liu KD, Humphreys BD, Gossett D, Xie Y, Norton JM, Kimmel PL, Star RA. Overcoming Translational Barriers in Acute Kidney Injury: A Report from an NIDDK Workshop. Clinical journal of the American Society of Nephrology : CJASN 2018. PMID: 29523680

Sung N, Aldrich JM, Shimabukuro DW, Matthay MA, Liu KD. Assessing Preventable Harms in the Intensive Care Unit: Data From a Tertiary Care Academic Medical Institution. American journal of medical quality : the official journal of the American College of Medical Quality 2018. PMID: 29473421

Federspiel CK, Itenov TS, Mehta K, Hsu RK, Bestle MH, Liu KD. Duration of acute kidney injury in critically ill patients. Annals of intensive care 2018. PMID: 29473104

Moore PK, Hsu RK, Liu KD. Management of Acute Kidney Injury: Core Curriculum 2018. American journal of kidney diseases : the official journal of the National Kidney Foundation 2018. PMID: 29478864

Lee BJ, Go AS, Parikh R, Leong TK, Tan TC, Walia S, Hsu RK, Liu KD, Hsu CY. Pre-admission proteinuria impacts risk of non-recovery after dialysis-requiring acute kidney injury. Kidney international 2018. PMID: 29352593

Schell-Chaple HM, Liu KD, Matthay MA, Puntillo KA. Rectal and Bladder Temperatures vs Forehead Core Temperatures Measured With SpotOn Monitoring System. American journal of critical care : an official publication, American Association of Critical-Care Nurses 2018. PMID: 29292274

Thompson BT, Chambers RC, Liu KD. Acute Respiratory Distress Syndrome. The New England journal of medicine 2017. PMID: 29117492

Ostermann M, Liu K. Pathophysiology of AKI. Best practice & research. Clinical anaesthesiology 2017. PMID: 29248138

Thornton KC, Schwarz JJ, Gross AK, Anderson WG, Liu KD, Romig MC, Schell-Chaple H, Pronovost PJ, Sapirstein A, Gropper MA, Lipshutz AKM. Preventing Harm in the ICU-Building a Culture of Safety and Engaging Patients and Families. Critical care medicine 2017. PMID: 28640023

Liu KD, Hsu CY, Yang J, Tan TC, Zheng S, Ordonez JD, Go AS. Acute Kidney Injury Ascertainment Is Affected by the Use of First Inpatient Versus Outpatient Baseline Serum Creatinine. Kidney international reports 2017. PMID: 29340333

Thompson BT, Chambers RC, Liu KD. Acute Respiratory Distress Syndrome. The New England journal of medicine 2017. PMID: 28792873

Pérez-Fernández X, Sabater-Riera J, Ballus-Noguera J, Cárdenas-Campos P, Moreno-González G, Alonso-Juste V, Corral-Velez V, Gutierrez-Arámbula D, Gumucio-Sanguino V, Betbesé-Roig A, Liu KD. No impact of surviving sepsis campaign care bundles in reducing sepsis-associated acute kidney injury
. Clinical nephrology 2017. PMID: 28655385

Schell-Chaple HM, Liu KD, Matthay MA, Sessler DI, Puntillo KA. Effects of IV Acetaminophen on Core Body Temperature and Hemodynamic Responses in Febrile Critically Ill Adults: A Randomized Controlled Trial. Critical care medicine 2017. PMID: 28319467

Kwong YD, Liu KD. AKI Adjudication: Do We Need It. Nephron 2017. PMID: 28614829

Palevsky PM, Liu KD. What endpoints should not be used for clinical studies of acute kidney injury? Intensive care medicine 2017. PMID: 28528490

Liu KD, Humphreys BD, Endre ZH. The ten barriers for translation of animal data on AKI to the clinical setting. Intensive care medicine 2017. PMID: 28451772

Park M, Hsu CY, Go AS, Feldman HI, Xie D, Zhang X, Mifflin T, Waikar SS, Sabbisetti VS, Bonventre JV, Coresh J, Nelson RG, Kimmel PL, Kusek JW, Rahman M, Schelling JR, Vasan RS, Liu KD. Urine Kidney Injury Biomarkers and Risks of Cardiovascular Disease Events and All-Cause Death: The CRIC Study. Clinical journal of the American Society of Nephrology : CJASN 2017. PMID: 28254771

Chawla LS, Bellomo R, Bihorac A, Goldstein SL, Siew ED, Bagshaw SM, Bittleman D, Cruz D, Endre Z, Fitzgerald RL, Forni L, Kane-Gill SL, Hoste E, Koyner J, Liu KD, Macedo E, Mehta R, Murray P, Nadim M, Ostermann M, Palevsky PM, Pannu N, Rosner M, Wald R, Zarbock A, Ronco C, Kellum JA, Acute Disease Quality Initiative Workgroup 16.. Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup. Nature reviews. Nephrology 2017. PMID: 28239173

