Janice Schwartz, MD

Professor of Medicine

Geriatrics

I graduated from Tulane Medical School, am a board-certified internist and cardiologist with significant experience in clinical pharmacology and geriatric medicine. My research goal has been to elucidate age-related and sex-related differences in pharmacokinetics and pharmacodynamics in order to improve medication therapy for older adults. I have studied models of aging from in vitro models of cardiac changes with aging to physiologic and pharmacokinetic investigations of healthy humans to population studies of community dwelling elderly, and frail elderly adults.

My current work focuses on improving medication use in the very oldest people, in optimizing outcomes in older people receiving polypharmacy, and the translation and optimization of new therapeutic agents such as anticoagulants during clinical use to benefit the very oldest and frailest patients. I recently completed a ORISE visiting Professorship in the Office of Clinical Pharmacology at the FDA stimulate initiatives to improve the drug evaluation and monitoring process for older adults and incorporate patient-centered outcomes into the drug evaluation process.

Education
1990 - Geriatrics, UCLA
1981 - Cardiology, Stanford University
1978 - Cardiology, Cedar Sinai Medical Center
1977 - Internal Medicine, Cedar-Sinai Medical Center
1975 - Internal Medicine, LACounty/USC
MD, 1974 - Medicine, Tulane University, School of Medicine
1970 - Biology, Newcomb College
Honors and Awards
  • Award of Excellence in Clinical Pharmacology, PhRMA, 2019
  • William Abrams Award in Geriatric Clinical Pharmacology, American Society of Clinical Pharmacology and Therapeutics, 2012
Websites
Publications
  1. Schwartz JB, Kogan SC, Fang MC. Preventing Bleeding With Direct-Acting Oral Anticoagulants. 2021. PMID: 34649705


  2. Liu Q, Schwartz JB, Slattum PW, Lau SWJ, Guinn D, Madabushi R, Burckart G, Califf R, Cerreta F, Cho C, Cook J, Gamerman J, Goldsmith P, van der Graaf PH, Gurwitz JH, Haertter S, Hilmer S, Huang SM, Inouye SK, Kanapuru B, Pirmohamed M, Posner P, Radziszewska B, Talbot HK, Temple R. Roadmap To 2030 For Drug Evaluation In Older Adults. 2021. PMID: 34656074


  3. Tarn DM, Shih KJ, Schwartz JB. Reasons for nonadherence to the direct oral anticoagulant apixaban for atrial fibrillation. Journal of the American Geriatrics Society 2021. PMID: 34453325


  4. Hilmer SN, Petrovic M, Le Couteur DG, Schwartz JB, Thuermann P. Development, evaluation and use of COVID-19 vaccines in older adults: Preliminary principles for the pandemic and beyond. British journal of clinical pharmacology 2021. PMID: 34342013


  5. Slattum PW, Schwartz JB. A challenge: The American Geriatric Society needs to address the lack of inclusion of older adults in new drug evaluation. Journal of the American Geriatrics Society 2021. PMID: 34062612


  6. Sukumar S, Cabero M, Tiu S, Fang MC, Kogan SC, Schwartz JB. Anti-factor Xa activity assays of direct-acting oral anticoagulants during clinical care: An observational study. Research and practice in thrombosis and haemostasis 2021. PMID: 34013157


  7. Tarn DM, Pletcher MJ, Tosqui R, Fernandez A, Tseng CH, Moriconi R, Bell DS, Barrientos M, Turner JA, Schwartz JB. Primary nonadherence to statin medications: Survey of patient perspectives. Preventive medicine reports 2021. PMID: 33842201


  8. Herr AE, Schwartz JB. Something Old and Something New: The Time Is Right for Geriatric Engineering Programs. Journal of the American Geriatrics Society 2021. PMID: 33421099


  9. Tarn DM, Barrientos M, Pletcher MJ, Cox K, Turner J, Fernandez A, Schwartz JB. Perceptions of Patients with Primary Nonadherence to Statin Medications. Journal of the American Board of Family Medicine : JABFM 2021. PMID: 33452090


  10. Tarn DM, Schwartz JB. Polypharmacy: A Five-Step Call to Action for Family Physicians. Family medicine 2020. PMID: 33151528


