Janice Schwartz, MD

Professor of Medicine

Geriatrics

I graduated from Tulane Medical School, am a board-certified internist and cardiologist with significant experience in clinical pharmacology and geriatric medicine. My research goal has been to elucidate age-related and sex-related differences in pharmacokinetics and pharmacodynamics in order to improve medication therapy for older people. I have studied models of aging from in vitro models of cardiac changes with aging to physiologic and pharmacokinetic investigations of healthy humans to population studies of community dwelling elderly, and most recently, frail elderly people.

My current work focuses on improving medication and vitamin use in the very oldest people, in optimizing outcomes in older people receiving polypharmacy, and the translation of new therapies and devices into clinical use to benefit the very oldest and frailest patients. to this end, I am working with the Office of Clinical Pharmacology at the FDA through an ORISE visiting Professorship. My efforts include trying to improve the drug evaluation and monitoring process for older adults, and translating medical knowledge related to aging and cardiovascular health for the public.

Education
1990 - Geriatrics, UCLA
1981 - Cardiology, Stanford University
1978 - Cardiology, Cedar Sinai Medical Center
1977 - Internal Medicine, Cedar-Sinai Medical Center
1975 - Internal Medicine, LACounty/USC
MD, 1974 - Medicine, Tulane University, School of Medicine
1970 - Biology, Newcomb College
Honors and Awards
  • Award of Excellence in Clinical Pharmacology, PhRMA, 2019
  • William Abrams Award in Geriatric Clinical Pharmacology, American Society of Clinical Pharmacology and Therapeutics, 2012
Publications
  1. Tarn DM, Barrientos M, Wang AY, Ramaprasad A, Fang MC, Schwartz JB. Prevalence and Knowledge of Potential Interactions Between Over-the-Counter Products and Apixaban. 2019. PMID: 31658372


  2. Sukumar S, Gulilat M, Linton B, Gryn SE, Dresser GK, Alfonsi JE, Schwarz UI, Kim RB, Schwartz JB. Apixaban Concentrations with Lower than Recommended Dosing in Older Adults with Atrial Fibrillation. 2019. PMID: 31112620


  3. Schwartz JB, Schmader KE, Hanlon JT, Abernethy DR, Gray S, Dunbar-Jacob J, Holmes HM, Murray MD, Roberts R, Joyner M, Peterson J, Lindeman D, Tai-Seale M, Downey L, Rich MW. Pharmacotherapy in Older Adults with Cardiovascular Disease: Report from an American College of Cardiology, American Geriatrics Society, and National Institute on Aging Workshop. 2018. PMID: 30536694


  4. Schwartz JB, Gallagher JC, Jorde R, Berg V, Walsh J, Eastell R, Evans AL, Bowles S, Naylor KE, Jones KS, Schoenmakers I, Holick M, Orwoll E, Nielson C, Kaufmann M, Jones G, Bouillon R, Lai J, Verotta D, Bikle D. Determination of Free 25(OH)D Concentrations and Their Relationships to Total 25(OH)D in Multiple Clinical Populations. 2018. PMID: 29955795


  5. Goetzl EJ, Nogueras-Ortiz C, Mustapic M, Mullins RJ, Abner EL, Schwartz JB, Kapogiannis D. Deficient neurotrophic factors of CSPG4-type neural cell exosomes in Alzheimer disease. 2018. PMID: 29924942


  6. Moore KL, Patel K, Boscardin WJ, Steinman MA, Ritchie C, Schwartz JB. Medication burden attributable to chronic co-morbid conditions in the very old and vulnerable. 2018. PMID: 29684077


  7. Goetzl EJ, Schwartz JB, Abner EL, Jicha GA, Kapogiannis D. High complement levels in astrocyte-derived exosomes of Alzheimer disease. 2018. PMID: 29406582


  8. Schwartz J, Merrill S, de Leon N, Thompson A, Fang M. Dosing Accuracy of Direct Oral Anticoagulants in an Academic Medical Center. 2017. PMID: 28699943


  9. Goetzl EJ, Schwartz JB, Mustapic M, Lobach IV, Daneman R, Abner EL, Jicha GA. Altered cargo proteins of human plasma endothelial cell-derived exosomes in atherosclerotic cerebrovascular disease. 2017. PMID: 28476896


  10. Schwartz JB. Dabigatran Compared With Rivaroxaban vs Warfarin. 2017. PMID: 28460097


  11. Ahmed GF, Bathena SP, Brundage RC, Leppik IE, Conway JM, Schwartz JB, Birnbaum AK. Pharmacokinetics and Saturable Absorption of Gabapentin in Nursing Home Elderly Patients. 2017. PMID: 28070716


  12. Goetzl EJ, Kapogiannis D, Schwartz JB, Lobach IV, Goetzl L, Abner EL, Jicha GA, Karydas AM, Boxer A, Miller BL. Decreased synaptic proteins in neuronal exosomes of frontotemporal dementia and Alzheimer's disease. 2016. PMID: 27601437


  13. Goetzl EJ, Mustapic M, Kapogiannis D, Eitan E, Lobach IV, Goetzl L, Schwartz JB, Miller BL. Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer's disease. 2016. PMID: 27511944


  14. Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Kapogiannis D. Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease. 2015. PMID: 26062630


