Yerem Yeghiazarians, MD

PROFESSOR OF CLINICAL MEDICINE

CLINICAL INTERESTS: Dr. Yerem Yeghiazarians is an interventional cardiologist with expertise in managing patients with coronary artery disease, acute coronary syndromes, valvular heart disease, cardiomyopathies, patent foramen ovale, and peripheral arterial diseases. Yeghiazarians earned an undergraduate degree from Brandeis University and a medical degree from the Johns Hopkins School of Medicine. He trained in internal medicine at Brigham and Women's Hospital, Harvard Medical School, where he served as chief medical resident and instructor in medicine. He also completed general and interventional adult cardiology training at the Brigham and Women's Hospital. He has been at UCSF since 2003.

RESEARCH INTERESTS: Dr. Yeghiazarians is the Director of the Translational Cardiac Stem Cell Program at UCSF. His research interests are to study the role of stem cells in improving the cardiac function after a myocardial infarction.

Publications

  1. Chang JL, Goldberg AN, Alt JA, Ashbrook L, Auckley D, Ayappa I, Bakhtiar H, Barrera JE, Bartley BL, Billings ME, Boon MS, Bosschieter P, Braverman I, Brodie K, Cabrera-Muffly C, Caesar R, Cahali MB, Cai Y, Cao M, Capasso R, Caples SM, Chahine LM, Chang CP, Chang KW, Chaudhary N, Cheong CSJ, Chowdhuri S, Cistulli PA, Claman D, Collen J, Coughlin K, Creamer J, Davis EM, Dupuy-McCauley KL, Durr ML, Dutt M, Ali ME, Elkassabany NM, Epstein LJ, Fiala JA, Freedman N, Gill K, Gillespie MB, Golisch L, Gooneratne N, Gottlieb DJ, Green KK, Gulati A, Gurubhagavatula I, Hayward N, Hoff PT, Hoffmann OMG, Holfinger SJ, Hsia J, Huntley C, Huoh KC, Huyett P, Inala S, Ishman S, Jella TK, Jobanputra AM, Johnson AP, Junna MR, Kado JT, Kaffenberger TM, Kapur VK, Kezirian EJ, Khan M, Kirsch DB, Kominsky A, Kryger M, Krystal AD, Kushida CA, Kuzniar TJ, Lam DJ, Lettieri CJ, Lim DC, Lin HC, Liu SYC, MacKay SG, Magalang UJ, Malhotra A, Maurer JT, May AM, Mitchell RB, Mokhlesi B, Mullins AE, Nada EM, Naik S, Nokes B, Olson MD, Pack AI, Pang EB, Pang KP, Patil SP, de Perck EV, Piccirillo JF, Pien GW, Piper AJ, Plawecki A, Quigg M, Ravesloot MJL, Redline S, Rotenberg BW, Ryden A, Sarmiento KF, Sbeih F, Schell AE, Schmickl CN, Schotland HM, Schwab RJ, Seo J, Shah N, Shelgikar AV, Shochat I, Soose RJ, Steele TO, Stephens E, Stepnowsky C, Strohl KP, Sutherland K, Suurna MV, Thaler E, Thapa S, Vanderveken OM, de Vries N, Weaver EM, Weir ID, Wolfe LF, Woodson BT, Won CHJ, Xu J, Yalamanchi P, Yaremchuk K, Yeghiazarians Y, Yu JL, Zeidler M, Rosen IM. International consensus statement on obstructive sleep apnea. International forum of allergy & rhinology 2022. PMID: 36068685


  2. Lee MS, Wadia S, Yeghiazarians Y, Matthews R, White CJ, Herrmann HC, O'Donnell W, McPherson J, Leesar MA, Kreutz RP, Brandman D, Gupta A, Mandras S, Kandzari DE. Cardiology Assessment of Patients Undergoing Evaluation for Orthotopic Liver Transplantation. Journal of the Society for Cardiovascular Angiography & Interventions 2022. PMID: 39132526


  3. Chen S, Gemelga G, Yeghiazarians Y. Is Vitamin D Supplementation an Effective Treatment for Hypertension? Current hypertension reports 2022. PMID: 35737199


  4. Nguyen V, Ameri K, Huynh K, Fredkin M, Grona R, Larpthaveesarp A, Gonzalez F, Yeghiazarians Y. Interleukin-15 modulates the response of cortical neurons to ischemia. Molecular and cellular neurosciences 2021. PMID: 34343628


