William Grossman, MD

Professor, Emeritus

CLINICAL INTERESTS; Dr. Grossman is a cardiologist and director of the Center for Prevention of Heart and Vascular Disease at Mission Bay. He is the Charles and Helen Schwab Endowed Chair in Preventive Cardiology at UCSF and a former chief of Cardiology at UCSF Medical Center. He specializes in treatments to prevent the development or progression of heart disease and cares for patients with hypertension (high blood pressure), dyslipidemia (abnormal cholesterol), coronary artery disease (previous or recent heart attack and angina), valvular heart disease, atrial fibrillation, cardiomyopathy and heart failure.

RESEARCH INTERESTS; Dr. Grossman has been a pioneer in research on diastolic function of the heart, and causes of cardiac muscle hypertrophy. He has also done research on the development of new treatments for heart failure, and valvular heart disease. He is editor of the textbook "Grossman's Cardiac Catheterization, Angiography and Intervention," which remains a standard in the field.

Publications

  1. Papolos A, Fan E, Wagle RR, Foster E, Boyle AJ, Yeghiazarians Y, MacGregor JS, Grossman W, Schiller NB, Ganz P, Tison GH. Echocardiographic determination of pulmonary arterial capacitance. The international journal of cardiovascular imaging 2019. PMID: 30968263


  2. Mulliken JS, Langelier C, Budak JZ, Miller S, Dynerman D, Hao S, Li LM, Crawford E, Lyden A, Woodworth MH, DeRisi JL, Desmond E, Browne C, Luu A, Grandis DJ, Grossman W, Deuse T, Melcher GP. Bergeyella cardium: Clinical Characteristics and Draft Genome of an Emerging Pathogen in Native and Prosthetic Valve Endocarditis. Open forum infectious diseases 2019. PMID: 31024974


  3. Grossman W, Paulus WJ. Myocardial stress and hypertrophy: a complex interface between biophysics and cardiac remodeling. Volume 123 of Issue 9. The Journal of clinical investigation 2013. PMID: 23999445


  4. Prochaska JJ, Grossman W, Young-Wolff KC, Benowitz NL. Validity of self-reported adult secondhand smoke exposure. Volume 24 of Issue 1. Tobacco control 2013. PMID: 23997071


  5. Ye J, Boyle A, Shih H, Sievers RE, Zhang Y, Prasad M, Su H, Zhou Y, Grossman W, Bernstein HS, Yeghiazarians Y. Sca-1+ cardiosphere-derived cells are enriched for Isl1-expressing cardiac precursors and improve cardiac function after myocardial injury. Volume 7 of Issue 1. PloS one 2012. PMID: 22272337


  6. Wang X, Takagawa J, Haddad DJ, Pinnamaneni K, Zhang Y, Sievers RE, Grossman W, Yeghiazarians Y, Springer ML. Advanced Donor Age Impairs Bone Marrow Cell Therapeutic Efficacy for Cardiac Disease. Volume S3. Journal of tissue science & engineering 2011. PMID: 22675670


  7. Salti SM, Hammelev EM, Grewal JL, Reddy ST, Zemple SJ, Grossman WJ, Grayson MH, Verbsky JW. Granzyme B regulates antiviral CD8+ T cell responses. Volume 187 of Issue 12. Journal of immunology (Baltimore, Md. : 1950) 2011. PMID: 22084442


  8. Prochaska JJ, Benowitz NL, Glantz SA, Hudmon KS, Grossman W. Cardiology Rx for Change: improving clinical attention to tobacco use and secondhand smoke exposure in cardiology. Volume 34 of Issue 12. Clinical cardiology 2011. PMID: 21987417


  9. Angeli FS, Amabile N, Shapiro M, Mirsky R, Bartlett L, Zhang Y, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Cytokine combination therapy with erythropoietin and granulocyte colony stimulating factor in a porcine model of acute myocardial infarction. Volume 24 of Issue 5-6. Cardiovascular drugs and therapy 2010. PMID: 20809214


  10. Heiss C, Schanz A, Amabile N, Jahn S, Chen Q, Wong ML, Rassaf T, Heinen Y, Cortese-Krott M, Grossman W, Yeghiazarians Y, Springer ML. Nitric oxide synthase expression and functional response to nitric oxide are both important modulators of circulating angiogenic cell response to angiogenic stimuli. Volume 30 of Issue 11. Arteriosclerosis, thrombosis, and vascular biology 2010. PMID: 20705916


  11. Zhang Y, Sievers RE, Prasad M, Mirsky R, Shih H, Wong ML, Angeli FS, Ye J, Takagawa J, Koskenvuo JW, Springer ML, Grossman W, Boyle AJ, Yeghiazarians Y. Timing of bone marrow cell therapy is more important than repeated injections after myocardial infarction. Volume 20 of Issue 4. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 2010. PMID: 20667749


