Volume 419 | International journal of cardiology
Authors: Helali J, Ramesh K, Brown J, Preciado-Ruiz C, Nguyen T, Tavane L, Ficara A, Wesbey G, Gonzalez JA, Bilchick KC, Salerno M, Robinson A
BACKGROUND
Late gadolinium enhancement (LGE) on cardiac MRI has been shown to predict adverse outcomes in a range of cardiac diseases. However, no study has systematically reviewed and analyzed the literature across all cardiac pathologies including rare diseases.
METHODS
PubMed, EMBASE and Web of Science were searched for studies evaluating the relationship between LGE burden and cardiovascular outcomes. Outcomes included all-cause mortality, MACE, sudden cardiac death, sustained VT or VF, appropriate ICD shock, heart transplant, and heart failure hospitalization. Only studies reporting hazards ratios with LGE as a continuous variable were included.
RESULTS
Of the initial 8928 studies, 95 studies (23,313 patients) were included across 19 clinical entities. The studies included ischemic cardiomyopathy (7182 patients, 33 studies), hypertrophic cardiomyopathy (5080 patients, 17 studies), non-ischemic cardiomyopathy not otherwise specified (2627 patients, 11 studies), and dilated cardiomyopathy (2345 patients, 14 studies). Among 42 studies that quantified LGE by percent myocardium, a 1 % increase in LGE burden was associated with life-threatening ventricular arrhythmias (LTVA) with a pooled hazard ratio of 1.04 (CI 1.02-1.05), and MACE with a pooled hazard ratio of 1.06 (CI 1.04-1.07). The risk of these events was similar across disease types, with minimal heterogeneity.
CONCLUSIONS
Despite mechanistic differences in myocardial injury, LGE appears to have a fairly consistent, dose-dependent effect on risk of LTVA, MACE, and mortality. These data can be applied to derive a patient's absolute risk of LTVA, and therefore can be clinically useful in informing decisions on primary prevention ICD implantation irrespective of the disease etiology.
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Family & community health
Authors: Rush CL, Brewer JR, Levey N, Presciutti AM, McDermott K, Pasinski R, Yousif N, Gholston M, Raju V, Greenberg J, Ritchie CS, Vranceanu AM
Science translational medicine
Authors: Babcock BR, Kosters A, Eddins DJ, Donaire MSB, Sarvadhavabhatla S, Pae V, Beltran F, Murray VW, Gill G, Xie G, Dobosh BS, Giacalone VD, Tirouvanziam RM, Ramonell RP, Jenks SA, Sanz I, Lee FE, Roan NR, Lee SA, Ghosn EEB
Circulation. Cardiovascular quality and outcomes
Authors: Chen JC, DeJong C, Agarwal M, Hairston AM, Durstenfeld MS, McKay V, Huffman MD, Hsue PY, Agarwal A
Journal of the American Medical Informatics Association : JAMIA
Authors: Apathy NC, Holmgren AJ, Nong P, Adler-Milstein J, Everson J
medRxiv : the preprint server for health sciences
Authors: Yiallourou S, Baril AA, Wiedner C, Misialek JR, Kline CE, Harrison S, Cannon E, Yang Q, Bernal R, Bisson A, Himali D, Cavuoto M, Weihs A, Beiser A, Gottesman RF, Leng Y, Lopez O, Lutsey PL, Purcell SM, Redline S, Seshadri S, Stone KL, Yaffe K, Ancoli-Israel S, Xiao Q, Vaou EO, Himali JJ, Pase MP
Blood
Authors: Kelly Schoenbeck, Isabelle Vu, Albert Lee, Mansa Devaki, Insiyah Merchant, Faaiz Ibrahim, Anand Dhruva, Catherine C. Smith, Neil P. Shah, Chloe Atreya
Blood
Authors: Michelle Wang, Krishna V. Komanduri, Debajyoti Datta, Ayan Patel, Barbee Whitaker, Artur Belov, Benjamin Rubin, Rohit Vashisht, Rosa Rodriguez-Monguio, Pelin Cinar, Steven Anderson, Atul Butte
Blood
Authors: Martha M.S. Sim, Ava Obenaus, Richard Maldonado, Jennie Le, Lesley Martínez Rodríguez, Barbara Bensing, Paul Sullam, Wendy Thomas, Nathan Sniadecki, Junmei Chen, Jose A. Lopez
Blood
Authors: Alvaro J Alencar, Olivia Bobek, Neha Mehta-Shah, Narendranath Epperla, Christine Lu-Emerson, Sarah C. Rutherford, Adam J. Olszewski, Thomas Ollila, Samuel Singer, Travis Dockter, Susan M. Geyer, Lori Rosenstein, Macarena De La Fuente, Eric D. Hsi, Shira N. Dinner, James L. Rubenstein, Nancy L. Bartlett, John P. Leonard