  5. Yeghiazarians Y, Jneid H, Tietjens JR, Redline S, Brown DL, El-Sherif N, Mehra R, Bozkurt B, Ndumele CE, Somers VK. Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation 2021. PMID: 34148375


  6. Stein NR, Ramakrishna S, Yeghiazarians Y. Premature coronary disease, in-stent restenosis and vascular complications in a young man with Behçet syndrome. BMJ case reports 2020. PMID: 32843407


  7. Ameri K, Bayardorj D, Samurkashian R, Fredkin M, Fuh E, Nguyen V, Yeghiazarians Y. Administration of Interleukin-15 peptide improves cardiac function in a mouse model of myocardial infarction. Journal of cardiovascular pharmacology 2019. PMID: 31815824


  8. Papolos A, Fan E, Wagle RR, Foster E, Boyle AJ, Yeghiazarians Y, MacGregor JS, Grossman W, Schiller NB, Ganz P, Tison GH. Echocardiographic determination of pulmonary arterial capacitance. The international journal of cardiovascular imaging 2019. PMID: 30968263


  9. Tietjens JR, Claman D, Kezirian EJ, De Marco T, Mirzayan A, Sadroonri B, Goldberg AN, Long C, Gerstenfeld EP, Yeghiazarians Y. Obstructive Sleep Apnea in Cardiovascular Disease: A Review of the Literature and Proposed Multidisciplinary Clinical Management Strategy. Journal of the American Heart Association 2019. PMID: 30590966


  10. Browne S, Jha AK, Ameri K, Marcus SG, Yeghiazarians Y, Healy KE. TGF-ß1/CD105 signaling controls vascular network formation within growth factor sequestering hyaluronic acid hydrogels. PloS one 2018. PMID: 29566045


  11. Geng X, Hwang J, Ye J, Shih H, Coulter B, Naudin C, Jun K, Sievers R, Yeghiazarians Y, Lee RJ, Boyle AJ. Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling. American journal of cardiovascular disease 2017. PMID: 28695053


  12. Ameri K, Samurkashian R, Yeghiazarians Y. Three-Dimensional Bioprinting: Emerging Technology in Cardiovascular Medicine. Circulation 2017. PMID: 28373522


  13. Kallianos K, Henry TS, Yeghiazarians Y, Zimmet J, Shunk KA, Tseng EE, Mahadevan V, Hope MD. Ferumoxytol MRA for transcatheter aortic valve replacement planning with renal insufficiency. International journal of cardiology 2016. PMID: 28100426


  14. Jha AK, Tharp KM, Browne S, Ye J, Stahl A, Yeghiazarians Y, Healy KE. Matrix metalloproteinase-13 mediated degradation of hyaluronic acid-based matrices orchestrates stem cell engraftment through vascular integration. Biomaterials 2016. PMID: 26967648


  15. Chen Q, Varga M, Wang X, Haddad DJ, An S, Medzikovic L, Derakhshandeh R, Kostyushev DS, Zhang Y, Clifford BT, Luu E, Danforth OM, Rafikov R, Gong W, Black SM, Suchkov SV, Fineman JR, Heiss C, Aschbacher K, Yeghiazarians Y, Springer ML. Overexpression of Nitric Oxide Synthase Restores Circulating Angiogenic Cell Function in Patients With Coronary Artery Disease: Implications for Autologous Cell Therapy for Myocardial Infarction. Journal of the American Heart Association 2016. PMID: 26738788


  16. Shrestha U, Sciammarella M, Alhassen F, Yeghiazarians Y, Ellin J, Verdin E, Boyle A, Seo Y, Botvinick EH, Gullberg GT. Measurement of absolute myocardial blood flow in humans using dynamic cardiac SPECT and 99mTc-tetrofosmin: Method and validation. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 2015. PMID: 26715603


  17. Ye J, Yeghiazarians Y. Cardiac stem cell therapy: Have we put too much hype in which cell type to use? Heart failure reviews 2015. PMID: 26024953


  18. Ye J, Gaur M, Zhang Y, Sievers RE, Woods BJ, Aurigui J, Bernstein HS, Yeghiazarians Y. Treatment with hESC-Derived Myocardial Precursors Improves Cardiac Function after a Myocardial Infarction. PloS one 2015. PMID: 26230835


