Ida Sim, PhD, MD


General Internal Medicine, General Internal Medicine UCSF Health

Ida Sim, MD, PhD is a primary care physician, informatics researcher, and entrepreneur. She is a Professor of Medicine at the University of California, San Francisco, where she co-directs Informatics and Research Innovation at UCSF's Clinical and Translational Sciences Institute, and is Director of Digital Health for the Division of General Internal Medicine. Dr. Sim is a global leader in the technology and policy of large-scale health data sharing.

She is a co-founder of Open mHealth, a non-profit organization that is breaking down barriers to mobile health app and data integration through an open software architecture. Open mHealth is an official working group of the IEEE Standards Association and soon to be a global IEEE standard. Dr. Sim has multiple grants from NIH, NSF, and AHRQ on mobile health methodology and digital health for primary care. In 2019, she co-developed CommonHealth, an open source software suite bringing to the Android ecosystem the equivalent of Apple Health's ability to access and share EHR data.

Dr. Sim is also co-founder of Vivli, the world's largest data sharing platform for participant-level clinical trial data. In 2005, she was the founding Project Coordinator of the World Health Organization's International Clinical Trials Registry Platform, where she led the establishment of the first global policy on clinical trial registration.

Dr. Sim has served on multiple advisory committees on health information infrastructure for clinical care and research, including committees of the National Research Council and National Academy of Medicine. She is a recipient of the United States Presidential Early Career Award for Scientists and Engineers (PECASE), a Fellow of the American College of Medical Informatics, and a member of the American Society for Clinical Investigation.

1997 - Fellowship, Health Services Research, Stanford University
PhD, 1997 - Medical Informatics, Stanford University
1993 - Primary Care Internal Medicine Residency, Massachussetts General Hospital
M.D., 1990 - , Stanford University
Honors and Awards
  • Elected Member, American Society for Clinical Investigation, 2010
  • Elected Fellow, American College of Medial Informatics, 2007
  • Leadership Award, American Medical Informatics Association, 2005
  • United States Presidential Early Career Award for Scientists and Engineers, White House Office of Science Technology and Policy, 2000
  1. Kury F, Butler A, Yuan C, Fu LH, Sun Y, Liu H, Sim I, Carini S, Weng C. Chia, a large annotated corpus of clinical trial eligibility criteria. 2020. PMID: 32855408

  2. Kravitz RL, Aguilera A, Chen EJ, Choi YK, Hekler E, Karr C, Kim KK, Phatak S, Sarkar S, Schueller SM, Sim I, Yang J, Schmid CH. Feasibility, Acceptability, and Influence of mHealth-Supported N-of-1 Trials for Enhanced Cognitive and Emotional Well-Being in US Volunteers. 2020. PMID: 32695740

  3. Sim I, Stebbins M, Bierer BE, Butte AJ, Drazen J, Dzau V, Hernandez AF, Krumholz HM, Lo B, Munos B, Perakslis E, Rockhold F, Ross JS, Terry SF, Yamamoto KR, Zarin DA, Li R. Time for NIH to lead on data sharing. 2020. PMID: 32193313

  4. Sim I. Mobile Devices and Health. 2019. PMID: 31483966

  5. Odineal DD, Marois MT, Ward D, Schmid CH, Cabrera R, Sim I, Wang Y, Wilsey B, Duan N, Henry SG, Kravitz RL. Effect of Mobile Device-Assisted N-of-1 Trial Participation on Analgesic Prescribing for Chronic Pain: Randomized Controlled Trial. 2019. PMID: 31463686

  6. Hekler EB, Klasnja P, Chevance G, Golaszewski NM, Lewis D, Sim I. Why we need a small data paradigm. 2019. PMID: 31311528

  7. Li T, Saldanha IJ, Jap J, Smith BT, Canner J, Hutfless SM, Branch V, Carini S, Chan W, de Bruijn B, Wallace BC, Walsh SA, Whamond EJ, Murad MH, Sim I, Berlin JA, Lau J, Dickersin K, Schmid CH. A randomized trial provided new evidence on the accuracy and efficiency of traditional vs electronically annotated abstraction approaches in systematic reviews. 2019. PMID: 31302205

  8. Zhang X, Hailu B, Tabor DC, Gold R, Sayre MH, Sim I, Jean-Francois B, Casnoff CA, Cullen T, Thomas VA, Artiles L, Williams K, Le PT, Aklin CF, James R. Role of Health Information Technology in Addressing Health Disparities: Patient, Clinician, and System Perspectives. 2019. PMID: 31095049