Hendrickson CM, Abbott J, Zhuo H, Liu KD, Calfee CS, Matthay MA. Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days. American journal of physiology. Lung cellular and molecular physiology 2017. PMID: 28213470

Famous KR, Delucchi K, Ware LB, Kangelaris KN, Liu KD, Thompson BT, Calfee CS. Acute Respiratory Distress Syndrome Subphenotypes Respond Differently to Randomized Fluid Management Strategy. American journal of respiratory and critical care medicine 2017. PMID: 27513822

Huang DT, Angus DC, Moss M, Thompson BT, Ferguson ND, Ginde A, Gong MN, Gundel S, Hayden DL, Hite RD, Hou PC, Hough CL, Iwashyna TJ, Liu KD, Talmor DS, Yealy DM, Reevaluation of Systemic Early Neuromuscular Blockade Protocol Committee and the National Institutes. Design and Rationale of the Reevaluation of Systemic Early Neuromuscular Blockade Trial for Acute Respiratory Distress Syndrome. Annals of the American Thoracic Society 2017. PMID: 27779896

Bhatraju PK, Mukherjee P, Robinson-Cohen C, O'Keefe GE, Frank AJ, Christie JD, Meyer NJ, Liu KD, Matthay MA, Calfee CS, Christiani DC, Himmelfarb J, Wurfel MM. Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death. Critical care (London, England) 2016. PMID: 27852290

Hsu CY, Xie D, Waikar SS, Bonventre JV, Zhang X, Sabbisetti V, Mifflin TE, Coresh J, Diamantidis CJ, He J, Lora CM, Miller ER, Nelson RG, Ojo AO, Rahman M, Schelling JR, Wilson FP, Kimmel PL, Feldman HI, Vasan RS, Liu KD. Urine biomarkers of tubular injury do not improve on the clinical model predicting chronic kidney disease progression. Kidney international 2016. PMID: 28029431

Liu KD, Siew ED, Reeves WB, Himmelfarb J, Go AS, Hsu CY, Bennett MR, Devarajan P, Ikizler TA, Kaufman JS, Kimmel PL, Chinchilli VM, Parikh CR. Storage Time and Urine Biomarker Levels in the ASSESS-AKI Study. PloS one 2016. PMID: 27788160

Gordon AC, Perkins GD, Singer M, McAuley DF, Orme RM, Santhakumaran S, Mason AJ, Cross M, Al-Beidh F, Best-Lane J, Brealey D, Nutt CL, McNamee JJ, Reschreiter H, Breen A, Liu KD, Ashby D. Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis. The New England journal of medicine 2016. PMID: 27705084

Ward SL, Quinn CM, Valentine SL, Sapru A, Curley MA, Willson DF, Liu KD, Matthay MA, Flori HR. Poor Adherence to Lung-Protective Mechanical Ventilation in Pediatric Acute Respiratory Distress Syndrome. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2016. PMID: 27513687

Liu KD, Palevsky PM. RRT in AKI: Start Early or Wait? Clinical journal of the American Society of Nephrology : CJASN 2016. PMID: 27672218

Roy J, Shou H, Xie D, Hsu JY, Yang W, Anderson AH, Landis JR, Jepson C, He J, Liu KD, Hsu CY, Feldman HI. Statistical Methods for Cohort Studies of CKD: Prediction Modeling. Clinical journal of the American Society of Nephrology : CJASN 2016. PMID: 27660302

Federspiel CK, Liu KD. Does Changing the Volume Matter? The Relationship of Urine Volume and Dialysis Intensity. Clinical journal of the American Society of Nephrology : CJASN 2016. PMID: 27449662

Liu KD, Vijayan A, Rosner MH, Shi J, Chawla LS, Kellum JA. Clinical adjudication in acute kidney injury studies: findings from the pivotal TIMP-2*IGFBP7 biomarker study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2016. PMID: 27342580

Waikar SS, Sabbisetti V, Ärnlöv J, Carlsson AC, Coresh J, Feldman HI, Foster MC, Fufaa GD, Helmersson-Karlqvist J, Hsu CY, Kimmel PL, Larsson A, Liu Y, Lind L, Liu KD, Mifflin TE, Nelson RG, Risérus U, Vasan RS, Xie D, Zhang X, Bonventre JV. Relationship of proximal tubular injury to chronic kidney disease as assessed by urinary kidney injury molecule-1 in five cohort studies. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2016. PMID: 27270293

Hendrickson CM, Howard BM, Kornblith LZ, Conroy AS, Nelson MF, Zhuo H, Liu KD, Manley GT, Matthay MA, Calfee CS, Cohen MJ. The acute respiratory distress syndrome following isolated severe traumatic brain injury. The journal of trauma and acute care surgery 2016. PMID: 26881489

Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Critical care (London, England) 2016. PMID: 27215212