  12. Heiss C, Jahn S, Taylor M, Real WM, Angeli FS, Wong ML, Amabile N, Prasad M, Rassaf T, Ottaviani JI, Mihardja S, Keen CL, Springer ML, Boyle A, Grossman W, Glantz SA, Schroeter H, Yeghiazarians Y. Improvement of endothelial function with dietary flavanols is associated with mobilization of circulating angiogenic cells in patients with coronary artery disease. Volume 56 of Issue 3. Journal of the American College of Cardiology 2010. PMID: 20620742


  13. Angeli FS, Smith C, Amabile N, Shapiro M, Bartlett L, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Granulocyte colony stimulating factor in myocardial infarction with low ejection fraction. Volume 51 of Issue 3. Cytokine 2010. PMID: 20609597


  14. Tomita-Mitchell A, Mahnke DK, Larson JM, Ghanta S, Feng Y, Simpson PM, Broeckel U, Duffy K, Tweddell JS, Grossman WJ, Routes JM, Mitchell ME. Multiplexed quantitative real-time PCR to detect 22q11.2 deletion in patients with congenital heart disease. Volume 42A of Issue 1. Physiological genomics 2010. PMID: 20551144


  15. Kelly ME, Juern AM, Grossman WJ, Schauer DW, Drolet BA. Immunosuppressive effects in infants treated with corticosteroids for infantile hemangiomas. Volume 146 of Issue 7. Archives of dermatology 2010. PMID: 20479291


  16. Yeghiazarians Y, Khan M, Angeli FS, Zhang Y, Jahn S, Prasad M, Mirsky R, Shih H, Minasi P, Boyle A, Grossman W. Cytokine combination therapy with long-acting erythropoietin and granulocyte colony stimulating factor improves cardiac function but is not superior than monotherapy in a mouse model of acute myocardial infarction. Volume 16 of Issue 8. Journal of cardiac failure 2010. PMID: 20670846


  17. Angeli FS, Amabile N, Burjonroppa S, Shapiro M, Bartlett L, Zhang Y, Virmani R, Chatterjee K, Boyle A, Grossman W, Yeghiazarians Y. Prolonged therapy with erythropoietin is safe and prevents deterioration of left ventricular systolic function in a porcine model of myocardial infarction. Volume 16 of Issue 7. Journal of cardiac failure 2010. PMID: 20610234


  18. Amabile N, Heiss C, Chang V, Angeli FS, Damon L, Rame EJ, McGlothlin D, Grossman W, De Marco T, Yeghiazarians Y. Increased CD62e(+) endothelial microparticle levels predict poor outcome in pulmonary hypertension patients. Volume 28 of Issue 10. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2009. PMID: 19782291


  19. Pons J, Huang Y, Takagawa J, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW, Su H. Combining angiogenic gene and stem cell therapies for myocardial infarction. Volume 11 of Issue 9. The journal of gene medicine 2009. PMID: 19554624


  20. Angeli FS, Shapiro M, Amabile N, Orcino G, Smith CS, Tacy T, Boyle AJ, Chatterjee K, Glantz SA, Grossman W, Yeghiazarians Y. Left ventricular remodeling after myocardial infarction: characterization of a swine model on beta-blocker therapy. Volume 59 of Issue 3. Comparative medicine 2009. PMID: 19619418


  21. Michaels AD, Tacy T, Teitel D, Shapiro M, Grossman W. Invasive left ventricular energetics during enhanced external counterpulsation. Volume 16 of Issue 3. American journal of therapeutics 2009. PMID: 19145208


  22. Yeghiazarians Y, Zhang Y, Prasad M, Shih H, Saini SA, Takagawa J, Sievers RE, Wong ML, Kapasi NK, Mirsky R, Koskenvuo J, Minasi P, Ye J, Viswanathan MN, Angeli FS, Boyle AJ, Springer ML, Grossman W. Injection of bone marrow cell extract into infarcted hearts results in functional improvement comparable to intact cell therapy. Volume 17 of Issue 7. Molecular therapy : the journal of the American Society of Gene Therapy 2009. PMID: 19384293


  23. Pons J, Huang Y, Arakawa-Hoyt J, Washko D, Takagawa J, Ye J, Grossman W, Su H. VEGF improves survival of mesenchymal stem cells in infarcted hearts. Volume 376 of Issue 2. Biochemical and biophysical research communications 2008. PMID: 18789891


  24. Heiss C, Amabile N, Lee AC, Real WM, Schick SF, Lao D, Wong ML, Jahn S, Angeli FS, Minasi P, Springer ML, Hammond SK, Glantz SA, Grossman W, Balmes JR, Yeghiazarians Y. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. Volume 51 of Issue 18. Journal of the American College of Cardiology 2008. PMID: 18452782


  25. Su H, Takagawa J, Huang Y, Arakawa-Hoyt J, Pons J, Grossman W, Kan YW. Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart. Volume 133 of Issue 2. International journal of cardiology 2008. PMID: 18295361


  26. Amabile N, Heiss C, Real WM, Minasi P, McGlothlin D, Rame EJ, Grossman W, De Marco T, Yeghiazarians Y. Circulating endothelial microparticle levels predict hemodynamic severity of pulmonary hypertension. Volume 177 of Issue 11. American journal of respiratory and critical care medicine 2008. PMID: 18310479


