Ida Sim, PhD, MD

PROF IN RES-HCOMP

General Internal Medicine, General Internal Medicine UCSF Health

Ida Sim, MD, PhD is a primary care physician, informatics researcher, and entrepreneur. She is a Professor of Medicine at the University of California, San Francisco, where she co-directs Informatics and Research Innovation at UCSF's Clinical and Translational Sciences Institute, and is Director of Digital Health for the Division of General Internal Medicine. Her current research focuses on the use of mobile apps and sensors to improve health and manage disease for populations and individuals, and to make clinical research faster and less expensive. She is a co-founder of Open mHealth, a non-profit organization that is breaking down barriers to mobile health app and data integration through an open software architecture. Open mHealth is an official working group of the IEEE Standards Association and is on track to becoming a global IEEE standard.

Dr. Sim is also an international leader in clinical trial data sharing. In 2005, Dr. Sim was the founding Project Coordinator of the World Health Organization's International Clinical Trials Registry Platform, where she led the establishment of the first global policy on clinical trial registration and defined the common 20-item Trial Registration Data Set that all registers worldwide adhere to. She served on the Institute of Medicine's committee on Strategies of Responsible Sharing of Clinical Trial Data and is a Co-founder of Vivli, the world's largest data sharing platform for participant-level clinical trial data.

Dr. Sim has served on multiple advisory committees on health information infrastructure for clinical care and research, including committees of the National Research Council and Institute of Medicine. She is a recipient of the United States Presidential Early Career Award for Scientists and Engineers (PECASE), a Fellow of the American College of Medical Informatics, and a member of the American Society for Clinical Investigation.

