Isabel Rodriguez-Barraquer, MD, PhD

Assistant Professor In Res

HIV, Infectious Disease, and Global Medicine, Infectious Diseases

My research focuses in applying novel epidemiological and statistical methods to understand the dynamics of infectious diseases and inform control interventions. While I am interested in infectious diseases generally, most of my work has focused on understanding shifts in the epidemiology of vector borne diseases including dengue, leishmaniasis, chikungunya, malaria and Zika.

Education
2019 - Diversity, Equity, and Inclusion Champion Training, University of California
MHS, 08/2012 - Biostatistics, Johns Hopkins University
PhD, 08/2012 - Epidemiology, Johns Hopkins University
MD, 06/2005 - Medicine, Pontificia Universidad Javeriana
Websites
Publications
  1. Lo NC, Nyathi S, Chapman LAC, Rodriguez-Barraquer I, Kushel M, Bibbins-Domingo K, Lewnard JA. Influenza, Varicella, and Mumps Outbreaks in US Migrant Detention Centers. 2020. PMID: 33119037


  2. Briggs J, Teyssier N, Nankabirwa JI, Rek J, Jagannathan P, Arinaitwe E, Bousema T, Drakeley C, Murray M, Crawford E, Hathaway N, Staedke SG, Smith D, Rosenthal PJ, Kamya M, Dorsey G, Rodriguez-Barraquer I, Greenhouse B. Sex-based differences in clearance of chronic Plasmodium falciparum infection. 2020. PMID: 33107430


  3. Huang AT, Garcia-Carreras B, Hitchings MDT, Yang B, Katzelnick LC, Rattigan SM, Borgert BA, Moreno CA, Solomon BD, Trimmer-Smith L, Etienne V, Rodriguez-Barraquer I, Lessler J, Salje H, Burke DS, Wesolowski A, Cummings DAT. A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity. 2020. PMID: 32943637


  4. Appa A, Takahashi S, Rodriguez-Barraquer I, Chamie G, Sawyer A, Duarte E, Hakim J, Turcios K, Vinden J, Janson O, Manglik A, Peluso MJ, Deeks SG, Henrich TJ, Torres L, Rodgers M, Hackett J, Chiu CY, Havlir D, Greenhouse B. Universal PCR and antibody testing demonstrate little to no transmission of SARS-CoV-2 in a rural community. 2020. PMID: 32839781


  5. Nankabirwa JI, Arinaitwe E, Rek J, Kilama M, Kizza T, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Briggs J, Greenhouse B, Bousema T, Drakeley C, Roos DS, Tomko SS, Smith DL, Kamya MR, Dorsey G. Malaria Transmission, Infection, and Disease following Sustained Indoor Residual Spraying of Insecticide in Tororo, Uganda. 2020. PMID: 32700666


  6. Bryant JE, Azman AS, Ferrari MJ, Arnold BF, Boni MF, Boum Y, Hayford K, Luquero FJ, Mina MJ, Rodriguez-Barraquer I, Wu JT, Wade D, Vernet G, Leung DT. Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward. 2020. PMID: 32430309


  7. Kamya MR, Kakuru A, Muhindo M, Arinaitwe E, Nankabirwa JI, Rek J, Bigira V, Kapisi J, Wanzira H, Achan J, Natureeba P, Gasasira A, Havlir D, Jagannathan P, Rosenthal PJ, Rodriguez-Barraquer I, Dorsey G. The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018. 2020. PMID: 32431280


  8. Huang AT, Garcia-Carreras B, Hitchings MDT, Yang B, Katzelnick LC, Rattigan SM, Borgert BA, Moreno CA, Solomon BD, Rodriguez-Barraquer I, Lessler J, Salje H, Burke D, Wesolowski A, Cummings DAT. A systematic review of antibody mediated immunity to coronaviruses: antibody kinetics, correlates of protection, and association of antibody responses with severity of disease. 2020. PMID: 32511434


  9. Kigozi SP, Kigozi RN, Epstein A, Mpimbaza A, Sserwanga A, Yeka A, Nankabirwa JI, Halliday K, Pullan RL, Rutazaana D, Sebuguzi CM, Opigo J, Kamya MR, Staedke SG, Dorsey G, Greenhouse B, Rodriguez-Barraquer I. Rapid shifts in the age-specific burden of malaria following successful control interventions in four regions of Uganda. 2020. PMID: 32228584