  27. Su H, Yeghiazarians Y, Lee A, Huang Y, Arakawa-Hoyt J, Ye J, Orcino G, Grossman W, Kan YW. AAV serotype 1 mediates more efficient gene transfer to pig myocardium than AAV serotype 2 and plasmid. The journal of gene medicine 2008. PMID: 18044793


  28. Cohen J, Grossman W, Michaels AD. Portable enhanced external counterpulsation for acute coronary syndrome and cardiogenic shock: a pilot study. Volume 30 of Issue 5. Clinical cardiology 2007. PMID: 17492675


  29. Takagawa J, Zhang Y, Wong ML, Sievers RE, Kapasi NK, Wang Y, Yeghiazarians Y, Lee RJ, Grossman W, Springer ML. Myocardial infarct size measurement in the mouse chronic infarction model: comparison of area- and length-based approaches. Volume 102 of Issue 6. Journal of applied physiology (Bethesda, Md. : 1985) 2007. PMID: 17347379


  30. Joho S, Ishizaka S, Sievers R, Foster E, Simpson PC, Grossman W. Left ventricular pressure-volume relationship in conscious mice. Volume 292 of Issue 1. American journal of physiology. Heart and circulatory physiology 2006. PMID: 16905597


  31. Su H, Huang Y, Takagawa J, Barcena A, Arakawa-Hoyt J, Ye J, Grossman W, Kan YW. AAV serotype-1 mediates early onset of gene expression in mouse hearts and results in better therapeutic effect. Gene therapy 2006. PMID: 16775632


  32. O'Connell TD, Swigart PM, Rodrigo MC, Ishizaka S, Joho S, Turnbull L, Tecott LH, Baker AJ, Foster E, Grossman W, Simpson PC. Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload. Volume 116 of Issue 4. The Journal of clinical investigation 2006. PMID: 16585965


  33. Lin W, Truong N, Grossman WJ, Haribhai D, Williams CB, Wang J, Martín MG, Chatila TA. Allergic dysregulation and hyperimmunoglobulinemia E in Foxp3 mutant mice. Volume 116 of Issue 5. The Journal of allergy and clinical immunology 2005. PMID: 16275384


  34. Springer ML, Sievers RE, Viswanathan MN, Yee MS, Foster E, Grossman W, Yeghiazarians Y. Closed-chest cell injections into mouse myocardium guided by high-resolution echocardiography. Volume 289 of Issue 3. American journal of physiology. Heart and circulatory physiology 2005. PMID: 15908468


  35. McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Volume 22 of Issue 1. Physiological genomics 2005. PMID: 15797971


  36. Revell PA, Grossman WJ, Thomas DA, Cao X, Behl R, Ratner JA, Lu ZH, Ley TJ. Granzyme B and the downstream granzymes C and/or F are important for cytotoxic lymphocyte functions. Volume 174 of Issue 4. Journal of immunology (Baltimore, Md. : 1950) 2005. PMID: 15699143


  37. Su H, Joho S, Huang Y, Barcena A, Arakawa-Hoyt J, Grossman W, Kan YW. Adeno-associated viral vector delivers cardiac-specific and hypoxia-inducible VEGF expression in ischemic mouse hearts. Volume 101 of Issue 46. Proceedings of the National Academy of Sciences of the United States of America 2004. PMID: 15534198


  38. Grossman WJ, Verbsky JW, Tollefsen BL, Kemper C, Atkinson JP, Ley TJ. Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Volume 104 of Issue 9. Blood 2004. PMID: 15238416


  39. Ishizaka S, Sievers RE, Zhu BQ, Rodrigo MC, Joho S, Foster E, Simpson PC, Grossman W. New technique for measurement of left ventricular pressure in conscious mice. Volume 286 of Issue 3. American journal of physiology. Heart and circulatory physiology 2003. PMID: 14563661


  40. O'Connell TD, Ishizaka S, Nakamura A, Swigart PM, Rodrigo MC, Simpson GL, Cotecchia S, Rokosh DG, Grossman W, Foster E, Simpson PC. The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse. Volume 111 of Issue 11. The Journal of clinical investigation 2003. PMID: 12782680


  41. Zhu BQ, Sievers RE, Browne AE, Lee RJ, Chatterjee K, Grossman W, Karliner JS, Parmley WW. Comparative effects of aspirin with ACE inhibitor or angiotensin receptor blocker on myocardial infarction and vascular function. Volume 4 of Issue 1. Journal of the renin-angiotensin-aldosterone system : JRAAS 2003. PMID: 12692751


  42. Angeja BG, Grossman W. Evaluation and management of diastolic heart failure. Volume 107 of Issue 5. Circulation 2003. PMID: 12578862


  43. Michaels AD, Accad M, Ports TA, Grossman W. Left ventricular systolic unloading and augmentation of intracoronary pressure and Doppler flow during enhanced external counterpulsation. Volume 106 of Issue 10. Circulation 2002. PMID: 12208799