  11. Tarn DM, Barrientos M, Wang AY, Ramaprasad A, Fang MC, Schwartz JB. Prevalence and Knowledge of Potential Interactions Between Over-the-Counter Products and Apixaban. Journal of the American Geriatrics Society 2019. PMID: 31658372


  12. Sukumar S, Gulilat M, Linton B, Gryn SE, Dresser GK, Alfonsi JE, Schwarz UI, Kim RB, Schwartz JB. Apixaban Concentrations with Lower than Recommended Dosing in Older Adults with Atrial Fibrillation. Journal of the American Geriatrics Society 2019. PMID: 31112620


  13. Winston CN, Goetzl EJ, Schwartz JB, Elahi FM, Rissman RA. Complement protein levels in plasma astrocyte-derived exosomes are abnormal in conversion from mild cognitive impairment to Alzheimer's disease dementia. Alzheimer's & dementia (Amsterdam, Netherlands) 2019. PMID: 31032394


  14. Schwartz JB, Schmader KE, Hanlon JT, Abernethy DR, Gray S, Dunbar-Jacob J, Holmes HM, Murray MD, Roberts R, Joyner M, Peterson J, Lindeman D, Tai-Seale M, Downey L, Rich MW. Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop. Journal of the American Geriatrics Society 2018. PMID: 30536694


  15. Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D. Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. The Journal of clinical endocrinology and metabolism 2018. PMID: 29955795


  16. Schwartz JB. Editorial Commentary: Blood pressure and cognition in the elderly. Trends in cardiovascular medicine 2018. PMID: 30072095


  17. Goetzl EJ, Nogueras-Ortiz C, Mustapic M, Mullins RJ, Abner EL, Schwartz JB, Kapogiannis D. Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018. PMID: 29924942


  18. Moore KL, Patel K, Boscardin WJ, Steinman MA, Ritchie C, Schwartz JB. Medication burden attributable to chronic co-morbid conditions in the very old and vulnerable. PloS one 2018. PMID: 29684077


  19. Goetzl EJ, Schwartz JB, Abner EL, Jicha GA, Kapogiannis D. High complement levels in astrocyte-derived exosomes of Alzheimer disease. Annals of neurology 2018. PMID: 29406582


  20. Schwartz JB, Woosley RL, Peck CC. Farewell to Our Good Friend, Outstanding Mentor, and Colleague Darrell R. Abernethy (1949-2017). Clinical pharmacology and therapeutics 2018. PMID: 29435985


  21. Goetzl EJ, Abner EL, Jicha GA, Kapogiannis D, Schwartz JB. Declining levels of functionally specialized synaptic proteins in plasma neuronal exosomes with progression of Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018. PMID: 29025866


  22. Schwartz JB. Authors Have Incorrectly Calculated Need for Renal Dose Adjustments for NOACs. Journal of the American College of Cardiology 2017. PMID: 29169485


  23. Schwartz J, Merrill S, de Leon N, Thompson A, Fang M. Dosing Accuracy of Direct Oral Anticoagulants in an Academic Medical Center. Journal of hospital medicine 2017. PMID: 28699943


  24. Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2017. PMID: 28476896


  25. Schwartz JB. Dabigatran Compared With Rivaroxaban vs Warfarin. JAMA internal medicine 2017. PMID: 28460097


  26. Schwartz JB, Rosano G, Channer KS. Letter to the Editor: "Effects of Testosterone Replacement on Electrocardiographic Parameters in Men: Findings From Two Randomized Trials". The Journal of clinical endocrinology and metabolism 2017. PMID: 28482077


  27. Ahmed GF, Bathena SP, Brundage RC, Leppik IE, Conway JM, Schwartz JB, Birnbaum AK. Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients. The AAPS journal 2017. PMID: 28070716


  28. Goetzl EJ, Kapogiannis D, Schwartz JB, Lobach IV, Goetzl L, Abner EL, Jicha GA, Karydas AM, Boxer A, Miller BL. Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016. PMID: 27601437


  29. Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach IV, Goetzl L, Schwartz JB, Miller BL. Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016. PMID: 27511944


