Publications

Department of Medicine faculty members published more than 3,600 peer-reviewed articles in 2024.

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American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Polyclonal Regulatory T Cell Therapy for Control of Inflammation in Kidney Transplants.

2017

Authors: Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

Evaluating Atypical Features of Femur Fractures: How Change in Radiological Criteria Influenced Incidence and Demography of Atypical Femur Fractures in a Community Setting.

2017

Authors: LeBlanc ES, Rosales AG, Black DM, Genant HK, Dell RM, Friess DM, Boardman DL, Bauer DC, de Papp A, Santora AC, Orwoll ES

Food research international (Ottawa, Ont.)

Taste receptors in the gut - A new target for health promoting properties in diet.

2017

Authors: Ekstrand B, Young JF, Rasmussen MK

Volume 134 | Diabetes research and clinical practice

Transitioning from intravenous to subcutaneous insulin in the medical intensive care unit.

2017

Authors: Zhou K, Williams MF, Esquivel MA, Song A, Rahman F, Bena J, Lam SW, Rathz DA, Lansang MC

View Abstract

BACKGROUND

There is a paucity of studies on transitions from IV insulin infusion (IVII) to subcutaneous (SC) insulin in the medical ICU (MICU).

METHODS

We conducted a retrospective study of patients admitted to the Cleveland Clinic MICU from June 2013 to January 2014 who received IVII. We compared blood glucose (BG) control between 3 cohorts based on timing of basal insulin dose: (1) NB (no basal), (2) IB (incorrect basal), (3) CB (correct basal) at 5 time points post-IVII discontinuation (1, 4, 8, 12, and 24h). Insulin doses used for transitioning were compared with 80% of estimated 24h IVII total. Analysis was done using chi-square, ANOVA and t-tests.

RESULTS

There were 269 patients (NB 166, IB 45, CB 58), 55% male with a mean age 58±16years. 103 patients (38%) had a transition attempted (IB 21%, CB 17%). The NB cohort had better BG than the IB cohort at all time points (p<0.001) but also lower HbA1c, prior DM diagnosis and home insulin use (p<0.001). IB and CB did not have significantly different BG with mean BG>180mg/dL at 4/5 time intervals. However, the dose of basal insulin used was less than 80% of estimated 24h IVII total (IB 21.4 vs 49.6U, CB 25vs 57.1U). Despite this, 15% of patients in the IB cohort and 24% of patients in the CB had hypoglycemic events.

CONCLUSION

The low rates of IV to SC insulin transitions raises the question of challenges to transitions.

View on PubMed

Scientific Reports

Imaging Active Infection in vivo Using D-Amino Acid Derived PET Radiotracers.

2017

Authors: Neumann KD, Villanueva-Meyer JE, Mutch CA, Flavell RR, Blecha JE, Kwak T, Sriram R, VanBrocklin HF, Rosenberg OS, Ohliger MA, Wilson DM

Journal of medicinal chemistry

Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs).

2017

Authors: Previti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J, Rosenthal PJ, Grasso S, Zappalà M

PloS one