  44. Nakamura A, Rokosh DG, Paccanaro M, Yee RR, Simpson PC, Grossman W, Foster E. LV systolic performance improves with development of hypertrophy after transverse aortic constriction in mice. American journal of physiology. Heart and circulatory physiology 2001. PMID: 11514276


  45. Portis T, Grossman WJ, Harding JC, Hess JL, Ratner L. Analysis of p53 inactivation in a human T-cell leukemia virus type 1 Tax transgenic mouse model. Journal of virology 2001. PMID: 11160722


  46. Grossman W. Defining diastolic dysfunction. Circulation 2000. PMID: 10790339


  47. Lynch JJ, Stump GL, Wallace AA, Painter CA, Thomas JM, Kusma SE, Gould RJ, Grossman W. EXP3174, the AII antagonist human metabolite of losartan, but not losartan nor the angiotensin-converting enzyme inhibitor captopril, prevents the development of lethal ischemic ventricular arrhythmias in a canine model of recent myocardial infarction. Journal of the American College of Cardiology 1999. PMID: 10483973


  48. Grossman WJ, Verbsky JW, Yang L, Berg LJ, Fields LE, Chaplin DD, Ratner L. Dysregulated myelopoiesis in mice lacking Jak3. Blood 1999. PMID: 10419884


  49. Grossman W. The role of sarcoplasmic reticulum proteins in heart disease: introduction. Annals of the New York Academy of Sciences 1998. PMID: 10603948


  50. Shen YT, Wiedmann RT, Greenland BD, Lynch JJ, Grossman W. Combined effects of angiotensin converting enzyme inhibition and angiotensin II receptor antagonism in conscious pigs with congestive heart failure. Cardiovascular research 1998. PMID: 9798526


  51. Gutstein DE, Flemmal K, Bruce E, Travers KE, Gwathmey JK, Ransil BJ, Markis JE, Grossman W, Morgan JP. Decreased inotropic but relatively preserved relaxation response to cyclic adenosine monophosphate-dependent agents in myopathic human myocardium. Journal of cardiac failure 1996. PMID: 8989643


  52. Pitt B, Chang P, Grossman W, Dunlay M, Timmermans PB. Rationale, background, and design of the randomized angiotensin receptor antagonist--angiotensin-converting enzyme inhibitor study (RAAS). The American journal of cardiology 1996. PMID: 8914876


  53. Shen YT, Wiedmann RT, Lynch JJ, Grossman W, Johnson RG. GH replacement fails to improve ventricular function in hypophysectomized rats with myocardial infarction. The American journal of physiology 1996. PMID: 8945883


  54. Sellke FW, Wang SY, Friedman M, Harada K, Edelman ER, Grossman W, Simons M. Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary microcirculation. The American journal of physiology 1994. PMID: 7943375


  55. Wang J, Flemal K, Qiu Z, Ablin L, Grossman W, Morgan JP. Ca2+ handling and myofibrillar Ca2+ sensitivity in ferret cardiac myocytes with pressure-overload hypertrophy. The American journal of physiology 1994. PMID: 8092296


  56. Harada K, Grossman W, Friedman M, Edelman ER, Prasad PV, Keighley CS, Manning WJ, Sellke FW, Simons M. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. The Journal of clinical investigation 1994. PMID: 7518840


  57. Watanabe J, Levine MJ, Bellotto F, Johnson RG, Grossman W. Left ventricular diastolic chamber stiffness and intramyocardial coronary capacitance in isolated dog hearts. Circulation 1993. PMID: 8252707


  58. Pagel PS, Grossman W, Haering JM, Warltier DC. Left ventricular diastolic function in the normal and diseased heart. Perspectives for the anesthesiologist (2). Anesthesiology 1993. PMID: 8238987


  59. Litwin SE, Grossman W. Diastolic dysfunction as a cause of heart failure. Journal of the American College of Cardiology 1993. PMID: 8376697


  60. Pagel PS, Grossman W, Haering JM, Warltier DC. Left ventricular diastolic function in the normal and diseased heart. Perspectives for the anesthesiologist (1). Anesthesiology 1993. PMID: 8214764


  61. Ho KK, Anderson KM, Kannel WB, Grossman W, Levy D. Survival after the onset of congestive heart failure in Framingham Heart Study subjects. Circulation 1993. PMID: 8319323


  62. Breall JA, Grossman W, Stillman IE, Gianturco LE, Kim D. Atherectomy of the subclavian artery for patients with symptomatic coronary-subclavian steal syndrome. Journal of the American College of Cardiology 1993. PMID: 8496520


  63. Breall JA, Watanabe J, Grossman W. Effect of zatebradine on contractility, relaxation and coronary blood flow. Journal of the American College of Cardiology 1993. PMID: 8426013


  64. Carrozza JP, Bentivegna LA, Williams CP, Kuntz RE, Grossman W, Morgan JP. Decreased myofilament responsiveness in myocardial stunning follows transient calcium overload during ischemia and reperfusion. Circulation research 1992. PMID: 1423931


