Publications
Department of Medicine faculty members published more than 3,600 peer-reviewed articles in 2024.
Journal of the American Geriatrics Society
2008
AIDS education and prevention : official publication of the International Society for AIDS Education
2008
Medical care
2008
Joint Commission journal on quality and patient safety
2008
Journal of the American Geriatrics Society
2008
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
2008
AIDS education and prevention : official publication of the International Society for AIDS Education
2008
Volume 5 of Issue 8 | Nature methods
2008
We are creating families of designer G protein-coupled receptors (GPCRs) to allow for precise spatiotemporal control of GPCR signaling in vivo. These engineered GPCRs, called receptors activated solely by synthetic ligands (RASSLs), are unresponsive to endogenous ligands but can be activated by nanomolar concentrations of pharmacologically inert, drug-like small molecules. Currently, RASSLs exist for the three major GPCR signaling pathways (G(s), G(i) and G(q)). We review these advances here to facilitate the use of these powerful and diverse tools.
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