Journal of genetic counseling
Authors: Lin GA, Trosman JR, Douglas MP, Weldon CB, Scheuner MT, Kurian A, Phillips KA
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Authors: Ordaz-Vázquez A, Torres-González P, Cruz-Hervert P, Ferreyra-Reyes L, Delgado-Sánchez G, García-García L, Kato-Maeda M, Ponce-De-León A, Sifuentes-Osornio J, Bobadilla-Del-Valle M
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
Authors: Yalçin F, Abraham R, Abraham TP
Journal of virology
Authors: Sufiawati I, Herrera R, Mayer W, Cai X, Borkakoti J, Lin V, Rosbe K, Tugizov SM
Volume 93 of Issue 10 | Journal of medical virology
Authors: Camargo JF, Lin RY, Komanduri KV
PROBLEM
The utility of the polymerase chain reaction (PCR) cycle threshold (C ) values in the management of patients with coronavirus disease 2019 (COVID-19) remains controversial.
METHODS
We assessed the correlation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) C values in nasopharyngeal swab samples with the oxygen requirements at the time of sample collection. Specimens were tested with the Simplexa PCR platform, which targets the SARS-CoV-2 ORF1ab and S genes.
RESULTS
We identified 23 COVID-19 patients with 49 C values available. While C values from ORF1ab and S genes were highly correlated for a given specimen, there was no correlation between C values for any of these target genes and the oxygen requirements of the patient at the time of sample collection. We found no differences in the initial nor the nadir C values between survivors and non-survivors or mild/moderate versus severe/critical illness at the maximum point of illness.
CONCLUSION
SARS-CoV-2 C values have limited value in the management of COVID-19.
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Volume 96 of Issue 10 | American journal of hematology
Authors: Lee EJ, Seshadri M, Bussel JB
Respiratory medicine case reports
Authors: Bawaadam H, Ivanick N, AlShelli I, Krishna G
Authors: Horwitz RI, Lobitz G, Mawn M, Conroy AH, Cullen MR, Sim I, Singer BH
Authors: Dodagatta-Marri E, Ma HY, Liang B, Li J, Meyer DS, Chen SY, Sun KH, Ren X, Zivak B, Rosenblum MD, Headley MB, Pinzas L, Reed NI, Del Cid JS, Hann BC, Yang S, Giddabasappa A, Noorbehesht K, Yang B, Dal Porto J, Tsukui T, Niessen K, Atakilit A, Akhurst RJ, Sheppard D
Journal of the American Geriatrics Society
Authors: Deardorff WJ, Binford SS, Cole I, James T, Rathfon M, Rennke S, Wallhagen M
