Blood
Authors: Leyte-Vidal A, Garrido Ruiz D, DeFilippis R, Leske IB, Rea D, Phan S, Miller KB, Hu F, Mase A, Shan Y, Hantschel O, Jacobson MP, Shah NP
Volume 39 of Issue 3 | Cardiovascular intervention and therapeutics
Authors: Warisawa T, Cook CM, Ahmad Y, Howard JP, Seligman H, Rajkumar C, Toya T, Doi S, Nakajima A, Nakayama M, Vera-Urquiza R, Yuasa S, Sato T, Kikuta Y, Kawase Y, Nishina H, Al-Lamee R, Sen S, Lerman A, Matsuo H, Akashi YJ, Escaned J, Davies JE
Despite guideline-based recommendation of the interchangeable use of instantaneous wave-free ratio (iFR) and fractional flow reserve (FFR) to guide revascularization decision-making, iFR/FFR could demonstrate different physiological or clinical outcomes in some specific patient or lesion subsets. Therefore, we sought to investigate the impact of difference between iFR and FFR-guided revascularization decision-making on clinical outcomes in patients with left main disease (LMD). In this international multicenter registry of LMD with physiological interrogation, we identified 275 patients in whom physiological assessment was performed with both iFR/FFR. Major adverse cardiovascular event (MACE) was defined as a composite of death, non-fatal myocardial infarction, and ischemia-driven target lesion revascularization. The receiver-operating characteristic analysis was performed for both iFR/FFR to predict MACE in respective patients in whom revascularization was deferred and performed. In 153 patients of revascularization deferral, MACE occurred in 17.0% patients. The optimal cut-off values of iFR and FFR to predict MACE were 0.88 (specificity:0.74; sensitivity:0.65) and 0.76 (specificity:0.81; sensitivity:0.46), respectively. The area under the curve (AUC) was significantly higher for iFR than FFR (0.74; 95%CI 0.62-0.85 vs. 0.62; 95%CI 0.48-0.75; p = 0.012). In 122 patients of coronary revascularization, MACE occurred in 13.1% patients. The optimal cut-off values of iFR and FFR were 0.92 (specificity:0.93; sensitivity:0.25) and 0.81 (specificity:0.047; sensitivity:1.00), respectively. The AUCs were not significantly different between iFR and FFR (0.57; 95%CI 0.40-0.73 vs. 0.46; 95%CI 0.31-0.61; p = 0.43). While neither baseline iFR nor FFR was predictive of MACE in patients in whom revascularization was performed, iFR-guided deferral seemed to be safer than FFR-guided deferral.
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AIDS and behavior
Authors: Brookins T, Reagan D, Tate M, Suprasert B, Taylor KD, Ruiz R, Miller K, Wilson EC, McFarland W
AIDS (London, England)
Authors: Kadiyala GN, Telwatte S, Wedrychowski A, Janssens J, Kim SJ, Kim P, Deeks S, Wong JK, Yukl SA
Breast cancer research and treatment
Authors: Hsu R, Al-Zubeidy B, Flores D, Nazarian A, Baugh A, Gonzalez E, Castanon S, Xiu J, Kang I, Spicer D, Lenz HJ, Dara L, Ademuyiwa FO, Korn WM, Irshad S, Chan IS, Roussos Torres ET
Physical review letters
Authors: Santiesteban SN, Li S, Abrams D, Alsalmi S, Androic D, Aniol K, Arrington J, Averett T, Ayerbe Gayoso C, Bane J, Barcus S, Barrow J, Beck A, Bellini V, Bhatt H, Bhetuwal D, Biswas D, Camsonne A, Castellanos J, Chen J, Chen JP, Chrisman D, Christy ME, Clarke C, Covrig S, Cruz-Torres R, Day D, Dutta D, Fuchey E, Gal C, Garibaldi F, Gautam TN, Gogami T, Gomez J, Guèye P, Hague TJ, Hansen JO, Hauenstein F, Henry W, Higinbotham DW, Holt RJ, Hyde C, Itabashi K, Kaneta M, Karki A, Katramatou AT, Keppel CE, King PM, Kurbany L, Kutz T, Lashley-Colthirst N, Li WB, Liu H, Liyanage N, Long E, Lovato A, Mammei J, Markowitz P, McClellan RE, Meddi F, Meekins D, Michaels R, Mihovilovic M, Moyer A, Nagao S, Nguyen D, Nycz M, Olson M, Ou L, Owen V, Palatchi C, Pandey B, Papadopoulou A, Park S, Petkovic T, Premathilake S, Punjabi V, Ransome RD, Reimer PE, Reinhold J, Riordan S, Rocco N, Rodriguez VM, Schmidt A, Schmookler B, Segarra EP, Shahinyan A, Širca S, Slifer K, Solvignon P, Su T, Suleiman R, Tang L, Tian Y, Tireman W, Tortorici F, Toyama Y, Uehara K, Urciuoli GM, Votaw D, Williamson J, Wojtsekhowski B, Wood S, Ye ZH, Zhang J, Zheng X, Jefferson Lab Hall A Collaboration
Nature medicine
Authors: Zamecnik CR, Sowa GM, Abdelhak A, Dandekar R, Bair RD, Wade KJ, Bartley CM, Kizer K, Augusto DG, Tubati A, Gomez R, Fouassier C, Gerungan C, Caspar CM, Alexander J, Wapniarski AE, Loudermilk RP, Eggers EL, Zorn KC, Ananth K, Jabassini N, Mann SA, Ragan NR, Santaniello A, Henry RG, Baranzini SE, Zamvil SS, Sabatino JJ, Bove RM, Guo CY, Gelfand JM, Cuneo R, von Büdingen HC, Oksenberg JR, Cree BAC, Hollenbach JA, Green AJ, Hauser SL, Wallin MT, DeRisi JL, Wilson MR
bioRxiv : the preprint server for biology
Authors: Matharu N, Zhao J, Sohota A, Deng L, Hung Y, Li Z, Sims J, Rattanasopha S, Meyer J, Carbone L, Kircher M, Ahituv N
Annals of internal medicine
Authors: Qaseem A, Obley AJ, Shamliyan T, Hicks LA, Harrod CS, Crandall CJ, Clinical Guidelines Committee of the American College of Physicians, Balk EM, Cooney TG, Cross JT, Fitterman N, Lin JS, Maroto M, Miller MC, Shekelle P, Tice JA, Tufte JE, Etxeandia-Ikobaltzeta I, Yost J
Current oncology reports
Authors: Abel MK, Wang A, Letourneau JM, Melisko ME, Cedars MI, Rosen MP
