Osteoarthritis and cartilage
Authors: Bauer DC, Hunter DJ, Abramson SB, Attur M, Corr M, Felson D, Heinegård D, Jordan JM, Kepler TB, Lane NE, Saxne T, Tyree B, Kraus VB
Volume 13 of Issue 6 | Cancer gene therapy
Authors: Tjin Tham Sjin RM, Naspinski J, Birsner AE, Li C, Chan R, Lo KM, Gillies S, Zurakowski D, Folkman J, Samulski J, Javaherian K
Developing continuous systemic delivery of endostatin has been a goal of many laboratories. We have employed a method of gene therapy utilizing different viral constructs. Here, we report that a new serotype of adeno-associated viruses, which incorporates canine endostatin, provides dose-dependent transgene expression in the circulation after intramuscular injection in mice. Elevated levels of endostatin remained stable in the circulation for at least 4 months. In vitro assays determined that the protein expressed was biologically active. Antitumor activities of the above construct demonstrated a U-shape curve, where the maximum activity was observed within a certain critical concentration range. These data suggest that an optimum dose range may be required to achieve therapeutic efficacy in large animal models.
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The American journal of tropical medicine and hygiene
Authors: Schwartz BS, Harris JB, Khan AI, Larocque RC, Sack DA, Malek MA, Faruque AS, Qadri F, Calderwood SB, Luby SP, Ryan ET
Cancer causes & control : CCC
Authors: O'Riordan DL, Field AE, Geller AC, Brooks DR, Aweh G, Colditz GA, Frazier AL
Chemical biology & drug design
Authors: Weisman JL, Liou AP, Shelat AA, Cohen FE, Guy RK, DeRisi JL
Genes, chromosomes & cancer
Authors: Horsley SW, Mackay A, Iravani M, Fenwick K, Valgeirsson H, Dexter T, Ashworth A, Kearney L
Health services research
Authors: Luft HS, Rappaport KM, Yelin EH, Aubry WM
Health services research
Authors: Halpin HA, McMenamin SB, Pourat N, Yelin E
Clinical evidence
Authors: Shlipak M
Transplant international : official journal of the European Society for Organ Transplantation
Authors: Vincenti F, de Andrés A, Becker T, Choukroun G, Cole E, González-Posada JM, Kumar MA, Moore R, Nadalin S, Nashan B, Rostaing L, Saito K, Yoshimura N
