Ida Sim, PhD, MD

PROF IN RES-HCOMP

Ida Sim, MD, PhD is a primary care physician, informatics researcher, and entrepreneur. She is a Professor of Medicine and UCSF Director of the UCSF UC Berkeley Joint Program in Computational Precision Health. Her other UCSF positions include Director of Digital Health for the Division of General Internal Medicine and Co-Director, Informatics and Research Innovation at UCSF's Clinical and Translational Sciences Institute. Dr. Sim is a global leader in the technology and policy of large-scale health data sharing.

Dr. Sim is a co-founder of Open mHealth, a non-profit organization that is breaking down barriers to mobile health app and data integration through an open software architecture. Open mHealth is an IEEE family of global standards. IEEE 1752.1 was officially approved in 2021. Dr. Sim has multiple grants from NIH, NSF, and AHRQ on mobile health methodology and digital health for primary care. In 2019, she co-developed CommonHealth, an open source software suite bringing to the Android ecosystem the equivalent of Apple Health's ability to access and share EHR data.

Dr. Sim is also co-founder of Vivli, the world's largest data sharing platform for participant-level clinical trial data. In 2005, she was the founding Project Coordinator of the World Health Organization's International Clinical Trials Registry Platform, where she led the establishment of the first global policy on clinical trial registration.

Dr. Sim has served on multiple advisory committees on health information infrastructure for clinical care and research, including committees of the National Research Council and National Academy of Medicine. She is a recipient of the United States Presidential Early Career Award for Scientists and Engineers (PECASE), a Fellow of the American College of Medical Informatics, and a member of the American Society for Clinical Investigation.

Education
1997 - Fellowship, Health Services Research, Stanford University
PhD, 1997 - Medical Informatics, Stanford University
1993 - Primary Care Internal Medicine Residency, Massachussetts General Hospital
M.D., 1990 - , Stanford University
Honors and Awards
  • STATUS2024 Health Science Leader, STAT News, 2024
  • Elected Member, National Academy of Medicine, 2022
  • Elected Member, American Society for Clinical Investigation, 2010
  • Elected Fellow, American College of Medial Informatics, 2007
  • Leadership Award, American Medical Informatics Association, 2005
  • United States Presidential Early Career Award for Scientists and Engineers, White House Office of Science Technology and Policy, 2000
Websites
Publications

  1. Sim I, Cassel C. The Ethics of Relational AI - Expanding and Implementing the Belmont Principles. The New England journal of medicine 2024. PMID: 39007542


  2. Block VJ, Koshal K, Wijangco J, Miller N, Sara N, Henderson K, Reihm J, Gopal A, Mohan SD, Gelfand JM, Guo CY, Oommen L, Nylander A, Rowson JA, Brown E, Sanders S, Rankin K, Lyles CR, Sim I, Bove R. A Closed-Loop Falls Monitoring and Prevention App for Multiple Sclerosis Clinical Practice: Human-Centered Design of the Multiple Sclerosis Falls InsightTrack. JMIR human factors 2024. PMID: 38206662


  3. Arvisais-Anhalt S, Ravi A, Weia B, Aarts J, Ahmad HB, Araj E, Bauml JA, Benham-Hutchins M, Boyd AD, Brecht-Doscher A, Butler-Henderson K, Butte A, Cardillo AB, Chilukuri N, Cho MK, Cohen JK, Craven CK, Crusco SJ, Dadabhoy F, Dash D, DeBolt C, Elkin PL, Fayanju OA, Fochtmann L, Graham JV, Hanna J, Hersh W, Hoffard MR, Hron J, Huang SS, Jackson BR, Kaplan B, Kelly W, Ko K, Koppel R, Kurapati N, Labbad G, Lee J, Lehmann CU, Leitner S, Liao ZC, Medford RJ, Melnick ER, Muniyappa AN, Murray S, Neinstein A, Nichols-Johnson V, Novak L, Ogan WS, Ozeran L, Pageler N, Pandita D, Perumbeti A, Petersen C, Pierce L, Puttagunta R, Ramaswamy P, Rogers KM, Rosenbloom T, Ryan A, Saleh S, Sarabu C, Schreiber R, Shaw KA, Sim I, Sirintrapun SJ, Solomonides A, Spector JD, Starren JB, Stoffel M, Subbian V, Swanson K, Tomes A, Trang K, Unertl KM, Weon JL, Whooley M, Wiley K, Williamson DF, Winkelstein P, Wong J, Xie J, Yarahuan JKW, Yung N, Zera C, Ratanawongsa N, Sadasivaiah S. Paging the Clinical Informatics Community: Respond STAT to Dobbs v Jackson's Women's Health Organization. Applied clinical informatics 2022. PMID: 36535703


