Ida Sim, PhD, MD

PROF IN RES-HCOMP

General Internal Medicine, General Internal Medicine UCSF Health

Ida Sim, MD, PhD is a primary care physician, informatics researcher, and entrepreneur. She is a Professor of Medicine at the University of California, San Francisco, where she co-directs Informatics and Research Innovation at UCSF's Clinical and Translational Sciences Institute, and is Director of Digital Health for the Division of General Internal Medicine. Dr. Sim is a global leader in the technology and policy of large-scale health data sharing.

She is a co-founder of Open mHealth, a non-profit organization that is breaking down barriers to mobile health app and data integration through an open software architecture. Open mHealth is an official working group of the IEEE Standards Association and soon to be a global IEEE standard. Dr. Sim has multiple grants from NIH, NSF, and AHRQ on mobile health methodology and digital health for primary care. In 2019, she co-developed CommonHealth, an open source software suite bringing to the Android ecosystem the equivalent of Apple Health's ability to access and share EHR data.

Dr. Sim is also co-founder of Vivli, the world's largest data sharing platform for participant-level clinical trial data. In 2005, she was the founding Project Coordinator of the World Health Organization's International Clinical Trials Registry Platform, where she led the establishment of the first global policy on clinical trial registration.

Dr. Sim has served on multiple advisory committees on health information infrastructure for clinical care and research, including committees of the National Research Council and National Academy of Medicine. She is a recipient of the United States Presidential Early Career Award for Scientists and Engineers (PECASE), a Fellow of the American College of Medical Informatics, and a member of the American Society for Clinical Investigation.

Education
1997 - Fellowship, Health Services Research, Stanford University
PhD, 1997 - Medical Informatics, Stanford University
1993 - Primary Care Internal Medicine Residency, Massachussetts General Hospital
M.D., 1990 - , Stanford University
Honors and Awards
  • Elected Member, American Society for Clinical Investigation, 2010
  • Elected Fellow, American College of Medial Informatics, 2007
  • Leadership Award, American Medical Informatics Association, 2005
  • United States Presidential Early Career Award for Scientists and Engineers, White House Office of Science Technology and Policy, 2000
Websites
Publications
  1. Kury F, Butler A, Yuan C, Fu LH, Sun Y, Liu H, Sim I, Carini S, Weng C. Chia, a large annotated corpus of clinical trial eligibility criteria. 2020. PMID: 32855408


  2. Kravitz RL, Aguilera A, Chen EJ, Choi YK, Hekler E, Karr C, Kim KK, Phatak S, Sarkar S, Schueller SM, Sim I, Yang J, Schmid CH. Feasibility, Acceptability, and Influence of mHealth-Supported N-of-1 Trials for Enhanced Cognitive and Emotional Well-Being in US Volunteers. 2020. PMID: 32695740


  3. Sim I, Stebbins M, Bierer BE, Butte AJ, Drazen J, Dzau V, Hernandez AF, Krumholz HM, Lo B, Munos B, Perakslis E, Rockhold F, Ross JS, Terry SF, Yamamoto KR, Zarin DA, Li R. Time for NIH to lead on data sharing. 2020. PMID: 32193313


  4. Sim I. Mobile Devices and Health. 2019. PMID: 31483966


  5. Odineal DD, Marois MT, Ward D, Schmid CH, Cabrera R, Sim I, Wang Y, Wilsey B, Duan N, Henry SG, Kravitz RL. Effect of Mobile Device-Assisted N-of-1 Trial Participation on Analgesic Prescribing for Chronic Pain: Randomized Controlled Trial. 2019. PMID: 31463686


  6. Hekler EB, Klasnja P, Chevance G, Golaszewski NM, Lewis D, Sim I. Why we need a small data paradigm. 2019. PMID: 31311528


  7. Li T, Saldanha IJ, Jap J, Smith BT, Canner J, Hutfless SM, Branch V, Carini S, Chan W, de Bruijn B, Wallace BC, Walsh SA, Whamond EJ, Murad MH, Sim I, Berlin JA, Lau J, Dickersin K, Schmid CH. A randomized trial provided new evidence on the accuracy and efficiency of traditional vs electronically annotated abstraction approaches in systematic reviews. 2019. PMID: 31302205


