Cheryl Stoddart, PhD
My research has focused on the use of the SCID-hu Thy/Liv mouse model for preclinical evaluation of antiviral compounds and immunomodulating agents. The Thy/Liv model is constructed by implantation of organs supportive of human multilineage hematopoiesis and T-cell development (e.g., fetal liver and thymus) into the immunodeficient C.B-17 scid/scid mouse. Since 2000, I have been the Principal Investigator for a sole-sourced contract from NIH/NIAID, Tissue-Based Small Animal Model for HIV Drug Discovery funded to carry out these drug evaluations. The model has also been shown to be receptive to the surgical implantation of a number of other hematopoietic and nonhematopoietic human organ systems, including lymph node, small and large intestine, lung, skin, pituitary, ovary, and placenta. Mice with such implanted organs represent potential models that could be used to discover and evaluate stem cell populations normally resident within each of these organs.
- Potential role of heat shock protein 90 (Hsp90) in HIV uncoating.
- An Albumin-Conjugated Peptide Exhibits Potent Anti-HIV Activity and Long In Vivo Half-Life.
- How the immune system ‘Grows up’: evidence supporting the existence of a layered immune system.
- Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation.
- Models of HIV-1 disease: A review of current status.
- Chapter 129 The SCID-hu Thy/Liv Mouse An Animal Model for HIV-1 Infection.