  4. Ida Sim, Marina Sirota. Data and Computation: A Contemporary Landscape. Intelligent Systems in Medicine and Health 2022. PMID:


  5. Liu H, Carini S, Chen Z, Phillips Hey S, Sim I, Weng C. Ontology-based categorization of clinical studies by their conditions. Journal of biomedical informatics 2022. PMID: 36283581


  6. Duan N, Norman D, Schmid C, Sim I, Kravitz RL. Personalized Data Science and Personalized (N-of-1) Trials: Promising Paradigms for Individualized Health Care. Harvard data science review 2022. PMID: 38009133


  7. Horwitz RI, Hayes-Conroy A, Singer BH, Cullen MR, Badal K, Sim I. Falling down the biological rabbit hole: Epstein-Barr virus, biography, and multiple sclerosis. The Journal of clinical investigation 2022. PMID: 36047497


  8. Ida Sim. Data Sharing and Reuse. 2022. PMID:


  9. Horwitz RI, Conroy AH, Cullen MR, Colella K, Mawn M, Singer BH, Sim I. Long COVID and Medicine's Two Cultures. 2022. PMID: 35417745


  10. Larson K, Sim I, von Isenburg M, Levenstein M, Rockhold F, Neumann S, D'Arcy C, Graham E, Zuckerman D, Li R. COVID-19 interventional trials: Analysis of data sharing intentions during a time of pandemic. 2022. PMID: 35182738


  11. Zeng B, Bove R, Carini S, Lee JS, Pollak JP, Schleimer E, Sim I. Standardized Integration of Person-Generated Data Into Routine Clinical Care. 2022. PMID: 35142627


  12. Horwitz RI, Singer BH, Hayes-Conroy A, Cullen MR, Mawn M, Colella K, Sim I. Biosocial Pathogenesis. 2022. PMID: 35104822


  13. Marcus GM, Modrow MF, Schmid CH, Sigona K, Nah G, Yang J, Chu TC, Joyce S, Gettabecha S, Ogomori K, Yang V, Butcher X, Hills MT, McCall D, Sciarappa K, Sim I, Pletcher MJ, Olgin JE. Individualized Studies of Triggers of Paroxysmal Atrial Fibrillation: The I-STOP-AFib Randomized Clinical Trial. 2021. PMID: 34775507


  14. Wang EY, Breyer BN, Lee AW, Rios N, Oni-Orisan A, Steinman MA, Sim I, Kenfield SA, Bauer SR. Perceptions of Older Men Using a Mobile Health App to Monitor Lower Urinary Tract Symptoms and Tamsulosin Side Effects: Mixed Methods Study. 2021. PMID: 34951599


  15. Lee AW, Kenfield SA, Wang EY, Enriquez A, Oni-Orisan A, Steinman MA, Sim I, Breyer BN, Bauer SR. Tracking Lower Urinary Tract Symptoms and Tamsulosin Side Effects Among Older Men Using a Mobile App (PERSONAL): Feasibility and Usability Study. 2021. PMID: 34889745


  16. Horwitz RI, Lobitz G, Mawn M, Conroy AH, Cullen MR, Sim I, Singer BH. Rethinking Table 1. 2021. PMID: 34800675


  17. Sim I, Cassel C. HIPAA and the Leak of "Deidentified" EHR Data. The New England journal of medicine 2021. PMID: 34525298


  18. Elizabeth Y. Wang, Benjamin N. Breyer, Austin Lee, Natalie Rios, Akinyemi Oni-Orisan, Michael A. Steinman, Ida Sim, Stacey A. Kenfield, Scott R. Bauer. MP28-03 PERCEPTIONS OF OLDER MEN USING A MOBILE HEALTH APPLICATION TO MONITOR LOWER URINARY TRACT SYMPTOMS AND TAMSULOSIN ADVERSE EFFECTS: MIXED-METHODS STUDY. Investigative Urology 2021. PMID:


  19. Kravitz RL, Marois M, Sim I, Ward D, Kanekar SS, Yu A, Dounias P, Yang J, Wang Y, Schmid CH. Chronic pain treatment preferences change following participation in N-of-1 trials, but not always in the expected direction. Journal of clinical epidemiology 2021. PMID: 34400254


  20. Horwitz RI, Lobitz G, Mawn M, Conroy AH, Cullen MR, Sim I, Singer BH. Biosocial medicine: Biology, biography, and the tailored care of the patient. 2021. PMID: 34430699