McSparron JI, Hayes MM, Poston JT, Thomson CC, Fessler HE, Stapleton RD, Carlos WG, Hinkle L, Liu K, Shieh S, Ali A, Rogers A, Shah NG, Slack D, Patel B, Wolfe K, Schweickert WD, Bakhru RN, Shin S, Sell RE, Luks AM. ATS Core Curriculum 2016: Part II. Adult Critical Care Medicine. Annals of the American Thoracic Society 2016. PMID: 27144797

Liu KD. Changing Faces of Critical Care Nephrology. Advances in chronic kidney disease 2016. PMID: 27113687

Pérez XL, Liu KD. Critical Care Updates for the Nephrologist, 2016. Advances in chronic kidney disease 2016. PMID: 27113688

Parks M, Liu KD. Acute kidney injury: Clinical trials in AKI: is the end in sight? Nature reviews. Nephrology 2016. PMID: 27026352

Weyker PD, Pérez XL, Liu KD. Management of Acute Kidney Injury and Acid-Base Balance in the Septic Patient. Clinics in chest medicine 2016. PMID: 27229644

Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, Nolin TD, Bihorac A, American Society of Nephrology Acute Kidney Injury Advisory Group. Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment. American journal of kidney diseases : the official journal of the National Kidney Foundation 2016. PMID: 26948834

Matthay MA, Liu KD. New Strategies for Effective Therapeutics in Critically Ill Patients. JAMA 2016. PMID: 26903328

de Caestecker M, Humphreys BD, Liu KD, Fissell WH, Cerda J, Nolin TD, Askenazi D, Mour G, Harrell FE, Pullen N, Okusa MD, Faubel S, ASN AKI Advisory Group. Bridging Translation by Improving Preclinical Study Design in AKI. Journal of the American Society of Nephrology : JASN 2015. PMID: 26538634

Bansal N, Carpenter MA, Weiner DE, Levey AS, Pfeffer M, Kusek JW, Cai J, Hunsicker LG, Park M, Bennett M, Liu KD, Hsu CY. Urine Injury Biomarkers and Risk of Adverse Outcomes in Recipients of Prevalent Kidney Transplants: The Folic Acid for Vascular Outcome Reduction in Transplantation Trial. Journal of the American Society of Nephrology : JASN 2015. PMID: 26538631

Ghannoum M, Calello DP, Lavergne V, Gosselin S, Liu KD, Roberts DM. The authors reply. Critical care medicine 2015. PMID: 26468727

Foster MC, Coresh J, Bonventre JV, Sabbisetti VS, Waikar SS, Mifflin TE, Nelson RG, Grams M, Feldman HI, Vasan RS, Kimmel PL, Hsu CY, Liu KD. Urinary Biomarkers and Risk of ESRD in the Atherosclerosis Risk in Communities Study. Clinical journal of the American Society of Nephrology : CJASN 2015. PMID: 26350438

Leventhal TM, Liu KD. What a Nephrologist Needs to Know About Acute Liver Failure. Advances in chronic kidney disease 2015. PMID: 26311599

Calello DP, Liu KD, Wiegand TJ, Roberts DM, Lavergne V, Gosselin S, Hoffman RS, Nolin TD, Ghannoum M, Extracorporeal Treatments in Poisoning Workgroup. Extracorporeal Treatment for Metformin Poisoning: Systematic Review and Recommendations From the Extracorporeal Treatments in Poisoning Workgroup. Critical care medicine 2015. PMID: 25860205

Heung M, Faubel S, Watnick S, Cruz DN, Koyner JL, Mour G, Liu KD, Cerda J, Okusa MD, Lukaszewski M, Vijayan A, American Society of Nephrology Acute Kidney Injury Advisory Group. Outpatient Dialysis for Patients with AKI: A Policy Approach to Improving Care. Clinical journal of the American Society of Nephrology : CJASN 2015. PMID: 26220818

Cerdá J, Liu KD, Cruz DN, Jaber BL, Koyner JL, Heung M, Okusa MD, Faubel S, AKI Advisory Group of the American Society of Nephrology. Promoting Kidney Function Recovery in Patients with AKI Requiring RRT. Clinical journal of the American Society of Nephrology : CJASN 2015. PMID: 26138260

Liu KD, Hsu CY. When change is not a good thing. Clinical chemistry 2015. PMID: 25991825

Beitler JR, Thompson BT, Matthay MA, Talmor D, Liu KD, Zhuo H, Hayden D, Spragg RG, Malhotra A. Estimating dead-space fraction for secondary analyses of acute respiratory distress syndrome clinical trials. Critical care medicine 2015. PMID: 25738857

Shieh SC, Liu KD. Finding the key to dialysis catheter lock. American journal of respiratory and critical care medicine 2015. PMID: 25932759

Wilson J, McKenna D, Liu KD, Matthay MA. Mesenchymal stem (stromal) cells for treatment of acute respiratory distress syndrome - authors' reply. The Lancet. Respiratory medicine 2015. PMID: 25890655

Kangelaris KN, Prakash A, Liu KD, Aouizerat B, Woodruff PG, Erle DJ, Rogers A, Seeley EJ, Chu J, Liu T, Osterberg-Deiss T, Zhuo H, Matthay MA, Calfee CS. Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS. Volume 308 of Issue 11. American journal of physiology. Lung cellular and molecular physiology 2015. PMID: 25795726