  8. Zhang X, Hailu B, Tabor DC, Gold R, Sayre MH, Sim I, Jean-Francois B, Casnoff CA, Cullen T, Thomas VA, Artiles L, Williams K, Le PT, Aklin CF, James R. Role of Health Information Technology in Addressing Health Disparities: Patient, Clinician, and System Perspectives. 2019. PMID: 31095049


  9. Kravitz RL, Sim I, Duan N. A Case for n-of-1 Trials-Reply. 2019. PMID: 30830192


  10. Kravitz RL, Schmid CH, Sim I. Finding Benefit in n-of-1 Trials-Reply. 2019. PMID: 30830195


  11. Fukushima M, Austin C, Sato N, Maruyama T, Navarro E, Rocca M, Demotes J, Haendel M, Volchenboum SL, Cowperthwaite M, Silverstein JC, Webb C, Sim I, Chase M, Speakman J, Augustine E, Ford DE, Kush R. The Global academic research organization network: Data sharing to cure diseases and enable learning health systems. 2018. PMID: 31245596


  12. Whitney RL, Ward DH, Marois MT, Schmid CH, Sim I, Kravitz RL. Patient Perceptions of Their Own Data in mHealth Technology-Enabled N-of-1 Trials for Chronic Pain: Qualitative Study. 2018. PMID: 30309834


  13. Kravitz RL, Schmid CH, Marois M, Wilsey B, Ward D, Hays RD, Duan N, Wang Y, MacDonald S, Jerant A, Servadio JL, Haddad D, Sim I. Effect of Mobile Device-Supported Single-Patient Multi-crossover Trials on Treatment of Chronic Musculoskeletal Pain: A Randomized Clinical Trial. 2018. PMID: 30193253


  14. Kumar S, Abowd G, Abraham WT, al'Absi M, Chau DHP, Ertin E, Estrin D, Ganesan D, Hnat T, Hossain SM, Ives Z, Kerr J, Marlin BM, Murphy S, Rehg JM, Nahum-Shani I, Shetty V, Sim I, Spring B, Srivastava M, Wetter D. Center of Excellence for Mobile Sensor Data-to-Knowledge (MD2K). Volume 16 of Issue 2. 2017. PMID: 29276451


  15. Saldanha IJ, Schmid CH, Lau J, Dickersin K, Berlin JA, Jap J, Smith BT, Carini S, Chan W, De Bruijn B, Wallace BC, Hutfless SM, Sim I, Murad MH, Walsh SA, Whamond EJ, Li T. Evaluating Data Abstraction Assistant, a novel software application for data abstraction during systematic reviews: protocol for a randomized controlled trial. Volume 5 of Issue 1. 2016. PMID: 27876082


  16. Bierer BE, Li R, Barnes M, Sim I. A Global, Neutral Platform for Sharing Trial Data. Volume 374 of Issue 25. 2016. PMID: 27168194


  17. He Z, Ryan P, Hoxha J, Wang S, Carini S, Sim I, Weng C. Multivariate analysis of the population representativeness of related clinical studies. Volume 60. 2016. PMID: 26820188


  18. Elliott JH, Grimshaw J, Altman R, Bero L, Goodman SN, Henry D, Macleod M, Tovey D, Tugwell P, White H, Sim I. Informatics: Make sense of health data. Volume 527 of Issue 7576. 2015. PMID: 26536942


  19. Kumar S, Abowd GD, Abraham WT, al'Absi M, Beck JG, Chau DH, Condie T, Conroy DE, Ertin E, Estrin D, Ganesan D, Lam C, Marlin B, Marsh CB, Murphy SA, Nahum-Shani I, Patrick K, Rehg JM, Sharmin M, Shetty V, Sim I, Spring B, Srivastava M, Wetter DW. Center of excellence for mobile sensor data-to-knowledge (MD2K). Volume 22 of Issue 6. 2015. PMID: 26555017


  20. Barr C, Marois M, Sim I, Schmid CH, Wilsey B, Ward D, Duan N, Hays RD, Selsky J, Servadio J, Schwartz M, Dsouza C, Dhammi N, Holt Z, Baquero V, MacDonald S, Jerant A, Sprinkle R, Kravitz RL. The PREEMPT study - evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial. Volume 16. 2015. PMID: 25881274


  21. He Z, Carini S, Sim I, Weng C. Visual aggregate analysis of eligibility features of clinical trials. Volume 54. 2015. PMID: 25615940


