BMJ (Clinical research ed.)
Authors: Deng Y, Polley EC, Wallach JD, Dhruva SS, Herrin J, Quinto K, Gandotra C, Crown W, Noseworthy P, Yao X, Lyon TD, Shah ND, Ross JS, McCoy RG
JAMA internal medicine
Authors: Dhruva SS, Ji RZ, Ross JS, Spatz ES, Redberg RF
JAMA network open
Authors: Wray CM
JAMA network open
Authors: Santhosh L, Witt L
JAMA internal medicine
Authors: Perumal D, Dudley RA, Gan S, Boscardin WJ, Gill A, Gelb AW, Lee SJ, Chen CL
Academic medicine : journal of the Association of American Medical Colleges
Authors: Chang A, Pierluissi E, Cornes S, Ishizaki A, Teherani A, Davis J, Hauer KE, Lucey CR
JAMA network open
Authors: Marquez C, Kerkhoff AD, Schrom J, Rojas S, Black D, Mitchell A, Wang CY, Pilarowski G, Ribeiro S, Jones D, Payan J, Manganelli S, Rojas S, Lemus J, Jain V, Chamie G, Tulier-Laiwa V, Petersen M, DeRisi J, Havlir DV
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Authors: Shitole SG, Lazar JM, Taub CC, Furlani AC, Konkle-Parker DJ, Dionne-Odom J, Fischl MA, Ofotokun I, Adimora AA, Topper EF, Golzar Y, Kassaye SG, Gustafson D, Anastos K, Hanna DB, Xue X, Tien PC, Kaplan RC, Kizer JR
Volume 33 of Issue 11 | Journal of cardiovascular electrophysiology
Authors: Huang E, Bernard ML, Elise Hiltbold A, Khatib S, Polin GM, Rogers PA, Dominic P, Morin DP
INTRODUCTION
Heart failure (HF) is a major cause of morbidity and mortality, with nearly half of all HF-related deaths resulting from sudden cardiac death (SCD), most often from an arrhythmic event. The pathophysiologic changes that occur in response to the hemodynamic stress of HF may lead to increased arrhythmogenesis. Theoretically, medications that block these arrhythmogenic substrates would decrease the risk of SCD. The combined angiotensin receptor and neprilysin inhibitor (ARNi; tradename Entresto) is the newest commercially available medication for the treatment of heart failure.
METHODS AND RESULTS
We reviewed and synthesized the available literature regarding sacubitril/valsartan and its effects on cardiac rhythm. ARNi has been shown to decrease cardiovascular mortality and hospitalization in patients with HF with reduced ejection fraction (HFrEF). Emerging evidence suggests that ARNi also may play a role in reducing arrhythmogenesis and thereby SCD.
CONCLUSION
This review summarizes the current data regarding this ARNi and its potential antiarrhythmic effects.
View on PubMed
European journal of heart failure
Authors: van Essen BJ, Tromp J, Ter Maaten JM, Greenberg BH, Gimpelewicz C, Felker GM, Davison BA, Severin T, Pang PS, Cotter G, Teerlink JR, Metra M, Voors AA