Hsu CY, Ballard S, Batlle D, Bonventre JV, Böttinger EP, Feldman HI, Klein JB, Coresh J, Eckfeldt JH, Inker LA, Kimmel PL, Kusek JW, Liu KD, Mauer M, Mifflin TE, Molitch ME, Nelsestuen GL, Rebholz CM, Rovin BH, Sabbisetti VS, Van Eyk JE, Vasan RS, Waikar SS, Whitehead KM, Nelson RG. Cross-Disciplinary Biomarkers Research: Lessons Learned by the CKD Biomarkers Consortium. Clinical journal of the American Society of Nephrology : CJASN 2015. PMID: 25739849

Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Matthay MA. Erratum to: plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive care medicine 2015. PMID: 25708422

Ghannoum M, Wiegand TJ, Liu KD, Calello DP, Godin M, Lavergne V, Gosselin S, Nolin TD, Hoffman RS, EXTRIP workgroup. Extracorporeal treatment for theophylline poisoning: systematic review and recommendations from the EXTRIP workgroup. Clinical toxicology (Philadelphia, Pa.) 2015. PMID: 25715736

Faubel S, Franch H, Vijayan A, Barron MA, Heung M, Liu KD, Koyner JL, Conner MJ. Preparing for renal replacement therapy in patients with the Ebola virus disease. Blood purification 2015. PMID: 25675963

Sapru A, Calfee CS, Liu KD, Kangelaris K, Hansen H, Pawlikowska L, Ware LB, Alkhouli MF, Abbott J, Abbot J, Matthay MA. Plasma soluble thrombomodulin levels are associated with mortality in the acute respiratory distress syndrome. Intensive care medicine 2015. PMID: 25643902

Grissom CK, Hirshberg EL, Dickerson JB, Brown SM, Lanspa MJ, Liu KD, Schoenfeld D, Tidswell M, Hite RD, Rock P, Miller RR, Morris AH, National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network. Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*. Critical care medicine 2015. PMID: 25599463

Schell-Chaple HM, Puntillo KA, Matthay MA, Liu KD. Body temperature and mortality in patients with acute respiratory distress syndrome. American journal of critical care : an official publication, American Association of Critical-Care Nurses 2015. PMID: 25554550

Wilson JG, Liu KD, Zhuo H, Caballero L, McMillan M, Fang X, Cosgrove K, Vojnik R, Calfee CS, Lee JW, Rogers AJ, Levitt J, Wiener-Kronish J, Bajwa EK, Leavitt A, McKenna D, Thompson BT, Matthay MA. Mesenchymal stem (stromal) cells for treatment of ARDS: a phase 1 clinical trial. Volume 3 of Issue 1. The Lancet. Respiratory medicine 2014. PMID: 25529339

Fufaa GD, Weil EJ, Nelson RG, Hanson RL, Bonventre JV, Sabbisetti V, Waikar SS, Mifflin TE, Zhang X, Xie D, Hsu CY, Feldman HI, Coresh J, Vasan RS, Kimmel PL, Liu KD. Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus. Diabetologia 2014. PMID: 25316431

Liu KD, Yang W, Go AS, Anderson AH, Feldman HI, Fischer MJ, He J, Kallem RR, Kusek JW, Master SR, Miller ER, Rosas SE, Steigerwalt S, Tao K, Weir MR, Hsu CY. Urine neutrophil gelatinase-associated lipocalin and risk of cardiovascular disease and death in CKD: results from the Chronic Renal Insufficiency Cohort (CRIC) Study. American journal of kidney diseases : the official journal of the National Kidney Foundation 2014. PMID: 25311702

Liu KD. Therapeutic strategies for clinical trials targeting renal recovery. Nephron. Clinical practice 2014. PMID: 25343832

Liu KD, Dong N, Truwit JD. Rosuvastatin for sepsis-associated ARDS. The New England journal of medicine 2014. PMID: 25184876

Hsieh SJ, Zhuo H, Benowitz NL, Thompson BT, Liu KD, Matthay MA, Calfee CS. Prevalence and impact of active and passive cigarette smoking in acute respiratory distress syndrome. Critical care medicine 2014. PMID: 24942512

Huddleston LL, Liu KD. Propofol as a panacea for acute kidney injury? Kidney international 2014. PMID: 25079022

Krupa A, Fol M, Rahman M, Stokes KY, Florence JM, Leskov IL, Khoretonenko MV, Matthay MA, Liu KD, Calfee CS, Tvinnereim A, Rosenfield GR, Kurdowska AK. Silencing Bruton's tyrosine kinase in alveolar neutrophils protects mice from LPS/immune complex-induced acute lung injury. American journal of physiology. Lung cellular and molecular physiology 2014. PMID: 25085625