  21. Coetzee T, Ball MP, Boutin M, Bronson A, Dexter DT, English RA, Furlong P, Goodman AD, Grossman C, Hernandez AF, Hinners JE, Hudson L, Kennedy A, Marchisotto MJ, Matrisian L, Myers E, Nowell WB, Nosek BA, Sherer T, Shore C, Sim I, Smolensky L, Williams C, Wood J, Terry SF. Correction: Data Sharing Goals for Nonprofit Funders of Clinical Trials. Journal of participatory medicine 2021. PMID: 34255670


  22. Ku JP, Sim I. Mobile Health: making the leap to research and clinics. NPJ digital medicine 2021. PMID: 33990671


  23. Coetzee T, Ball MP, Boutin M, Bronson A, Dexter DT, English RA, Furlong P, Goodman AD, Grossman C, Hernandez AF, Hinners JE, Hudson L, Kennedy A, Marchisotto MJ, Myers E, Nowell WB, Nosek BA, Sherer T, Shore C, Sim I, Smolensky L, Williams C, Wood J, Terry SF, Matrisian L. Data Sharing Goals for Nonprofit Funders of Clinical Trials. Journal of participatory medicine 2021. PMID: 33779573


  24. Li R, von Isenburg M, Levenstein M, Neumann S, Wood J, Sim I. COVID-19 trials: declarations of data sharing intentions at trial registration and at publication. Trials 2021. PMID: 33602275


  25. Bent B, Sim I, Dunn JP. Digital Medicine Community Perspectives and Challenges: Survey Study. JMIR mHealth and uHealth 2021. PMID: 33533721


  26. Li R, Wood J, Baskaran A, Neumann S, Graham E, Levenstein M, Sim I. Timely access to trial data in the context of a pandemic: the time is now. BMJ open 2020. PMID: 33122319


  27. Lo B, Sim I. Ethical Framework for Assessing Manual and Digital Contact Tracing for COVID-19. Annals of internal medicine 2020. PMID: 33076694


  28. Kury F, Butler A, Yuan C, Fu LH, Sun Y, Liu H, Sim I, Carini S, Weng C. Chia, a large annotated corpus of clinical trial eligibility criteria. Scientific data 2020. PMID: 32855408


  29. Bent B, Wang K, Grzesiak E, Jiang C, Qi Y, Jiang Y, Cho P, Zingler K, Ogbeide FI, Zhao A, Runge R, Sim I, Dunn J. The digital biomarker discovery pipeline: An open-source software platform for the development of digital biomarkers using mHealth and wearables data. Journal of Clinical and Translational Science 2020. PMID: 33948242


  30. Bauer SR, Breyer BN, Oni-Orisan A, Steinman MA, Sim I, McCulloch CE, Kenfield SA. PERSONAL: Feasibility Study Protocol for Placebo-Controlled, Randomized n-of-1 Trials of Tamsulosin for Lower Urinary Tract Symptoms. 2020. PMID: 34713020


  31. Kravitz RL, Aguilera A, Chen EJ, Choi YK, Hekler E, Karr C, Kim KK, Phatak S, Sarkar S, Schueller SM, Sim I, Yang J, Schmid CH. Feasibility, Acceptability, and Influence of mHealth-Supported N-of-1 Trials for Enhanced Cognitive and Emotional Well-Being in US Volunteers. Frontiers in public health 2020. PMID: 32695740


  32. Ida Sim. Data Sharing and Reuse. Principles and Practice of Clinical Trials 2020. PMID:


  33. Sim I, Stebbins M, Bierer BE, Butte AJ, Drazen J, Dzau V, Hernandez AF, Krumholz HM, Lo B, Munos B, Perakslis E, Rockhold F, Ross JS, Terry SF, Yamamoto KR, Zarin DA, Li R. Time for NIH to lead on data sharing. Science (New York, N.Y.) 2020. PMID: 32193313


  34. Sim I. Mobile Devices and Health. The New England journal of medicine 2019. PMID: 31483966


  35. Li R, Sim I. How Clinical Trial Data Sharing Platforms Can Advance the Study of Biomarkers. The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics 2019. PMID: 31560635


  36. Odineal DD, Marois MT, Ward D, Schmid CH, Cabrera R, Sim I, Wang Y, Wilsey B, Duan N, Henry SG, Kravitz RL. Effect of Mobile Device-Assisted N-of-1 Trial Participation on Analgesic Prescribing for Chronic Pain: Randomized Controlled Trial. Journal of general internal medicine 2019. PMID: 31463686