  10. Cattarino L, Rodriguez-Barraquer I, Imai N, Cummings DAT, Ferguson NM. Mapping global variation in dengue transmission intensity. 2020. PMID: 31996463


  11. Kakande E, Greenhouse B, Bajunirwe F, Drakeley C, Nankabirwa JI, Walakira A, Nsobya SL, Katureebe A, Rek J, Arinaitwe E, Rosenthal PJ, Kamya MR, Dorsey G, Rodriguez-Barraquer I. Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study. 2020. PMID: 31941490


  12. Zinszer K, Charland K, Vahey S, Jahagirdar D, Rek JC, Arinaitwe E, Nankabirwa J, Morrison K, Sadoine ML, Tutt-Guérette MA, Staedke SG, Kamya MR, Greenhouse B, Rodriguez-Barraquer I, Dorsey G. The impact of multiple rounds of indoor residual spraying on malaria incidence and haemoglobin levels in a high transmission setting. 2019. PMID: 31599325


  13. Borchering RK, Huang AT, Mier-Y-Teran-Romero L, Rojas DP, Rodriguez-Barraquer I, Katzelnick LC, Martinez SD, King GD, Cinkovich SC, Lessler J, Cummings DAT. Impacts of Zika emergence in Latin America on endemic dengue transmission. 2019. PMID: 31844054


  14. Cooper L, Kang SY, Bisanzio D, Maxwell K, Rodriguez-Barraquer I, Greenhouse B, Drakeley C, Arinaitwe E, G Staedke S, Gething PW, Eckhoff P, Reiner RC, Hay SI, Dorsey G, Kamya MR, Lindsay SW, Grenfell BT, Smith DL. Pareto rules for malaria super-spreaders and super-spreading. 2019. PMID: 31477710


  15. Perkins TA, Rodriguez-Barraquer I, Manore C, Siraj AS, España G, Barker CM, Johansson MA, Reiner RC. Heterogeneous local dynamics revealed by classification analysis of spatially disaggregated time series data. 2019. PMID: 31607654


  16. Briggs J, Ategeka J, Kajubi R, Ochieng T, Kakuru A, Ssemanda C, Wasswa R, Jagannathan P, Greenhouse B, Rodriguez-Barraquer I, Kamya M, Dorsey G. Impact of microscopic and submicroscopic parasitemia during pregnancy on placental malaria in a high-transmission setting in Uganda. 2019. PMID: 30891605


  17. Rodriguez-Barraquer I, Salje H, Cummings DA. Opportunities for improved surveillance and control of dengue from age-specific case data. 2019. PMID: 31120419


  18. Salje H, Paul KK, Paul R, Rodriguez-Barraquer I, Rahman Z, Alam MS, Rahman M, Al-Amin HM, Heffelfinger J, Gurley E. Nationally-representative serostudy of dengue in Bangladesh allows generalizable disease burden estimates. 2019. PMID: 30958263


  19. Nankabirwa JI, Briggs J, Rek J, Arinaitwe E, Nayebare P, Katrak S, Staedke SG, Rosenthal PJ, Rodriguez-Barraquer I, Kamya MR, Dorsey G, Greenhouse B. Persistent parasitemia despite dramatic reduction in malaria incidence after 3 rounds of indoor residual spraying in Tororo, Uganda. 2018. PMID: 30383230


  20. Ruchusatsawat K, Wongjaroen P, Posanacharoen A, Rodriguez-Barraquer I, Sangkitporn S, Cummings DAT, Salje H. Long-term circulation of Zika virus in Thailand: an observational study. 2019. PMID: 30826189


  21. Rodriguez-Barraquer I, Costa F, Nascimento EJM, Nery N, Castanha PMS, Sacramento GA, Cruz J, Carvalho M, De Olivera D, Hagan JE, Adhikarla H, Wunder EA, Coêlho DF, Azar SR, Rossi SL, Vasilakis N, Weaver SC, Ribeiro GS, Balmaseda A, Harris E, Nogueira ML, Reis MG, Marques ETA, Cummings DAT, Ko AI. Impact of preexisting dengue immunity on Zika virus emergence in a dengue endemic region. 2019. PMID: 30733412