Liu KD, Wilson JG, Zhuo H, Caballero L, McMillan ML, Fang X, Cosgrove K, Calfee CS, Lee JW, Kangelaris KN, Gotts JE, Rogers AJ, Levitt JE, Wiener-Kronish JP, Delucchi KL, Leavitt AD, McKenna DH, Thompson BT, Matthay MA. Design and implementation of the START (STem cells for ARDS Treatment) trial, a phase 1/2 trial of human mesenchymal stem/stromal cells for the treatment of moderate-severe acute respiratory distress syndrome. Volume 4. Annals of intensive care 2014. PMID: 25593740

Moseson EM, Zhuo H, Chu J, Stein JC, Matthay MA, Kangelaris KN, Liu KD, Calfee CS. Intensive care unit scoring systems outperform emergency department scoring systems for mortality prediction in critically ill patients: a prospective cohort study. Journal of intensive care 2014. PMID: 25960880

Orme RM, Perkins GD, McAuley DF, Liu KD, Mason AJ, Morelli A, Singer M, Ashby D, Gordon AC. An efficacy and mechanism evaluation study of Levosimendan for the Prevention of Acute oRgan Dysfunction in Sepsis (LeoPARDS): protocol for a randomized controlled trial. Trials 2014. PMID: 24894386

Asmussen S, Ito H, Traber DL, Lee JW, Cox RA, Hawkins HK, McAuley DF, McKenna DH, Traber LD, Zhuo H, Wilson J, Herndon DN, Prough DS, Liu KD, Matthay MA, Enkhbaatar P. Human mesenchymal stem cells reduce the severity of acute lung injury in a sheep model of bacterial pneumonia. Thorax 2014. PMID: 24891325

Truwit JD, Bernard GR, Steingrub J, Matthay MA, Liu KD, Albertson TE, Brower RG, Shanholtz C, Rock P, Douglas IS, deBoisblanc BP, Hough CL, Hite RD, Thompson BT. Rosuvastatin for sepsis-associated acute respiratory distress syndrome. The New England journal of medicine 2014. PMID: 24835849

Koyner JL, Cerdá J, Goldstein SL, Jaber BL, Liu KD, Shea JA, Faubel S, Acute Kidney Injury Advisory Group of the American Society of Nephrology. The daily burden of acute kidney injury: a survey of U.S. nephrologists on World Kidney Day. American journal of kidney diseases : the official journal of the National Kidney Foundation 2014. PMID: 24815216

Wong HR, Liu KD, Kangelaris KN, Lahni P, Calfee CS. Performance of interleukin-27 as a sepsis diagnostic biomarker in critically ill adults. Journal of critical care 2014. PMID: 24848949

Hsu CY, Liu KD. Cardiovascular events after AKI: a new dimension. Journal of the American Society of Nephrology : JASN 2014. PMID: 24503240

Asija R, Roth SJ, Hanley FL, Peng L, Liu K, Abbott J, Zhuo H, Matthay M. Reperfusion pulmonary edema in children with tetralogy of Fallot, pulmonary atresia, and major aortopulmonary collateral arteries undergoing unifocalization procedures: A pilot study examining potential pathophysiologic mechanisms and clinical significanc The Journal of thoracic and cardiovascular surgery 2014. PMID: 24534681

Kwon SH, Liu KD, Mostov KE. Intercellular transfer of GPRC5B via exosomes drives HGF-mediated outward growth. Current biology : CB 2014. PMID: 24412205

Kallet RH, Zhuo H, Liu KD, Calfee CS, Matthay MA. The association between physiologic dead-space fraction and mortality in subjects with ARDS enrolled in a prospective multi-center clinical trial. Respiratory care 2013. PMID: 24381187

Wilson JG, Butcher BW, Liu KD. Evolving practices in critical care and their influence on acute kidney injury. Current opinion in critical care 2013. PMID: 24240818

Parikh CR, Butrymowicz I, Yu A, Chinchilli VM, Park M, Hsu CY, Reeves WB, Devarajan P, Kimmel PL, Siew ED, Liu KD. Urine stability studies for novel biomarkers of acute kidney injury. American journal of kidney diseases : the official journal of the National Kidney Foundation 2013. PMID: 24200462

Bonventre JV, Basile D, Liu KD, McKay D, Molitoris BA, Nath KA, Nickolas TL, Okusa MD, Palevsky PM, Schnellmann R, Rys-Sikora K, Kimmel PL, Star RA, Kidney Research National Dialogue (KRND). AKI: a path forward. Clinical journal of the American Society of Nephrology : CJASN 2013. PMID: 23868899

Liu KD, Yang W, Hsu CY. The authors reply. Kidney international 2013. PMID: 23812370

Lameire NH, Bagga A, Cruz D, De Maeseneer J, Endre Z, Kellum JA, Liu KD, Mehta RL, Pannu N, Van Biesen W, Vanholder R. Acute kidney injury: an increasing global concern. Lancet (London, England) 2013. PMID: 23727171

