David Klonoff, MD

Clinical Professor Volunteer

Endocrinology and Metabolism

David C. Klonoff, M.D. is an endocrinologist specializing in the development and use of diabetes technology. He is Medical Director of the Dorothy L. and James E. Frank Diabetes Research Institute of Mills-Peninsula Medical Center in San Mateo, California and a Clinical Professor of Medicine at UCSF. Dr. Klonoff received the American Diabetes Association’s 2019 Outstanding Physician Clinician Award. He received an FDA Director’s Special Citation Award in 2010 for outstanding contributions related to diabetes technology. In 2012 Dr. Klonoff was elected as a Fellow of the American Institute of Medical and Biological Engineering (AIMBE) and cited as among the top 2% of the world’s bioengineers for his engineering work in diabetes technology. He received the 2012 Gold Medal Oration and Distinguished Scientist Award from the Dr. Mohan’s Diabetes Specialities Centre and Madras Diabetes Research Foundation of Chennai, India. Dr. Klonoff was invited to speak to the US Congressional Diabetes Caucus in 2017, participate in the White House Health and Cybersecurity Roundtable in 2015, and speak at the European Parliament in 2010. He is the Founding Editor-in-Chief of Journal of Diabetes Science and Technology. He has authored over 280 publications in PubMed journals including four of the first ten articles on diabetes device cybersecurity. His h-index is 52. Dr. Klonoff has been a Principal Investigator on over 120 clinical trials of diabetes drugs and devices. He was the lead investigator for the largest multinational insulin study for Novo and for the first randomized controlled multicenter trial of an outpatient artificial pancreas product by Medtronic, whose results were published in the New England Journal of Medicine. He chaired the scientific advisory board for the first FDA-cleared insulin patch pump and participated in developing the first FDA-cleared dedicated diabetes telemedicine system. Dr. Klonoff coined the term “diabetes technology” and founded the Diabetes Technology Meeting and the Hospital Diabetes Meeting. He is senior editor of the first book about diabetes digital health. Dr. Klonoff has chaired or served on 59 grant review panels including for NIH, CDC, NASA, NSF, US Army, NOAA, ADA, and JDRF; plus agencies in 11 foreign countries. He is Chair of the Scientific Advisory Board of the TexasA&M/UCLA/FIU/Rice PATHS-UP Engineering Research Center and a member of the Scientific Advisory Board of the Singapore General Hospital Diabetes Clinic of the Future. He chaired the first and second CLSI POCT05 Performance Metrics for Continuous Interstitial Glucose Monitoring Panel, the Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline Panel, and the Continuous Ketone Monitoring Consensus Panel. Dr. Klonoff is a graduate of UC Berkeley, where he was elected to Phi Beta Kappa in his junior year, and UCSF Medical School, where he was elected to Alpha Omega Alpha in his junior year. His postgraduate training included two years at UCLA Hospital and three years at UCSF Hospitals. He is Chair of the IEEE 2621 Standards for Wireless Diabetes Device Security Assurance Committee and he chaired DTSec and DTMoSt, the world’s 1st and 2nd consensus medical device cybersecurity standards. For this work Dr. Klonoff was featured in an article in Wired Magazine.


PRESENT ACADEMIC AND PROFESSIONAL POSITION

2006-Present Editor-in-Chief, Journal of Diabetes Science and Technology
2000-Present Medical Director, Dorothy L. and James E. Frank Diabetes Research Institute,
Mills-Peninsula Medical Center, San Mateo, California
1995-Present Clinical Professor, Department of Medicine, U.C. San Francisco

EDUCATION

1972-1976 University of California at San Francisco: M.D.
1968-1972 University of California at Berkeley: B.S. in Genetics (with Highest Honors)

Education
Endocrinology Fellow, 1981 - Metabolic Research Unit, UC San Francisco
Resident, 1979 - Internal Medicine, UC San Francisco
Intern and Resident, 1978 - Internal Medicine, UCLA Hospital
MD, 1976 - School of Medicine, UC San Francisco
BS, 1972 - Genetics, UC Berkeley
Honors and Awards
  • Outstanding Physician-Clinician in Diabetes Award, American Diabetes Association, 2019
  • Visiting Professor, Tokyo University of Agriculture and Technology, Graduate School of Engineering, 2016
  • FRCP (Edin), Fellow of Royal College of Physicians of Edinburgh, 2014
  • Fellow AIMBE, American Institute of Medical and Biological Engineering, 2013
  • Gold Medal Oration Award, Madras (India) Diabetes Research Foundation, 2012
  • Director's Citation, FDA, 2010
  • FACP, American College of Physicians, 1991
  • Alpha Omega Alpha (Junior Year), UC San Francisco, 1975
  • Phi Beta Kappa (Junior Year), UC Berkeley, 1971
Websites
Publications
  1. Huang J, Yeung AM, Nguyen KT, Xu NY, Preiser JC, Rushakoff RJ, Seley JJ, Umpierrez GE, Wallia A, Drincic AT, Gianchandani R, Lansang MC, Masharani U, Mathioudakis N, Pasquel FJ, Schmidt S, Shah VN, Spanakis EK, Stuhr A, Treiber GM, Klonoff DC. Hospital Diabetes Meeting 2022. Journal of diabetes science and technology 2022. PMID: 35904143


  2. Klonoff DC, Nguyen KT, Xu NY, Gutierrez A, Espinoza JC, Vidmar AP. Use of Continuous Glucose Monitors by People Without Diabetes: An Idea Whose Time Has Come? Journal of diabetes science and technology 2022. PMID: 35856435


  3. Xu NY, Nguyen KT, Krouwer JS, Akturk HK, Shah VN, Klonoff DC. Retained Diabetes Devices-A Literature Review. Journal of diabetes science and technology 2022. PMID: 35787699


  4. Klonoff DC, Xu NY, Nguyen KT, Kerr D, Mehta C, Umpierrez GE, Brooks GA. Trimetazidine Blocks Lipid Oxidation-Should it be Repurposed for Prevention and Treatment of Diabetic Ketoacidosis? 2022. PMID: 35652624


  5. Weinstock RS, Bode BW, Garg SK, Klonoff DC, El Sanadi C, Geho WB, Muchmore DB, Penn MS. Reduced hypoglycaemia using liver-targeted insulin in individuals with type 1 diabetes. 2022. PMID: 35546449


  6. Xu NY, Nguyen KT, DuBord AY, Klonoff DC, Goldman JM, Shah SN, Spanakis EK, Madlock-Brown C, Sarlati S, Rafiq A, Wirth A, Kerr D, Khanna R, Weinstein S, Espinoza J. The Launch of the iCoDE Standard Project. 2022. PMID: 35533135


  7. Gessler S, Porsch U, Klonoff DC, Marquant M. A New Digital Point-of-Care Tool With Advanced Blood Glucose Measuring Technology. 2022. PMID: 35510612


  8. Xu NY, Nguyen KT, DuBord AY, Pickup J, Sherr JL, Teymourian H, Cengiz E, Ginsberg BH, Cobelli C, Ahn D, Bellazzi R, Bequette BW, Gandrud Pickett L, Parks L, Spanakis EK, Masharani U, Akturk HK, Melish JS, Kim S, Kang GE, Klonoff DC. Diabetes Technology Meeting 2021. 2022. PMID: 35499170


  9. Klonoff DC, Buckingham B, Christiansen JS, Montori VM, Tamborlane WV, Vigersky RA, Wolpert H. Corrigendum to: Continuous Glucose Monitoring: An Endocrine Society Clinical Practice Guideline. 2021. PMID: 34878114