  19. Genet M, Chuan Lee L, Ge L, Acevedo-Bolton G, Jeung N, Martin A, Cambronero N, Boyle A, Yeghiazarians Y, Kozerke S, Guccione JM. A Novel Method for Quantifying Smooth Regional Variations in Myocardial Contractility Within an Infarcted Human Left Ventricle Based on Delay-Enhanced Magnetic Resonance Imaging. Journal of biomechanical engineering 2015. PMID: 25994000


  20. Jha AK, Mathur A, Svedlund FL, Ye J, Yeghiazarians Y, Healy KE. Molecular weight and concentration of heparin in hyaluronic acid-based matrices modulates growth factor retention kinetics and stem cell fate. Journal of controlled release : official journal of the Controlled Release Society 2015. PMID: 25931306


  21. Ameri K, Jahangiri A, Rajah AM, Tormos KV, Nagarajan R, Pekmezci M, Nguyen V, Wheeler ML, Murphy MP, Sanders TA, Jeffrey SS, Yeghiazarians Y, Rinaudo PF, Costello JF, Aghi MK, Maltepe E. HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth. Cell reports 2015. PMID: 25683712


  22. Jha AK, Tharp KM, Ye J, Santiago-Ortiz JL, Jackson WM, Stahl A, Schaffer DV, Yeghiazarians Y, Healy KE. Enhanced survival and engraftment of transplanted stem cells using growth factor sequestering hydrogels. Biomaterials 2015. PMID: 25682155


  23. Glenn DJ, Cardema MC, Ni W, Zhang Y, Yeghiazarians Y, Grapov D, Fiehn O, Gardner DG. Cardiac steatosis potentiates angiotensin II effects in the heart. Volume 308 of Issue 4. American journal of physiology. Heart and circulatory physiology 2014. PMID: 25485904


  24. Shrestha U, Botvinick EH, Yeghiazarians Y, Seo Y, Gullberg GT. Quantitative Signature of Coronary Steal in a Patient with Occluded Coronary Arteries Supported by Collateral Circulation Using Dynamic SPECT. IEEE Nuclear Science Symposium conference record. Nuclear Science Symposium 2014. PMID: 27081301


  25. Feng K, Gupta V, Terrazas E, Yeghiazarians Y, Ports T, Gregoratos G, Tavakol M, Roberts JP, Boyle A. Trans-radial versus trans-femoral access in patients with end-stage liver disease undergoing cardiac catheterization. American journal of cardiovascular disease 2014. PMID: 25360391


  26. Gupta V, Feng K, Cheruvu P, Boyer N, Yeghiazarians Y, Ports TA, Zimmet J, Shunk K, Boyle AJ. High femoral artery bifurcation predicts contralateral high bifurcation: implications for complex percutaneous cardiovascular procedures requiring large caliber and/or dual access. The Journal of invasive cardiology 2014. PMID: 25198481


  27. Pandit J, Gupta V, Boyer N, Yeghiazarians Y, Ports TA, Boyle AJ. Patient and physician perspectives on outcomes weighting in revascularization. The POWR study. International journal of cardiology 2014. PMID: 25194864


  28. Boyer N, Gupta R, Schevchuck A, Hindnavis V, Maliske S, Sheldon M, Drachman D, Yeghiazarians Y. Coronary artery aneurysms in acute coronary syndrome: case series, review, and proposed management strategy. The Journal of invasive cardiology 2014. PMID: 24907086


  29. Yeghiazarians Y, Honbo N, Imhof I, Woods B, Aguilera V, Ye J, Boyle AJ, Karliner JS. IL-15: a novel prosurvival signaling pathway in cardiomyocytes. Journal of cardiovascular pharmacology 2014. PMID: 24805144


  30. Ye J, Yeghiazarians Y. Cardiac stem cell therapy: review of the native cardiac progenitor cells and future direction. Journal of cardiovascular pharmacology 2014. PMID: 23674056


  31. Boyle AJ, Hwang J, Ye J, Shih H, Jun K, Zhang Y, Fang Q, Sievers R, Yeghiazarians Y, Lee RJ. The effects of aging on apoptosis following myocardial infarction. Cardiovascular therapeutics 2013. PMID: 24279384


  32. Horn P, Amabile N, Angeli FS, Sansone R, Stegemann B, Kelm M, Springer ML, Yeghiazarians Y, Schroeter H, Heiss C. Dietary flavanol intervention lowers the levels of endothelial microparticles in coronary artery disease patients. The British journal of nutrition 2013. PMID: 24286443


