John Newman, MD, PhD
Dr. Newman is a geriatrician, basic science researcher, and educator at the Buck Institute for Research on Aging and in the Division of Geriatrics at UCSF. As a physician-scientist, Dr. Newman hopes to translate what we are learning of the pathways that control fundamental mechanisms of aging into therapies that will improve the health and preserve the independence of older adults.
His research work as an Assistant Professor at the Buck Institute, in sunny Novato, focuses on how ketone bodies, small molecules that our bodies make for energy when we fast or exercise, also act as molecular signals to control inflammation and gene expression. The signaling functions of ketone bodies may be translational targets for protecting cognition and improving resilience in older adults. This is one example how environmental cues like diet and fasting signal through small metabolites in our cells to regulate the genes and pathways that in turn control aging. Dr. Newman is particularly interested in testing if harnessing these signals can protect older adults from the risks of hospitalization like delirium and functional decline.
Dr. Newman attends on the inpatient medicine service and the acute care of elders unit at the San Francisco VA Medical Center, with a clinical focus on delirium and functional decline. He teaches students, residents, and fellows about geriatric clinical problems, as well as about the biology of aging and emerging translational science in geriatrics. He works as a part of the national Geroscience Network to develop frameworks and resources for testing interventions that target fundamental mechanisms of aging in clinical trials. He seeks to bridge the community of basic scientists that study aging to geriatricians and other clinicians who study the clinical problems of aging in order to develop innovative translational therapies.
Dr. Newman completed an MD/PhD at the University of Washington in Seattle, then residency training in Internal Medicine and a fellowship in Geriatrics at UCSF before joining the faculty in 2014. He joined the faculty of the Buck Institute in 2018. Dr. Newman is a 2014 Beeson Scholar from the National Institute on Aging and the American Federation of Aging Research. His work has also been supported by generous funding from the Larry L. Hillblom Foundation and the Glenn Foundation for Medical Research.
Assistant Professor, Buck Institute for Research on Aging
Assistant Professor, Division of Geriatrics at UCSF
Geriatrician, San Francisco VA Medical Center
Honors and Awards
- Outstanding Junior Investigator of the Year, American Geriatrics Society, 2018
- New Investigator Award, American Geriatrics Society, 2015
- Beeson Scholar, National Institute on Aging and American Federation for Aging Research, 2014-2019
- John S. Spice Award in Aging, Larry L. Hillblom Foundation, 2014
- Award of Excellence in Scientific Leadership, Gladstone Institute of Virology and Immunology, 2013
- Glenn Award for Research in Biological Mechanisms of Aging, Paul F. Glenn Foundation, 2013
- Postdoctoral Fellowship, Larry L. Hillblom Foundation, 2012-2015
- Hartford Scholar, John A. Hartford Foundation, 2011-2013
- From discoveries in ageing research to therapeutics for healthy ageing.
- Creating the Next Generation of Translational Geroscientists.
- Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series.
- Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet.
- Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice.
- ß-Hydroxybutyrate: A Signaling Metabolite.
- Frameworks for Proof-of-Concept Clinical Trials of Interventions That Target Fundamental Aging Processes.
- Strategies and Challenges in Clinical Trials Targeting Human Aging.
- Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity.
- Dextromethorphan-Quinidine for Agitation in Alzheimer Disease.
- Copyright and Bedside Cognitive Testing: Why We Need Alternatives to the Mini-Mental State Examination.
- ß-hydroxybutyrate: much more than a metabolite.
- SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.
- Ketone bodies as signaling metabolites.
- Long-term outcomes in elderly survivors of cardiac arrest.
- Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
- Copyright at the Bedside: Should We Stop the Spread?
- Suppression of oxidative stress by ß-hydroxybutyrate, an endogenous histone deacetylase inhibitor.
- Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease.
- Mitochondrial sirtuins: regulators of protein acylation and metabolism.
- The conserved Cockayne syndrome B-piggyBac fusion protein (CSB-PGBD3) affects DNA repair and induces both interferon-like and innate antiviral responses in CSB-null cells.
- Copyright and open access at the bedside.
- Leriche syndrome.
- An abundant evolutionarily conserved CSB-PiggyBac fusion protein expressed in Cockayne syndrome.
- Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardization.
- Cockayne syndrome group B protein (CSB) plays a general role in chromatin maintenance and remodeling.
- L2L: a simple tool for discovering the hidden significance in microarray expression data.
- Measuring the immeasurable.
- The Caenorhabditis elegans EGL-15 signaling pathway implicates a DOS-like multisubstrate adaptor protein in fibroblast growth factor signal transduction.