  9. Kravitz RL, Sim I, Duan N. A Case for n-of-1 Trials-Reply. 2019. PMID: 30830192

  10. Kravitz RL, Schmid CH, Sim I. Finding Benefit in n-of-1 Trials-Reply. 2019. PMID: 30830195

  11. Fukushima M, Austin C, Sato N, Maruyama T, Navarro E, Rocca M, Demotes J, Haendel M, Volchenboum SL, Cowperthwaite M, Silverstein JC, Webb C, Sim I, Chase M, Speakman J, Augustine E, Ford DE, Kush R. The Global academic research organization network: Data sharing to cure diseases and enable learning health systems. 2018. PMID: 31245596

  12. Whitney RL, Ward DH, Marois MT, Schmid CH, Sim I, Kravitz RL. Patient Perceptions of Their Own Data in mHealth Technology-Enabled N-of-1 Trials for Chronic Pain: Qualitative Study. 2018. PMID: 30309834

  13. Kravitz RL, Schmid CH, Marois M, Wilsey B, Ward D, Hays RD, Duan N, Wang Y, MacDonald S, Jerant A, Servadio JL, Haddad D, Sim I. Effect of Mobile Device-Supported Single-Patient Multi-crossover Trials on Treatment of Chronic Musculoskeletal Pain: A Randomized Clinical Trial. 2018. PMID: 30193253

  14. Kumar S, Abowd G, Abraham WT, al'Absi M, Chau DHP, Ertin E, Estrin D, Ganesan D, Hnat T, Hossain SM, Ives Z, Kerr J, Marlin BM, Murphy S, Rehg JM, Nahum-Shani I, Shetty V, Sim I, Spring B, Srivastava M, Wetter D. Center of Excellence for Mobile Sensor Data-to-Knowledge (MD2K). Volume 16 of Issue 2. 2017. PMID: 29276451

  15. Saldanha IJ, Schmid CH, Lau J, Dickersin K, Berlin JA, Jap J, Smith BT, Carini S, Chan W, De Bruijn B, Wallace BC, Hutfless SM, Sim I, Murad MH, Walsh SA, Whamond EJ, Li T. Evaluating Data Abstraction Assistant, a novel software application for data abstraction during systematic reviews: protocol for a randomized controlled trial. Volume 5 of Issue 1. 2016. PMID: 27876082

  16. Bierer BE, Li R, Barnes M, Sim I. A Global, Neutral Platform for Sharing Trial Data. Volume 374 of Issue 25. 2016. PMID: 27168194

  17. He Z, Ryan P, Hoxha J, Wang S, Carini S, Sim I, Weng C. Multivariate analysis of the population representativeness of related clinical studies. Volume 60. 2016. PMID: 26820188

  18. Elliott JH, Grimshaw J, Altman R, Bero L, Goodman SN, Henry D, Macleod M, Tovey D, Tugwell P, White H, Sim I. Informatics: Make sense of health data. Volume 527 of Issue 7576. 2015. PMID: 26536942

  19. Kumar S, Abowd GD, Abraham WT, al'Absi M, Beck JG, Chau DH, Condie T, Conroy DE, Ertin E, Estrin D, Ganesan D, Lam C, Marlin B, Marsh CB, Murphy SA, Nahum-Shani I, Patrick K, Rehg JM, Sharmin M, Shetty V, Sim I, Spring B, Srivastava M, Wetter DW. Center of excellence for mobile sensor data-to-knowledge (MD2K). Volume 22 of Issue 6. 2015. PMID: 26555017

  20. Barr C, Marois M, Sim I, Schmid CH, Wilsey B, Ward D, Duan N, Hays RD, Selsky J, Servadio J, Schwartz M, Dsouza C, Dhammi N, Holt Z, Baquero V, MacDonald S, Jerant A, Sprinkle R, Kravitz RL. The PREEMPT study - evaluating smartphone-assisted n-of-1 trials in patients with chronic pain: study protocol for a randomized controlled trial. Volume 16. 2015. PMID: 25881274

  21. He Z, Carini S, Sim I, Weng C. Visual aggregate analysis of eligibility features of clinical trials. Volume 54. 2015. PMID: 25615940

  22. Ross J, Neylan T, Weiner M, Chao L, Samuelson K, Sim I. Towards Constructing a New Taxonomy for Psychiatry Using Self-reported Symptoms. Volume 216. 2015. PMID: 26262149

