Ethan Weiss, MD


Cardiology UCSF Health

CLINICAL INTERESTS: Dr. Ethan Weiss is a cardiologist specializing in general cardiology. His special interests include preventive cardiology, genetics of coronary disease, risk assessment, and heart disease in the young.

RESEARCH INTERESTS: In his research, Dr. Weiss uses genetic models to better understand the mechanism of metabolic disorders such as obesity, fatty liver disease, and diabetes. He also studies the blood clotting system and has interest in identifying novel ways to safely block clots associated with diseases such as heart attack and stroke without causing an increase in bleeding.

M.D., 1996 - School of Medicine, Johns Hopkins University
Clinical Fellowship, - School of Medicine - Cardiology, University of California, San Francisco
  1. Locke SR, Falkenhain K, Lowe DA, Lee T, Singer J, Weiss EJ, Little JP. Comparing the Keyto App and Device with Weight Watchers' WW App for Weight Loss: Protocol for a Randomized Trial. 2020. PMID: 32804087

  2. Panizza, Chloe E
    Wong, Michael C
    Kelly, Nisa
    Liu, Yong En
    Shvetsov, Yurii B
    Lowe, Dylan A
    Weiss, Ethan J
    Heymsfield, Steven B
    Kennedy, Samantha
    Boushey, Carol J
    Maskarinec, Gertraud
    Shepherd, John A. Diet Quality and Visceral Adiposity among a Multiethnic Population of Young, Middle, and Older Aged Adults 2020. PMID:

  3. Weiss EJ. Billy Idol. 2020. PMID: 32063587

  4. Corbit KC, Wilson CG, Lowe D, Tran JL, Vera NB, Clasquin M, Mattis AN, Weiss EJ. Adipocyte JAK2 mediates spontaneous metabolic liver disease and hepatocellular carcinoma. 2019. PMID: 31393852

  5. Corbit KC, Camporez JPG, Edmunds LR, Tran JL, Vera NB, Erion DM, Deo RC, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling. Volume 67 of Issue 2. 2017. PMID: 29203511

  6. Lee AP, Mulligan K, Schambelan M, Murphy EJ, Weiss EJ. Growth hormone receptor antagonism with pegvisomant in insulin resistant non-diabetic men: A phase II pilot study. Volume 6. 2017. PMID: 28713554

  7. Corbit KC, Camporez JP, Tran JL, Wilson CG, Lowe DA, Nordstrom SM, Ganeshan K, Perry RJ, Shulman GI, Jurczak MJ, Weiss EJ. Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance. Volume 2 of Issue 3. 2017. PMID: 28194444

  8. Wilson CG, Tran JL, Erion DM, Vera NB, Febbraio M, Weiss EJ. Hepatocyte-Specific Disruption of CD36 Attenuates Fatty Liver and Improves Insulin Sensitivity in HFD-Fed Mice. Volume 157 of Issue 2. 2015. PMID: 26650570

  9. Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ. Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH. Volume 27 of Issue 8. 2013. PMID: 23782652

  10. Hsue PY, Scherzer R, Grunfeld C, Nordstrom SM, Schnell A, Kohl LP, Nitta E, Martin JN, Deeks SG, Weiss EJ. HIV infection is associated with decreased thrombin generation. Volume 54 of Issue 8. 2012. PMID: 22438347

  11. Nordstrom SM, Tran JL, Sos BC, Wagner KU, Weiss EJ. Liver-derived IGF-I contributes to GH-dependent increases in lean mass and bone mineral density in mice with comparable levels of circulating GH. Volume 25 of Issue 7. 2011. PMID: 21527499

  12. Sos BC, Harris C, Nordstrom SM, Tran JL, Balázs M, Caplazi P, Febbraio M, Applegate MA, Wagner KU, Weiss EJ. Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2. Volume 121 of Issue 4. 2011. PMID: 21364286

  13. Williams MS, Weiss EJ, Sabatine MS, Simon DI, Bahou WF, Becker LC, Parise LV, Dauerman HL, French PA, Smyth SS, Becker RC. Genetic regulation of platelet receptor expression and function: application in clinical practice and drug development. Volume 30 of Issue 12. 2010. PMID: 21084706

  14. Nordstrom SM, Holliday BA, Sos BC, Smyth JW, Levy RE, Dukes JW, Lord ST, Weiss EJ. Increased thrombosis susceptibility and altered fibrin formation in STAT5-deficient mice. Volume 116 of Issue 25. 2010. PMID: 20823455

  15. Nordstrom SM, Weiss EJ. Sex differences in thrombosis. Volume 1 of Issue 1. 2008. PMID: 21083002

  16. Wong JH, Dukes J, Levy RE, Sos B, Mason SE, Fong TS, Weiss EJ. Sex differences in thrombosis in mice are mediated by sex-specific growth hormone secretion patterns. Volume 118 of Issue 8. 2008. PMID: 18618017

  17. Weiss EJ, Hamilton JR, Lease KE, Coughlin SR. Protection against thrombosis in mice lacking PAR3. Volume 100 of Issue 9. 2002. PMID: 12384423

  18. Sambrano GR, Weiss EJ, Zheng YW, Huang W, Coughlin SR. Role of thrombin signalling in platelets in haemostasis and thrombosis. 2001. PMID: 11544528

  19. Shapiro MJ, Weiss EJ, Faruqi TR, Coughlin SR. Protease-activated receptors 1 and 4 are shut off with distinct kinetics after activation by thrombin. 2000. PMID: 10837487

  20. Nakanishi-Matsui M, Zheng YW, Sulciner DJ, Weiss EJ, Ludeman MJ, Coughlin SR. PAR3 is a cofactor for PAR4 activation by thrombin. 2000. PMID: 10766244

  21. Goldschmidt-Clermont PJ, Coleman LD, Pham YM, Cooke GE, Shear WS, Weiss EJ, Kral BG, Moy TF, Yook RM, Blumenthal RS, Becker DM, Becker LC, Bray PF. Higher prevalence of GPIIIa PlA2 polymorphism in siblings of patients with premature coronary heart disease. Volume 123 of Issue 12. 1999. PMID: 10583927

  22. Bray PF, Weiss EJ, Tayback M, Goldschmidt-Clermont PJ. PlA1/A2 polymorphism of platelet glycoprotein IIIa and risk of cardiovascular disease. Volume 349 of Issue 9058. 1997. PMID: 9107268

  23. Vandervoort J, Weiss EJ, Somnay K, Tham TC, Wong RC, Carr-Locke DL. Self-expanding metal stent for obstructing adenocarcinoma of the sigmoid. Volume 44 of Issue 6. 1996. PMID: 8979071

  24. Weiss EJ, Bray PF, Tayback M, Schulman SP, Kickler TS, Becker LC, Weiss JL, Gerstenblith G, Goldschmidt-Clermont PJ. A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis. Volume 334 of Issue 17. 1996. PMID: 8598867

  25. Weiss EJ, Goldschmidt-Clermont PJ, Grigoryev D, Jin Y, Kickler TS, Bray PF. A monoclonal antibody (SZ21) specific for platelet GPIIIa distinguishes P1A1 from P1A2. Volume 46 of Issue 5. 1995. PMID: 8838346