  10. Kerr D, Klonoff D. Breakthrough technology for in-hospital glucose monitoring. 2022. PMID: 35378067


  11. Klonoff DC, Wang J, Rodbard D, Kohn MA, Li C, Liepmann D, Kerr D, Ahn D, Peters AL, Umpierrez GE, Seley JJ, Xu NY, Nguyen KT, Simonson G, Agus MSD, Al-Sofiani ME, Armaiz-Pena G, Bailey TS, Basu A, Battelino T, Bekele SY, Benhamou PY, Bequette BW, Blevins T, Breton MD, Castle JR, Chase JG, Chen KY, Choudhary P, Clements MA, Close KL, Cook CB, Danne T, Doyle FJ, Drincic A, Dungan KM, Edelman SV, Ejskjaer N, Espinoza JC, Fleming GA, Forlenza GP, Freckmann G, Galindo RJ, Gomez AM, Gutow HA, Heinemann L, Hirsch IB, Hoang TD, Hovorka R, Jendle JH, Ji L, Joshi SR, Joubert M, Koliwad SK, Lal RA, Lansang MC, Lee WA, Leelarathna L, Leiter LA, Lind M, Litchman ML, Mader JK, Mahoney KM, Mankovsky B, Masharani U, Mathioudakis NN, Mayorov A, Messler J, Miller JD, Mohan V, Nichols JH, Nørgaard K, O'Neal DN, Pasquel FJ, Philis-Tsimikas A, Pieber T, Phillip M, Polonsky WH, Pop-Busui R, Rayman G, Rhee EJ, Russell SJ, Shah VN, Sherr JL, Sode K, Spanakis EK, Wake DJ, Waki K, Wallia A, Weinberg ME, Wolpert H, Wright EE, Zilbermint M, Kovatchev B. A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings. 2022. PMID: 35348391


  12. Heinemann L, Nguyen KT, Xu NY, Gilbert GH, Klonoff DC. Treating an Unconscious Patient With Diabetes Wearing a Device Attached to Their Body. 2022. PMID: 35293265


  13. Meo SA, Meo AS, Al-Jassir FF, Klonoff DC. Omicron SARS-CoV-2 new variant: global prevalence and biological and clinical characteristics. 2021. PMID: 34982465


  14. Rajagopalan H, Lopez-Talavera JC, Klonoff DC, Cherrington AD. A Gut-Centric Model of Metabolic Homeostasis. 2021. PMID: 34697950


  15. Nguyen KT, Xu NY, Zhang JY, Shang T, DuBord AY, Heinemann L, Krisiunas EP, Stumpe T, Seid DA, Klonoff DC. Green Diabetes Summit 2021. 2021. PMID: 34672207


  16. Klonoff DC, Nguyen KT, Xu NY, Arnold MA. Noninvasive Glucose Monitoring: In God We Trust-All Others Bring Data. 2021. PMID: 34672216


  17. Pieber TR, Bajaj HS, Heller SR, Jia T, Khunti K, Klonoff DC, Ladelund S, Leiter LA, Wagner L, Philis-Tsimikas A. Impact of kidney function on the safety and efficacy of insulin degludec versus insulin glargine U300 in people with type 2 diabetes: A post hoc analysis of the CONCLUDE trial. 2021. PMID: 34605127


  18. Nguyen KT, Xu NY, Zhang JY, Heinemann L, Krisiunas EP, Stumpe T, Seid DA, Bonilla R, Bouret L, Burkot W, DuBord AY, Gold K, Pfützner A, Shang T, Klonoff DC. The Diabetes Technology Society Green Declaration. 2021. PMID: 34654334


  19. Nguyen KT, Xu NY, Zhang JY, Shang T, Basu A, Bergenstal RM, Castorino K, Chen KY, Kerr D, Koliwad SK, Laffel LM, Mathioudakis N, Midyett LK, Miller JD, Nichols JH, Pasquel FJ, Prahalad P, Prausnitz MR, Seley JJ, Sherr JL, Spanakis EK, Umpierrez GE, Wallia A, Klonoff DC. Continuous Ketone Monitoring Consensus Report 2021. 2021. PMID: 34605694


  20. Xu NY, Nguyen KT, Mehta C, Klonoff DC. Antioxidant-Induced Pseudohyperglycemia Due to Interference of Measurements by Blood Glucose Monitors. Journal of diabetes science and technology 2021. PMID: 34474582


  21. Klonoff DC, Bassock S, Engels E, Frederiksen M, Marber M, Qvist M, Sparre T, Snitker S. Semaglutide single-dose pen-injector: Post hoc analysis of summative usability testing for weight management. Diabetes, obesity & metabolism 2021. PMID: 34338402


  22. Zhang JY, Shang T, Krisiunas E, Liepmann D, Klonoff DC. The Availability of Sharps Disposal Bins: A Survey of Airports in California. Journal of diabetes science and technology 2021. PMID: 34459272


  23. Goldenberg RM, Aroda VR, Billings LK, Christiansen ASL, Meller Donatsky A, Parvaresh Rizi E, Podgorski G, Raslova K, Klonoff DC, Bergenstal RM. Effect of insulin degludec versus insulin glargine U100 on time in range: SWITCH PRO, a crossover study of basal insulin-treated adults with type 2 diabetes and risk factors for hypoglycaemia. Diabetes, obesity & metabolism 2021. PMID: 34322967


  24. Heinemann L, Klonoff DC. Input of Patients for New Diabetes Technology Products. Journal of diabetes science and technology 2021. PMID: 34384263


  25. Zhang JY, Shang T, Krisiunas E, Heinemann L, Liepmann D, Klonoff DC. The Need for Sharps Waste Disposal Guidelines for Commercial Airports. Journal of diabetes science and technology 2021. PMID: 34328026


  26. Meo SA, Abukhalaf AA, Alessa OM, Alarifi AS, Sami W, Klonoff DC. Effect of Environmental Pollutants PM2.5, CO, NO2, and O3 on the Incidence and Mortality of SARS-CoV-2 Infection in Five Regions of the USA. International journal of environmental research and public health 2021. PMID: 34360104


  27. Spanakis EK, Yoo A, Ajayi ON, Siddiqui T, Khan MM, Seliger SL, Klonoff DC, Feng Z, Sorkin JD. Excess Mortality in COVID-19-Positive Versus COVID-19-Negative Inpatients With Diabetes: A Nationwide Study. Diabetes care 2021. PMID: 34233926


  28. Shang T, Zhang JY, Bequette BW, Raymond JK, Coté G, Sherr JL, Castle J, Pickup J, Pavlovic Y, Espinoza J, Messer LH, Heise T, Mendez CE, Kim S, Ginsberg BH, Masharani U, Galindo RJ, Klonoff DC. Diabetes Technology Meeting 2020. Journal of diabetes science and technology 2021. PMID: 34196228


  29. Klonoff DC, Messler J, Valk T, Jagannathan R, Pasquel FJ, Umpierrez GE. Clinical Trials of COVID-19 Therapies Should Account for Diabetes and Hyperglycemia. Journal of diabetes science and technology 2021. PMID: 34159841


  30. Heinemann L, Klonoff DC. Diabetes Technology and Waste: A Complex Story. Journal of diabetes science and technology 2021. PMID: 34137289


  31. Shang T, Zhang JY, Thomas A, Arnold MA, Vetter BN, Heinemann L, Klonoff DC. Products for Monitoring Glucose Levels in the Human Body with Noninvasive Optical, Noninvasive Fluid Sampling, or Minimally Invasive Technologies. Journal of diabetes science and technology 2021. PMID: 34120487


  32. Shang T, Zhang JY, Dawson J, Klonoff DC. Benefits of Conformity Assessment for Cybersecurity Standards of Diabetes Devices and Other Medical Devices. Journal of diabetes science and technology 2021. PMID: 34024136


  33. Klonoff DC, Shang T, Zhang JY, Cengiz E, Mehta C, Kerr D. Digital Connectivity: The Sixth Vital Sign. Journal of diabetes science and technology 2021. PMID: 33980049


  34. Zhang JY, Shang T, Koliwad SK, Klonoff DC. Continuous Ketone Monitoring: A New Paradigm for Physiologic Monitoring. Journal of diabetes science and technology 2021. PMID: 33834884


  35. Perez-Guzman MC, Shang T, Zhang JY, Jornsay D, Klonoff DC. Continuous Glucose Monitoring in the Hospital. Endocrinology and metabolism (Seoul, Korea) 2021. PMID: 33789033


  36. Shang T, Zhang JY, Klonoff DC. The FDA Pilot Accreditation Scheme for Conformity: Will It Pertain to Cybersecurity of Diabetes Devices? Journal of diabetes science and technology 2021. PMID: 33724056


  37. Zhang JY, Shang T, Chattaraj S, Cohen O, Heschel M, Vigersky RA, Heinemann L, Nørgaard K, Svensson J, Buckingham B, Klonoff DC. Advances in Insulin Pump Infusion Sets Symposium Report. Journal of diabetes science and technology 2021. PMID: 33703930