  33. Boyer N, Beyer A, Gupta V, Dehghani H, Hindnavis V, Shunk K, Zimmet J, Yeghiazarians Y, Ports T, Boyle A. The effects of intra-arterial vasodilators on radial artery size and spasm: implications for contemporary use of trans-radial access for coronary angiography and percutaneous coronary intervention. Cardiovascular revascularization medicine : including molecular interventions 2013. PMID: 24095616


  34. Ye J, Hom DS, Hwang J, Yeghiazarians Y, Lee RJ, Boyle AJ. Aging Impairs the Proliferative Capacity of Cardiospheres, Cardiac Progenitor Cells and Cardiac Fibroblasts: Implications for Cell Therapy. Journal of clinical medicine 2013. PMID: 26237065


  35. Ameri K, Rajah AM, Nguyen V, Sanders TA, Jahangiri A, Delay M, Donne M, Choi HJ, Tormos KV, Yeghiazarians Y, Jeffrey SS, Rinaudo PF, Rowitch DH, Aghi M, Maltepe E. Nuclear localization of the mitochondrial factor HIGD1A during metabolic stress. PloS one 2013. PMID: 23646141


  36. Beyer AT, Ng R, Singh A, Zimmet J, Shunk K, Yeghiazarians Y, Ports TA, Boyle AJ. Topical nitroglycerin and lidocaine to dilate the radial artery prior to transradial cardiac catheterization: a randomized, placebo-controlled, double-blind clinical trial: the PRE-DILATE Study. International journal of cardiology 2013. PMID: 23582415


  37. Amabile N, Guignabert C, Montani D, Yeghiazarians Y, Boulanger CM, Humbert M. Cellular microparticles in the pathogenesis of pulmonary hypertension. The European respiratory journal 2012. PMID: 23258792


  38. Ye J, Boyle AJ, Shih H, Sievers RE, Wang ZE, Gormley M, Yeghiazarians Y. CD45-positive cells are not an essential component in cardiosphere formation. Cell and tissue research 2012. PMID: 23064904


  39. Majure DT, Hallaux M, Yeghiazarians Y, Boyle AJ. Topical nitroglycerin and lidocaine locally vasodilate the radial artery without affecting systemic blood pressure: a dose-finding phase I study. Journal of critical care 2012. PMID: 22699036


  40. Angeli FS, Zhang Y, Sievers R, Jun K, Yim S, Boyle A, Yeghiazarians Y. Injection of human bone marrow and mononuclear cell extract into infarcted mouse hearts results in functional improvement. The open cardiovascular medicine journal 2012. PMID: 22550548


  41. Koskenvuo JW, Sievers RE, Zhang Y, Angeli FS, Lee B, Shih H, Ye J, Boyle AJ, Yeghiazarians Y. Fractionation of mouse bone-marrow cells limits functional efficacy in non-reperfused mouse model of acute myocardial infarction. Annals of medicine 2012. PMID: 22494088


  42. Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y. Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. Volume 7 of Issue 1. PloS one 2012. PMID: 22272337


  43. Wang X, Takagawa J, Haddad DJ, Pinnamaneni K, Zhang Y, Sievers RE, Grossman W, Yeghiazarians Y, Springer ML. Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. Volume S3. Journal of tissue science & engineering 2011. PMID: 22675670


  44. Yeghiazarians Y, Gaur M, Zhang Y, Sievers RE, Ritner C, Prasad M, Boyle A, Bernstein HS. Myocardial improvement with human embryonic stem cell-derived cardiomyocytes enriched by p38MAPK inhibition. Cytotherapy 2011. PMID: 22040108


  45. Aschbacher K, Chen Q, Varga M, Haddad DJ, Yeghiazarians Y, Epel E, Wolkowitz OM, Springer ML. Higher fasting glucose levels are associated with reduced circulating angiogenic cell migratory capacity among healthy individuals. American journal of cardiovascular disease 2011. PMID: 22254209


  46. Chen S, Law CS, Grigsby CL, Olsen K, Hong TT, Zhang Y, Yeghiazarians Y, Gardner DG. Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy. Volume 124 of Issue 17. Circulation 2011. PMID: 21947295