  23. He Z, Carini S, Hao T, Sim I, Weng C. A method for analyzing commonalities in clinical trial target populations. Volume 2014. 2014. PMID: 25954450

  24. Brennan PF, Valdez R, Alexander G, Arora S, Bernstam EV, Edmunds M, Kirienko N, Martin RD, Sim I, Skiba D, Rosenbloom T. Patient-centered care, collaboration, communication, and coordination: a report from AMIA's 2013 Policy Meeting. Volume 22 of Issue e1. 2014. PMID: 25359545

  25. DePasse JW, Chen CE, Sawyer A, Jethwani K, Sim I. Academic Medical Centers as digital health catalysts. Volume 2 of Issue 3. 2014. PMID: 26250503

  26. Sim I, Tu SW, Carini S, Lehmann HP, Pollock BH, Peleg M, Wittkowski KM. The Ontology of Clinical Research (OCRe): an informatics foundation for the science of clinical research. Volume 52. 2013. PMID: 24239612

  27. Roumiantseva D, Carini S, Sim I, Wagner TH. Sponsorship and design characteristics of trials registered in Volume 34 of Issue 2. 2013. PMID: 23380028

  28. Ochs C, Agrawal A, Perl Y, Halper M, Tu SW, Carini S, Sim I, Noy N, Musen M, Geller J. Deriving an abstraction network to support quality assurance in OCRe. Volume 2012. 2012. PMID: 23304341

  29. Sim I, Carini S, Tu SW, Detwiler LT, Brinkley J, Mollah SA, Burke K, Lehmann HP, Chakraborty S, Wittkowski KM, Pollock BH, Johnson TM, Huser V. Ontology-based federated data access to human studies information. Volume 2012. 2012. PMID: 23304360

  30. Chen C, Haddad D, Selsky J, Hoffman JE, Kravitz RL, Estrin DE, Sim I. Making sense of mobile health data: an open architecture to improve individual- and population-level health. Volume 14 of Issue 4. 2012. PMID: 22875563

  31. Boland MR, Tu SW, Carini S, Sim I, Weng C. EliXR-TIME: A Temporal Knowledge Representation for Clinical Research Eligibility Criteria. Volume 2012. 2012. PMID: 22779055

  32. Bhavnani SK, Carini S, Ross J, Sim I. Network analysis of clinical trials on depression: implications for comparative effectiveness research. Volume 2010. 2010. PMID: 21346939

  33. Estrin D, Sim I. Health care delivery. Open mHealth architecture: an engine for health care innovation. Volume 330 of Issue 6005. 2010. PMID: 21051617

  34. Kiritchenko S, de Bruijn B, Carini S, Martin J, Sim I. ExaCT: automatic extraction of clinical trial characteristics from journal publications. Volume 10. 2010. PMID: 20920176

  35. Tu SW, Peleg M, Carini S, Bobak M, Ross J, Rubin D, Sim I. A practical method for transforming free-text eligibility criteria into computable criteria. Volume 44 of Issue 2. 2010. PMID: 20851207

  36. Ross J, Tu S, Carini S, Sim I. Analysis of eligibility criteria complexity in clinical trials. Volume 2010. 2010. PMID: 21347148

  37. Wynden R, Weiner MG, Sim I, Gabriel D, Casale M, Carini S, Hastings S, Ervin D, Tu S, Gennari JH, Anderson N, Mobed K, Lakshminarayanan P, Massary M, Cucina RJ. Ontology mapping and data discovery for the translational investigator. Volume 2010. 2010. PMID: 21347152

  38. Sim I, Carini S, Tu S, Wynden R, Pollock BH, Mollah SA, Gabriel D, Hagler HK, Scheuermann RH, Lehmann HP, Wittkowski KM, Nahm M, Bakken S. The human studies database project: federating human studies design data using the ontology of clinical research. Volume 2010. 2010. PMID: 21347149

  39. Weng C, Tu SW, Sim I, Richesson R. Formal representation of eligibility criteria: a literature review. Volume 43 of Issue 3. 2009. PMID: 20034594

  40. Carini S, Pollock BH, Lehmann HP, Bakken S, Barbour EM, Gabriel D, Hagler HK, Harper CR, Mollah SA, Nahm M, Nguyen HH, Scheuermann RH, Sim I. Development and evaluation of a study design typology for human research. Volume 2009. 2009. PMID: 20351827