  37. Hekler EB, Klasnja P, Chevance G, Golaszewski NM, Lewis D, Sim I. Why we need a small data paradigm. BMC medicine 2019. PMID: 31311528


  38. Li T, Saldanha IJ, Jap J, Smith BT, Canner J, Hutfless SM, Branch V, Carini S, Chan W, de Bruijn B, Wallace BC, Walsh SA, Whamond EJ, Murad MH, Sim I, Berlin JA, Lau J, Dickersin K, Schmid CH. A randomized trial provided new evidence on the accuracy and efficiency of traditional vs electronically annotated abstraction approaches in systematic reviews. Journal of clinical epidemiology 2019. PMID: 31302205


  39. Zhang X, Hailu B, Tabor DC, Gold R, Sayre MH, Sim I, Jean-Francois B, Casnoff CA, Cullen T, Thomas VA, Artiles L, Williams K, Le PT, Aklin CF, James R. Role of Health Information Technology in Addressing Health Disparities: Patient, Clinician, and System Perspectives. Medical care 2019. PMID: 31095049


  40. Kravitz RL, Sim I, Duan N. A Case for n-of-1 Trials-Reply. JAMA internal medicine 2019. PMID: 30830192


  41. Kravitz RL, Schmid CH, Sim I. Finding Benefit in n-of-1 Trials-Reply. JAMA internal medicine 2019. PMID: 30830195


  42. Fukushima M, Austin C, Sato N, Maruyama T, Navarro E, Rocca M, Demotes J, Haendel M, Volchenboum SL, Cowperthwaite M, Silverstein JC, Webb C, Sim I, Chase M, Speakman J, Augustine E, Ford DE, Kush R. The Global academic research organization network: Data sharing to cure diseases and enable learning health systems. Learning health systems 2018. PMID: 31245596


  43. . Moving Data Sharing Forward: The Launch of the Vivli Platform. 2018. PMID:


  44. Whitney RL, Ward DH, Marois MT, Schmid CH, Sim I, Kravitz RL. Patient Perceptions of Their Own Data in mHealth Technology-Enabled N-of-1 Trials for Chronic Pain: Qualitative Study. JMIR mHealth and uHealth 2018. PMID: 30309834


  45. Kravitz RL, Schmid CH, Marois M, Wilsey B, Ward D, Hays RD, Duan N, Wang Y, MacDonald S, Jerant A, Servadio JL, Haddad D, Sim I. Effect of Mobile Device-Supported Single-Patient Multi-crossover Trials on Treatment of Chronic Musculoskeletal Pain: A Randomized Clinical Trial. JAMA internal medicine 2018. PMID: 30193253


  46. Kumar S, Abowd G, Abraham WT, al'Absi M, Chau DHP, Ertin E, Estrin D, Ganesan D, Hnat T, Hossain SM, Ives Z, Kerr J, Marlin BM, Murphy S, Rehg JM, Nahum-Shani I, Shetty V, Sim I, Spring B, Srivastava M, Wetter D. Center of Excellence for Mobile Sensor Data-to-Knowledge (MD2K). Volume 16 of Issue 2. IEEE pervasive computing 2017. PMID: 29276451


  47. Saldanha IJ, Schmid CH, Lau J, Dickersin K, Berlin JA, Jap J, Smith BT, Carini S, Chan W, De Bruijn B, Wallace BC, Hutfless SM, Sim I, Murad MH, Walsh SA, Whamond EJ, Li T. Evaluating Data Abstraction Assistant, a novel software application for data abstraction during systematic reviews: protocol for a randomized controlled trial. Volume 5 of Issue 1. Systematic reviews 2016. PMID: 27876082


  48. Bierer BE, Li R, Barnes M, Sim I. A Global, Neutral Platform for Sharing Trial Data. Volume 374 of Issue 25. The New England journal of medicine 2016. PMID: 27168194


  49. Sim I. Two Ways of Knowing: Big Data and Evidence-Based Medicine. Annals of internal medicine 2016. PMID: 26809201


  50. He Z, Ryan P, Hoxha J, Wang S, Carini S, Sim I, Weng C. Multivariate analysis of the population representativeness of related clinical studies. Volume 60. Journal of biomedical informatics 2016. PMID: 26820188


  51. Elliott JH, Grimshaw J, Altman R, Bero L, Goodman SN, Henry D, Macleod M, Tovey D, Tugwell P, White H, Sim I. Informatics: Make sense of health data. Volume 527 of Issue 7576. Nature 2015. PMID: 26536942