  30. Schwartz JB, Kane L, Bikle D. Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial. Journal of the American Geriatrics Society 2016. PMID: 26782853


  31. Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Kapogiannis D. Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease. Neurology 2015. PMID: 26062630


  32. Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Carlson OD, Mustapic M, Kapogiannis D. Low neural exosomal levels of cellular survival factors in Alzheimer's disease. Annals of clinical and translational neurology 2015. PMID: 26273689


  33. Dai X, Hummel SL, Salazar JB, Taffet GE, Zieman S, Schwartz JB. Cardiovascular physiology in the older adults. Journal of geriatric cardiology : JGC 2015. PMID: 26089840


  34. Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. Liver international : official journal of the International Association for the Study of the Liver 2015. PMID: 25757956


  35. Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2014. PMID: 25342129


  36. Schwartz JB. Primary prevention: do the very elderly require a different approach? Trends in cardiovascular medicine 2014. PMID: 25560975


  37. Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. Alzheimer's & dementia : the journal of the Alzheimer's Association 2014. PMID: 25130657


  38. Steinman MA, Miao Y, Boscardin WJ, Komaiko KD, Schwartz JB. Prescribing quality in older veterans: a multifocal approach. Journal of general internal medicine 2014. PMID: 25002159


  39. Moore KL, Boscardin WJ, Steinman MA, Schwartz JB. Patterns of chronic co-morbid medical conditions in older residents of U.S. nursing homes: differences between the sexes and across the agespan. The journal of nutrition, health & aging 2014. PMID: 24676326


  40. Schwartz JB, Moore KL, Yin M, Sharma A, Merenstein D, Islam T, Golub ET, Tien PC, Adeyemi OM. Relationship of vitamin D, HIV, HIV treatment, and lipid levels in the Women's Interagency HIV Study of HIV-infected and uninfected women in the United States. Journal of the International Association of Providers of AIDS Care 2014. PMID: 24668135


  41. Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D. Variability in free 25(OH) vitamin D levels in clinical populations. The Journal of steroid biochemistry and molecular biology 2013. PMID: 24240067


  42. Kane L, Moore K, Lütjohann D, Bikle D, Schwartz JB. Vitamin D3 effects on lipids differ in statin and non-statin-treated humans: superiority of free 25-OH D levels in detecting relationships. The Journal of clinical endocrinology and metabolism 2013. PMID: 24030939


  43. Mitsuhashi M, Taub DD, Kapogiannis D, Eitan E, Zukley L, Mattson MP, Ferrucci L, Schwartz JB, Goetzl EJ. Aging enhances release of exosomal cytokine mRNAs by Aß1-42-stimulated macrophages. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2013. PMID: 24014820


  44. Steinman MA, Lee SJ, John Boscardin W, Miao Y, Fung KZ, Moore KL, Schwartz JB. Patterns of multimorbidity in elderly veterans. Volume 60 of Issue 10. Journal of the American Geriatrics Society 2012. PMID: 23035702


  45. Taub DD, Hesdorffer CS, Ferrucci L, Madara K, Schwartz JB, Goetzl EJ. Distinct energy requirements for human memory CD4 T-cell homeostatic functions. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012. PMID: 22972918


  46. Moore KL, Boscardin WJ, Steinman MA, Schwartz JB. Age and sex variation in prevalence of chronic medical conditions in older residents of U.S. nursing homes. Journal of the American Geriatrics Society 2012. PMID: 22463062


  47. Hesdorffer CS, Malchinkhuu E, Biragyn A, Mabrouk OS, Kennedy RT, Madara K, Taub DD, Longo DL, Schwartz JB, Ferrucci L, Goetzl EJ. Distinctive immunoregulatory effects of adenosine on T cells of older humans. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011. PMID: 22121051


  48. Goetzl EJ, Schwartz JB, Huang MC. Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia. Journal of clinical immunology 2011. PMID: 21671128


  49. Schwartz JB, Volterrani M, Caminiti G, Marazzi G, Fini M, Rosano GM, Iellamo F. Effects of testosterone on the Q-T interval in older men and older women with chronic heart failure. International journal of andrology 2011. PMID: 21615419