Agrawal A, Matthay MA, Kangelaris KN, Stein J, Chu JC, Imp BM, Cortez A, Abbott J, Liu KD, Calfee CS. Plasma angiopoietin-2 predicts the onset of acute lung injury in critically ill patients. American journal of respiratory and critical care medicine 2013. PMID: 23328529

Palevsky PM, Liu KD, Brophy PD, Chawla LS, Parikh CR, Thakar CV, Tolwani AJ, Waikar SS, Weisbord SD. KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. American journal of kidney diseases : the official journal of the National Kidney Foundation 2013. PMID: 23499048

Park M, Vittinghoff E, Liu KD, Shlipak MG, Hsu CY. Urine Biomarkers Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Kidney Injury Molecule-1 (KIM-1) Have Different Patterns in Heart Failure Exacerbation. Biomarker insights 2013. PMID: 23531625

Liu KD, Yang W, Anderson AH, Feldman HI, Demirjian S, Hamano T, He J, Lash J, Lustigova E, Rosas SE, Simonson MS, Tao K, Hsu CY. Urine neutrophil gelatinase-associated lipocalin levels do not improve risk prediction of progressive chronic kidney disease. Kidney international 2013. PMID: 23344473

Liu KD. Critical care nephrology: update in critical care for the nephrologist. Advances in chronic kidney disease 2013. PMID: 23265590

Butcher BW, Liu KD. Fluid overload in AKI: epiphenomenon or putative effect on mortality? Current opinion in critical care 2012. PMID: 23037878

Agrawal A, Zhuo H, Brady S, Levitt J, Steingrub J, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Matthay MA, Liu KD. Pathogenetic and predictive value of biomarkers in patients with ALI and lower severity of illness: results from two clinical trials. American journal of physiology. Lung cellular and molecular physiology 2012. PMID: 22865551

Ghannoum M, Nolin TD, Goldfarb DS, Roberts DM, Mactier R, Mowry JB, Dargan PI, Maclaren R, Hoegberg LC, Laliberté M, Calello D, Kielstein JT, Anseeuw K, Winchester JF, Burdmann EA, Bunchman TE, Li Y, Juurlink DN, Lavergne V, Megarbane B, Gosselin S, Liu KD, Hoffman RS, Extracorporeal Treatments in Poisoning Workgroup. Extracorporeal treatment for thallium poisoning: recommendations from the EXTRIP Workgroup. Clinical journal of the American Society of Nephrology : CJASN 2012. PMID: 22837270

Lavergne V, Nolin TD, Hoffman RS, Roberts D, Gosselin S, Goldfarb DS, Kielstein JT, Mactier R, Maclaren R, Mowry JB, Bunchman TE, Juurlink D, Megarbane B, Anseeuw K, Winchester JF, Dargan PI, Liu KD, Hoegberg LC, Li Y, Calello DP, Burdmann EA, Yates C, Laliberté M, Decker BS, Mello-Da-Silva CA, Lavonas E, Ghannoum M. The EXTRIP (EXtracorporeal TReatments In Poisoning) workgroup: guideline methodology. Clinical toxicology (Philadelphia, Pa.) 2012. PMID: 22578059

Molitoris BA, Okusa MD, Palevsky PM, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene TH, Faubel SG, Kellum JA, Wald R, Chertow GM, Levin A, Waikar SS, Murray PT, Parikh CR, Shaw AD, Go AS, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Mehta RL, Stokes JB, Thompson AM, Thompson BT, Westenfelder CS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA. Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings. Clinical journal of the American Society of Nephrology : CJASN 2012. PMID: 22442184

Okusa MD, Molitoris BA, Palevsky PM, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Faubel S, Kellum JA, Wald R, Chertow GM, Levin A, Waikar SS, Murray PT, Parikh CR, Shaw AD, Go AS, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene TH, Mehta RL, Stokes JB, Thompson AM, Thompson BT, Westenfelder CS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA. Design of clinical trials in acute kidney injury: a report from an NIDDK workshop--prevention trials. Clinical journal of the American Society of Nephrology : CJASN 2012. PMID: 22442188

Palevsky PM, Molitoris BA, Okusa MD, Levin A, Waikar SS, Wald R, Chertow GM, Murray PT, Parikh CR, Shaw AD, Go AS, Faubel SG, Kellum JA, Chinchilli VM, Liu KD, Cheung AK, Weisbord SD, Chawla LS, Kaufman JS, Devarajan P, Toto RM, Hsu CY, Greene T, Mehta RL, Stokes JB, Thompson AM, Thompson BT, Westenfelder CS, Tumlin JA, Warnock DG, Shah SV, Xie Y, Duggan EG, Kimmel PL, Star RA. Design of clinical trials in acute kidney injury: report from an NIDDK workshop on trial methodology. Clinical journal of the American Society of Nephrology : CJASN 2012. PMID: 22442182

Faubel S, Chawla LS, Chertow GM, Goldstein SL, Jaber BL, Liu KD, Acute Kidney Injury Advisory Group of the American Society of Nephrology. Ongoing clinical trials in AKI. Clinical journal of the American Society of Nephrology : CJASN 2012. PMID: 22442183