  65. Cohen DJ, Kuntz RE, Gordon SP, Piana RN, Safian RD, McKay RG, Baim DS, Grossman W, Diver DJ. Predictors of long-term outcome after percutaneous balloon mitral valvuloplasty. The New England journal of medicine 1992. PMID: 1406834


  66. Takahashi T, Allen PD, Lacro RV, Marks AR, Dennis AR, Schoen FJ, Grossman W, Marsh JD, Izumo S. Expression of dihydropyridine receptor (Ca2+ channel) and calsequestrin genes in the myocardium of patients with end-stage heart failure. The Journal of clinical investigation 1992. PMID: 1326001


  67. Amende I, Bentivegna LA, Zeind AJ, Wenzlaff P, Grossman W, Morgan JP. Intracellular calcium and ventricular function. Effects of nisoldipine on global ischemia in the isovolumic, coronary-perfused heart. The Journal of clinical investigation 1992. PMID: 1602012


  68. Kugelmass AD, Manning WJ, Piana RN, Weintraub RM, Baim DS, Grossman W. Coronary arteriovenous fistula presenting as congestive heart failure. Catheterization and cardiovascular diagnosis 1992. PMID: 1499058


  69. Takahashi T, Schunkert H, Isoyama S, Wei JY, Nadal-Ginard B, Grossman W, Izumo S. Age-related differences in the expression of proto-oncogene and contractile protein genes in response to pressure overload in the rat myocardium. The Journal of clinical investigation 1992. PMID: 1531837


  70. Hajjar RJ, Grossman W, Gwathmey JK. Responsiveness of the myofilaments to Ca2+ in human heart failure: implications for Ca2+ and force regulation. Basic research in cardiology 1992. PMID: 1497567


  71. McKay RG, Penny WF, Wyman RM, Clay W, Carr JG, Bernhard WF, Grossman W. Hemodynamic evaluation of a chronically implanted, electrically powered left ventricular assist system: responses to acute circulatory stress. Journal of the American College of Cardiology 1991. PMID: 1960330


  72. Grossman W. Diastolic dysfunction in congestive heart failure. The New England journal of medicine 1991. PMID: 1834939


  73. Manning WJ, Atkinson DJ, Grossman W, Paulin S, Edelman RR. First-pass nuclear magnetic resonance imaging studies using gadolinium-DTPA in patients with coronary artery disease. Journal of the American College of Cardiology 1991. PMID: 1894870


  74. Warren SE, Grossman W. Prognosis in heart failure: is systolic or diastolic dysfunction more important? Herz 1991. PMID: 1820300


  75. Takahashi T, Levine MJ, Grossman W. Regional diastolic mechanics of ischemic and nonischemic myocardium in the pig heart. Journal of the American College of Cardiology 1991. PMID: 2007722


  76. Gwathmey JK, Warren SE, Briggs GM, Copelas L, Feldman MD, Phillips PJ, Callahan M, Schoen FJ, Grossman W, Morgan JP. Diastolic dysfunction in hypertrophic cardiomyopathy. Effect on active force generation during systole. The Journal of clinical investigation 1991. PMID: 1999483


  77. Momomura S, Ferguson JJ, Miller MJ, Parker JA, Grossman W. Regional myocardial blood flow and left ventricular diastolic properties in pacing-induced ischemia. Journal of the American College of Cardiology 1991. PMID: 1993800


  78. Grossman W. Diastolic function and heart failure: an overview. European heart journal 1990. PMID: 2188838


  79. Morgan JP, Erny RE, Allen PD, Grossman W, Gwathmey JK. Abnormal intracellular calcium handling, a major cause of systolic and diastolic dysfunction in ventricular myocardium from patients with heart failure. Circulation 1990. PMID: 2153479


  80. Grossman W. Diastolic dysfunction and congestive heart failure. Circulation 1990. PMID: 2137051


  81. Weinstein JS, Grossman W, Weintraub RM, Thurer RL, Johnson RG, Morgan KG. Differences in alpha-adrenergic responsiveness between human internal mammary arteries and saphenous veins. Circulation 1989. PMID: 2566395


  82. Levine MJ, Weinstein JS, Diver DJ, Berman AD, Wyman RM, Cunningham MJ, Safian RD, Grossman W, McKay RG. Progressive improvement in pulmonary vascular resistance after percutaneous mitral valvuloplasty. Circulation 1989. PMID: 2713972


  83. Hirsch AT, Gervino EV, Nakao S, Come PC, Silverman KJ, Grossman W. The effect of caffeine on exercise tolerance and left ventricular function in patients with coronary artery disease. Annals of internal medicine 1989. PMID: 2930092


  84. Kihara Y, Gwathmey JK, Grossman W, Morgan JP. Mechanisms of positive inotropic effects and delayed relaxation produced by DPI 201-106 in mammalian working myocardium: effects on intracellular calcium handling. British journal of pharmacology 1989. PMID: 2743084