  50. Schwartz JB, Kane L, Moore K, Wu AH. Failure of pharmacogenetic-based dosing algorithms to identify older patients requiring low daily doses of warfarin. Journal of the American Medical Directors Association 2011. PMID: 21450231


  51. Huang MC, Greig NH, Luo W, Tweedie D, Schwartz JB, Longo DL, Ferrucci L, Ershler WB, Goetzl EJ. Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide. Clinical immunology (Orlando, Fla.) 2010. PMID: 21130040


  52. Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL. Gender specificity of altered human immune cytokine profiles in aging. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010. PMID: 20453111


  53. Schwartz JB, Verotta D. Population analyses of atorvastatin clearance in patients living in the community and in nursing homes. Clinical pharmacology and therapeutics 2009. PMID: 19571802


  54. Schwartz JB and Abernethy, DR. 2009; 85 (1): 3-10.. Clin Pharmacol Ther Aging and medications: Past, Present, Future. 2009. PMID:


  55. Verotta D, Schwartz JB.. Clin Pharmacol Ther Population analyses of atorvastatin in patients living in the community and nursing homes. 2009. PMID:


  56. Schwartz JB. The current state of knowledge on age, sex, and their interactions on clinical pharmacology. Clinical pharmacology and therapeutics 2007. PMID: 17495875


  57. Alexander KP, Chen AY, Newby LK, Schwartz JB, Redberg RF, Hochman JS, Roe MT, Gibler WB, Ohman EM, Peterson ED. Sex differences in major bleeding with glycoprotein IIb/IIIa inhibitors: results from the CRUSADE (Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines) initiative. Volume 114 of Issue 13. Circulation 2006. PMID: 16982940


  58. Schwartz JB. Erythromycin breath test results in elderly, very elderly, and frail elderly persons. Clinical pharmacology and therapeutics 2006. PMID: 16678546


  59. Kang D, Verotta D, Schwartz JB. Population analyses of amlodipine in patients living in the community and patients living in nursing homes. Clinical pharmacology and therapeutics 2006. PMID: 16413246


  60. Kang D, Schwartz JB, Verotta D. Sample size computations for PK/PD population models. Journal of pharmacokinetics and pharmacodynamics 2005. PMID: 16284914


  61. Schwartz JB, Redberg RF. What does the Medicare prescription drug legislation mean for the American cardiologist? Volume 14 of Issue 6. The American journal of geriatric cardiology 2005. PMID: 16276130


  62. Kadish AH, Greenland P, Limacher MC, Frishman WH, Daugherty SA, Schwartz JB. Estrogen and progestin use and the QT interval in postmenopausal women. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 2004. PMID: 15485516


  63. Kang D, Schwartz JB, Verotta D. A sample size computation method for non-linear mixed effects models with applications to pharmacokinetics models. Statistics in medicine 2004. PMID: 15287084


  64. Schwartz JB. Sudden cardiac death among women in the United States. Circulation 2003. PMID: 14638535


  65. Kang D, Verotta D, Krecic-Shepard ME, Modi NB, Gupta SK, Schwartz JB. Population analyses of sustained-release verapamil in patients: effects of sex, race, and smoking. Clinical pharmacology and therapeutics 2003. PMID: 12545141


  66. Schwartz JB. The influence of sex on pharmacokinetics. Clinical pharmacokinetics 2003. PMID: 12537512


  67. Haller C, Schwartz JB. Pharmacologic agents for weight reduction. The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 2002. PMID: 12380196


  68. Schwartz JB. Peripheral arterial disease: drug therapy. The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 2002. PMID: 12192882


  69. Schwartz JB. Pharmacogenetics: has it reached the clinic? The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 2002. PMID: 11974670


  70. Schwartz JB. Anticoagulant and thrombolytic therapies in women. The journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia 2002. PMID: 11859682


  71. Schwartz JB. Drug Interactions in the Elderly With Coronary Artery Disease - Do These Interfere With Effective Therapy? The American journal of geriatric cardiology 1998. PMID: 11416440


  72. Schwartz JB. Age-Related Pharmacodynamic Changes in the Elderly: Treatment Considerations in Heart Failure. The American journal of geriatric cardiology 1996. PMID: 11416366