The American journal of cardiology
Authors: DesJardin JT, Healy MJ, Nah G, Vittinghoff E, Agarwal A, Marcus GM, Velez JMG, Tseng ZH, Parikh NI
Clinical liver disease
Authors: Fozouni L, Lai JC
JCI insight
Authors: Antolic A, Wakimoto H, Jiao Z, Gorham JM, DePalma SR, Lemieux ME, Conner DA, Lee DY, Qi J, Seidman JG, Bradner JE, Brown JD, Haldar SM, Seidman CE, Burke MA
Proceedings of the National Academy of Sciences of the United States of America
Authors: Chen IP, Ott M
JAMA internal medicine
Authors: Sinha P, Matthay MA, Calfee CS
JCO oncology practice
Authors: Huppert LA, Melisko ME, Glastonbury CM, Khanafshar E, Daud AI
Clinical liver disease
Authors: Sarkar M, Suzuki A
Annals of the rheumatic diseases
Authors: Gianfrancesco M, Hyrich KL, Yazdany J, Machado PM, Robinson PC
American journal of respiratory and critical care medicine
Authors: Furusawa H, Cardwell JH, Okamoto T, Walts AD, Konigsberg IR, Kurche JS, Bang TJ, Schwarz MI, Brown KK, Kropski JA, Rojas M, Cool CD, Lee JS, Wolters PJ, Yang IV, Schwartz DA
Volume 117 of Issue 28 | Proceedings of the National Academy of Sciences of the United States of America
Authors: Hurabielle C, Link VM, Bouladoux N, Han SJ, Merrill ED, Lightfoot YL, Seto N, Bleck CKE, Smelkinson M, Harrison OJ, Linehan JL, Tamoutounour S, Lionakis MS, Kaplan MJ, Nakajima S, Belkaid Y
Under steady-state conditions, the immune system is poised to sense and respond to the microbiota. As such, immunity to the microbiota, including T cell responses, is expected to precede any inflammatory trigger. How this pool of preformed microbiota-specific T cells contributes to tissue pathologies remains unclear. Here, using an experimental model of psoriasis, we show that recall responses to commensal skin fungi can significantly aggravate tissue inflammation. Enhanced pathology caused by fungi preexposure depends on Th17 responses and neutrophil extracellular traps and recapitulates features of the transcriptional landscape of human lesional psoriatic skin. Together, our results propose that recall responses directed to skin fungi can directly promote skin inflammation and that exploration of tissue inflammation should be assessed in the context of recall responses to the microbiota.
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