Volume 28 | Molecular therapy. Methods & clinical development
Authors: Corey D, Haeseleer F, Hou J, Corey L
Adoptive therapy with genetically engineered T cells offers potential for infectious disease treatment in immunocompromised persons. HIV/simian immunodeficiency virus (SIV)-infected cells express phosphatidylserine (PS) early post infection. We tested whether chimeric engulfment receptor (CER) T cells designed to recognize PS-expressing cells could eliminate SIV-infected cells. Lentiviral CER constructs composed of the extracellular domain of T cell immunoglobulin and mucin domain containing 4 (TIM-4), the PS receptor, and engulfment signaling domains were transduced into primary rhesus macaque (RM) T cells. We measured PS binding and T cell engulfment of RM CD4+ T cells infected with SIV expressing GFP and , TIM-4 CER CD4+ T cells effectively killed SIV-infected cells, which was dependent on TIM-4 binding to PS. Enhanced killing of SIV-infected CD4+ T cells by CER and chimeric antigen receptor T cell combinations was also observed. This installation of innate immune functions into T cells presents an opportunity to enhance elimination of SIV-infected cells, and studies to evaluate their effect are warranted.
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Blood
Authors: Shirley S. Mo, Huimin Geng, Miguel Cerejo, Kwun Wah Wen, David A. Solomon, James L. Rubenstein
Blood
Authors: Cheryl Peretz, Vanessa E. Kennedy, Anushka Walia, Cyrille Delley, Andrew Koh, Elaine Tran, Iain Clark, Corey Hayford, Yi Xue, Chris D'Amato, Kristina Fontanez, Ritu P. Roy, Adam Olshen, Aaron C. Logan, Alexander E. Perl, Adam Abate, Catherine Smith
Blood
Authors: Vanessa E. Kennedy, Cheryl Peretz, Paul Lee, Brenda Chyla, Yan Sun, Monique Dail, Jason Hill, Elaine Tran, Andrew Koh, Jessica K. Altman, Naval Daver, Mark J. Levis, James McCloskey, Alexander Perl, Catherine Smith
Nursing outlook
Authors: Salomon RE, Dobbins S, Harris C, Haeusslein L, Lin CX, Reeves K, Richoux S, Roussett G, Shin J, Dawson-Rose C
Heart rhythm
Authors: Qiu H, Zhang H, Han DD, Derakhshandeh R, Wang X, Goyal N, Navabzadeh M, Rao P, Wilson EE, Mohammadi L, Olgin JE, Springer ML
Journal of acquired immune deficiency syndromes (1999)
Authors: Hahn AW, Ruderman SA, Nance RM, Whitney BW, Eltonsy S, Haidar L, Delaney J, Drumright LN, Ma J, Mayer KH, O'Cleirigh C, Napravnik S, Eron JJ, Christopoulos K, Bamford L, Cachay E, Jacobson JM, Willig A, Cropsey K, Chander G, Crane HM, Fredericksen RJ
Microbiology spectrum
Authors: Ersoy SC, Gon?alves B, Cavaco G, Manna AC, Sobral RG, Nast CC, Proctor RA, Chambers HF, Cheung A, Bayer AS
Palliative medicine
Authors: Ouchi K, Lee RS, Block SD, Aaronson EL, Hasdianda MA, Wang W, Rossmassler S, Palan Lopez R, Berry D, Sudore R, Schonberg MA, Tulsky JA
Journal of pain and symptom management
Authors: Walling AM, Ast K, Harrison JM, Dy SM, Ersek M, Hanson LC, Kamal AH, Ritchie CS, Teno JM, Rotella JD, Periyakoil VS, Ahluwalia SC