  52. Kumar S, Abowd GD, Abraham WT, al'Absi M, Beck JG, Chau DH, Condie T, Conroy DE, Ertin E, Estrin D, Ganesan D, Lam C, Marlin B, Marsh CB, Murphy SA, Nahum-Shani I, Patrick K, Rehg JM, Sharmin M, Shetty V, Sim I, Spring B, Srivastava M, Wetter DW. Center of excellence for mobile sensor data-to-knowledge (MD2K). Volume 22 of Issue 6. Journal of the American Medical Informatics Association : JAMIA 2015. PMID: 26555017


  53. Barr C, Marois M, Sim I, Schmid CH, Wilsey B, Ward D, Duan N, Hays RD, Selsky J, Servadio J, Schwartz M, Dsouza C, Dhammi N, Holt Z, Baquero V, MacDonald S, Jerant A, Sprinkle R, Kravitz RL. The PREEMPT study - evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial. Volume 16. Trials 2015. PMID: 25881274


  54. He Z, Carini S, Sim I, Weng C. Visual aggregate analysis of eligibility features of clinical trials. Volume 54. Journal of biomedical informatics 2015. PMID: 25615940


  55. Ross J, Neylan T, Weiner M, Chao L, Samuelson K, Sim I. Towards Constructing a New Taxonomy for Psychiatry Using Self-reported Symptoms. Volume 216. Studies in health technology and informatics 2015. PMID: 26262149


  56. He Z, Carini S, Hao T, Sim I, Weng C. A method for analyzing commonalities in clinical trial target populations. Volume 2014. AMIA ... Annual Symposium proceedings. AMIA Symposium 2014. PMID: 25954450


  57. Brennan PF, Valdez R, Alexander G, Arora S, Bernstam EV, Edmunds M, Kirienko N, Martin RD, Sim I, Skiba D, Rosenbloom T. Patient-centered care, collaboration, communication, and coordination: a report from AMIA's 2013 Policy Meeting. Volume 22 of Issue e1. Journal of the American Medical Informatics Association : JAMIA 2014. PMID: 25359545


  58. DePasse JW, Chen CE, Sawyer A, Jethwani K, Sim I. Academic Medical Centers as digital health catalysts. Volume 2 of Issue 3. Healthcare (Amsterdam, Netherlands) 2014. PMID: 26250503


  59. Sim I, Tu SW, Carini S, Lehmann HP, Pollock BH, Peleg M, Wittkowski KM. The Ontology of Clinical Research (OCRe): an informatics foundation for the science of clinical research. Volume 52. Journal of biomedical informatics 2013. PMID: 24239612


  60. Roumiantseva D, Carini S, Sim I, Wagner TH. Sponsorship and design characteristics of trials registered in ClinicalTrials.gov. Volume 34 of Issue 2. Contemporary clinical trials 2013. PMID: 23380028


  61. Ochs C, Agrawal A, Perl Y, Halper M, Tu SW, Carini S, Sim I, Noy N, Musen M, Geller J. Deriving an abstraction network to support quality assurance in OCRe. Volume 2012. AMIA ... Annual Symposium proceedings. AMIA Symposium 2012. PMID: 23304341


  62. Sim I, Carini S, Tu SW, Detwiler LT, Brinkley J, Mollah SA, Burke K, Lehmann HP, Chakraborty S, Wittkowski KM, Pollock BH, Johnson TM, Huser V. Ontology-based federated data access to human studies information. Volume 2012. AMIA ... Annual Symposium proceedings. AMIA Symposium 2012. PMID: 23304360


  63. Chen C, Haddad D, Selsky J, Hoffman JE, Kravitz RL, Estrin DE, Sim I. Making sense of mobile health data: an open architecture to improve individual- and population-level health. Volume 14 of Issue 4. Journal of medical Internet research 2012. PMID: 22875563


  64. Boland MR, Tu SW, Carini S, Sim I, Weng C. EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria. Volume 2012. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 2012. PMID: 22779055


  65. . Study Protocol Representation. 2012. PMID:


  66. . Information Technology research challenges for healthcare: from discovery to delivery. 2011. PMID:


  67. Bhavnani SK, Carini S, Ross J, Sim I. Network analysis of clinical trials on depression: implications for comparative effectiveness research. Volume 2010. AMIA ... Annual Symposium proceedings. AMIA Symposium 2010. PMID: 21346939


