American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists
Authors: Stolldorf DP, Mixon AS, Auerbach AD, Aylor AR, Shabbir H, Schnipper J, Kripalani S
Cell reports
Authors: Jackson ND, Everman JL, Chioccioli M, Feriani L, Goldfarbmuren KC, Sajuthi SP, Rios CL, Powell R, Armstrong M, Gomez J, Michel C, Eng C, Oh SS, Rodriguez-Santana J, Cicuta P, Reisdorph N, Burchard EG, Seibold MA
Annals of internal medicine
Authors: McCaw ZR, Tian L, Vassy JL, Ritchie CS, Lee CC, Kim DH, Wei LJ
Circulation. Arrhythmia and electrophysiology
Authors: Parameswaran R, Kalman JM, Royse A, Goldblatt J, Larobina M, Watts T, Walters TE, Nalliah CJ, Wong G, Al-Kaisey A, Anderson RD, Voskoboinik A, Sugumar H, Chieng D, Sanders P, Kistler PM, Gerstenfeld EP, Lee G
Clinical cancer research : an official journal of the American Association for Cancer Research
Authors: Kelley RK, Meyer T, Rimassa L, Merle P, Park JW, Yau T, Chan SL, Blanc JF, Tam VC, Tran A, Dadduzio V, Markby DW, Kaldate R, Cheng AL, El-Khoueiry AB, Abou-Alfa GK
PloS one
Authors: Bahrainwala L, Knoblauch AM, Andriamiadanarivo A, Diab MM, McKinney J, Small PM, Kahn JG, Fair E, Rakotosamimanana N, Grandjean Lapierre S
International journal of environmental research and public health
Authors: Almoznino G, Abramovitz I, Kessler Baruch O, Kedem R, Protter NE, Levine J, Bader T, Yavnai N, Zur D, Mijiritsky E, Shay B
Volume 117 of Issue 29 | Proceedings of the National Academy of Sciences of the United States of America
Authors: Müller NF, Stolz U, Dudas G, Stadler T, Vaughan TG
Reassortment is an important source of genetic diversity in segmented viruses and is the main source of novel pathogenic influenza viruses. Despite this, studying the reassortment process has been constrained by the lack of a coherent, model-based inference framework. Here, we introduce a coalescent-based model that allows us to explicitly model the joint coalescent and reassortment process. In order to perform inference under this model, we present an efficient Markov chain Monte Carlo algorithm to sample rooted networks and the embedding of phylogenetic trees within networks. This algorithm provides the means to jointly infer coalescent and reassortment rates with the reassortment network and the embedding of segments in that network from full-genome sequence data. Studying reassortment patterns of different human influenza datasets, we find large differences in reassortment rates across different human influenza viruses. Additionally, we find that reassortment events predominantly occur on selectively fitter parts of reassortment networks showing that on a population level, reassortment positively contributes to the fitness of human influenza viruses.
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Journal of Clinical and Translational Science
Authors: Towfighi A, Orechwa AZ, Aragón TJ, Atkins M, Brown AF, Brown J, Carrasquillo O, Carson S, Fleisher P, Gustafson E, Herman DK, Inkelas M, Liu W, Meeker D, Mehta T, Miller DC, Paul-Brutus R, Potter MB, Rittner SS, Rodriguez B, Rusch D, Skinner A, Yee HF
