Pediatric research
Authors: Nagata JM, Singh G, Sajjad OM, Ganson KT, Testa A, Jackson DB, Assari S, Murray SB, Bibbins-Domingo K, Baker FC
Journal of clinical microbiology
Authors: Fasching CL, Servellita V, McKay B, Nagesh V, Broughton JP, Sotomayor-Gonzalez A, Wang B, Brazer N, Reyes K, Streithorst J, Deraney RN, Stanfield E, Hendriks CG, Fung B, Miller S, Ching J, Chen JS, Chiu CY
Journal of the American Geriatrics Society
Authors: Harrison JD, Sudore RL, Auerbach AD, Shah S, Oreper S, Wheeler MM, Fang MC
Nature communications
Authors: De Ravin SS, Liu S, Sweeney CL, Brault J, Whiting-Theobald N, Ma M, Liu T, Choi U, Lee J, O'Brien SA, Quackenbush P, Estwick T, Karra A, Docking E, Kwatemaa N, Guo S, Su L, Sun Z, Zhou S, Puck J, Cowan MJ, Notarangelo LD, Kang E, Malech HL, Wu X
Volume 3 of Issue 7 | Cell reports. Medicine
Authors: Feyaerts D, Hédou J, Gillard J, Chen H, Tsai ES, Peterson LS, Ando K, Manohar M, Do E, Dhondalay GKR, Fitzpatrick J, Artandi M, Chang I, Snow TT, Chinthrajah RS, Warren CM, Wittman R, Meyerowitz JG, Ganio EA, Stelzer IA, Han X, Verdonk F, Gaudillière DK, Mukherjee N, Tsai AS, Rumer KK, Jacobsen DR, Bjornson-Hooper ZB, Jiang S, Saavedra SF, Valdés Ferrer SI, Kelly JD, Furman D, Aghaeepour N, Angst MS, Boyd SD, Pinsky BA, Nolan GP, Nadeau KC, Gaudillière B, McIlwain DR
The biological determinants underlying the range of coronavirus 2019 (COVID-19) clinical manifestations are not fully understood. Here, over 1,400 plasma proteins and 2,600 single-cell immune features comprising cell phenotype, endogenous signaling activity, and signaling responses to inflammatory ligands are cross-sectionally assessed in peripheral blood from 97 patients with mild, moderate, and severe COVID-19 and 40 uninfected patients. Using an integrated computational approach to analyze the combined plasma and single-cell proteomic data, we identify and independently validate a multi-variate model classifying COVID-19 severity (multi-class area under the curve [AUC] = 0.799, p = 4.2e-6; multi-class AUC = 0.773, p = 7.7e-6). Examination of informative model features reveals biological signatures of COVID-19 severity, including the dysregulation of JAK/STAT, MAPK/mTOR, and nuclear factor κB (NF-κB) immune signaling networks in addition to recapitulating known hallmarks of COVID-19. These results provide a set of early determinants of COVID-19 severity that may point to therapeutic targets for prevention and/or treatment of COVID-19 progression.
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American Journal of Medicine Open
Authors: Pytell JD, Li X, Thompson C, Lesko CR, McCaul ME, Hutton H, Scott Batey D, Cachay E, Mayer KH, Napravnik S, Christopoulos K, Yang C, Crane HM, Chander G, Lau B
Pharmaceutics
Authors: Gupta Y, Sharma N, Singh S, Romero JG, Rajendran V, Mogire RM, Kashif M, Beach J, Jeske W, Ogutu BR, Kanzok SM, Akala HM, Legac J, Rosenthal PJ, Rademacher DJ, Durvasula R, Singh AP, Rathi B, Kempaiah P
European heart journal. Cardiovascular Imaging
Authors: Frimodt-Møller KE, Olsen FJ, Biering-Sørensen SR, Lassen MCH, Møgelvang R, Schnohr P, Jensen G, Gislason G, Marcus GM, Biering-Sørensen T
Journal of general internal medicine
Authors: Fitz M, Adams W, Heincelman M, Haist S, Whelan K, Cox L, Cao UT, Hingle S, Raff A, Houghton B, Fitzpatrick J, Nall R, Foster J, Appelbaum J, Grum C, Donovan A, Kiken S, Abraham R, Hlafka M, Miller C, Bansal S, Paauw D, Lai CJ, Pincavage A, Agarwal G, Burns C, Holzer H, Lappé K, John V, Barker B, Mingioni N, Rao D, Zakowski L, Chakraborti C, Williams W, Kelly W
Gastroenterology
Authors: Medina SP, Wong AC, El-Nachef N
