The American journal of managed care
Authors: Wang G, Kuppermann M, Kim B, Phillips KA, Ladabaum U
Volume 30 of Issue 5 | Nature biotechnology
Authors: Carter SL, Cibulskis K, Helman E, McKenna A, Shen H, Zack T, Laird PW, Onofrio RC, Winckler W, Weir BA, Beroukhim R, Pellman D, Levine DA, Lander ES, Meyerson M, Getz G
We describe a computational method that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations. The method, named ABSOLUTE, can detect subclonal heterogeneity and somatic homozygosity, and it can calculate statistical sensitivity for detection of specific aberrations. We used ABSOLUTE to analyze exome sequencing data from 214 ovarian carcinoma tumor-normal pairs. This analysis identified both pervasive subclonal somatic point-mutations and a small subset of predominantly clonal and homozygous mutations, which were overrepresented in the tumor suppressor genes TP53 and NF1 and in a candidate tumor suppressor gene CDK12. We also used ABSOLUTE to infer absolute allelic copy-number profiles from 3,155 diverse cancer specimens, revealing that genome-doubling events are common in human cancer, likely occur in cells that are already aneuploid, and influence pathways of tumor progression (for example, with recessive inactivation of NF1 being less common after genome doubling). ABSOLUTE will facilitate the design of clinical sequencing studies and studies of cancer genome evolution and intra-tumor heterogeneity.
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Gastroenterology
Authors: Arielle L. Klepper, Francis J. Eng, James D. Dieterich, Jose Walewski, Julio A. Gutierrez, Myron E. Schwartz, Daniel S. Fierer, Thomas Schiano, Andrea D. Branch
The Journal of Immunology
Authors: K Mark Ansel, Molly Thomas, Sarah Abdul-Wajid, Marisella Panduro, Joshua Babiarz, Misha Rajaram, Prescott Woodruff, Lewis Lanier, Vigo Heissmeyer
International Journal of Transgender Health
Authors: Madeline B. Deutsch
The Journal of Immunology
Authors: Jordan Price, Dodge Kemmer, Imelda Balboni, David Haddon, Gil Mandelbaum, Guillaume Delepine, Jeremy Sokolove, Anthony Shum, Sarah Browne, Paul Utz
Current opinion in nephrology and hypertension
Authors: McClellan AC, Plantinga L, McClellan WM
Arteriosclerosis Thrombosis and Vascular Biology
Authors: Claire K Mulvey, Jane F Ferguson, Karen Terembula, Jennifer Tabita-Martinez, Rhia Shah, Parth Patel, M H Usman, Rachana Shah, Nehal N Mehta, Daniel J Rader, Muredach P Reilly
Arteriosclerosis Thrombosis and Vascular Biology
Authors: Jane F Ferguson, Claire K Mulvey, Rhia Shah, Parth Patel, Stephanie Kong, Jennifer Tabita-Martinez, Karen Terembula, Nehal N Mehta, Rachana Shah, Muredach P Reilly
JACC. Cardiovascular interventions
Authors: Elmariah S, Arzamendi D, Llanos A, Margey RJ, Inglessis I, Passeri JJ, Mehrotra P, Baker JN, Rosenfield K, Agnihotri AK, Vlahakes GJ, Palacios IF