  38. Klonoff DC, Shang T, Zhang J. Automated Insulin Dosing Systems or Automated Insulin Delivery Systems? It is Time for Consistency. Journal of diabetes science and technology 2021. PMID: 33650456


  39. Lee I, Probst D, Klonoff D, Sode K. Continuous glucose monitoring systems - Current status and future perspectives of the flagship technologies in biosensor research. Biosensors & bioelectronics 2021. PMID: 33775474


  40. Zhang JY, Shang T, Ahn D, Chen K, Coté G, Espinoza J, Mendez CE, Spanakis EK, Thompson B, Wallia A, Wisk LE, Kerr D, Klonoff DC. How to Best Protect People With Diabetes From the Impact of SARS-CoV-2: Report of the International COVID-19 and Diabetes Summit. Journal of diabetes science and technology 2021. PMID: 33476193


  41. Freckmann G, Nichols JH, Hinzmann R, Klonoff DC, Ju Y, Diem P, Makris K, Slingerland RJ. Standardization process of continuous glucose monitoring: Traceability and performance. Clinica chimica acta; international journal of clinical chemistry 2021. PMID: 33359497


  42. Klonoff DC, Messler JC, Umpierrez GE, Peng L, Booth R, Crowe J, Garrett V, McFarland R, Pasquel FJ. Association Between Achieving Inpatient Glycemic Control and Clinical Outcomes in Hospitalized Patients With COVID-19: A Multicenter, Retrospective Hospital-Based Analysis. Diabetes care 2020. PMID: 33323475


  43. Klonoff DC, Zhang JY, Shang T, Mehta C, Kerr D. Pharmacoadherence: An Opportunity for Digital Health to Inform the Third Dimension of Pharmacotherapy for Diabetes. Journal of diabetes science and technology 2020. PMID: 33289578


  44. Klonoff DC. Diagnosing diabetes mellitus from smartphone-based vascular signals. Nature reviews. Endocrinology 2020. PMID: 33060831


  45. Meo SA, Abukhalaf AA, Alomar AA, Alessa OM, Sami W, Klonoff DC. Effect of environmental pollutants PM-2.5, carbon monoxide, and ozone on the incidence and mortality of SARS-COV-2 infection in ten wildfire affected counties in California. The Science of the total environment 2020. PMID: 33321340


  46. Hanna RF, Ward TJ, Chow DS, Lagana SM, Moreira RK, Emond JC, Weintraub JL, Prince MR. An evaluation of the sensitivity of MRI at detecting hepatocellular carcinoma in cirrhotic patients utilizing an explant reference standard. Clinical imaging 2014. PMID: 33034163


  47. Meo SA, Abukhalaf AA, Alomar AA, AlMutairi FJ, Usmani AM, Klonoff DC. Impact of lockdown on COVID-19 prevalence and mortality during 2020 pandemic: observational analysis of 27 countries. European journal of medical research 2020. PMID: 33168104


  48. Shepard JA, Breton M, Nimri R, Roberts JTF, Street T, Klonoff D, Barnard-Kelly K. User and Healthcare Professional Perspectives on Do-It-Yourself Artificial Pancreas Systems: A Need for Guidelines. Journal of diabetes science and technology 2020. PMID: 33000636


  49. Galindo RJ, Umpierrez GE, Rushakoff RJ, Basu A, Lohnes S, Nichols JH, Spanakis EK, Espinoza J, Palermo NE, Awadjie DG, Bak L, Buckingham B, Cook CB, Freckmann G, Heinemann L, Hovorka R, Mathioudakis N, Newman T, O'Neal DN, Rickert M, Sacks DB, Seley JJ, Wallia A, Shang T, Zhang JY, Han J, Klonoff DC. Continuous Glucose Monitors and Automated Insulin Dosing Systems in the Hospital Consensus Guideline. Journal of diabetes science and technology 2020. PMID: 32985262


  50. Meo SA, Zaidi SZA, Shang T, Zhang JY, Al-Khlaiwi T, Bukhari IA, Akram J, Klonoff DC. Biological, molecular and pharmacological characteristics of chloroquine, hydroxychloroquine, convalescent plasma, and remdesivir for COVID-19 pandemic: A comparative analysis. Journal of King Saud University. Science 2020. PMID: 32921965


  51. Gibney MA, Fitz-Patrick D, Klonoff DC, Whooley S, Lu B, Yue W, Glezer S. User experiences with second-generation 32-gauge x 4?mm vs. thinner comparator pen needles: prospective randomized trial. Current medical research and opinion 2020. PMID: 32723109


  52. Umpierrez G, Rushakoff R, Seley JJ, Zhang JY, Shang T, Han J, Spanakis EK, Alexanian S, Drincic A, Kulasa K, Mendez CE, Tanton D, Wallia A, Zilbermint M, Klonoff DC. Hospital Diabetes Meeting 2020. Journal of diabetes science and technology 2020. PMID: 32783456


  53. Wake DJ, Gibb FW, Kar P, Kennon B, Klonoff DC, Rayman G, Rutter MK, Sainsbury C, Semple RK. Endocrinology in the time of COVID-19: Remodelling Diabetes Services and Promoting Innovation. European journal of endocrinology 2020. PMID: 32508313


  54. Galindo RJ, Aleppo G, Klonoff DC, Spanakis EK, Agarwal S, Vellanki P, Olson DE, Umpierrez GE, Davis GM, Pasquel FJ. Implementation of Continuous Glucose Monitoring in the Hospital: Emergent Considerations for Remote Glucose Monitoring During the COVID-19 Pandemic. Journal of diabetes science and technology 2020. PMID: 32536205


  55. Klonoff DC. The Coronavirus 2019 Pandemic and Diabetes: An International Perspective. Journal of diabetes science and technology 2020. PMID: 32517506


  56. Bode B, Garrett V, Messler J, McFarland R, Crowe J, Booth R, Klonoff DC. Glycemic Characteristics and Clinical Outcomes of COVID-19 Patients Hospitalized in the United States. Journal of diabetes science and technology 2020. PMID: 32389027


  57. Meo SA, Abukhalaf AA, Alomar AA, Sattar K, Klonoff DC. COVID-19 Pandemic: Impact of Quarantine on Medical Students' Mental Wellbeing and Learning Behaviors. Pakistan journal of medical sciences 2020. PMID: 32582313


  58. Meo SA, Al-Khlaiwi T, Usmani AM, Meo AS, Klonoff DC, Hoang TD. Biological and Epidemiological Trends in the Prevalence and Mortality due to Outbreaks of Novel Coronavirus COVID-19. Journal of King Saud University. Science 2020. PMID: 32292261


  59. Klonoff DC, Umpierrez GE. COVID-19 in patients with diabetes: risk factors that increase morbidity. Metabolism: clinical and experimental 2020. PMID: 32275971


  60. Meo SA, Klonoff DC, Akram J. Efficacy of chloroquine and hydroxychloroquine in the treatment of COVID-19. European review for medical and pharmacological sciences 2020. PMID: 32373993


  61. Han J, Heinemann L, Ginsberg BH, Alva S, Appel M, Bess S, Chen KY, Freckmann G, Harris DR, Hartwig M, Hinzmann R, Kerr D, Krouwer J, Morrow L, Nichols J, Pfützner A, Pleus S, Rice M, Sacks DB, Schlueter K, Vesper HW, Klonoff DC. The YSI 2300 Analyzer Replacement Meeting Report. Journal of diabetes science and technology 2020. PMID: 32174135


  62. Nguyen M, Han J, Spanakis EK, Kovatchev B, Klonoff DC. A Review of Continuous Glucose Monitoring Based Composite Metrics for Glycemic Control. Diabetes technology & therapeutics 2020. PMID: 32069094


  63. Billings LK, Agner BFR, Altuntas Y, Grøn R, Halladin N, Klonoff DC, Tentolouris N, Jódar E. The Benefit of Insulin Degludec/Liraglutide (IDegLira) Compared With Basal-Bolus Insulin Therapy is Consistent Across Participant Subgroups With Type 2 Diabetes in the DUAL VII Randomized Trial. Journal of diabetes science and technology 2020. PMID: 32107930


  64. Klonoff DC, Heinemann L, Cook CB, Thompson BM, Kerr D, Han J, Krisiunas EP. The Diabetes Technology Society Green Diabetes Initiative. Journal of diabetes science and technology 2020. PMID: 32019344