  85. Ferguson JJ, Miller MJ, Aroesty JM, Sahagian P, Grossman W, McKay RG. Assessment of right atrial pressure-volume relations in patients with and without an atrial septal defect. Journal of the American College of Cardiology 1989. PMID: 2918169


  86. Wei JY, Li Y, Lincoln T, Grossman W, Mendelowitz D. Chronic exercise training protects aged cardiac muscle against hypoxia. The Journal of clinical investigation 1989. PMID: 2921320


  87. Wyman RM, Farhi ER, Bing OH, Johnson RG, Weintraub RM, Grossman W. Comparative effects of hypoxia and ischemia in the isolated, blood-perfused dog heart: evaluation of left ventricular diastolic chamber distensibility and wall thickness. Circulation research 1989. PMID: 2909295


  88. Feldman MD, Alderman JD, Aroesty JM, Royal HD, Ferguson JJ, Owen RM, Grossman W, McKay RG. Depression of systolic and diastolic myocardial reserve during atrial pacing tachycardia in patients with dilated cardiomyopathy. The Journal of clinical investigation 1988. PMID: 3183060


  89. Safian RD, Warren SE, Berman AD, Diver DJ, McKay LL, Come PC, Grossman W, McKay RG. Improvement in symptoms and left ventricular performance after balloon aortic valvuloplasty in patients with aortic stenosis and depressed left ventricular ejection fraction. Circulation 1988. PMID: 3180377


  90. Berman AD, Weinstein JS, Safian RD, Diver DJ, Grossman W, McKay RG. Combined aortic and mitral balloon valvuloplasty in patients with critical aortic and mitral valve stenosis: results in six cases. Journal of the American College of Cardiology 1988. PMID: 3366995


  91. Isoyama S, Grossman W, Wei JY. Effect of age on myocardial adaptation to volume overload in the rat. The Journal of clinical investigation 1988. PMID: 2968366


  92. Warren SE, Royal HD, Markis JE, Grossman W, McKay RG. Time course of left ventricular dilation after myocardial infarction: influence of infarct-related artery and success of coronary thrombolysis. Journal of the American College of Cardiology 1988. PMID: 3335689


  93. McKay RG, Safian RD, Berman AD, Diver DJ, Weinstein JS, Wyman RM, Cunningham MJ, McKay LL, Baim DS, Grossman W. Combined percutaneous aortic valvuloplasty and transluminal coronary angioplasty in adult patients with calcific aortic stenosis and coronary artery disease. Circulation 1987. PMID: 2960472


  94. Gwathmey JK, Copelas L, MacKinnon R, Schoen FJ, Feldman MD, Grossman W, Morgan JP. Abnormal intracellular calcium handling in myocardium from patients with end-stage heart failure. Circulation research 1987. PMID: 3608112


  95. Lorell BH, Grossman W. Cardiac hypertrophy: the consequences for diastole. Journal of the American College of Cardiology 1987. PMID: 2952703


  96. Safian RD, Mandell VS, Thurer RE, Hutchins GM, Schnitt SJ, Grossman W, McKay RG. Postmortem and intraoperative balloon valvuloplasty of calcific aortic stenosis in elderly patients: mechanisms of successful dilation. Journal of the American College of Cardiology 1987. PMID: 2950156


  97. Feldman MD, Copelas L, Gwathmey JK, Phillips P, Warren SE, Schoen FJ, Grossman W, Morgan JP. Deficient production of cyclic AMP: pharmacologic evidence of an important cause of contractile dysfunction in patients with end-stage heart failure. Circulation 1987. PMID: 2433073


  98. McKay RG, Miller MJ, Ferguson JJ, Momomura S, Sahagian P, Grossman W, Pasternak RC. Assessment of left ventricular end-systolic pressure-volume relations with an impedance catheter and transient inferior vena cava occlusion: use of this system in the evaluation of the cardiotonic effects of dobutamine, milrinone, Posicor and epinephrine. Journal of the American College of Cardiology 1986. PMID: 3760389


  99. Bourdillon PD, Paulus WJ, Serizawa T, Grossman W. Effects of verapamil on regional myocardial diastolic function in pacing-induced ischemia in dogs. The American journal of physiology 1986. PMID: 3766760


  100. McKay RG, Pfeffer MA, Pasternak RC, Markis JE, Come PC, Nakao S, Alderman JD, Ferguson JJ, Safian RD, Grossman W. Left ventricular remodeling after myocardial infarction: a corollary to infarct expansion. Circulation 1986. PMID: 3757183


  101. Li Y, Lincoln T, Mendelowitz D, Grossman W, Wei JY. Age-related differences in effect of exercise training on cardiac muscle function in rats. The American journal of physiology 1986. PMID: 3728687


  102. McKay RG, Aroesty JM, Heller GV, Royal HD, Warren SE, Grossman W. Assessment of the end-systolic pressure-volume relationship in human beings with the use of a time-varying elastance model. Circulation 1986. PMID: 3708783


  103. McKay RG, Safian RD, Lock JE, Mandell VS, Thurer RL, Schnitt SJ, Grossman W. Balloon dilatation of calcific aortic stenosis in elderly patients: postmortem, intraoperative, and percutaneous valvuloplasty studies. Circulation 1986. PMID: 2423269