Education
PhD, 1997 - Medical Informatics, Stanford University
M.D., 1990 - , Stanford University
Honors and Awards
  • Elected Member, American Society for Clinical Investigation, 2010
  • Elected Fellow, American College of Medial Informatics, 2007
  • Leadership Award, American Medical Informatics Association, 2005
  • United States Presidential Early Career Award for Scientists and Engineers, White House Office of Science Technology and Policy, 2000
Websites
Publications
  1. Effect of Mobile Device-Assisted N-of-1 Trial Participation on Analgesic Prescribing for Chronic Pain: Randomized Controlled Trial.
  2. Why we need a small data paradigm.
  3. A randomized trial provided new evidence on the accuracy and efficiency of traditional vs electronically annotated abstraction approaches in systematic reviews.
  4. Role of Health Information Technology in Addressing Health Disparities: Patient, Clinician, and System Perspectives.
  5. A Case for n-of-1 Trials-Reply.
  6. Finding Benefit in n-of-1 Trials-Reply.
  7. The Global academic research organization network: Data sharing to cure diseases and enable learning health systems.
  8. Patient Perceptions of Their Own Data in mHealth Technology-Enabled N-of-1 Trials for Chronic Pain: Qualitative Study.
  9. Effect of Mobile Device-Supported Single-Patient Multi-crossover Trials on Treatment of Chronic Musculoskeletal Pain: A Randomized Clinical Trial.
  10. Center of Excellence for Mobile Sensor Data-to-Knowledge (MD2K).
  11. Evaluating Data Abstraction Assistant, a novel software application for data abstraction during systematic reviews: protocol for a randomized controlled trial.
  12. A Global, Neutral Platform for Sharing Trial Data.
  13. Multivariate analysis of the population representativeness of related clinical studies.
  14. Informatics: Make sense of health data.
  15. Center of excellence for mobile sensor data-to-knowledge (MD2K).
  16. The PREEMPT study - evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial.
  17. Visual aggregate analysis of eligibility features of clinical trials.
  18. Towards Constructing a New Taxonomy for Psychiatry Using Self-reported Symptoms.
  19. A method for analyzing commonalities in clinical trial target populations.
  20. Patient-centered care, collaboration, communication, and coordination: a report from AMIA's 2013 Policy Meeting.
  21. Academic Medical Centers as digital health catalysts.
  22. The Ontology of Clinical Research (OCRe): an informatics foundation for the science of clinical research.
  23. Sponsorship and design characteristics of trials registered in ClinicalTrials.gov.
  24. Deriving an abstraction network to support quality assurance in OCRe.
  25. Ontology-based federated data access to human studies information.
  26. Making sense of mobile health data: an open architecture to improve individual- and population-level health.
  27. EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria.
  28. Network analysis of clinical trials on depression: implications for comparative effectiveness research.
  29. Health care delivery. Open mHealth architecture: an engine for health care innovation.
  30. ExaCT: automatic extraction of clinical trial characteristics from journal publications.
  31. A practical method for transforming free-text eligibility criteria into computable criteria.
  32. Analysis of eligibility criteria complexity in clinical trials.
  33. Ontology mapping and data discovery for the translational investigator.
  34. The human studies database project: federating human studies design data using the ontology of clinical research.
  35. Formal representation of eligibility criteria: a literature review.
  36. Development and evaluation of a study design typology for human research.
  37. Compliance of clinical trial registries with the World Health Organization minimum data set: a survey.
  38. Synergies and distinctions between computational disciplines in biomedical research: perspective from the Clinical andTranslational Science Award programs.
  39. Unintended consequences of health information technology: a need for biomedical informatics.
  40. Keeping raw data in context.
  41. Changes to NIH grant system may backfire.
  42. An interactive tool for visualizing design heterogeneity in clinical trials.
  43. Automated information extraction of key trial design elements from clinical trial publications.
  44. Characterizing primary care research: PCROM versus BRIDG.
  45. Publication of clinical trials supporting successful new drug applications: a literature analysis.
  46. The Primary Care Research Object Model (PCROM): a computable information model for practice-based primary care research.
  47. Reporting the findings of clinical trials: a discussion paper.
  48. Trial registration for public trust: making the case for medical devices.
  49. [Principles of the international registry of protocols and clinical trial results based on health interventions in human beings: Ottawa Declaration (part 1)].
  50. Clinical trial registration: transparency is the watchword.
  51. Assessing clinical trial results.
  52. International clinical trial registration: any progress?
  53. A taxonomic description of computer-based clinical decision support systems.
  54. National Center for Biomedical Ontology: advancing biomedicine through structured organization of scientific knowledge.
  55. RuleEd, a web-based semantic network interface for constructing and revising computable eligibility rules.
  56. Beyond trial registration: a global trial bank for clinical trial reporting.
  57. The value of electronic health records in solo or small group practices.
  58. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1).
  59. Quantifying the gap between proof and practice.
  60. An ontology of randomized controlled trials for evidence-based practice: content specification and evaluation using the competency decomposition method.
  61. Physicians' use of electronic medical records: barriers and solutions.
  62. Characteristics of outpatient clinical decision support systems: a taxonomic description.
  63. Electronic medical records in solo/small groups: a qualitative study of physician user types.
  64. EyePACS: an open source clinical communication system for eye care.
  65. Trial bank publishing: phase I results.
  66. A new framework for describing and quantifying the gap between proof and practice.
  67. A framework for classifying decision support systems.
  68. SysBank: a knowledge base for systematic reviews of randomized clinical trials.
  69. The Trial Bank system: capturing randomized trials for evidence-based medicine.
  70. Evidence-based practice for mere mortals: the role of informatics and health services research.
  71. Antibiotic treatment of acute bronchitis in smokers: a systematic review.
  72. Clinical decision support systems for the practice of evidence-based medicine.
  73. Electronic trial banks: a complementary method for reporting randomized trials.
  74. Meta-analyses and large randomized, controlled trials.
  75. Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death.
  76. Growing pains of meta-analysis.
  77. A meta-analysis of randomized trials comparing coronary artery bypass grafting with percutaneous transluminal coronary angioplasty in multivessel coronary artery disease.
  78. A trial bank model for the publication of clinical trials.
  79. Physician's information customizer (PIC): using a shareable user model to filter the medical literature.
  80. The NGF complex from the African rat Mastomys natalensis.
  81. Synthesis and antiviral activity of metabolites of rimantadine.
  82. Hyperthermia-induced inhibition of respiration and mitochondrial protein denaturation in CHL cells.
  83. Estrous cycle variations in cholecystokinin and substance P concentrations in discrete areas of the rat brain.
  84. Cholecystokinin and substance P concentrations in discrete areas of the rat brain: sex differences.