Heart rhythm
Authors: Cheung CC, Sarcon A, Belhassen B, Scheinman M
Heart rhythm
Authors: Scheinman MM
Volume 29 of Issue 2 | Cell host & microbe
Authors: Huang X, Hurabielle C, Drummond RA, Bouladoux N, Desai JV, Sim CK, Belkaid Y, Lionakis MS, Segre JA
Candida auris is an emerging multi-drug-resistant human fungal pathogen. C. auris skin colonization results in environmental shedding, which underlies hospital transmissions, and predisposes patients to subsequent infections. We developed a murine skin topical exposure model for C. auris to dissect risk factors for colonization and to test interventions that might protect patients. We demonstrate that C. auris establishes long-term residence within the skin tissue compartment, which would elude clinical surveillance. The four clades of C. auris, with geographically distinct origins, differ in their abilities to colonize murine skin, mirroring epidemiologic findings. The IL-17 receptor signaling and specific arms of immunity protect mice from long-term C. auris skin colonization. We further determine that commonly used chlorhexidine antiseptic serves as a protective and decolonizing agent against C. auris. This translational model facilitates an integrated approach to develop strategies to combat the unfolding global outbreaks of C. auris and other skin-associated microbial pathogens.
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Authors: Alice Guh, Lauren C Korhonen, Lisa Gail Winston, Brittany Martin, Helen Johnston, Geoffrey Brousseau, Elizabeth Basiliere, Danyel M Olson, Scott Fridkin, Lucy E Wilson, Rebecca Perlmutter, Stacy Holzbauer, Maria Bye, Erin C Phipps, Kristina Flores, Ghinwa Dumyati, Deborah Nelson, Trupti Hatwar, Valerie Ocampo, Marion Kainer, Clifford McDonald
Open forum infectious diseases
Authors: Blake Hansen, Tao Liu, Lauri Bazerman, Mari-Lynn Drainoni, Fizza S Gillani, Edward Cachay, Katerina Christopoulos, Heidi Crane, Mari Kitahata, Kenneth H Mayer, Richard Moore, Sonia Napravnik, Aadia Rana, Benigno Rodriguez, Curt Beckwith
Open forum infectious diseases
Authors: Ayesha Ashley Appa, Meredith Adamo, Stephenie Le, Jennifer Davis, Lisa Gail Winston, Sarah B Doernberg, Henry Chambers, Marlene Martin, Phillip Coffin, Vivek Jain
Open forum infectious diseases
Authors: Kyla Sherwood, Jennifer M Babik
Open forum infectious diseases
Authors: Jennifer Claytor, Omar Viramontes, Stephanie Conner, Kwun Wah Wen, Kendall Beck, Timothy J Henrich, Peter Chin-Hong, Peter Chin-Hong, Michael J Peluso
PloS one
Authors: Iverson NR, Lau CY, Abe-Jones Y, Fang MC, Kangelaris KN, Prasad P, Shah SJ, Najafi N
Open forum infectious diseases
Authors: June L Chan, Elizabeth Nazarian, Kimberlee A Musser, Monica Fung, Sarah B Doernberg, Stephanie M Pouch, Stephanie M Pouch, Surbhi Leekha, Judith A Anesi, Rosy Priya Kodiyanplakkal, Sarah Turbett, Maroya Spalding Walters, Lauren Epstein, Lauren Epstein