  41. Moja LP, Moschetti I, Nurbhai M, Compagnoni A, Liberati A, Grimshaw JM, Chan AW, Dickersin K, Krleza-Jeric K, Moher D, Sim I, Volmink J. Compliance of clinical trial registries with the World Health Organization minimum data set: a survey. Volume 10. 2009. PMID: 19624821

  42. Bernstam EV, Hersh WR, Johnson SB, Chute CG, Nguyen H, Sim I, Nahm M, Weiner MG, Miller P, DiLaura RP, Overcash M, Lehmann HP, Eichmann D, Athey BD, Scheuermann RH, Anderson N, Starren J, Harris PA, Smith JW, Barbour E, Silverstein JC, Krusch DA, Nagarajan R, Becich MJ. Synergies and distinctions between computational disciplines in biomedical research: perspective from the Clinical andTranslational Science Award programs. Volume 84 of Issue 7. 2009. PMID: 19550198

  43. Bernstam EV, Hersh WR, Sim I, Eichmann D, Silverstein JC, Smith JW, Becich MJ. Unintended consequences of health information technology: a need for biomedical informatics. Volume 43 of Issue 5. 2009. PMID: 19508898

  44. Sim I, Chute CG, Lehmann H, Nagarajan R, Nahm M, Scheuermann RH. Keeping raw data in context. Volume 323 of Issue 5915. 2009. PMID: 19197039

  45. Karp PD, Sherlock G, Gerlt JA, Sim I, Paulsen I, Babbitt PC, Laderoute K, Hunter L, Sternberg P, Wooley J, Bourne PE. Changes to NIH grant system may backfire. Volume 322 of Issue 5905. 2008. PMID: 19023064

  46. Hernandez ME, Carini S, Storey MA, Sim I. An interactive tool for visualizing design heterogeneity in clinical trials. 2008. PMID: 18998925

  47. de Bruijn B, Carini S, Kiritchenko S, Martin J, Sim I. Automated information extraction of key trial design elements from clinical trial publications. 2008. PMID: 18999067

  48. Speedie SM, Taweel A, Sim I, Arvanitis TN, Arvanitis T, Delaney B, Peterson KA. Characterizing primary care research: PCROM versus BRIDG. 2008. PMID: 18998919

  49. Lee K, Bacchetti P, Sim I. Publication of clinical trials supporting successful new drug applications: a literature analysis. Volume 5 of Issue 9. 2008. PMID: 18816163

  50. Speedie SM, Taweel A, Sim I, Arvanitis TN, Delaney B, Peterson KA. The Primary Care Research Object Model (PCROM): a computable information model for practice-based primary care research. Volume 15 of Issue 5. 2008. PMID: 18579829

  51. Ghersi D, Clarke M, Berlin J, Gülmezoglu A, Kush R, Lumbiganon P, Moher D, Rockhold F, Sim I, Wager E. Reporting the findings of clinical trials: a discussion paper. Volume 86 of Issue 6. 2008. PMID: 18568282

  52. Sim I. Trial registration for public trust: making the case for medical devices. Volume 23 Suppl 1. 2008. PMID: 18095047

  53. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. [Principles of the international registry of protocols and clinical trial results based on health interventions in human beings: Ottawa Declaration (part 1)]. Volume 19 of Issue 6. 2006. PMID: 16968596

  54. Sim I, Chan AW, Gülmezoglu AM, Evans T, Pang T. Clinical trial registration: transparency is the watchword. Volume 367 of Issue 9523. 2006. PMID: 16714166

  55. Chan AW, Sim I, Gülmezoglu AM, Unterlerchner P, Karam G, Pang T. Assessing clinical trial results. Volume 312 of Issue 5772. 2006. PMID: 16634140

  56. Gülmezoglu AM, Sim I. International clinical trial registration: any progress? Volume 118 of Issue 1-2. 2006. PMID: 16489516

  57. Berlin A, Sorani M, Sim I. A taxonomic description of computer-based clinical decision support systems. Volume 39 of Issue 6. 2006. PMID: 16442854

  58. Rubin DL, Lewis SE, Mungall CJ, Misra S, Westerfield M, Ashburner M, Sim I, Chute CG, Solbrig H, Storey MA, Smith B, Day-Richter J, Noy NF, Musen MA. National Center for Biomedical Ontology: advancing biomedicine through structured organization of scientific knowledge. Volume 10 of Issue 2. 2006. PMID: 16901225