  47. Wang X, Takagawa J, Lam VC, Haddad DJ, Tobler DL, Mok PY, Zhang Y, Clifford BT, Pinnamaneni K, Saini SA, Su R, Bartel MJ, Sievers RE, Carbone L, Kogan S, Yeghiazarians Y, Hermiston M, Springer ML. Donor myocardial infarction impairs the therapeutic potential of bone marrow cells by an interleukin-1-mediated inflammatory response. Science translational medicine 2011. PMID: 21918107


  48. Boyle AJ, Yeghiazarians Y, Shih H, Hwang J, Ye J, Sievers R, Zheng D, Palasubramaniam J, Palasubramaniam D, Karschimkus C, Whitbourn R, Jenkins A, Wilson AM. Myocardial production and release of MCP-1 and SDF-1 following myocardial infarction: differences between mice and man. Journal of translational medicine 2011. PMID: 21910857


  49. Koskenvuo JW, Mirsky R, Zhang Y, Helenius H, Angeli FS, De Marco T, Boyle AJ, Yeghiazarians Y. Evidence of diminished coronary flow in pulmonary hypertension: explaining angina pectoris in this patient group? Clinical physiology and functional imaging 2011. PMID: 21981460


  50. Ng R, Yeghiazarians Y. Post myocardial infarction cardiogenic shock: a review of current therapies. Journal of intensive care medicine 2011. PMID: 21747126


  51. Lao D, Parasher PS, Cho KC, Yeghiazarians Y. Atherosclerotic renal artery stenosis--diagnosis and treatment. Mayo Clinic proceedings 2011. PMID: 21719621


  52. Mirsky R, Jahn S, Koskenvuo JW, Sievers RE, Yim SM, Ritner C, Bernstein HS, Angeli FS, Boyle AJ, De Marco T, Yeghiazarians Y. Treatment of pulmonary arterial hypertension with circulating angiogenic cells. American journal of physiology. Lung cellular and molecular physiology 2011. PMID: 21398496


  53. Boyle AJ, Shih H, Hwang J, Ye J, Lee B, Zhang Y, Kwon D, Jun K, Zheng D, Sievers R, Angeli F, Yeghiazarians Y, Lee R. Cardiomyopathy of aging in the mammalian heart is characterized by myocardial hypertrophy, fibrosis and a predisposition towards cardiomyocyte apoptosis and autophagy. Experimental gerontology 2011. PMID: 21377520


  54. Glenn DJ, Wang F, Nishimoto M, Cruz MC, Uchida Y, Holleran WM, Zhang Y, Yeghiazarians Y, Gardner DG. A murine model of isolated cardiac steatosis leads to cardiomyopathy. Volume 57 of Issue 2. Hypertension (Dallas, Tex. : 1979) 2011. PMID: 21220706


  55. Hoffmayer KS, Zellner C, Kwan DM, Konety S, Foster E, Moore P, Yeghiazarians Y. Closure of a para-valvular aortic leak: with the use of 2 AMPLATZER devices and real-time 2- and 3-dimensional transesophageal echocardiography. Texas Heart Institute journal 2011. PMID: 21423478


  56. Angeli FS, Amabile N, Shapiro M, Mirsky R, Bartlett L, Zhang Y, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Cytokine combination therapy with erythropoietin and granulocyte colony stimulating factor in a porcine model of acute myocardial infarction. Volume 24 of Issue 5-6. Cardiovascular drugs and therapy 2010. PMID: 20809214


  57. Ochoa VM, Yeghiazarians Y. Subclavian artery stenosis: a review for the vascular medicine practitioner. Vascular medicine (London, England) 2010. PMID: 21078767


  58. Yong CM, Sharma M, Ochoa V, Abnousi F, Roberts J, Bass NM, Niemann CU, Shiboski S, Prasad M, Tavakol M, Ports TA, Gregoratos G, Yeghiazarians Y, Boyle AJ. Multivessel coronary artery disease predicts mortality, length of stay, and pressor requirements after liver transplantation. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2010. PMID: 21031539


  59. Zellner C, Ports TA, Yeghiazarians Y, Boyle AJ. Sterile radial artery granuloma after transradial procedures: a unique and avoidable complication. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2010. PMID: 20976748


  60. Zellner C, Yeghiazarians Y, Ports TA, Ursell P, Boyle AJ. Sterile radial artery granuloma after transradial cardiac catheterization. Cardiovascular revascularization medicine : including molecular interventions 2010. PMID: 21640939


  61. Patel MR, Jneid H, Derdeyn CP, Klein LW, Levine GN, Lookstein RA, White CJ, Yeghiazarians Y, Rosenfield K. Arteriotomy closure devices for cardiovascular procedures: a scientific statement from the American Heart Association. Circulation 2010. PMID: 20921445