  65. Philis-Tsimikas A, Klonoff DC, Khunti K, Bajaj HS, Leiter LA, Hansen MV, Troelsen LN, Ladelund S, Heller S, Pieber TR. Risk of hypoglycaemia with insulin degludec versus insulin glargine U300 in insulin-treated patients with type 2 diabetes: the randomised, head-to-head CONCLUDE trial. Diabetologia 2020. PMID: 31984443


  66. Klonoff DC, Florez JC, German M, Fleming A. The Need for Precision Medicine to be Applied to Diabetes. Journal of diabetes science and technology 2020. PMID: 31903769


  67. Heinemann L, Klonoff DC. An Opportunity to Increase the Benefit of CGM Usage: The Need to Train the Patients Adequately. Journal of diabetes science and technology 2019. PMID: 31876181


  68. Klonoff DC, Fleming A, Gabbay R. The Need to Change Regulatory Evaluation of Hypoglycemia in Trials of Diabetes Treatments. Journal of diabetes science and technology 2019. PMID: 31744326


  69. Han J, Nichols JH, Rice M, Klonoff DC. The End of the Road for the YSI 2300 Analyzer: Where Do We Go Now? Journal of diabetes science and technology 2019. PMID: 31711305


  70. Abusamaan MS, Klonoff DC, Mathioudakis N. Predictors of Time-to-Repeat Point-of-Care Glucose Following Hypoglycemic Events in Hospitalized Patients. Journal of diabetes science and technology 2019. PMID: 31640421


  71. Heinemann L, Grodsky GM, Klonoff DC. Journal of Diabetes Science and Technology: A Success Story! Journal of diabetes science and technology 2019. PMID: 31617406


  72. Klonoff DC, Gabbay RA, Kerr D. Barriers and Solutions to a Recently Noted Failure of Diabetes Care Outcomes to Improve From 2005 to 2016 in the United States. Journal of diabetes science and technology 2019. PMID: 31595785


  73. Chen E, King F, Kohn M, Spanakis EK, Breton MD, Klonoff DC. A Review of Predictive Low Glucose Suspend and its Effectiveness in Preventing Nocturnal Hypoglycemia. Diabetes technology & therapeutics 2019. PMID: 31335193


  74. Klonoff D, Bode B, Cohen N, Penn M, Geho WB, Muchmore DB. Divergent Hypoglycemic Effects of Hepatic-Directed Prandial Insulin: A Six-Month Phase 2b Study in Type 1 Diabetes. Diabetes care 2019. PMID: 31551249


  75. Han J, King F, Klonoff D, Drincic A, Crosby KP, Robinson T, Gabbay RA, Oley L, Ahn D, Evans B, Salber P, Cruz M, Ginsberg B, Adi S, Armstrong D, Kerr D. Digital Diabetes Congress 2019. Journal of diabetes science and technology 2019. PMID: 31466480


  76. Klonoff DC, Evans B, Zweig M, Day S, Kerr D. Is Digital Health for Diabetes in an Investment Bubble? Journal of diabetes science and technology 2019. PMID: 31470739


  77. Kerr D, King F, Klonoff DC. Digital Health Interventions for Diabetes: Everything to Gain and Nothing to Lose. Diabetes spectrum : a publication of the American Diabetes Association 2019. PMID: 31462878


  78. Klonoff D, Han J. The First Recall of a Diabetes Device Because of Cybersecurity Risks. Journal of diabetes science and technology 2019. PMID: 31313589


  79. Reidy C, Klonoff DC, Barnard-Kelly KD. Supporting Good Intentions With Good Evidence: How to Increase the Benefits of Diabetes Social Media. Journal of diabetes science and technology 2019. PMID: 31096768


  80. Bergenstal RM, Peyrot M, Dreon DM, Aroda VR, Bailey TS, Brazg RL, Frias JP, Johnson ML, Klonoff DC, Kruger DF, Ramtoola S, Rosenstock J, Serusclat P, Weinstock RS, Naik RG, Shearer DM, Zraick V, Levy BL. Implementation of Basal-Bolus Therapy in Type 2 Diabetes: A Randomized Controlled Trial Comparing Bolus Insulin Delivery Using an Insulin Patch with an Insulin Pen. Diabetes technology & therapeutics 2019. PMID: 31025878


  81. Klonoff DC, Gutierrez A, Fleming A, Kerr D. Real-World Evidence Should Be Used in Regulatory Decisions About New Pharmaceutical and Medical Device Products for Diabetes. Journal of diabetes science and technology 2019. PMID: 30943790


  82. Klonoff DC. Hemoglobinopathies and Hemoglobin A1c in Diabetes Mellitus. Journal of diabetes science and technology 2019. PMID: 30897962


  83. Klonoff DC, Aron D, Cohen RM, Home P, John WG, Little RR, Nathan DM, Sacks DB. The Need for Accuracy in Hemoglobin A1c Proficiency Testing: Why the Proposed CLIA Rule of 2019 Is a Step Backward. Journal of diabetes science and technology 2019. PMID: 30897963


  84. Klonoff DC. The New FDA Real-World Evidence Program to Support Development of Drugs and Biologics. Journal of diabetes science and technology 2019. PMID: 30862182


  85. Heinemann L, Klonoff DC, Kubiak T. Elderly Patients With Diabetes: Special Aspects to Consider. Journal of diabetes science and technology 2019. PMID: 30854888


  86. Klonoff DC. The Expanding Role of Real-World Evidence Trials in Health Care Decision Making. Journal of diabetes science and technology 2019. PMID: 30841738


  87. Klonoff DC. Behavioral Theory: The Missing Ingredient for Digital Health Tools to Change Behavior and Increase Adherence. Journal of diabetes science and technology 2019. PMID: 30678472


  88. Klonoff DC, King F, Kerr D. New Opportunities for Digital Health to Thrive. Journal of diabetes science and technology 2019. PMID: 30678473


  89. Klonoff DC, Evans ML, Lane W, Kempe HP, Renard E, DeVries JH, Graungaard T, Hyseni A, Gondolf T, Battelino T. A randomized, multicentre trial evaluating the efficacy and safety of fast-acting insulin aspart in continuous subcutaneous insulin infusion in adults with type 1 diabetes (onset 5). Diabetes, obesity & metabolism 2018. PMID: 30537180


  90. King F, Klonoff DC, Ahn D, Adi S, Berg EG, Bian J, Chen K, Drincic A, Heyl M, Magee M, Mulvaney S, Pavlovic Y, Prahalad P, Ryan M, Sabharwal A, Shah S, Spanakis E, Thompson BM, Thompson M, Wang J. Diabetes Technology Society Report on the FDA Digital Health Software Precertification Program Meeting. Journal of diabetes science and technology 2018. PMID: 30394807


  91. King F, Klonoff DC, Kerr D, Hu J, Lyles C, Quinn C, Adi S, Chen K, Hood K, Salber P, de Clercq C, Hu J, Gabbay R. Digital Diabetes Congress 2018. Journal of diabetes science and technology 2018. PMID: 30376739


  92. King F, Ahn D, Hsiao V, Porco T, Klonoff DC. A Review of Blood Glucose Monitor Accuracy. Diabetes technology & therapeutics 2018. PMID: 30376362


  93. Klonoff DC, Umpierrez GE, Rice MJ. A Milestone in Point of Care Capillary Blood Glucose Monitoring of Critically Ill Hospitalized Patients. Journal of diabetes science and technology 2018. PMID: 30246543


  94. Kerr D, Klonoff DC. Digital Diabetes Data and Artificial Intelligence: A Time for Humility Not Hubris. Journal of diabetes science and technology 2018. PMID: 30182736


  95. Barnard KD, Ziegler R, Klonoff DC, Braune K, Petersen B, Rendschmidt T, Finan D, Kowalski A, Heinemann L. Open Source Closed-Loop Insulin Delivery Systems: A Clash of Cultures or Merging of Diverse Approaches? Journal of diabetes science and technology 2018. PMID: 30079769


  96. Klonoff DC, Parkes JL, Kovatchev BP, Kerr D, Bevier WC, Brazg RL, Christiansen M, Bailey TS, Nichols JH, Kohn MA. Investigation of the Accuracy of 18 Marketed Blood Glucose Monitors. Diabetes care 2018. PMID: 29898901