  59. Sim I, Detmer DE. Beyond trial registration: a global trial bank for clinical trial reporting. Volume 2 of Issue 11. 2005. PMID: 16220999

  60. Miller RH, West C, Brown TM, Sim I, Ganchoff C. The value of electronic health records in solo or small group practices. Volume 24 of Issue 5. 2005. PMID: 16162555

  61. Krleza-Jeric K, Chan AW, Dickersin K, Sim I, Grimshaw J, Gluud C. Principles for international registration of protocol information and results from human trials of health related interventions: Ottawa statement (part 1). Volume 330 of Issue 7497. 2005. PMID: 15845980

  62. Sim I, Cummings SR. Quantifying the gap between proof and practice. Volume 8 of Issue 4. 2004. PMID: 16379955

  63. Miller RH, Sim I. Physicians' use of electronic medical records: barriers and solutions. Volume 23 of Issue 2. 2004. PMID: 15046136

  64. Berlin A, Sorani M, Sim I. Characteristics of outpatient clinical decision support systems: a taxonomic description. Volume 107 of Issue Pt 1. 2004. PMID: 15360878

  65. Miller RH, Sim I, Newman J. Electronic medical records in solo/small groups: a qualitative study of physician user types. Volume 107 of Issue Pt 1. 2004. PMID: 15360895

  66. Cuadros J, Sim I. EyePACS: an open source clinical communication system for eye care. Volume 107 of Issue Pt 1. 2004. PMID: 15360804

  67. Sim I, Carini S, Olasov B, Jeng S. Trial bank publishing: phase I results. Volume 107 of Issue Pt 2. 2004. PMID: 15361060

  68. Sim I, Cummings SR. A new framework for describing and quantifying the gap between proof and practice. Volume 41 of Issue 8. 2003. PMID: 12886168

  69. Sim I, Berlin A. A framework for classifying decision support systems. 2003. PMID: 14728243

  70. Sim I, Sanders GD, McDonald KM. Evidence-based practice for mere mortals: the role of informatics and health services research. Volume 17 of Issue 4. 2002. PMID: 11972727

  71. Linder JA, Sim I. Antibiotic treatment of acute bronchitis in smokers: a systematic review. Volume 17 of Issue 3. 2002. PMID: 11929510

  72. Sim I, Gorman P, Greenes RA, Haynes RB, Kaplan B, Lehmann H, Tang PC. Clinical decision support systems for the practice of evidence-based medicine. 2001. PMID: 11687560

  73. Sim I, Owens DK, Lavori PW, Rennels GD. Electronic trial banks: a complementary method for reporting randomized trials. 2000. PMID: 11059477

  74. Sim I, Lavori P. Meta-analyses and large randomized, controlled trials. Volume 338 of Issue 1. 1998. PMID: 9424568

  75. Sim I, McDonald KM, Lavori PW, Norbutas CM, Hlatky MA. Quantitative overview of randomized trials of amiodarone to prevent sudden cardiac death. Volume 96 of Issue 9. 1997. PMID: 9386144

  76. Sim I, Hlatky MA. Growing pains of meta-analysis. Volume 313 of Issue 7059. 1996. PMID: 8819428

  77. Sim I, Rennels G. A trial bank model for the publication of clinical trials. 1995. PMID: 8563415

  78. Burcham TS, Sim I, Bolin LM, Shooter EM. The NGF complex from the African rat Mastomys natalensis. Volume 16 of Issue 6. 1991. PMID: 1791910

  79. Manchand PS, Cerruti RL, Martin JA, Hill CH, Merrett JH, Keech E, Belshe RB, Connell EV, Sim IS. Synthesis and antiviral activity of metabolites of rimantadine. 1990. PMID: 2362279

  80. Lepock JR, Cheng KH, Al-Qysi H, Sim I, Koch CJ, Kruuv J. Hyperthermia-induced inhibition of respiration and mitochondrial protein denaturation in CHL cells. Volume 3 of Issue 2. 1987. PMID: 3036971

  81. Frankfurt M, Siegel RA, Sim I, Wuttke W. Estrous cycle variations in cholecystokinin and substance P concentrations in discrete areas of the rat brain. Volume 42 of Issue 3. 1986. PMID: 2419781

  82. Frankfurt M, Siegel RA, Sim I, Wuttke W. Cholecystokinin and substance P concentrations in discrete areas of the rat brain: sex differences. Volume 358 of Issue 1-2. 1985. PMID: 2416392