  104. McKay RG, Lock JE, Keane JF, Safian RD, Aroesty JM, Grossman W. Percutaneous mitral valvuloplasty in an adult patient with calcific rheumatic mitral stenosis. Journal of the American College of Cardiology 1986. PMID: 3711499


  105. Miller MJ, McKay RG, Ferguson JJ, Sahagian P, Nakao S, Come PC, Grossman W. Right atrial pressure-volume relationships in tricuspid regurgitation. Circulation 1986. PMID: 3948376


  106. Monrad ES, Baim DS, Smith HS, Lanoue AS, Silverman KJ, Gervino EV, Grossman W. Assessment of long-term therapy with milrinone and the effects of milrinone withdrawal. Circulation 1986. PMID: 3510776


  107. Nakao S, Come PC, Miller MJ, Momomura S, Sahagian P, Ransil BJ, Grossman W. Effects of supine and lateral positions on cardiac output and intracardiac pressures: an experimental study. Circulation 1986. PMID: 3948362


  108. Baim DS, Colucci WS, Monrad ES, Smith HS, Wright RF, Lanoue A, Gauthier DF, Ransil BJ, Grossman W, Braunwald E. Survival of patients with severe congestive heart failure treated with oral milrinone. Journal of the American College of Cardiology 1986. PMID: 3950244


  109. Grossman W. Assessment of regional myocardial function. Journal of the American College of Cardiology 1986. PMID: 3944352


  110. Bourdillon PD, Bettmann MA, McCracken S, Poole-Wilson PA, Grossman W. Effects of a new nonionic and a conventional ionic contrast agent on coronary sinus ionized calcium and left ventricular hemodynamics in dogs. Journal of the American College of Cardiology 1985. PMID: 4031299


  111. Alderman J, Grossman W. Are beta-adrenergic-blocking drugs useful in the treatment of dilated cardiomyopathy? Circulation 1985. PMID: 2859129


  112. Paulus WJ, Grossman W, Serizawa T, Bourdillon PD, Pasipoularides A, Mirsky I. Different effects of two types of ischemia on myocardial systolic and diastolic function. The American journal of physiology 1985. PMID: 3993809


  113. Monrad ES, Baim DS, Smith HS, Lanoue A, Brauwald E, Grossman W. Effects of milrinone on coronary hemodynamics and myocardial energetics in patients with congestive heart failure. Circulation 1985. PMID: 3986984


  114. Aroesty JM, McKay RG, Heller GV, Royal HD, Als AV, Grossman W. Simultaneous assessment of left ventricular systolic and diastolic dysfunction during pacing-induced ischemia. Circulation 1985. PMID: 3986979


  115. Borow KM, Come PC, Neumann A, Baim DS, Braunwald E, Grossman W. Physiologic assessment of the inotropic, vasodilator and afterload reducing effects of milrinone in subjects without cardiac disease. The American journal of cardiology 1985. PMID: 3984901


  116. Monrad ES, McKay RG, Baim DS, Colucci WS, Fifer MA, Heller GV, Royal HD, Grossman W. Improvement in indexes of diastolic performance in patients with congestive heart failure treated with milrinone. Circulation 1984. PMID: 6499142


  117. Momomura S, Bradley AB, Grossman W. Left ventricular diastolic pressure-segment length relations and end-diastolic distensibility in dogs with coronary stenoses. An angina physiology model. Circulation research 1984. PMID: 6744530


  118. McKay RG, Aroesty JM, Heller GV, Silverman KJ, Parker JA, Als AV, Come PC, Kolodny GM, Grossman W. The pacing stress test reexamined: correlation of pacing-induced hemodynamic changes with the amount of myocardium at risk. Journal of the American College of Cardiology 1984. PMID: 6715706


  119. Baumstark A, Swensson RG, Hessel SJ, Levin DC, Grossman W, Mann JT, Abrams HL. Evaluating the radiographic assessment of pulmonary venous hypertension in chronic heart disease. AJR. American journal of roentgenology 1984. PMID: 6609566


  120. Heller GV, Aroesty JM, Parker JA, McKay RG, Silverman KJ, Als AV, Come PC, Kolodny GM, Grossman W. The pacing stress test: thallium-201 myocardial imaging after atrial pacing. Diagnostic value in detecting coronary artery disease compared with exercise testing. Journal of the American College of Cardiology 1984. PMID: 6707369


  121. McKay RG, Spears JR, Aroesty JM, Baim DS, Royal HD, Heller GV, Lincoln W, Salo RW, Braunwald E, Grossman W. Instantaneous measurement of left and right ventricular stroke volume and pressure-volume relationships with an impedance catheter. Circulation 1984. PMID: 6697458


  122. McKay RG, Aroesty JM, Heller GV, Royal H, Parker JA, Silverman KJ, Kolodny GM, Grossman W. Left ventricular pressure-volume diagrams and end-systolic pressure-volume relations in human beings. Journal of the American College of Cardiology 1984. PMID: 6420453