  68. Estrin D, Sim I. Health care delivery. Open mHealth architecture: an engine for health care innovation. Volume 330 of Issue 6005. Science (New York, N.Y.) 2010. PMID: 21051617


  69. Kiritchenko S, de Bruijn B, Carini S, Martin J, Sim I. ExaCT: automatic extraction of clinical trial characteristics from journal publications. Volume 10. BMC medical informatics and decision making 2010. PMID: 20920176


  70. Tu SW, Peleg M, Carini S, Bobak M, Ross J, Rubin D, Sim I. A practical method for transforming free-text eligibility criteria into computable criteria. Volume 44 of Issue 2. Journal of biomedical informatics 2010. PMID: 20851207


  71. Ross J, Tu S, Carini S, Sim I. Analysis of eligibility criteria complexity in clinical trials. Volume 2010. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 2010. PMID: 21347148


  72. Wynden R, Weiner MG, Sim I, Gabriel D, Casale M, Carini S, Hastings S, Ervin D, Tu S, Gennari JH, Anderson N, Mobed K, Lakshminarayanan P, Massary M, Cucina RJ. Ontology mapping and data discovery for the translational investigator. Volume 2010. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 2010. PMID: 21347152


  73. Sim I, Carini S, Tu S, Wynden R, Pollock BH, Mollah SA, Gabriel D, Hagler HK, Scheuermann RH, Lehmann HP, Wittkowski KM, Nahm M, Bakken S. The human studies database project: federating human studies design data using the ontology of clinical research. Volume 2010. AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science 2010. PMID: 21347149


  74. Weng C, Tu SW, Sim I, Richesson R. Formal representation of eligibility criteria: a literature review. Volume 43 of Issue 3. Journal of biomedical informatics 2009. PMID: 20034594


  75. Carini S, Pollock BH, Lehmann HP, Bakken S, Barbour EM, Gabriel D, Hagler HK, Harper CR, Mollah SA, Nahm M, Nguyen HH, Scheuermann RH, Sim I. Development and evaluation of a study design typology for human research. Volume 2009. AMIA ... Annual Symposium proceedings. AMIA Symposium 2009. PMID: 20351827


  76. Moja LP, Moschetti I, Nurbhai M, Compagnoni A, Liberati A, Grimshaw JM, Chan AW, Dickersin K, Krleza-Jeric K, Moher D, Sim I, Volmink J. Compliance of clinical trial registries with the World Health Organization minimum data set: a survey. Volume 10. Trials 2009. PMID: 19624821


  77. Bernstam EV, Hersh WR, Johnson SB, Chute CG, Nguyen H, Sim I, Nahm M, Weiner MG, Miller P, DiLaura RP, Overcash M, Lehmann HP, Eichmann D, Athey BD, Scheuermann RH, Anderson N, Starren J, Harris PA, Smith JW, Barbour E, Silverstein JC, Krusch DA, Nagarajan R, Becich MJ. Synergies and distinctions between computational disciplines in biomedical research: perspective from the Clinical andTranslational Science Award programs. Volume 84 of Issue 7. Academic medicine : journal of the Association of American Medical Colleges 2009. PMID: 19550198


  78. Bernstam EV, Hersh WR, Sim I, Eichmann D, Silverstein JC, Smith JW, Becich MJ. Unintended consequences of health information technology: a need for biomedical informatics. Volume 43 of Issue 5. Journal of biomedical informatics 2009. PMID: 19508898


  79. Sim I, Chute CG, Lehmann H, Nagarajan R, Nahm M, Scheuermann RH. Keeping raw data in context. Volume 323 of Issue 5915. Science (New York, N.Y.) 2009. PMID: 19197039


  80. Karp PD, Sherlock G, Gerlt JA, Sim I, Paulsen I, Babbitt PC, Laderoute K, Hunter L, Sternberg P, Wooley J, Bourne PE. Changes to NIH grant system may backfire. Volume 322 of Issue 5905. Science (New York, N.Y.) 2008. PMID: 19023064


  81. Hernandez ME, Carini S, Storey MA, Sim I. An interactive tool for visualizing design heterogeneity in clinical trials. AMIA ... Annual Symposium proceedings. AMIA Symposium 2008. PMID: 18998925


  82. de Bruijn B, Carini S, Kiritchenko S, Martin J, Sim I. Automated information extraction of key trial design elements from clinical trial publications. AMIA ... Annual Symposium proceedings. AMIA Symposium 2008. PMID: 18999067