  97. Kerr D, Gabbay RA, Klonoff DC. Finding Real Value From Digital Diabetes Health: Is Digital Health Dead or in Need of Resuscitation? Journal of diabetes science and technology 2018. PMID: 29719978


  98. Thompson B, Korytkowski M, Klonoff DC, Cook CB. Consensus Statement on Use of Continuous Subcutaneous Insulin Infusion Therapy in the Hospital. Journal of diabetes science and technology 2018. PMID: 29681173


  99. Okurita M, Suzuki N, Loew N, Yoshida H, Tsugawa W, Mori K, Kojima K, Klonoff DC, Sode K. Engineered fungus derived FAD-dependent glucose dehydrogenase with acquired ability to utilize hexaammineruthenium(III) as an electron acceptor. Bioelectrochemistry (Amsterdam, Netherlands) 2018. PMID: 29727765


  100. Yuan S, Fernando A, Klonoff DC. Standards for Medical Device Cybersecurity in 2018. Journal of diabetes science and technology 2018. PMID: 29575925


  101. Kerr D, Axelrod C, Hoppe C, Klonoff DC. Diabetes and technology in 2030: a utopian or dystopian future? Diabetic medicine : a journal of the British Diabetic Association 2018. PMID: 29356078


  102. Klonoff DC, Kerr D. Smart Pens Will Improve Insulin Therapy. Journal of diabetes science and technology 2018. PMID: 29411641


  103. Klonoff DC, Kerr D. Overcoming Barriers to Adoption of Digital Health Tools for Diabetes. Journal of diabetes science and technology 2017. PMID: 28969460


  104. Gao W, Brooks GA, Klonoff DC. Wearable physiological systems and technologies for metabolic monitoring. Journal of applied physiology (Bethesda, Md. : 1985) 2017. PMID: 28970200


  105. Klonoff DC, Kerr D. A Simplified Approach Using Rate of Change Arrows to Adjust Insulin With Real-Time Continuous Glucose Monitoring. Journal of diabetes science and technology 2017. PMID: 28884599


  106. Klonoff DC, Ahn D, Drincic A. Continuous glucose monitoring: A review of the technology and clinical use. Diabetes research and clinical practice 2017. PMID: 28965029


  107. Klonoff DC, Kerr D, Wong JC, Pavlovic Y, Koliwad S, Hu J, Salber P, Aguilera A, Long W, Hamilton G, Chen KY, Adi S. Digital Diabetes Congress 2017. Journal of diabetes science and technology 2017. PMID: 28786320


  108. Klonoff DC, Kerr D, Kleidermacher D. Now Is the Time for a Security and Safety Standard for Consumer Smartphones Controlling Diabetes Devices. Journal of diabetes science and technology 2017. PMID: 28728436


  109. Liang Y, Wanderer J, Nichols JH, Klonoff D, Rice MJ. Blood Gas Analyzer Accuracy of Glucose Measurements. Mayo Clinic proceedings 2017. PMID: 28645518


  110. Wallia A, Umpierrez GE, Rushakoff RJ, Klonoff DC, Rubin DJ, Hill Golden S, Cook CB, Thompson B. Consensus Statement on Inpatient Use of Continuous Glucose Monitoring. Journal of diabetes science and technology 2017. PMID: 28429611


  111. Klonoff DC, Freckmann G, Heinemann L. Insulin Pump Occlusions: For Patients Who Have Been Around the (Infusion) Block. Journal of diabetes science and technology 2017. PMID: 28355924


  112. Ginsberg BH, Klonoff DC, Crabtree VP. Meeting Report: The Fourth Artificial Pancreas Workshop: Testing and Adoption of Current and Emerging Technologies. Journal of diabetes science and technology 2017. PMID: 28349709


  113. Klonoff DC, Alexander Fleming G, Muchmore DB, Frier BM. Hypoglycemia evaluation and reporting in diabetes: Importance for the development of new therapies. Diabetes/metabolism research and reviews 2017. PMID: 28054743


  114. Klonoff DC, Nayberg I, Stauder U, Oualali H, Domenger C. Half-Unit Insulin Pens: Disease Management in Patients With Diabetes Who Are Sensitive to Insulin. Journal of diabetes science and technology 2016. PMID: 27898389


  115. Drincic A, Prahalad P, Greenwood D, Klonoff DC. Evidence-based Mobile Medical Applications in Diabetes. Endocrinology and metabolism clinics of North America 2016. PMID: 27823614


  116. Pohlmeier H, Berard L, Brulle-Wohlhueter C, Wu J, Dahmen R, Nowotny I, Klonoff D. Ease of Use of the Insulin Glargine 300 U/mL Pen Injector in Insulin-Naïve People With Type 2 Diabetes. Journal of diabetes science and technology 2016. PMID: 27664062


  117. Klonoff DC, Kerr D. Digital Diabetes Communication: There's an App for That. Journal of diabetes science and technology 2016. PMID: 27464752


  118. Wallia A, Umpierrez GE, Nasraway SA, Klonoff DC. Round Table Discussion on Inpatient Use of Continuous Glucose Monitoring at the International Hospital Diabetes Meeting. Journal of diabetes science and technology 2016. PMID: 27286715


  119. Sode K, Loew N, Ohnishi Y, Tsuruta H, Mori K, Kojima K, Tsugawa W, LaBelle JT, Klonoff DC. Novel fungal FAD glucose dehydrogenase derived from Aspergillus niger for glucose enzyme sensor strips. Biosensors & bioelectronics 2016. PMID: 27573296


  120. Hatada M, Tsugawa W, Kamio E, Loew N, Klonoff DC, Sode K. Development of a screen-printed carbon electrode based disposable enzyme sensor strip for the measurement of glycated albumin. Biosensors & bioelectronics 2016. PMID: 27522349


  121. Andelin M, Kropff J, Matuleviciene V, Joseph JI, Attvall S, Theodorsson E, Hirsch IB, Imberg H, Dahlqvist S, Klonoff D, Haraldsson B, DeVries JH, Lind M. Assessing the Accuracy of Continuous Glucose Monitoring (CGM) Calibrated With Capillary Values Using Capillary or Venous Glucose Levels as a Reference. Journal of diabetes science and technology 2016. PMID: 26810924


  122. Carter AW, Heinemann L, Klonoff DC. Quality Control of Insulins and Biosimilar Insulins: What Do We Know? Journal of diabetes science and technology 2016. PMID: 26989067


  123. Klonoff DC, Lias C, Beck S, Parkes JL, Kovatchev B, Vigersky RA, Arreaza-Rubin G, Burk RD, Kowalski A, Little R, Nichols J, Petersen M, Rawlings K, Sacks DB, Sampson E, Scott S, Seley JJ, Slingerland R, Vesper HW. Development of the Diabetes Technology Society Blood Glucose Monitor System Surveillance Protocol. Journal of diabetes science and technology 2016. PMID: 26481642


  124. Klonoff DC, Kleidermacher DN. Now Is the Time for a Cybersecurity Standard for Connected Diabetes Devices. Journal of diabetes science and technology 2016. PMID: 27460624


  125. Kameya M, Tsugawa W, Yamada-Tajima M, Hatada M, Suzuki K, Sakaguchi-Mikami A, Ferri S, Klonoff DC, Sode K. Electrochemical sensing system employing fructosamine 6-kinase enables glycated albumin measurement requiring no proteolytic digestion. Biotechnology journal 2016. PMID: 27067959


  126. Klonoff DC. Telemedicine for Diabetes: Economic Considerations. Journal of diabetes science and technology 2016. PMID: 26856626


  127. Klonoff DC. Telemedicine for Diabetes: Current and Future Trends. Journal of diabetes science and technology 2015. PMID: 26682960


  128. Klonoff DC. What Do Your Fingernails Say About You? Can They Indicate That You Have Diabetes? Journal of diabetes science and technology 2015. PMID: 26518486


  129. Klonoff DC, Draznin B, Drincic A, Dungan K, Gianchandani R, Inzucchi SE, Nichols JH, Rice MJ, Seley JJ. PRIDE Statement on the Need for a Moratorium on the CMS Plan to Cite Hospitals for Performing Point-of-Care Capillary Blood Glucose Monitoring on Critically Ill Patients. The Journal of clinical endocrinology and metabolism 2015. PMID: 26398626