Kangelaris KN, Sapru A, Calfee CS, Liu KD, Pawlikowska L, Witte JS, Vittinghoff E, Zhuo H, Auerbach AD, Ziv E, Matthay MA. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury. Volume 141 of Issue 5. Chest 2011. PMID: 22207676

Liu KD, Thompson BT, Ancukiewicz M, Steingrub JS, Douglas IS, Matthay MA, Wright P, Peterson MW, Rock P, Hyzy RC, Anzueto A, Truwit JD. Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Critical care medicine 2011. PMID: 21785346

Matthay MA, Brower RG, Carson S, Douglas IS, Eisner M, Hite D, Holets S, Kallet RH, Liu KD, MacIntyre N, Moss M, Schoenfeld D, Steingrub J, Thompson BT. Randomized, placebo-controlled clinical trial of an aerosolized ß2-agonist for treatment of acute lung injury. American journal of respiratory and critical care medicine 2011. PMID: 21562125

Britos M, Smoot E, Liu KD, Thompson BT, Checkley W, Brower RG, National Institutes of Health Acute Respiratory Distress Syndrome Network Investigators. The value of positive end-expiratory pressure and Fio₂ criteria in the definition of the acute respiratory distress syndrome. Critical care medicine 2011. PMID: 21532473

Zhang M, Hsu R, Hsu CY, Kordesch K, Nicasio E, Cortez A, McAlpine I, Brady S, Zhuo H, Kangelaris KN, Stein J, Calfee CS, Liu KD. FGF-23 and PTH levels in patients with acute kidney injury: A cross-sectional case series study. Annals of intensive care 2011. PMID: 21906363

Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Matthay MA, Liu KD. Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study. Annals of intensive care 2011. PMID: 21906356

Flori HR, Church G, Liu KD, Gildengorin G, Matthay MA. Positive fluid balance is associated with higher mortality and prolonged mechanical ventilation in pediatric patients with acute lung injury. Critical care research and practice 2011. PMID: 21687578

Matthay MA, Liu KD. Con: corticosteroids are not indicated for treatment of acute lung injury from H1N1 viral pneumonia. American journal of respiratory and critical care medicine 2011. PMID: 21531953

Grams ME, Estrella MM, Coresh J, Brower RG, Liu KD. Fluid balance, diuretic use, and mortality in acute kidney injury. Volume 6 of Issue 5. Clinical journal of the American Society of Nephrology : CJASN 2011. PMID: 21393482

Sapru A, Pawlikowska L, Liu KD, Khush KK, Ann-Baxter-Lowe L, Hayden V, Menza RL, Convery M, Poon A, Landeck M, Zaroff JG, Matthay MA. Single-nucleotide polymorphisms in the ß-adrenergic receptor genes are associated with lung allograft utilization. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2011. PMID: 20869266

Liu KD, Chertow GM. Curbing the use of ultrasonography in the diagnosis of acute kidney injury: Penny wise or pound foolish?: Comment on "Renal ultrasonography in the evaluation of acute kidney injury". Archives of internal medicine 2010. PMID: 21098349

Matthay MA, Thompson BT, Read EJ, McKenna DH, Liu KD, Calfee CS, Lee JW. Therapeutic potential of mesenchymal stem cells for severe acute lung injury. Chest 2010. PMID: 20923800

Ong T, McClintock DE, Kallet RH, Ware LB, Matthay MA, Liu KD. Ratio of angiopoietin-2 to angiopoietin-1 as a predictor of mortality in acute lung injury patients. Critical care medicine 2010. PMID: 20581666

Go AS, Parikh CR, Ikizler TA, Coca S, Siew ED, Chinchilli VM, Hsu CY, Garg AX, Zappitelli M, Liu KD, Reeves WB, Ghahramani N, Devarajan P, Faulkner GB, Tan TC, Kimmel PL, Eggers P, Stokes JB. The assessment, serial evaluation, and subsequent sequelae of acute kidney injury (ASSESS-AKI) study: design and methods. BMC nephrology 2010. PMID: 20799966

Liu KD. Acute kidney injury: is acute kidney injury a risk factor for long-term mortality? Nature reviews. Nephrology 2010. PMID: 20585317

Johnson XD, Liu KD. Acute renal syndrome/renal angina: a new paradigm for studies of acute kidney injury? Clinical journal of the American Society of Nephrology : CJASN 2010. PMID: 20378643

Liu KD, Glidden DV. Clinical trials for acute kidney injury: design challenges and possible solutions. Current drug targets 2009. PMID: 19715539

Brown LM, Liu KD, Matthay MA. Measurement of extravascular lung water using the single indicator method in patients: research and potential clinical value. American journal of physiology. Lung cellular and molecular physiology 2009. PMID: 19617309

Liu KD, Altmann C, Smits G, Krawczeski CD, Edelstein CL, Devarajan P, Faubel S. Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Critical care (London, England) 2009. PMID: 19570208