  83. Speedie SM, Taweel A, Sim I, Arvanitis TN, Arvanitis T, Delaney B, Peterson KA. Characterizing primary care research: PCROM versus BRIDG. AMIA ... Annual Symposium proceedings. AMIA Symposium 2008. PMID: 18998919


  84. Lee K, Bacchetti P, Sim I. Publication of clinical trials supporting successful new drug applications: a literature analysis. Volume 5 of Issue 9. PLoS medicine 2008. PMID: 18816163


  85. Speedie SM, Taweel A, Sim I, Arvanitis TN, Delaney B, Peterson KA. The Primary Care Research Object Model (PCROM): a computable information model for practice-based primary care research. Volume 15 of Issue 5. Journal of the American Medical Informatics Association : JAMIA 2008. PMID: 18579829


  86. Ghersi D, Clarke M, Berlin J, Gülmezoglu A, Kush R, Lumbiganon P, Moher D, Rockhold F, Sim I, Wager E. Reporting the findings of clinical trials: a discussion paper. Volume 86 of Issue 6. Bulletin of the World Health Organization 2008. PMID: 18568282


  87. Sim I. Trial registration for public trust: making the case for medical devices. Volume 23 Suppl 1. Journal of general internal medicine 2008. PMID: 18095047


  88. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. [Principles of the international registry of protocols and clinical trial results based on health interventions in human beings: Ottawa Declaration (part 1)]. Volume 19 of Issue 6. Revista panamericana de salud publica = Pan American journal of public health 2006. PMID: 16968596


  89. Sim I, Chan AW, Gülmezoglu AM, Evans T, Pang T. Clinical trial registration: transparency is the watchword. Volume 367 of Issue 9523. Lancet (London, England) 2006. PMID: 16714166


  90. Chan AW, Sim I, Gülmezoglu AM, Unterlerchner P, Karam G, Pang T. Assessing clinical trial results. Volume 312 of Issue 5772. Science (New York, N.Y.) 2006. PMID: 16634140


  91. Gülmezoglu AM, Sim I. International clinical trial registration: any progress? Volume 118 of Issue 1-2. Wiener klinische Wochenschrift 2006. PMID: 16489516


  92. Berlin A, Sorani M, Sim I. A taxonomic description of computer-based clinical decision support systems. Volume 39 of Issue 6. Journal of biomedical informatics 2006. PMID: 16442854


  93. Rubin DL, Lewis SE, Mungall CJ, Misra S, Westerfield M, Ashburner M, Sim I, Chute CG, Solbrig H, Storey MA, Smith B, Day-Richter J, Noy NF, Musen MA. National Center for Biomedical Ontology: advancing biomedicine through structured organization of scientific knowledge. Volume 10 of Issue 2. Omics : a journal of integrative biology 2006. PMID: 16901225


  94. Olasov B, Sim I. RuleEd, a web-based semantic network interface for constructing and revising computable eligibility rules. AMIA ... Annual Symposium proceedings. AMIA Symposium 2006. PMID: 17238670


  95. Sim I, Detmer DE. Beyond trial registration: a global trial bank for clinical trial reporting. Volume 2 of Issue 11. PLoS medicine 2005. PMID: 16220999


  96. Miller RH, West C, Brown TM, Sim I, Ganchoff C. The value of electronic health records in solo or small group practices. Volume 24 of Issue 5. Health affairs (Project Hope) 2005. PMID: 16162555


  97. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1). Volume 330 of Issue 7497. BMJ (Clinical research ed.) 2005. PMID: 15845980


  98. Sim I, Cummings SR. Quantifying the gap between proof and practice. Volume 8 of Issue 4. Evidence-based cardiovascular medicine 2004. PMID: 16379955


  99. Sim I, Olasov B, Carini S. An ontology of randomized controlled trials for evidence-based practice: content specification and evaluation using the competency decomposition method. Volume 37 of Issue 2. Journal of biomedical informatics 2004. PMID: 15120657


  100. Miller RH, Sim I. Physicians' use of electronic medical records: barriers and solutions. Volume 23 of Issue 2. Health affairs (Project Hope) 2004. PMID: 15046136


  101. Berlin A, Sorani M, Sim I. Characteristics of outpatient clinical decision support systems: a taxonomic description. Volume 107 of Issue Pt 1. Studies in health technology and informatics 2004. PMID: 15360878


  102. Miller RH, Sim I, Newman J. Electronic medical records in solo/small groups: a qualitative study of physician user types. Volume 107 of Issue Pt 1. Studies in health technology and informatics 2004. PMID: 15360895