  22. Rodríguez-Barraquer I, Salje H, Cummings DA. Dengue pre-vaccination screening and positive predictive values. 2019. PMID: 30712834


  23. Lauren M. Kucirka, Isabel Rodriguez-Barraquer, Jeanne Sheffield, Justin Lessler. 645: Revisiting the evidence underlying Zika travel restrictions: quantifying risk for pregnant travelers and their partners. 2019. PMID:


  24. Kang SY, Battle KE, Gibson HS, Cooper LV, Maxwell K, Kamya M, Lindsay SW, Dorsey G, Greenhouse B, Rodriguez-Barraquer I, Reiner RCJ, Smith DL, Bisanzio D. Heterogeneous exposure and hotspots for malaria vectors at three study sites in Uganda. 2018. PMID: 30706054


  25. Greenhouse B, Smith DL, Rodríguez-Barraquer I, Mueller I, Drakeley CJ. Taking Sharper Pictures of Malaria with CAMERAs: Combined Antibodies to Measure Exposure Recency Assays. 2018. PMID: 30298804


  26. Katzelnick LC, Coello Escoto A, McElvany BD, Chávez C, Salje H, Luo W, Rodriguez-Barraquer I, Jarman R, Durbin AP, Diehl SA, Smith DJ, Whitehead SS, Cummings DAT. Viridot: An automated virus plaque (immunofocus) counter for the measurement of serological neutralizing responses with application to dengue virus. 2018. PMID: 30356267


  27. Katzelnick LC, Ben-Shachar R, Mercado JC, Rodriguez-Barraquer I, Elizondo D, Arguello S, Nuñez A, Ojeda S, Sanchez N, Lopez Mercado B, Gresh L, Burger-Calderon R, Kuan G, Gordon A, Balmaseda A, Harris E. Dynamics and determinants of the force of infection of dengue virus from 1994 to 2015 in Managua, Nicaragua. 2018. PMID: 30266790


  28. Rodriguez-Barraquer I, Arinaitwe E, Jagannathan P, Kamya MR, Rosenthal PJ, Rek J, Dorsey G, Nankabirwa J, Staedke SG, Kilama M, Drakeley C, Ssewanyana I, Smith DL, Greenhouse B. Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure. 2018. PMID: 30044224


  29. Jagannathan P, Kakuru A, Okiring J, Muhindo MK, Natureeba P, Nakalembe M, Opira B, Olwoch P, Nankya F, Ssewanyana I, Tetteh K, Drakeley C, Beeson J, Reiling L, Clark TD, Rodriguez-Barraquer I, Greenhouse B, Wallender E, Aweeka F, Prahl M, Charlebois ED, Feeney ME, Havlir DV, Kamya MR, Dorsey G. Dihydroartemisinin-piperaquine for intermittent preventive treatment of malaria during pregnancy and risk of malaria in early childhood: A randomized controlled trial. 2018. PMID: 30016328


  30. Salje H, Cummings DAT, Rodriguez-Barraquer I, Katzelnick LC, Lessler J, Klungthong C, Thaisomboonsuk B, Nisalak A, Weg A, Ellison D, Macareo L, Yoon IK, Jarman R, Thomas S, Rothman AL, Endy T, Cauchemez S. Reconstruction of antibody dynamics and infection histories to evaluate dengue risk. 2018. PMID: 29795354


  31. Siraj AS, Rodriguez-Barraquer I, Barker CM, Tejedor-Garavito N, Harding D, Lorton C, Lukacevic D, Oates G, Espana G, Kraemer MUG, Manore C, Johansson MA, Tatem AJ, Reiner RC, Perkins TA. Spatiotemporal incidence of Zika and associated environmental drivers for the 2015-2016 epidemic in Colombia. 2018. PMID: 29688216


  32. Azman AS, Bouhenia M, Iyer AS, Rumunu J, Laku RL, Wamala JF, Rodriguez-Barraquer I, Lessler J, Gignoux E, Luquero FJ, Leung DT, Gurley ES, Ciglenecki I. High Hepatitis E Seroprevalence Among Displaced Persons in South Sudan. 2017. PMID: 28719276


  33. Kirsch TD, Moseson H, Massaquoi M, Nyenswah TG, Goodermote R, Rodriguez-Barraquer I, Lessler J, Cumings DA, Peters DH. Impact of interventions and the incidence of ebola virus disease in Liberia-implications for future epidemics. 2017. PMID: 28207062