  130. Pfützner A, Sachsenheimer D, Grenningloh M, Heschel M, Walther-Johannesen L, Gharabli R, Klonoff D. Using Insulin Infusion Sets in CSII for Longer Than the Recommended Usage Time Leads to a High Risk for Adverse Events: Results From a Prospective Randomized Crossover Study. Journal of diabetes science and technology 2015. PMID: 26341262


  131. Armstrong DG, Kleidermacher DN, Klonoff DC, Slepian MJ. Cybersecurity Regulation of Wireless Devices for Performance and Assurance in the Age of "Medjacking". Journal of diabetes science and technology 2015. PMID: 26319227


  132. Klonoff D, Nayberg I, Thonius M, See F, Abdel-Tawab M, Erbstein F, Haak T. Accuracy and Injection Force of the Gla-300 Injection Device Compared With Other Commercialized Disposable Insulin Pens. Journal of diabetes science and technology 2015. PMID: 26311720


  133. Klonoff DC, Prahalad P. Performance of Cleared Blood Glucose Monitors. Journal of diabetes science and technology 2015. PMID: 25990294


  134. Cembrowski G, Lyon ME, Klonoff DC. Glucose data-mining study inconclusive. Canadian journal of diabetes 2015. PMID: 26028478


  135. Klonoff D, Nayberg I, Erbstein F, Cali A, Brulle-Wohlhueter C, Haak T. Usability of the Gla-300 Injection Device Compared With Three Other Commercialized Disposable Insulin Pens: Results of an Interview-Based Survey. Journal of diabetes science and technology 2015. PMID: 26002837


  136. Weiss R, Garg SK, Bergenstal RM, Klonoff DC, Bode BW, Bailey TS, Thrasher J, Schwartz F, Welsh JB, Kaufman FR. Predictors of Hypoglycemia in the ASPIRE In-Home Study and Effects of Automatic Suspension of Insulin Delivery. Journal of diabetes science and technology 2015. PMID: 25986629


  137. Klonoff DC. Cybersecurity for Connected Diabetes Devices. Journal of diabetes science and technology 2015. PMID: 25883162


  138. Klonoff DC. Trends in FDA regulation of software to control insulin dosing. Journal of diabetes science and technology 2015. PMID: 25872966


  139. Klonoff D, Nayberg I, Rabbone I, Domenger C, Stauder U, Oualali H, Danne T. Functional Evaluation of the Reusable JuniorSTAR® Half-Unit Insulin Pen. Journal of diabetes science and technology 2015. PMID: 25633967


  140. Klonoff DC. Precision medicine for managing diabetes. Journal of diabetes science and technology 2015. PMID: 25550409


  141. Klonoff DC. Afrezza inhaled insulin: the fastest-acting FDA-approved insulin on the market has favorable properties. Journal of diabetes science and technology 2014. PMID: 25355710


  142. Landau Z, Klonoff D, Nayberg I, Feldman D, Levit SB, Lender D, Mosenzon O, Raz I, Wainstein J. Improved pharmacokinetic and pharmacodynamic profiles of insulin analogues using InsuPatch, a local heating device. Diabetes/metabolism research and reviews 2014. PMID: 24610683


  143. Pfützner A, Raz I, Bitton G, Klonoff D, Nagar R, Hermanns N, Haak T. Improved insulin absorption by means of standardized injection site modulation results in a safer and more efficient prandial insulin treatment. A review of the existing clinical data. Journal of diabetes science and technology 2014. PMID: 25352633


  144. Matuleviciene V, Joseph JI, Andelin M, Hirsch IB, Attvall S, Pivodic A, Dahlqvist S, Klonoff D, Haraldsson B, Lind M. A clinical trial of the accuracy and treatment experience of the Dexcom G4 sensor (Dexcom G4 system) and Enlite sensor (guardian REAL-time system) tested simultaneously in ambulatory patients with type 1 diabetes. Diabetes technology & therapeutics 2014. PMID: 25233297


  145. Klonoff DC, Vigersky RA, Nichols JH, Rice MJ. Timely hospital glucose measurement: here today, gone tomorrow? Mayo Clinic proceedings 2014. PMID: 25199860


  146. Klonoff DC, Reyes JS. Hospital diabetes meeting: Arlington, Virginia, May 13, 2014. Journal of diabetes science and technology 2014. PMID: 25172880


  147. Klonoff DC. Point-of-Care Blood Glucose Meter Accuracy in the Hospital Setting. Diabetes spectrum : a publication of the American Diabetes Association 2014. PMID: 26246776


  148. Kovatchev BP, Wakeman CA, Breton MD, Kost GJ, Louie RF, Tran NK, Klonoff DC. Computing the surveillance error grid analysis: procedure and examples. Journal of diabetes science and technology 2014. PMID: 25562887


  149. Klonoff DC, Lias C, Vigersky R, Clarke W, Parkes JL, Sacks DB, Kirkman MS, Kovatchev B. The surveillance error grid. Journal of diabetes science and technology 2014. PMID: 25562886


  150. Garg SK, Brazg RL, Bailey TS, Buckingham BA, Slover RH, Klonoff DC, Shin J, Welsh JB, Kaufman FR. Hypoglycemia begets hypoglycemia: the order effect in the ASPIRE in-clinic study. Diabetes technology & therapeutics 2014. PMID: 24405492


  151. Klonoff DC. New Wearable Computers Move Ahead: Google Glass and Smart Wigs. Journal of diabetes science and technology 2014. PMID: 24876529


  152. Heinemann L, Klonoff DC. Freedom of speech and science: can companies force us to withdraw data they don't like? Journal of diabetes science and technology 2013. PMID: 24124934


  153. Pfützner A, Klonoff DC, Pardo S, Parkes JL. Technical aspects of the Parkes error grid. Journal of diabetes science and technology 2013. PMID: 24124954


  154. Klonoff D, Nayberg I, Rabbone I, Landgraf W, Domenger C, Danne T. Evaluation of the JuniorSTAR® Half-unit Insulin Pen in Young People with Type 1 Diabetes - User Perspectives. European endocrinology 2013. PMID: 29922358


  155. Chaudhry T, Klonoff DC. SMBG out of control: the need for educating patients about control solution. The Diabetes educator 2013. PMID: 23897920


  156. Klonoff DC, Bergenstal RM, Garg SK, Bode BW, Meredith M, Slover RH, Ahmann A, Welsh JB, Lee SW. ASPIRE In-Home: rationale, design, and methods of a study to evaluate the safety and efficacy of automatic insulin suspension for nocturnal hypoglycemia. Journal of diabetes science and technology 2013. PMID: 23911183


  157. Klonoff DC, Reyes JS. Do currently available blood glucose monitors meet regulatory standards? 1-day public meeting in Arlington, Virginia. Journal of diabetes science and technology 2013. PMID: 23911191


  158. Draznin B, Gilden J, Golden SH, Inzucchi SE, Baldwin D, Bode BW, Boord JB, Braithwaite SS, Cagliero E, Dungan KM, Falciglia M, Figaro MK, Hirsch IB, Klonoff D, Korytkowski MT, Kosiborod M, Lien LF, Magee MF, Masharani U, Maynard G, McDonnell ME, Moghissi ES, Rasouli N, Rubin DJ, Rushakoff RJ, Sadhu AR, Schwartz S, Seley JJ, Umpierrez GE, Vigersky RA, Low CC, Wexler DJ. Pathways to quality inpatient management of hyperglycemia and diabetes: a call to action. Diabetes care 2013. PMID: 23801791


  159. Bergenstal RM, Klonoff DC, Garg SK, Bode BW, Meredith M, Slover RH, Ahmann AJ, Welsh JB, Lee SW, Kaufman FR. Threshold-based insulin-pump interruption for reduction of hypoglycemia. The New England journal of medicine 2013. PMID: 23789889


  160. Heinemann L, Klonoff DC. Blood glucose meter market: this world is undergoing drastic changes. Journal of diabetes science and technology 2013. PMID: 23759389


  161. Klonoff DC. The current status of mHealth for diabetes: will it be the next big thing? Journal of diabetes science and technology 2013. PMID: 23759409


  162. Pfützner A, Bailey T, Campos C, Kahn D, Ambers E, Niemeyer M, Guerrero G, Klonoff D, Nayberg I. Accuracy and preference assessment of prefilled insulin pen versus vial and syringe with diabetes patients, caregivers, and healthcare professionals. Current medical research and opinion 2013. PMID: 23402225