  15. Goetzl EJ, Boxer A, Schwartz JB, Abner EL, Petersen RC, Miller BL, Carlson OD, Mustapic M, Kapogiannis D. Low neural exosomal levels of cellular survival factors in Alzheimer's disease. 2015. PMID: 26273689


  16. Dai X, Hummel SL, Salazar JB, Taffet GE, Zieman S, Schwartz JB. Cardiovascular physiology in the older adults. 2015. PMID: 26089840


  17. Lai JC, Bikle DD, Lizaola B, Hayssen H, Terrault NA, Schwartz JB. Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction. 2015. PMID: 25757956


  18. Kapogiannis D, Boxer A, Schwartz JB, Abner EL, Biragyn A, Masharani U, Frassetto L, Petersen RC, Miller BL, Goetzl EJ. Dysfunctionally phosphorylated type 1 insulin receptor substrate in neural-derived blood exosomes of preclinical Alzheimer's disease. 2014. PMID: 25342129


  19. Fiandaca MS, Kapogiannis D, Mapstone M, Boxer A, Eitan E, Schwartz JB, Abner EL, Petersen RC, Federoff HJ, Miller BL, Goetzl EJ. Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study. 2014. PMID: 25130657


  20. Steinman MA, Miao Y, Boscardin WJ, Komaiko KD, Schwartz JB. Prescribing quality in older veterans: a multifocal approach. 2014. PMID: 25002159


  21. Schwartz JB, Moore KL, Yin M, Sharma A, Merenstein D, Islam T, Golub ET, Tien PC, Adeyemi OM. Relationship of vitamin D, HIV, HIV treatment, and lipid levels in the Women's Interagency HIV Study of HIV-infected and uninfected women in the United States. 2014. PMID: 24668135


  22. Schwartz JB, Lai J, Lizaola B, Kane L, Weyland P, Terrault NA, Stotland N, Bikle D. Variability in free 25(OH) vitamin D levels in clinical populations. 2013. PMID: 24240067


  23. Mitsuhashi M, Taub DD, Kapogiannis D, Eitan E, Zukley L, Mattson MP, Ferrucci L, Schwartz JB, Goetzl EJ. Aging enhances release of exosomal cytokine mRNAs by Aß1-42-stimulated macrophages. 2013. PMID: 24014820


  24. Steinman MA, Lee SJ, John Boscardin W, Miao Y, Fung KZ, Moore KL, Schwartz JB. Patterns of multimorbidity in elderly veterans. Volume 60 of Issue 10. 2012. PMID: 23035702


  25. Taub DD, Hesdorffer CS, Ferrucci L, Madara K, Schwartz JB, Goetzl EJ. Distinct energy requirements for human memory CD4 T-cell homeostatic functions. 2012. PMID: 22972918


  26. Moore KL, Boscardin WJ, Steinman MA, Schwartz JB. Age and sex variation in prevalence of chronic medical conditions in older residents of U.S. nursing homes. 2012. PMID: 22463062


  27. Hesdorffer CS, Malchinkhuu E, Biragyn A, Mabrouk OS, Kennedy RT, Madara K, Taub DD, Longo DL, Schwartz JB, Ferrucci L, Goetzl EJ. Distinctive immunoregulatory effects of adenosine on T cells of older humans. 2011. PMID: 22121051


  28. Schwartz JB, Volterrani M, Caminiti G, Marazzi G, Fini M, Rosano GM, Iellamo F. Effects of testosterone on the Q-T interval in older men and older women with chronic heart failure. 2011. PMID: 21615419


  29. Huang MC, Greig NH, Luo W, Tweedie D, Schwartz JB, Longo DL, Ferrucci L, Ershler WB, Goetzl EJ. Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide. 2010. PMID: 21130040


  30. Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL. Gender specificity of altered human immune cytokine profiles in aging. 2010. PMID: 20453111


  31. Schwartz JB and Abernethy, DR. 2009; 85 (1): 3-10.. Clin Pharmacol Ther 2009. PMID:


  32. Verotta D, Schwartz JB.. Clin Pharmacol Ther 2009. PMID:


  33. Kang D, Schwartz JB, Verotta D. Sample size computations for PK/PD population models. 2005. PMID: 16284914


  34. Schwartz JB, Redberg RF. What does the Medicare prescription drug legislation mean for the American cardiologist? Volume 14 of Issue 6. 2005. PMID: 16276130


  35. Kadish AH, Greenland P, Limacher MC, Frishman WH, Daugherty SA, Schwartz JB. Estrogen and progestin use and the QT interval in postmenopausal women. 2004. PMID: 15485516


  36. Schwartz JB. Sudden cardiac death among women in the United States. 2003. PMID: 14638535


  37. Kang D, Verotta D, Krecic-Shepard ME, Modi NB, Gupta SK, Schwartz JB. Population analyses of sustained-release verapamil in patients: effects of sex, race, and smoking. 2003. PMID: 12545141


  38. Schwartz JB. The influence of sex on pharmacokinetics. 2003. PMID: 12537512


  39. Haller C, Schwartz JB. Pharmacologic agents for weight reduction. 2002. PMID: 12380196


  40. Schwartz JB. Peripheral arterial disease: drug therapy. 2002. PMID: 12192882


  41. Schwartz JB. Pharmacogenetics: has it reached the clinic? 2002. PMID: 11974670


  42. Schwartz JB. Anticoagulant and thrombolytic therapies in women. 2002. PMID: 11859682