  62. Gaur M, Ritner C, Sievers R, Pedersen A, Prasad M, Bernstein HS, Yeghiazarians Y. Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes. Cytotherapy 2010. PMID: 20586669


  63. Heiss C, Schanz A, Amabile N, Jahn S, Chen Q, Wong ML, Rassaf T, Heinen Y, Cortese-Krott M, Grossman W, Yeghiazarians Y, Springer ML. Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli. Volume 30 of Issue 11. Arteriosclerosis, thrombosis, and vascular biology 2010. PMID: 20705916


  64. Zhang Y, Sievers RE, Prasad M, Mirsky R, Shih H, Wong ML, Angeli FS, Ye J, Takagawa J, Koskenvuo JW, Springer ML, Grossman W, Boyle AJ, Yeghiazarians Y. Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Volume 20 of Issue 4. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2010. PMID: 20667749


  65. Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. Volume 56 of Issue 3. Journal of the American College of Cardiology 2010. PMID: 20620742


  66. Angeli FS, Smith C, Amabile N, Shapiro M, Bartlett L, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Granulocyte colony stimulating factor in myocardial infarction with low ejection fraction. Volume 51 of Issue 3. Cytokine 2010. PMID: 20609597


  67. Yeghiazarians Y, Khan M, Angeli FS, Zhang Y, Jahn S, Prasad M, Mirsky R, Shih H, Minasi P, Boyle A, Grossman W. Cytokine combination therapy with long-acting erythropoietin and granulocyte colony stimulating factor improves cardiac function but is not superior than monotherapy in a mouse model of acute myocardial infarction. Volume 16 of Issue 8. Journal of cardiac failure 2010. PMID: 20670846


  68. Angeli FS, Amabile N, Burjonroppa S, Shapiro M, Bartlett L, Zhang Y, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Prolonged therapy with erythropoietin is safe and prevents deterioration of left ventricular systolic function in a porcine model of myocardial infarction. Volume 16 of Issue 7. Journal of cardiac failure 2010. PMID: 20610234


  69. Koskenvuo JW, Mirsky R, Zhang Y, Angeli FS, Jahn S, Alastalo TP, Schiller NB, Boyle AJ, Chatterjee K, De Marco T, Yeghiazarians Y. A comparison of echocardiography to invasive measurement in the evaluation of pulmonary arterial hypertension in a rat model. The international journal of cardiovascular imaging 2010. PMID: 20140524


  70. Frey P, Yeghiazarians Y. Cardiac CT and percutaneous mitral annuloplasty: a vision of the future? The Journal of invasive cardiology 2010. PMID: 20124592


  71. Armstrong EJ, Bhave P, Wong D, Ursell PC, Kaplan L, Yeghiazarians Y, Ai WZ. Left ventricular rupture due to HIV-associated T-cell lymphoma. Texas Heart Institute journal 2010. PMID: 20844622


  72. Singh AK, Yeghiazarians Y. Making a smooth vascular exit--does your kidney function matter? The Journal of invasive cardiology 2010. PMID: 20048392


  73. Amabile N, Heiss C, Chang V, Angeli FS, Damon L, Rame EJ, McGlothlin D, Grossman W, De Marco T, Yeghiazarians Y. Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patients. Volume 28 of Issue 10. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2009. PMID: 19782291


  74. Ota R, Kurihara C, Tsou TL, Young WL, Yeghiazarians Y, Chang M, Mobashery S, Sakamoto A, Hashimoto T. Roles of matrix metalloproteinases in flow-induced outward vascular remodeling. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2009. PMID: 19513084


  75. Angeli FS, Shapiro M, Amabile N, Orcino G, Smith CS, Tacy T, Boyle AJ, Chatterjee K, Glantz SA, Grossman W, Yeghiazarians Y. Left ventricular remodeling after myocardial infarction: characterization of a swine model on beta-blocker therapy. Volume 59 of Issue 3. Comparative medicine 2009. PMID: 19619418


  76. Ochoa V, Yeghiazarians Y. Patent foramen ovale and atrial septal aneurysm: achieving closure. The Journal of invasive cardiology 2009. PMID: 19494409


  77. Lao D, Yeghiazarians Y. Pre-PCI white blood cell count: should we care? The Journal of invasive cardiology 2009. PMID: 19411719