Liu KD, Looney MR, Matthay MA. Inhaled activated protein C: a novel therapy for acute lung injury? Critical care (London, England) 2009. PMID: 19519935

Neyrinck AP, Liu KD, Howard JP, Matthay MA. Protective mechanisms of activated protein C in severe inflammatory disorders. British journal of pharmacology 2009. PMID: 19466992

Church GD, Matthay MA, Liu K, Milet M, Flori HR. Blood product transfusions and clinical outcomes in pediatric patients with acute lung injury. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 2009. PMID: 19307809

Ong T, Stuart-Killion RB, Daniel BM, Presnell LB, Zhuo H, Matthay MA, Liu KD. Higher pulmonary dead space may predict prolonged mechanical ventilation after cardiac surgery. Pediatric pulmonology 2009. PMID: 19382217

Liu KD, Lo L, Hsu CY. Some methodological issues in studying the long-term renal sequelae of acute kidney injury. Current opinion in nephrology and hypertension 2009. PMID: 19318944

Lo L, Liu KD, Hsu CY. Long-term outcomes after acute kidney injury: where we stand and how we can move forward. American journal of kidney diseases : the official journal of the National Kidney Foundation 2009. PMID: 19303684

Liu KD. Critical care nephrology: Core Curriculum 2009. American journal of kidney diseases : the official journal of the National Kidney Foundation 2009. PMID: 19303680

Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE. Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis. American journal of physiology. Renal physiology 2008. PMID: 19116242

Liu KD. Impact of acute kidney injury on lung injury. American journal of physiology. Lung cellular and molecular physiology 2008. PMID: 18996900

Liu KD, Levitt J, Zhuo H, Kallet RH, Brady S, Steingrub J, Tidswell M, Siegel MD, Soto G, Peterson MW, Chesnutt MS, Phillips C, Weinacker A, Thompson BT, Eisner MD, Matthay MA. Randomized clinical trial of activated protein C for the treatment of acute lung injury. American journal of respiratory and critical care medicine 2008. PMID: 18565951

Liu KD, Matthay MA. Protein C as a surrogate end-point for clinical trials of sepsis. Critical care (London, England) 2008. PMID: 18492215

Liu KD, Brakeman PR. Renal repair and recovery. Critical care medicine 2008. PMID: 18382192

Lindemann MJ, Hu Z, Benczik M, Liu KD, Gaffen SL. Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway. The Journal of biological chemistry 2008. PMID: 18348982

Waikar SS, Liu KD, Chertow GM. Diagnosis, epidemiology and outcomes of acute kidney injury. Clinical journal of the American Society of Nephrology : CJASN 2008. PMID: 18337550

Liu KD, Matthay MA. Advances in critical care for the nephrologist: acute lung injury/ARDS. Clinical journal of the American Society of Nephrology : CJASN 2008. PMID: 18199848

Liu KD, Glidden DV, Eisner MD, Parsons PE, Ware LB, Wheeler A, Korpak A, Thompson BT, Chertow GM, Matthay MA. Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury. Critical care medicine 2007. PMID: 18074478

Liu KD, Datta A, Yu W, Brakeman PR, Jou TS, Matthay MA, Mostov KE. Rac1 is required for reorientation of polarity and lumen formation through a PI 3-kinase-dependent pathway. American journal of physiology. Renal physiology 2007. PMID: 17804488

Cepkova M, Kapur V, Ren X, Quinn T, Zhuo H, Foster E, Liu KD, Matthay MA. Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury. Chest 2007. PMID: 17573490

Waikar SS, Liu KD, Chertow GM. The incidence and prognostic significance of acute kidney injury. Current opinion in nephrology and hypertension 2007. PMID: 17420666

Liu KD, Himmelfarb J, Paganini E, Ikizler TA, Soroko SH, Mehta RL, Chertow GM. Timing of initiation of dialysis in critically ill patients with acute kidney injury. Clinical journal of the American Society of Nephrology : CJASN 2006. PMID: 17699307

Liu KD, Matthay MA, Chertow GM. Evolving practices in critical care and potential implications for management of acute kidney injury. Clinical journal of the American Society of Nephrology : CJASN 2006. PMID: 17699299

Mostov K, Brakeman P, Datta A, Gassama A, Katz L, Kim M, Leroy P, Levin M, Liu K, Martin F, O'Brien LE, Verges M, Su T, Tang K, Tanimizu N, Yamaji T, Yu W. Formation of multicellular epithelial structures. Novartis Foundation symposium 2005. PMID: 16355541

Gaffen SL, Liu KD. Overview of interleukin-2 function, production and clinical applications. Cytokine 2004. PMID: 15473953

Kallet RH, Liu K, Tang J. Management of acidosis during lung-protective ventilation in acute respiratory distress syndrome. Respiratory care clinics of North America 2003. PMID: 14984065

Liu KD. Molecular mechanisms of recovery from acute renal failure. Critical care medicine 2003. PMID: 12907887