Publications

Department of Medicine faculty members published more than 3,600 peer-reviewed articles in 2024.

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Critical care (London, England)

Protein C as a surrogate end-point for clinical trials of sepsis.

2008

Authors: Liu KD, Matthay MA

Gastrointestinal endoscopy

Presentation and management of acute fistulization of a foregut duplication cyst.

2008

Authors: Sarkar M, Wood R, Oh Y, Hecht TE, Kaiser L, Wasserstein A, Kochman ML

The New England journal of medicine

Artesunate for the treatment of severe falciparum malaria.

2008

Authors: Rosenthal PJ

Volume 70 of Issue 4 | Psychosomatic medicine

Depression and cardiac function in patients with stable coronary heart disease: findings from the Heart and Soul Study.

2008

Authors: Lett H, Ali S, Whooley M

View Abstract

OBJECTIVE

To determine whether depression is associated with worse cardiac disease severity in patients with stable coronary heart disease (CHD). There is considerable evidence that depression is a risk factor for adverse cardiovascular events in patients with CHD. However, a frequent criticism of this literature is that the association between depression and adverse cardiovascular outcomes may be confounded by worse baseline cardiac disease severity in depressed patients.

METHOD

In a sample of 1020 outpatients with stable CHD, we examined the association between major depression (assessed using the Computerized National Institute of Mental Health Diagnostic Interview Schedule) with measures of cardiac disease severity, including systolic dysfunction, diastolic dysfunction, exercise-induced ischemia, and cardiac wall motion abnormalities. Cross-sectional univariate and multivariate models controlling for demographic and clinical variables were computed.

RESULTS

Of the 1020 participants, 224 (22%) had current (past month) major depression. After adjustment for age, major depression was not associated with systolic dysfunction, diastolic dysfunction, inducible ischemia, or cardiac wall motion abnormalities. Similarly, multivariate models revealed no significant relationship between major depression and cardiac disease severity.

CONCLUSIONS

Overall, we found little evidence that depression is associated with worse cardiac disease severity. This suggests that greater baseline cardiac disease severity is unlikely to be responsible for the increased risk of CHD events in depressed patients.

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AIDS (London, England)

Role of HIV and human herpesvirus-8 infection in pulmonary arterial hypertension.

2008

Authors: Hsue PY, Deeks SG, Farah HH, Palav S, Ahmed SY, Schnell A, Ellman AB, Huang L, Dollard SC, Martin JN

AIDS (London, England)

Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance.

2008

Authors: Liu L, May S, Richman DD, Hecht FM, Markowitz M, Daar ES, Routy JP, Margolick JB, Collier AC, Woelk CH, Little SJ, Smith DM

AIDS (London, England)

CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection.

2008

Authors: Baker JV, Peng G, Rapkin J, Abrams DI, Silverberg MJ, MacArthur RD, Cavert WP, Henry WK, Neaton JD

Volume 40 of Issue 12 | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Safe endoscopic treatment of large colonic lipomas using endoscopic looping technique.

2008

Authors: Kaltenbach T, Milkes D, Friedland S, Soetikno R

View Abstract

PURPOSE

Colonic lipomas are benign, submucosal tumours that are usually asymptomatic. Typically, they are incidentally diagnosed during colonoscopy. Due to a low prevalence, the natural history of lipomas remains largely unknown. While large (>2 cm) lesions can cause symptoms and complications, their endoscopic treatment is not routinely recommended because of prior reports of a high rate of perforation.

METHODS

We used a standardized technique of polypectomy, using endoscopic looping to resect large colonic lipomas in 8 patients and followed their clinical outcomes.

RESULTS

The mean lipoma size was 3.8+/-1.2 cm (range 2.5-6 cm). No patient developed bleeding or perforation. On follow-up (mean=13.5 months, range 2-29), there was one small residual lesion.