  78. Garcia JA, Agostoni P, Green NE, Maddux JT, Chen SY, Messenger JC, Casserly IP, Hansgen A, Wink O, Movassaghi B, Groves BM, Van Den Heuvel P, Verheye S, Van Langenhove G, Vermeersch P, Van den Branden F, Yeghiazarians Y, Michaels AD, Carroll JD. Rotational vs. standard coronary angiography: an image content analysis. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2009. PMID: 19180661


  79. Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Volume 17 of Issue 7. Molecular therapy : the journal of the American Society of Gene Therapy 2009. PMID: 19384293


  80. Natarajan S, Heiss C, Yeghiazarians Y, Fineman JR, Teitel DF, Tacy TA. Peripheral arterial function in infants and young children with one-ventricle physiology and hypoxemia. The American journal of cardiology 2009. PMID: 19268746


  81. Sharma M, Yong C, Majure D, Zellner C, Roberts JP, Bass NM, Ports TA, Yeghiazarians Y, Gregoratos G, Boyle AJ. Safety of cardiac catheterization in patients with end-stage liver disease awaiting liver transplantation. The American journal of cardiology 2009. PMID: 19231345


  82. Zellner C, Boyle A, Yeghiazarians Y. Magnesium sulfate for transradial cardiac catheterization: teaching an old dog new tricks. The Journal of invasive cardiology 2008. PMID: 18829999


  83. Keymel S, Kalka C, Rassaf T, Yeghiazarians Y, Kelm M, Heiss C. Impaired endothelial progenitor cell function predicts age-dependent carotid intimal thickening. Basic research in cardiology 2008. PMID: 18704258


  84. Smith CS, Yeghiazarians Y. Another kind of broken heart. The American journal of medicine 2008. PMID: 18691480


  85. Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. Volume 51 of Issue 18. Journal of the American College of Cardiology 2008. PMID: 18452782


  86. Heiss C, Wong ML, Block VI, Lao D, Real WM, Yeghiazarians Y, Lee RJ, Springer ML. Pleiotrophin induces nitric oxide dependent migration of endothelial progenitor cells. Journal of cellular physiology 2008. PMID: 17960557


  87. Sharma M, Yeghiazarians Y. Stent thrombosis--a complication best avoided. The Journal of invasive cardiology 2008. PMID: 18398231


  88. Amabile N, Heiss C, Real WM, Minasi P, McGlothlin D, Rame EJ, Grossman W, De Marco T, Yeghiazarians Y. Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension. Volume 177 of Issue 11. American journal of respiratory and critical care medicine 2008. PMID: 18310479


  89. Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW. AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid. The journal of gene medicine 2008. PMID: 18044793


  90. Heiss C, Sievers RE, Amabile N, Momma TY, Chen Q, Natarajan S, Yeghiazarians Y, Springer ML. In vivo measurement of flow-mediated vasodilation in living rats using high-resolution ultrasound. American journal of physiology. Heart and circulatory physiology 2007. PMID: 18055528


  91. Smith CS, Yeghiazarians Y. DES for SVG stenosis -- we all want to do it, but are we there yet? The Journal of invasive cardiology 2007. PMID: 17906341


  92. Sharma M, Yeghiazarians Y. Secrets of success in unprotected left main intervention: patient and lesion selection. The Journal of invasive cardiology 2007. PMID: 17827508


  93. Burjonroppa SC, Boyle AJ, Yeghiazarians Y. Is it time to burst the "balloon" for high-risk patients? The Journal of invasive cardiology 2007. PMID: 17712203


  94. Fan Y, Ye J, Shen F, Zhu Y, Yeghiazarians Y, Zhu W, Chen Y, Lawton MT, Young WL, Yang GY. Interleukin-6 stimulates circulating blood-derived endothelial progenitor cell angiogenesis in vitro. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2007. PMID: 17519976


  95. Larose E, Kinlay S, Selwyn AP, Yeghiazarians Y, Yucel EK, Kacher DF, Libby P, Ganz P. Improved characterization of atherosclerotic plaques by gadolinium contrast during intravascular magnetic resonance imaging of human arteries. Atherosclerosis 2007. PMID: 17391676


  96. Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. Volume 102 of Issue 6. Journal of applied physiology (Bethesda, Md. : 1985) 2007. PMID: 17347379