  34. Flasche S, Jit M, Rodríguez-Barraquer I, Coudeville L, Recker M, Koelle K, Milne G, Hladish TJ, Perkins TA, Cummings DA, Dorigatti I, Laydon DJ, España G, Kelso J, Longini I, Lourenco J, Pearson CA, Reiner RC, Mier-Y-Terán-Romero L, Vannice K, Ferguson N. The Long-Term Safety, Public Health Impact, and Cost-Effectiveness of Routine Vaccination with a Recombinant, Live-Attenuated Dengue Vaccine (Dengvaxia): A Model Comparison Study. 2016. PMID: 27898668


  35. Kirsch TD, Moseson H, Massaquoi M, Nyenswah TG, Goodermote R, Rodriguez-Barraquer I, Lessler J, Cumings D, Peters DH. Impact of interventions and the incidence of ebola virus disease in Liberia-implications for future epidemics. 2016. PMID: 27794520


  36. Ferguson NM, Rodríguez-Barraquer I, Dorigatti I, Mier-Y-Teran-Romero L, Laydon DJ, Cummings DA. Benefits and risks of the Sanofi-Pasteur dengue vaccine: Modeling optimal deployment. 2016. PMID: 27701113


  37. Justin Lessler, Andrew S. Azman, M. Kate Grabowski, Henrik Salje, Isabel Rodriguez-Barraquer. Erratum to: Trends in the Mechanistic and Dynamic Modeling of Infectious Diseases. 2016. PMID:


  38. Rodriguez-Barraquer I, Arinaitwe E, Jagannathan P, Boyle MJ, Tappero J, Muhindo M, Kamya MR, Dorsey G, Drakeley C, Ssewanyana I, Smith DL, Greenhouse B. Quantifying Heterogeneous Malaria Exposure and Clinical Protection in a Cohort of Ugandan Children. 2016. PMID: 27481862


  39. Lessler J, Chaisson LH, Kucirka LM, Bi Q, Grantz K, Salje H, Carcelen AC, Ott CT, Sheffield JS, Ferguson NM, Cummings DA, Metcalf CJ, Rodriguez-Barraquer I. Assessing the global threat from Zika virus. 2016. PMID: 27417495


  40. Lessler J, Azman AS, Grabowski MK, Salje H, Rodriguez-Barraquer I. Trends in the Mechanistic and Dynamic Modeling of Infectious Diseases. 2016. PMID: 32226711


  41. Isabel Rodríguez-Barraquer, Henrik Salje, Justin Lessler, Derek AT Cummings. Predicting intensities of Zika infection and microcephaly using transmission intensities of other arboviruses. 2016. PMID:


  42. Rodriguez-Barraquer I, Salje H, Cummings DA. Dengue Vaccine in Regions of Endemic Disease. 2016. PMID: 27050220


  43. Kaitlin Rainwater-Lovett, Isabel Rodriguez-Barraquer, William J. Moss. Chapter 18 Viral Epidemiology Tracking Viruses with Smartphones and Social Media. 2016. PMID:


  44. Clapham HE, Rodriguez-Barraquer I, Azman AS, Althouse BM, Salje H, Gibbons RV, Rothman AL, Jarman RG, Nisalak A, Thaisomboonsuk B, Kalayanarooj S, Nimmannitya S, Vaughn DW, Green S, Yoon IK, Cummings DA. Dengue Virus (DENV) Neutralizing Antibody Kinetics in Children After Symptomatic Primary and Postprimary DENV Infection. 2015. PMID: 26704615


  45. Althouse BM, Scarpino SV, Meyers LA, Ayers JW, Bargsten M, Baumbach J, Brownstein JS, Castro L, Clapham H, Cummings DA, Del Valle S, Eubank S, Fairchild G, Finelli L, Generous N, George D, Harper DR, Hébert-Dufresne L, Johansson MA, Konty K, Lipsitch M, Milinovich G, Miller JD, Nsoesie EO, Olson DR, Paul M, Polgreen PM, Priedhorsky R, Read JM, Rodríguez-Barraquer I, Smith DJ, Stefansen C, Swerdlow DL, Thompson D, Vespignani A, Wesolowski A. Enhancing disease surveillance with novel data streams: challenges and opportunities. 2015. PMID: 27990325