  163. Bergenstal RM, Ahmann AJ, Bailey T, Beck RW, Bissen J, Buckingham B, Deeb L, Dolin RH, Garg SK, Goland R, Hirsch IB, Klonoff DC, Kruger DF, Matfin G, Mazze RS, Olson BA, Parkin C, Peters A, Powers MA, Rodriguez H, Southerland P, Strock ES, Tamborlane W, Wesley DM. Recommendations for standardizing glucose reporting and analysis to optimize clinical decision making in diabetes: the ambulatory glucose profile. Journal of diabetes science and technology 2013. PMID: 23567014


  164. Klonoff DC. Twelve modern digital technologies that are transforming decision making for diabetes and all areas of health care. Journal of diabetes science and technology 2013. PMID: 23566983


  165. Bergenstal RM, Ahmann AJ, Bailey T, Beck RW, Bissen J, Buckingham B, Deeb L, Dolin RH, Garg SK, Goland R, Hirsch IB, Klonoff DC, Kruger DF, Matfin G, Mazze RS, Olson BA, Parkin C, Peters A, Powers MA, Rodriguez H, Southerland P, Strock ES, Tamborlane W, Wesley DM. Recommendations for standardizing glucose reporting and analysis to optimize clinical decision making in diabetes: the Ambulatory Glucose Profile (AGP). Diabetes technology & therapeutics 2013. PMID: 23448694


  166. Klonoff DC. Overview of fluorescence glucose sensing: a technology with a bright future. Journal of diabetes science and technology 2012. PMID: 23294768


  167. Klonoff DC. The current status of bolus calculator decision-support software. Journal of diabetes science and technology 2012. PMID: 23063023


  168. Garg S, Brazg RL, Bailey TS, Buckingham BA, Slover RH, Klonoff DC, Shin J, Welsh JB, Kaufman FR. Reduction in duration of hypoglycemia by automatic suspension of insulin delivery: the in-clinic ASPIRE study. Diabetes technology & therapeutics 2012. PMID: 22316089


  169. Klonoff DC. The need for clinical accuracy guidelines for blood glucose monitors. Journal of diabetes science and technology 2012. PMID: 22401316


  170. Paul N, Kohno T, Klonoff DC. A review of the security of insulin pump infusion systems. Journal of diabetes science and technology 2011. PMID: 22226278


  171. Klonoff DC, Blonde L, Cembrowski G, Chacra AR, Charpentier G, Colagiuri S, Dailey G, Gabbay RA, Heinemann L, Kerr D, Nicolucci A, Polonsky W, Schnell O, Vigersky R, Yale JF. Consensus report: the current role of self-monitoring of blood glucose in non-insulin-treated type 2 diabetes. Journal of diabetes science and technology 2011. PMID: 22226276


  172. Klonoff DC. Improving the safety of blood glucose monitoring. Journal of diabetes science and technology 2011. PMID: 22226247


  173. Brazg RL, Bailey TS, Garg S, Buckingham BA, Slover RH, Klonoff DC, Nguyen X, Shin J, Welsh JB, Lee SW. The ASPIRE study: design and methods of an in-clinic crossover trial on the efficacy of automatic insulin pump suspension in exercise-induced hypoglycemia. Journal of diabetes science and technology 2011. PMID: 22226267


  174. Klonoff DC, Buckingham B, Christiansen JS, Montori VM, Tamborlane WV, Vigersky RA, Wolpert H. Continuous glucose monitoring: an Endocrine Society Clinical Practice Guideline. The Journal of clinical endocrinology and metabolism 2011. PMID: 21976745


  175. Klonoff DC, Zimliki CL, Stevens LA, Beaston P, Pinkos A, Choe SY, Arreaza-Rubín G, Heetderks W. Innovations in technology for the treatment of diabetes: clinical development of the artificial pancreas (an autonomous system). Journal of diabetes science and technology 2011. PMID: 21722597


  176. Klonoff DC. Intensive insulin therapy in critically ill hospitalized patients: making it safe and effective. Journal of diabetes science and technology 2011. PMID: 21722591


  177. Klonoff DC. Smart sensors for maintaining physiologic homeostasis. Journal of diabetes science and technology 2011. PMID: 21722562


  178. Klonoff DC. Hospital diabetes: why quality of care matters to both patients and hospitals. Journal of diabetes science and technology 2011. PMID: 21303618


  179. Klonoff DC. Incretin therapy for type 2 diabetes mellitus. Advances in therapy 2010. PMID: 20978879


  180. Klonoff DC, Perz JF. Assisted monitoring of blood glucose: special safety needs for a new paradigm in testing glucose. Journal of diabetes science and technology 2010. PMID: 20920422


  181. Klonoff DC. Regulatory controversies surround blood glucose monitoring devices. Journal of diabetes science and technology 2010. PMID: 20307381


  182. Zhang Y, Jones PL, Klonoff DC. Second insulin pump safety meeting: summary report. Journal of diabetes science and technology 2010. PMID: 20307411


  183. Klonoff DC. The need for a glycemia modeling comparison workshop to facilitate development of an artificial pancreas. Journal of diabetes science and technology 2010. PMID: 20167161


  184. Klonoff DC. The beneficial effects of a Paleolithic diet on type 2 diabetes and other risk factors for cardiovascular disease. Journal of diabetes science and technology 2009. PMID: 20144375


  185. Klonoff DC, Cobelli C, Kovatchev B, Zisser HC. Progress in development of an artificial pancreas. Journal of diabetes science and technology 2009. PMID: 20144412


  186. Klonoff DC, True MW. The missing element of telemedicine for diabetes: decision support software. Journal of diabetes science and technology 2009. PMID: 20144411


  187. Klonoff DC. The personalized medicine for diabetes meeting summary report. Journal of diabetes science and technology 2009. PMID: 20144312


  188. Klonoff DC. Using telemedicine to improve outcomes in diabetes--an emerging technology. Journal of diabetes science and technology 2009. PMID: 20144303


  189. Klonoff DC. A sweetened beverage tax is needed to combat the obesity epidemicas well as related absenteeism and presenteeism. Journal of diabetes science and technology 2009. PMID: 20144275


  190. Fleming GA, Klonoff DC. Glutamic Acid decarboxylase therapy for recent-onset type 1 diabetes: are we at the end or the beginning of finding a cure? Journal of diabetes science and technology 2009. PMID: 20144352


  191. Klonoff DC, Reyes JS. Insulin pump safety meeting: summary report. Journal of diabetes science and technology 2009. PMID: 20144372


  192. Klonoff DC. The increasing incidence of diabetes in the 21st century. Journal of diabetes science and technology 2009. PMID: 20046646


  193. Klonoff DC, Bergenstal R, Blonde L, Boren SA, Church TS, Gaffaney J, Jovanovic L, Kendall DM, Kollman C, Kovatchev BP, Leippert C, Owens DR, Polonsky WH, Reach G, Renard E, Riddell MC, Rubin RR, Schnell O, Siminiero LM, Vigersky RA, Wilson DM, Wollitzer AO. Consensus report of the coalition for clinical research-self-monitoring of blood glucose. Journal of diabetes science and technology 2008. PMID: 19885292


  194. Klonoff DC. Designing an artificial pancreas system to be compatible with other medical devices. Journal of diabetes science and technology 2008. PMID: 19885256


  195. Klonoff DC, Greenway F. Drugs in the pipeline for the obesity market. Journal of diabetes science and technology 2008. PMID: 19885278


  196. Rosenstock J, Bergenstal R, Defronzo RA, Hirsch IB, Klonoff D, Boss AH, Kramer D, Petrucci R, Yu W, Levy B. Efficacy and safety of Technosphere inhaled insulin compared with Technosphere powder placebo in insulin-naive type 2 diabetes suboptimally controlled with oral agents. Diabetes care 2008. PMID: 18678610


  197. Klonoff DC. Spending for diabetes drugs is increasing in the United States. Journal of diabetes science and technology 2008. PMID: 19885226


  198. Klonoff DC. Personalized medicine for diabetes. Journal of diabetes science and technology 2008. PMID: 19885196


  199. Klonoff DC. Summary of Seventh Annual Diabetes Technology Meeting October 25-27, 2007 San Francisco, California. Journal of diabetes science and technology 2008. PMID: 19885363


