Publications

Department of Medicine faculty members published more than 3,000 peer-reviewed articles in 2022.

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Nature

T cells specific for α-myosin drive immunotherapy-related myocarditis.

2022

Authors: Axelrod ML, Meijers WC, Screever EM, Qin J, Carroll MG, Sun X, Tannous E, Zhang Y, Sugiura A, Taylor BC, Hanna A, Zhang S, Amancherla K, Tai W, Wright JJ, Wei SC, Opalenik SR, Toren AL, Rathmell JC, Ferrell PB, Phillips EJ, Mallal S, Johnson DB, Allison JP, Moslehi JJ, Balko JM

Neurosurgery

Racial Differences in Postoperative Opioid Prescribing Practices in Spine Surgical Patients.

2022

Authors: Letchuman V, He L, Mummaneni PV, Agarwal N, Campbell LJ, Shabani S, Chan AK, Abrecht CR, Miller C, Sankaran S, Rambachan A, Croci R, Berven SH, Chou D, Holly LT, Guan Z

Journal of general internal medicine

Defining Multimorbidity in Older Patients Hospitalized with Medical Conditions.

2022

Authors: Jain S, Rosenbaum PR, Reiter JG, Ramadan OI, Hill AS, Hashemi S, Brown RT, Kelz RR, Fleisher LA, Silber JH

Journal of hepatology

Title: On Building a Better Mousetrap Response to: "Towards Optimally Replacing the Current Version of MELD".

2022

Authors: Ge J, Kim WR, Lai JC, Kwong AJ

eLife

The <i>CIC-ERF</i> co-deletion underlies fusion-independent activation of ETS family member, ETV1, to drive prostate cancer progression.

2022

Authors: Gupta N, Song H, Wu W, Ponce RK, Lin YK, Kim JW, Small EJ, Feng FY, Huang FW, Okimoto RA

JACC. CardioOncology

Early Treatment of Cardiac ATTR: "To Remove the Weeds, You Have to Get the Roots".

2022

Authors: Lenihan D, Cheng RK

Blood

Development of a Novel Bleeding Quality of Life Patient-Reported Outcome Measure for Older Adults.

2022

Authors: Anna L Parks, Alyssa Lopez, Stacey L. Slager, Margaret C. Fang, Mark A. Supiano, Patti P Katz, Daniel M. Witt

Volume 28 | Molecular therapy. Methods & clinical development

Novel engineered chimeric engulfment receptors trigger T cell effector functions against SIV-infected CD4+ T cells.

2022

Authors: Corey D, Haeseleer F, Hou J, Corey L

View Abstract

Adoptive therapy with genetically engineered T cells offers potential for infectious disease treatment in immunocompromised persons. HIV/simian immunodeficiency virus (SIV)-infected cells express phosphatidylserine (PS) early post infection. We tested whether chimeric engulfment receptor (CER) T cells designed to recognize PS-expressing cells could eliminate SIV-infected cells. Lentiviral CER constructs composed of the extracellular domain of T cell immunoglobulin and mucin domain containing 4 (TIM-4), the PS receptor, and engulfment signaling domains were transduced into primary rhesus macaque (RM) T cells. We measured PS binding and T cell engulfment of RM CD4+ T cells infected with SIV expressing GFP and , TIM-4 CER CD4+ T cells effectively killed SIV-infected cells, which was dependent on TIM-4 binding to PS. Enhanced killing of SIV-infected CD4+ T cells by CER and chimeric antigen receptor T cell combinations was also observed. This installation of innate immune functions into T cells presents an opportunity to enhance elimination of SIV-infected cells, and studies to evaluate their effect are warranted.

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Blood

Next-Generation Sequencing of Newly-Diagnosed Primary CNS Lymphoma Reveals Alterations in BTG1, ETV6, and 6p Are Associated with Chemoresistance and Inferior Progression-Free Survival.

2022

Authors: Shirley S. Mo, Huimin Geng, Miguel Cerejo, Kwun Wah Wen, David A. Solomon, James L. Rubenstein

Blood

Multiomic Single-Cell Sequencing of Mixed Phenotypic Acute Leukemia (MPAL) Reveals Complex Immunophenotypic, Transcriptional, and Genetic Heterogeneity.

2022

Authors: Cheryl Peretz, Vanessa E. Kennedy, Anushka Walia, Cyrille Delley, Andrew Koh, Elaine Tran, Iain Clark, Corey Hayford, Yi Xue, Chris D'Amato, Kristina Fontanez, Ritu P. Roy, Adam Olshen, Aaron C. Logan, Alexander E. Perl, Adam Abate, Catherine Smith