  97. Stone PH, Coskun AU, Kinlay S, Popma JJ, Sonka M, Wahle A, Yeghiazarians Y, Maynard C, Kuntz RE, Feldman CL. Regions of low endothelial shear stress are the sites where coronary plaque progresses and vascular remodelling occurs in humans: an in vivo serial study. European heart journal 2007. PMID: 17347172


  98. Mishell JM, Vakharia KT, Ports TA, Yeghiazarians Y, Michaels AD. Determination of adequate coronary stent expansion using StentBoost, a novel fluoroscopic image processing technique. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2007. PMID: 17139686


  99. Zhang Y, Takagawa J, Sievers RE, Khan MF, Viswanathan MN, Springer ML, Foster E, Yeghiazarians Y. Validation of the wall motion score and myocardial performance indexes as novel techniques to assess cardiac function in mice after myocardial infarction. American journal of physiology. Heart and circulatory physiology 2006. PMID: 17028161


  100. Lee AC, Foster E, Yeghiazarians Y. Anomalous origin of the left coronary artery from the pulmonary artery: a case series and brief review. Congenital heart disease 2006. PMID: 18377554


  101. Harris IS, Lee E, Yeghiazarians Y, Drew BJ, Michaels AD. Phonocardiographic timing of third and fourth heart sounds during acute myocardial infarction. Journal of electrocardiology 2006. PMID: 16777517


  102. Feldman CL, Coskun AU, Yeghiazarians Y, Kinlay S, Wahle A, Olszewski ME, Rossen JD, Sonka M, Popma JJ, Orav J, Kuntz RE, Stone PH. Remodeling characteristics of minimally diseased coronary arteries are consistent along the length of the artery. The American journal of cardiology 2005. PMID: 16377275


  103. Larose E, Yeghiazarians Y, Libby P, Yucel EK, Aikawa M, Kacher DF, Aikawa E, Kinlay S, Schoen FJ, Selwyn AP, Ganz P. Characterization of human atherosclerotic plaques by intravascular magnetic resonance imaging. Circulation 2005. PMID: 16203910


  104. Akhtar M, Vakharia KT, Mishell J, Gera A, Ports TA, Yeghiazarians Y, Michaels AD. Randomized study of the safety and clinical utility of rotational vs. standard coronary angiography using a flat-panel detector. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2005. PMID: 16082684


  105. Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y. Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. Volume 289 of Issue 3. American journal of physiology. Heart and circulatory physiology 2005. PMID: 15908468


  106. Stone PH, Coskun AU, Yeghiazarians Y, Kinlay S, Popma JJ, Kuntz RE, Feldman CL. Prediction of sites of coronary atherosclerosis progression: In vivo profiling of endothelial shear stress, lumen, and outer vessel wall characteristics to predict vascular behavior. Current opinion in cardiology 2003. PMID: 14597887


  107. Coskun AU, Yeghiazarians Y, Kinlay S, Clark ME, Ilegbusi OJ, Wahle A, Sonka M, Popma JJ, Kuntz RE, Feldman CL, Stone PH. Reproducibility of coronary lumen, plaque, and vessel wall reconstruction and of endothelial shear stress measurements in vivo in humans. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2003. PMID: 12929106


  108. Stone PH, Coskun AU, Kinlay S, Clark ME, Sonka M, Wahle A, Ilegbusi OJ, Yeghiazarians Y, Popma JJ, Orav J, Kuntz RE, Feldman CL. Effect of endothelial shear stress on the progression of coronary artery disease, vascular remodeling, and in-stent restenosis in humans: in vivo 6-month follow-up study. Circulation 2003. PMID: 12860915


  109. Stone PH, Yeghiazarians Y. Early glycoprotein IIb/IIIa inhibitors in patients with non-ST-segment elevation myocardial infarction: are we ready to open the floodgates? Journal of the American College of Cardiology 2003. PMID: 12849659


  110. Yeghiazarians Y, Stone PH. ST-Segment Elevation Myocardial Infarction. Current treatment options in cardiovascular medicine 2002. PMID: 11792225


  111. Yeghiazarians Y, Braunstein JB, Askari A, Stone PH. Unstable angina pectoris. The New England journal of medicine 2000. PMID: 10631280


  112. Wangh LJ, DeGrace D, Sanchez JA, Gold A, Yeghiazarians Y, Wiedemann K, Daniels S. Efficient reactivation of Xenopus erythrocyte nuclei in Xenopus egg extracts. Journal of cell science 1995. PMID: 7673338