  46. Salje H, Cauchemez S, Alera MT, Rodriguez-Barraquer I, Thaisomboonsuk B, Srikiatkhachorn A, Lago CB, Villa D, Klungthong C, Tac-An IA, Fernandez S, Velasco JM, Roque VG, Nisalak A, Macareo LR, Levy JW, Cummings D, Yoon IK. Reconstruction of 60 Years of Chikungunya Epidemiology in the Philippines Demonstrates Episodic and Focal Transmission. 2015. PMID: 26410592


  47. Rodríguez-Barraquer I, Solomon SS, Kuganantham P, Srikrishnan AK, Vasudevan CK, Iqbal SH, Balakrishnan P, Solomon S, Mehta SH, Cummings DA. The Hidden Burden of Dengue and Chikungunya in Chennai, India. 2015. PMID: 26181441


  48. Rodriguez-Barraquer I, Mier-Y-Teran-Romero L, Ferguson N, Burke DS, Cummings DAT. Differential efficacy of dengue vaccine by immune status. 2015. PMID: 25943936


  49. Li T, Eappen AG, Richman AM, Billingsley PF, Abebe Y, Li M, Padilla D, Rodriguez-Barraquer I, Sim BK, Hoffman SL. Robust, reproducible, industrialized, standard membrane feeding assay for assessing the transmission blocking activity of vaccines and drugs against Plasmodium falciparum. 2015. PMID: 25890243


  50. Lessler J, Rodriguez-Barraquer I, Cummings DA, Garske T, Van Kerkhove M, Mills H, Truelove S, Hakeem R, Albarrak A, Ferguson NM. Estimating Potential Incidence of MERS-CoV Associated with Hajj Pilgrims to Saudi Arabia, 2014. 2014. PMID: 25685624


  51. Salje H, Rodríguez-Barraquer I, Rainwater-Lovett K, Nisalak A, Thaisomboonsuk B, Thomas SJ, Fernandez S, Jarman RG, Yoon IK, Cummings DA. Variability in dengue titer estimates from plaque reduction neutralization tests poses a challenge to epidemiological studies and vaccine development. 2014. PMID: 24967885


  52. T. A. Perkins, R. C. Reiner, I. Rodriguez-Barraquer, D. L. Smith, T. W. Scott, D. A. T. Cummings. A review of transmission models of dengue: a quantitative and qualitative analysis of model features. 2014. PMID:


  53. Rodriguez-Barraquer I, Mier-y-Teran-Romero L, Schwartz IB, Burke DS, Cummings DA. Potential opportunities and perils of imperfect dengue vaccines. 2013. PMID: 24269318


  54. Rodríguez-Barraquer I, Buathong R, Iamsirithaworn S, Nisalak A, Lessler J, Jarman RG, Gibbons RV, Cummings DA. Revisiting Rayong: shifting seroprofiles of dengue in Thailand and their implications for transmission and control. 2013. PMID: 24197388


  55. Rodriguez-Barraquer I, Mier-y-Teran-Romero L, Burke DS, Cummings DA. Challenges in the interpretation of dengue vaccine trial results. 2013. PMID: 24009782


  56. Rainwater-Lovett K, Rodriguez-Barraquer I, Cummings DA, Lessler J. Variation in dengue virus plaque reduction neutralization testing: systematic review and pooled analysis. 2012. PMID: 23020074


  57. Rubiano LC, Miranda MC, Muvdi Arenas S, Montero LM, Rodríguez-Barraquer I, Garcerant D, Prager M, Osorio L, Rojas MX, Pérez M, Nicholls RS, Gore Saravia N. Noninferiority of miltefosine versus meglumine antimoniate for cutaneous leishmaniasis in children. 2012. PMID: 22238470


  58. Rodriguez-Barraquer I, Cordeiro MT, Braga C, de Souza WV, Marques ET, Cummings DA. From re-emergence to hyperendemicity: the natural history of the dengue epidemic in Brazil. 2011. PMID: 21245922


  59. Rodríguez-Barraquer I, Góngora R, Prager M, Pacheco R, Montero LM, Navas A, Ferro C, Miranda MC, Saravia NG. Etiologic agent of an epidemic of cutaneous leishmaniasis in Tolima, Colombia. 2008. PMID: 18256429