Publications

Department of Medicine faculty members published more than 3,600 peer-reviewed articles in 2024.

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The Othmer and DeSouza test for screening of somatisation disorder: is it useful in general practice?

2001

Authors: Zaballa P, Crega Y, Grandes G, Peralta C

The Journal of surgical research

Preimplant vein intimal thickness is not a predictor of bypass graft stenosis.

2001

Authors: James DC, Durrani T, Wixon CL, Hughes JD, Westerband A, Mills JL

Volume 158 of Issue 3 | The American journal of pathology

PG490-88, a derivative of triptolide, blocks bleomycin-induced lung fibrosis.

2001

Authors: Krishna G, Liu K, Shigemitsu H, Gao M, Raffin TA, Rosen GD

View Abstract

In this study we evaluate the antifibrotic properties of PG-490-88, a water-soluble derivative of triptolide. Triptolide is an oxygenated diterpene that is derived from a traditional Chinese herb that has potent immunosuppressive and antitumor activity. We used the intratracheal bleomycin mouse model and found that PG490-88 inhibits fibrosis in the bleomycin group when given the same day or 5 days after bleomycin. PG490-88 also markedly reduced the number of myofibroblasts in the bleomycin treatment group. An enzyme-linked immunosorbent assay of transforming growth factor (TGF)-beta in the bronchoalveolar lavage fluid showed a significant decrease in TGF-beta in the PG490-88-treated groups compared to the bleomycin-treated group. Additionally, triptolide blocked bleomycin-induced increase in TGF-beta mRNA in cultured normal human lung fibroblasts. The efficacy of PG490-88 when administered late after bleomycin installation suggests a potential role in the treatment of idiopathic pulmonary fibrosis.

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Journal of acquired immune deficiency syndromes (1999)