  22. Ross J, Neylan T, Weiner M, Chao L, Samuelson K, Sim I. Towards Constructing a New Taxonomy for Psychiatry Using Self-reported Symptoms. Volume 216. 2015. PMID: 26262149


  23. He Z, Carini S, Hao T, Sim I, Weng C. A method for analyzing commonalities in clinical trial target populations. Volume 2014. 2014. PMID: 25954450


  24. Brennan PF, Valdez R, Alexander G, Arora S, Bernstam EV, Edmunds M, Kirienko N, Martin RD, Sim I, Skiba D, Rosenbloom T. Patient-centered care, collaboration, communication, and coordination: a report from AMIA's 2013 Policy Meeting. Volume 22 of Issue e1. 2014. PMID: 25359545


  25. DePasse JW, Chen CE, Sawyer A, Jethwani K, Sim I. Academic Medical Centers as digital health catalysts. Volume 2 of Issue 3. 2014. PMID: 26250503


  26. Sim I, Tu SW, Carini S, Lehmann HP, Pollock BH, Peleg M, Wittkowski KM. The Ontology of Clinical Research (OCRe): an informatics foundation for the science of clinical research. Volume 52. 2013. PMID: 24239612


  27. Roumiantseva D, Carini S, Sim I, Wagner TH. Sponsorship and design characteristics of trials registered in ClinicalTrials.gov. Volume 34 of Issue 2. 2013. PMID: 23380028


  28. Ochs C, Agrawal A, Perl Y, Halper M, Tu SW, Carini S, Sim I, Noy N, Musen M, Geller J. Deriving an abstraction network to support quality assurance in OCRe. Volume 2012. 2012. PMID: 23304341


  29. Sim I, Carini S, Tu SW, Detwiler LT, Brinkley J, Mollah SA, Burke K, Lehmann HP, Chakraborty S, Wittkowski KM, Pollock BH, Johnson TM, Huser V. Ontology-based federated data access to human studies information. Volume 2012. 2012. PMID: 23304360


  30. Chen C, Haddad D, Selsky J, Hoffman JE, Kravitz RL, Estrin DE, Sim I. Making sense of mobile health data: an open architecture to improve individual- and population-level health. Volume 14 of Issue 4. 2012. PMID: 22875563


  31. Boland MR, Tu SW, Carini S, Sim I, Weng C. EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria. Volume 2012. 2012. PMID: 22779055


  32. Bhavnani SK, Carini S, Ross J, Sim I. Network analysis of clinical trials on depression: implications for comparative effectiveness research. Volume 2010. 2010. PMID: 21346939


  33. Estrin D, Sim I. Health care delivery. Open mHealth architecture: an engine for health care innovation. Volume 330 of Issue 6005. 2010. PMID: 21051617


  34. Kiritchenko S, de Bruijn B, Carini S, Martin J, Sim I. ExaCT: automatic extraction of clinical trial characteristics from journal publications. Volume 10. 2010. PMID: 20920176


  35. Tu SW, Peleg M, Carini S, Bobak M, Ross J, Rubin D, Sim I. A practical method for transforming free-text eligibility criteria into computable criteria. Volume 44 of Issue 2. 2010. PMID: 20851207


  36. Ross J, Tu S, Carini S, Sim I. Analysis of eligibility criteria complexity in clinical trials. Volume 2010. 2010. PMID: 21347148


  37. Wynden R, Weiner MG, Sim I, Gabriel D, Casale M, Carini S, Hastings S, Ervin D, Tu S, Gennari JH, Anderson N, Mobed K, Lakshminarayanan P, Massary M, Cucina RJ. Ontology mapping and data discovery for the translational investigator. Volume 2010. 2010. PMID: 21347152


  38. Sim I, Carini S, Tu S, Wynden R, Pollock BH, Mollah SA, Gabriel D, Hagler HK, Scheuermann RH, Lehmann HP, Wittkowski KM, Nahm M, Bakken S. The human studies database project: federating human studies design data using the ontology of clinical research. Volume 2010. 2010. PMID: 21347149


  39. Weng C, Tu SW, Sim I, Richesson R. Formal representation of eligibility criteria: a literature review. Volume 43 of Issue 3. 2009. PMID: 20034594


  40. Carini S, Pollock BH, Lehmann HP, Bakken S, Barbour EM, Gabriel D, Hagler HK, Harper CR, Mollah SA, Nahm M, Nguyen HH, Scheuermann RH, Sim I. Development and evaluation of a study design typology for human research. Volume 2009. 2009. PMID: 20351827