  200. Klonoff DC. The "catalyst to better diabetes care act of 2007". Journal of diabetes science and technology 2008. PMID: 19885339


  201. Klonoff DC. Business and economics of diabetes. Journal of diabetes science and technology 2008. PMID: 19885170


  202. Klonoff DC, Buse JB, Nielsen LL, Guan X, Bowlus CL, Holcombe JH, Wintle ME, Maggs DG. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Current medical research and opinion 2008. PMID: 18053320


  203. Klonoff DC. The benefits of implanted glucose sensors. Journal of diabetes science and technology 2007. PMID: 19885150


  204. Klonoff DC. Bariatric surgery for obese adolescents. Journal of diabetes science and technology 2007. PMID: 19885106


  205. Klonoff DC. Dirlotapide, a U.S. Food and Drug Administration-approved first-in-class obesity drug for dogs-will humans be next? Journal of diabetes science and technology 2007. PMID: 19885086


  206. Klonoff DC. Replacements for trans fats-will there be an oil shortage? Journal of diabetes science and technology 2007. PMID: 19885099


  207. Klonoff DC. Subcutaneous continuous glucose monitoring in severe burn patients. Critical care medicine 2007. PMID: 17446759


  208. Klonoff DC. Summary of Sixth Annual Diabetes Technology Meeting, November 2-4, 2006, Atlanta, Georgia. Journal of diabetes science and technology 2007. PMID: 19888416


  209. Klonoff DC. Technology to treat hyperglycemia in trauma. Journal of diabetes science and technology 2007. PMID: 19888398


  210. Klonoff DC. Benefits and limitations of self-monitoring of blood glucose. Journal of diabetes science and technology 2007. PMID: 19888392


  211. Klonoff DC. The artificial pancreas: how sweet engineering will solve bitter problems. Journal of diabetes science and technology 2007. PMID: 19888383


  212. Nichols JH, Klonoff DC. The need for performance standards for continuous glucose monitors. Journal of diabetes science and technology 2007. PMID: 19888385


  213. Klonoff DC. A review of continuous glucose monitoring technology. Diabetes technology & therapeutics 2005. PMID: 16241880


  214. Crowe DJ, Klonoff DC. Time synching or time sinking? Diabetes technology & therapeutics 2005. PMID: 16241864


  215. Klonoff DC. Pyruvate therapy for severe hypoglycemia. Diabetes technology & therapeutics 2005. PMID: 16120029


  216. Klonoff DC. Continuous glucose monitoring: roadmap for 21st century diabetes therapy. Diabetes care 2005. PMID: 15855600


  217. Simmons M, Gillett D, Catanzaro B, Jacobs B, Klonoff DC, Sage B. An adaptive drug infusion system. Diabetes technology & therapeutics 2004. PMID: 15628815


  218. Klonoff DC. A flaw in the use of sulfonylurea screening to diagnose sulfonylurea overdosages. Diabetes technology & therapeutics 2003. PMID: 12828830


  219. Klonoff DC. Microdialysis of interstitial fluid for continuous glucose measurement. Diabetes technology & therapeutics 2003. PMID: 14511409


  220. Klonoff DC. Technology for portable measurement of blood lactate. Diabetes technology & therapeutics 2003. PMID: 14709194


  221. Klonoff DC. The link between diabetes, military metabolic monitoring, and NASA. Diabetes technology & therapeutics 2003. PMID: 12833916


  222. Klonoff DC. Current, emerging, and future trends in metabolic monitoring. Diabetes technology & therapeutics 2002. PMID: 12450438


  223. Hopmeier M, Glenn JF, Goldstein R, Hines J, Friedl K, Hunter-Schaedle K, Laughlin M, Loew M, Klonoff D. Technologies for Metabolic Monitoring (TMM): a new research initiative. Diabetes technology & therapeutics 2002. PMID: 12396749


  224. Klonoff DC. FDA approves new glucose test for adult diabetics. Diabetes technology & therapeutics 2001. PMID: 11478334


  225. Klonoff DC. Special funding boosts type 1 diabetes research. Diabetes technology & therapeutics 2001. PMID: 11478335


  226. Klonoff DC. The need for hypoglycemia detection and prevention in type 1 diabetes. Diabetes technology & therapeutics 2001. PMID: 11911168


  227. Klonoff DC. The pen is mightier than the needle (and syringe). Diabetes technology & therapeutics 2001. PMID: 11911176


  228. Klonoff DC, Schwartz DM. An economic analysis of interventions for diabetes. Diabetes care 2000. PMID: 10868871


  229. Klonoff DC. Allen M. Spiegel, M.D., named Director of NIDDK. Diabetes technology & therapeutics 2000. PMID: 11467311


  230. Klonoff DC. Clinical chemistry and clinical toxicology devices advisory panel recommendation on Glucowatch. Diabetes technology & therapeutics 2000. PMID: 11467313


  231. Klonoff DC. NIAID spearheads collaborative network for clinical research on immune tolerance. Diabetes technology & therapeutics 2000. PMID: 11467312


  232. Klonoff DC. Serum fructosamine as a screening test for type 2 diabetes. Diabetes technology & therapeutics 2000. PMID: 11469616


  233. Klonoff DC. Diabetes Prevention Program meets recruitment goals. Diabetes technology & therapeutics 1999. PMID: 11475280


  234. Klonoff DC. FDA Clinical Chemistry and Clinical Toxicology Devices Panel. Diabetes technology & therapeutics 1999. PMID: 11475293


  235. Klonoff DC. FDA approves new Glucose Monitoring System. Diabetes technology & therapeutics 1999. PMID: 11475279


  236. Klonoff DC. Inhaled insulin. Diabetes technology & therapeutics 1999. PMID: 11475277


  237. Klonoff DC. New labeling and use changes for Rezulin. Diabetes technology & therapeutics 1999. PMID: 11484719


  238. Klonoff DC. New products and new technologies for diabetes. Diabetes technology & therapeutics 1999. PMID: 11475267


  239. Klonoff DC. The UCSF Diabetes Symposium: Research Breakthroughs in Diabetes. Diabetes technology & therapeutics 1999. PMID: 11512541


  240. Klonoff DC. The promise of optical sensing strategies for glucose. Diabetes technology & therapeutics 1999. PMID: 11474823


  241. Klonoff DC. Noninvasive blood glucose monitoring. Diabetes care 1997. PMID: 9051401


  242. Klonoff DC, Barrett BJ, Nolte MS, Cohen RM, Wyderski R. Hypoglycemia following inadvertent and factitious sulfonylurea overdosages. Diabetes care 1995. PMID: 7497872


  243. Klonoff DC, Wiskocil RL. Inappropriate drug prescribing. JAMA 1995. PMID: 7837357


  244. Klonoff DC. Chronic fatigue syndrome. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1992. PMID: 1445980


  245. Demeure MJ, Klonoff DC, Karam JH, Duh QY, Clark OH. Insulinomas associated with multiple endocrine neoplasia type I: the need for a different surgical approach. Surgery 1991. PMID: 1684067


  246. Klonoff DC, Kahn DG, Rosenzweig W, Wilson CB. Hyperprolactinemia in a patient with a pituitary and an ovarian dermoid tumor: case report. Neurosurgery 1990. PMID: 2308685


  247. Klonoff DC, Andrews BT, Obana WG. Stroke associated with cocaine use. Archives of neurology 1989. PMID: 2673163


  248. Klonoff DC. Association of hyperinsulinemia with chlorpropamide toxicity. The American journal of medicine 1988. PMID: 3276184


  249. Kahn DG, Garfinkle JM, Klonoff DC, Pembrook LJ, Morrow DJ. Cryptosporidial and cytomegaloviral hepatitis and cholecystitis. Archives of pathology & laboratory medicine 1987. PMID: 2820346


  250. Klonoff DC, Greenspan FS. The thyroid nodule. Advances in internal medicine 1982. PMID: 7041541


  251. Klonoff DC. Macroamylasemia and other immunoglobulin-complexed enzyme disorders. The Western journal of medicine 1980. PMID: 6162278


  252. Mohsenifar Z, Klonoff D, Cassan S. Propionibacterium acnes pneumonia in a patient with lymphoma. Infection 1979. PMID: 478654