  103. Cuadros J, Sim I. EyePACS: an open source clinical communication system for eye care. Volume 107 of Issue Pt 1. Studies in health technology and informatics 2004. PMID: 15360804


  104. Sim I, Carini S, Olasov B, Jeng S. Trial bank publishing: phase I results. Volume 107 of Issue Pt 2. Studies in health technology and informatics 2004. PMID: 15361060


  105. Sim I, Cummings SR. A new framework for describing and quantifying the gap between proof and practice. Volume 41 of Issue 8. Medical care 2003. PMID: 12886168


  106. Sim I, Berlin A. A framework for classifying decision support systems. AMIA ... Annual Symposium proceedings. AMIA Symposium 2003. PMID: 14728243


  107. Carini S, Sim I. SysBank: a knowledge base for systematic reviews of randomized clinical trials. AMIA ... Annual Symposium proceedings. AMIA Symposium 2003. PMID: 14728309


  108. Sim I, Olasov B, Carini S. The Trial Bank system: capturing randomized trials for evidence-based medicine. AMIA ... Annual Symposium proceedings. AMIA Symposium 2003. PMID: 14728579


  109. Sim I, Sanders GD, McDonald KM. Evidence-based practice for mere mortals: the role of informatics and health services research. Journal of general internal medicine 2002. PMID: 11972727


  110. Linder JA, Sim I. Antibiotic treatment of acute bronchitis in smokers: a systematic review. Volume 17 of Issue 3. Journal of general internal medicine 2002. PMID: 11929510


  111. Sim I, Gorman P, Greenes RA, Haynes RB, Kaplan B, Lehmann H, Tang PC. Clinical decision support systems for the practice of evidence-based medicine. Journal of the American Medical Informatics Association : JAMIA 2001. PMID: 11687560


  112. Sim I, Owens DK, Lavori PW, Rennels GD. Electronic trial banks: a complementary method for reporting randomized trials. Medical decision making : an international journal of the Society for Medical Decision Making 2000. PMID: 11059477


  113. Sim I, Lavori P. Meta-analyses and large randomized, controlled trials. Volume 338 of Issue 1. The New England journal of medicine 1998. PMID: 9424568


  114. Sim I, McDonald KM, Lavori PW, Norbutas CM, Hlatky MA. Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death. Volume 96 of Issue 9. Circulation 1997. PMID: 9386144


  115. Sim I, Hlatky MA. Growing pains of meta-analysis. Volume 313 of Issue 7059. BMJ (Clinical research ed.) 1996. PMID: 8819428


  116. . S12 Standardized computer-based reporting of clinical trials: In support of meta-analysis. 1996. PMID:


  117. Sim I, Gupta M, McDonald K, Bourassa MG, Hlatky MA. A meta-analysis of randomized trials comparing coronary artery bypass grafting with percutaneous transluminal coronary angioplasty in multivessel coronary artery disease. Volume 76 of Issue 14. The American journal of cardiology 1995. PMID: 7484855


  118. Sim I, Rennels G. A trial bank model for the publication of clinical trials. Proceedings. Symposium on Computer Applications in Medical Care 1995. PMID: 8563415


  119. Pratt W, Sim I. Physician's information customizer (PIC): using a shareable user model to filter the medical literature. Volume 8 Pt 2. Medinfo. MEDINFO 1995. PMID: 8591472


  120. Burcham TS, Sim I, Bolin LM, Shooter EM. The NGF complex from the African rat Mastomys natalensis. Volume 16 of Issue 6. Neurochemical research 1991. PMID: 1791910


  121. Manchand PS, Cerruti RL, Martin JA, Hill CH, Merrett JH, Keech E, Belshe RB, Connell EV, Sim IS. Synthesis and antiviral activity of metabolites of rimantadine. Journal of medicinal chemistry 1990. PMID: 2362279


  122. Lepock JR, Cheng KH, Al-Qysi H, Sim I, Koch CJ, Kruuv J. Hyperthermia-induced inhibition of respiration and mitochondrial protein denaturation in CHL cells. Volume 3 of Issue 2. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 1987. PMID: 3036971


  123. Frankfurt M, Siegel RA, Sim I, Wuttke W. Estrous cycle variations in cholecystokinin and substance P concentrations in discrete areas of the rat brain. Volume 42 of Issue 3. Neuroendocrinology 1986. PMID: 2419781


  124. Frankfurt M, Siegel RA, Sim I, Wuttke W. Cholecystokinin and substance P concentrations in discrete areas of the rat brain: sex differences. Volume 358 of Issue 1-2. Brain research 1985. PMID: 2416392