  41. Moja LP, Moschetti I, Nurbhai M, Compagnoni A, Liberati A, Grimshaw JM, Chan AW, Dickersin K, Krleza-Jeric K, Moher D, Sim I, Volmink J. Compliance of clinical trial registries with the World Health Organization minimum data set: a survey. Volume 10. 2009. PMID: 19624821


  42. Bernstam EV, Hersh WR, Johnson SB, Chute CG, Nguyen H, Sim I, Nahm M, Weiner MG, Miller P, DiLaura RP, Overcash M, Lehmann HP, Eichmann D, Athey BD, Scheuermann RH, Anderson N, Starren J, Harris PA, Smith JW, Barbour E, Silverstein JC, Krusch DA, Nagarajan R, Becich MJ. Synergies and distinctions between computational disciplines in biomedical research: perspective from the Clinical andTranslational Science Award programs. Volume 84 of Issue 7. 2009. PMID: 19550198


  43. Bernstam EV, Hersh WR, Sim I, Eichmann D, Silverstein JC, Smith JW, Becich MJ. Unintended consequences of health information technology: a need for biomedical informatics. Volume 43 of Issue 5. 2009. PMID: 19508898


  44. Sim I, Chute CG, Lehmann H, Nagarajan R, Nahm M, Scheuermann RH. Keeping raw data in context. Volume 323 of Issue 5915. 2009. PMID: 19197039


  45. Karp PD, Sherlock G, Gerlt JA, Sim I, Paulsen I, Babbitt PC, Laderoute K, Hunter L, Sternberg P, Wooley J, Bourne PE. Changes to NIH grant system may backfire. Volume 322 of Issue 5905. 2008. PMID: 19023064


  46. Hernandez ME, Carini S, Storey MA, Sim I. An interactive tool for visualizing design heterogeneity in clinical trials. 2008. PMID: 18998925


  47. de Bruijn B, Carini S, Kiritchenko S, Martin J, Sim I. Automated information extraction of key trial design elements from clinical trial publications. 2008. PMID: 18999067


  48. Speedie SM, Taweel A, Sim I, Arvanitis TN, Arvanitis T, Delaney B, Peterson KA. Characterizing primary care research: PCROM versus BRIDG. 2008. PMID: 18998919


  49. Lee K, Bacchetti P, Sim I. Publication of clinical trials supporting successful new drug applications: a literature analysis. Volume 5 of Issue 9. 2008. PMID: 18816163


  50. Speedie SM, Taweel A, Sim I, Arvanitis TN, Delaney B, Peterson KA. The Primary Care Research Object Model (PCROM): a computable information model for practice-based primary care research. Volume 15 of Issue 5. 2008. PMID: 18579829


  51. Ghersi D, Clarke M, Berlin J, Gülmezoglu A, Kush R, Lumbiganon P, Moher D, Rockhold F, Sim I, Wager E. Reporting the findings of clinical trials: a discussion paper. Volume 86 of Issue 6. 2008. PMID: 18568282


  52. Sim I. Trial registration for public trust: making the case for medical devices. Volume 23 Suppl 1. 2008. PMID: 18095047


  53. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. [Principles of the international registry of protocols and clinical trial results based on health interventions in human beings: Ottawa Declaration (part 1)]. Volume 19 of Issue 6. 2006. PMID: 16968596


  54. Sim I, Chan AW, Gülmezoglu AM, Evans T, Pang T. Clinical trial registration: transparency is the watchword. Volume 367 of Issue 9523. 2006. PMID: 16714166


  55. Chan AW, Sim I, Gülmezoglu AM, Unterlerchner P, Karam G, Pang T. Assessing clinical trial results. Volume 312 of Issue 5772. 2006. PMID: 16634140


  56. Gülmezoglu AM, Sim I. International clinical trial registration: any progress? Volume 118 of Issue 1-2. 2006. PMID: 16489516


  57. Berlin A, Sorani M, Sim I. A taxonomic description of computer-based clinical decision support systems. Volume 39 of Issue 6. 2006. PMID: 16442854


  58. Rubin DL, Lewis SE, Mungall CJ, Misra S, Westerfield M, Ashburner M, Sim I, Chute CG, Solbrig H, Storey MA, Smith B, Day-Richter J, Noy NF, Musen MA. National Center for Biomedical Ontology: advancing biomedicine through structured organization of scientific knowledge. Volume 10 of Issue 2. 2006. PMID: 16901225


  59. Sim I, Detmer DE. Beyond trial registration: a global trial bank for clinical trial reporting. Volume 2 of Issue 11. 2005. PMID: 16220999


  60. Miller RH, West C, Brown TM, Sim I, Ganchoff C. The value of electronic health records in solo or small group practices. Volume 24 of Issue 5. 2005. PMID: 16162555


  61. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1). Volume 330 of Issue 7497. 2005. PMID: 15845980


  62. Sim I, Cummings SR. Quantifying the gap between proof and practice. Volume 8 of Issue 4. 2004. PMID: 16379955


  63. Miller RH, Sim I. Physicians' use of electronic medical records: barriers and solutions. Volume 23 of Issue 2. 2004. PMID: 15046136


  64. Berlin A, Sorani M, Sim I. Characteristics of outpatient clinical decision support systems: a taxonomic description. Volume 107 of Issue Pt 1. 2004. PMID: 15360878


  65. Miller RH, Sim I, Newman J. Electronic medical records in solo/small groups: a qualitative study of physician user types. Volume 107 of Issue Pt 1. 2004. PMID: 15360895


  66. Cuadros J, Sim I. EyePACS: an open source clinical communication system for eye care. Volume 107 of Issue Pt 1. 2004. PMID: 15360804


  67. Sim I, Carini S, Olasov B, Jeng S. Trial bank publishing: phase I results. Volume 107 of Issue Pt 2. 2004. PMID: 15361060


  68. Sim I, Cummings SR. A new framework for describing and quantifying the gap between proof and practice. Volume 41 of Issue 8. 2003. PMID: 12886168


  69. Sim I, Berlin A. A framework for classifying decision support systems. 2003. PMID: 14728243


  70. Sim I, Sanders GD, McDonald KM. Evidence-based practice for mere mortals: the role of informatics and health services research. Volume 17 of Issue 4. 2002. PMID: 11972727


  71. Linder JA, Sim I. Antibiotic treatment of acute bronchitis in smokers: a systematic review. Volume 17 of Issue 3. 2002. PMID: 11929510


  72. Sim I, Gorman P, Greenes RA, Haynes RB, Kaplan B, Lehmann H, Tang PC. Clinical decision support systems for the practice of evidence-based medicine. 2001. PMID: 11687560


  73. Sim I, Owens DK, Lavori PW, Rennels GD. Electronic trial banks: a complementary method for reporting randomized trials. 2000. PMID: 11059477


  74. Sim I, Lavori P. Meta-analyses and large randomized, controlled trials. Volume 338 of Issue 1. 1998. PMID: 9424568


  75. Sim I, McDonald KM, Lavori PW, Norbutas CM, Hlatky MA. Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death. Volume 96 of Issue 9. 1997. PMID: 9386144


  76. Sim I, Hlatky MA. Growing pains of meta-analysis. Volume 313 of Issue 7059. 1996. PMID: 8819428


  77. Sim I, Rennels G. A trial bank model for the publication of clinical trials. 1995. PMID: 8563415


  78. Burcham TS, Sim I, Bolin LM, Shooter EM. The NGF complex from the African rat Mastomys natalensis. Volume 16 of Issue 6. 1991. PMID: 1791910


  79. Manchand PS, Cerruti RL, Martin JA, Hill CH, Merrett JH, Keech E, Belshe RB, Connell EV, Sim IS. Synthesis and antiviral activity of metabolites of rimantadine. 1990. PMID: 2362279


  80. Lepock JR, Cheng KH, Al-Qysi H, Sim I, Koch CJ, Kruuv J. Hyperthermia-induced inhibition of respiration and mitochondrial protein denaturation in CHL cells. Volume 3 of Issue 2. 1987. PMID: 3036971


  81. Frankfurt M, Siegel RA, Sim I, Wuttke W. Estrous cycle variations in cholecystokinin and substance P concentrations in discrete areas of the rat brain. Volume 42 of Issue 3. 1986. PMID: 2419781


  82. Frankfurt M, Siegel RA, Sim I, Wuttke W. Cholecystokinin and substance P concentrations in discrete areas of the rat brain: sex differences. Volume 358 of Issue 1-2. 1985. PMID: 2416392