  123. Paulus WJ, Lorell BH, Craig WE, Wynne J, Murgo JP, Grossman W. Comparison of the effects of nitroprusside and nifedipine on diastolic properties in patients with hypertrophic cardiomyopathy: altered left ventricular loading or improved muscle inactivation? Journal of the American College of Cardiology 1983. PMID: 6685150


  124. Friesinger GC, Adams DF, Bourassa MG, Carlson E, Elliott LP, Gessner IH, Greenspan RH, Grossman W, Judkins MP, Kennedy JW. Optimal resources for examination of the heart and lungs: cardiac catheterization and radiographic facilities. Examination of the Chest and Cardiovascular System Study Group. Circulation 1983. PMID: 6681267


  125. Dervan JP, Baim DS, Cherniles J, Grossman W. Transluminal angioplasty of occluded coronary arteries: use of a movable guide wire system. Circulation 1983. PMID: 6225561


  126. Spears JR, Sandor T, Als AV, Malagold M, Markis JE, Grossman W, Serur JR, Paulin S. Computerized image analysis for quantitative measurement of vessel diameter from cineangiograms. Circulation 1983. PMID: 6861322


  127. Kern MJ, Ganz P, Horowitz JD, Gaspar J, Barry WH, Lorell BH, Grossman W, Mudge GH. Potentiation of coronary vasoconstriction by beta-adrenergic blockade in patients with coronary artery disease. Circulation 1983. PMID: 6133636


  128. Spears JR, Marais HJ, Serur J, Pomerantzeff O, Geyer RP, Sipzener RS, Weintraub R, Thurer R, Paulin S, Gerstin R, Grossman W. In vivo coronary angioscopy. Journal of the American College of Cardiology 1983. PMID: 6833670


  129. Konstam MA, Idoine J, Wynne J, Grossman W, Cohn L, Beck JR, Kozlowski J, Holman BL. Right ventricular function in adults with pulmonary hypertension with and without atrial septal defect. The American journal of cardiology 1983. PMID: 6301257


  130. Bourdillon PD, Lorell BH, Mirsky I, Paulus WJ, Wynne J, Grossman W. Increased regional myocardial stiffness of the left ventricle during pacing-induced angina in man. Circulation 1983. PMID: 6848219


  131. Borow KM, Green LH, Grossman W, Braunwald E. Left ventricular end-systolic stress-shortening and stress-length relations in human. Normal values and sensitivity to inotropic state. The American journal of cardiology 1982. PMID: 7148706


  132. Carabello BA, Grossman W, Gunther S. Ejection performance in AS. Circulation 1982. PMID: 7055884


  133. Lorell BH, Paulus WJ, Grossman W, Wynne J, Cohn PF. Modification of abnormal left ventricular diastolic properties by nifedipine in patients with hypertrophic cardiomyopathy. Circulation 1982. PMID: 7198942


  134. Paulus WJ, Serizawa T, Grossman W. Altered left ventricular diastolic properties during pacing-induced ischemia in dogs with coronary stenoses. Potentiation by caffeine. Circulation research 1982. PMID: 7055856


  135. Friedman PL, Brown EJ, Gunther S, Alexander RW, Barry WH, Mudge GH, Grossman W. Coronary vasoconstrictor effect of indomethacin in patients with coronary-artery disease. The New England journal of medicine 1981. PMID: 7290132


  136. Lorell BH, Turi Z, Grossman W. Modification of left ventricular response to pacing tachycardia in nifedipine in patients with coronary artery disease. The American journal of medicine 1981. PMID: 7282755


  137. Markis JE, Malagold M, Parker JA, Silverman KJ, Barry WH, Als AV, Paulin S, Grossman W, Braunwald E. Myocardial salvage after intracoronary thrombolysis with streptokinase in acute myocardial infarction. The New England journal of medicine 1981. PMID: 7266630


  138. Rude RE, Turi Z, Brown EJ, Lorell BH, Colucci WS, Mudge GH, Taylor CR, Grossman W. Acute effects of oral pirbuterol on myocardial oxygen metabolism and systemic hemodynamics in chronic congestive heart failure. Circulation 1981. PMID: 7237712


  139. Serizawa T, Vogel WM, Apstein CS, Grossman W. Comparison of acute alterations in left ventricular relaxation and diastolic chamber stiffness induced by hypoxia and ischemia. Role of myocardial oxygen supply-demand imbalance. The Journal of clinical investigation 1981. PMID: 7251868


  140. Gunther S, Green L, Muller JE, Mudge GH, Grossman W. Prevention of nifedipine of abnormal coronary vasoconstriction in patients with coronary artery disease. Circulation 1981. PMID: 7471341


  141. Gunther S, Muller JE, Mudge GH, Grossman W. Therapy of coronary vasoconstriction in patients with coronary artery disease. The American journal of cardiology 1981. PMID: 6779618


  142. Lorell BH, Paulus WJ, Grossman W, Wynne J, Cohn PF, Braunwald E. Improved diastolic function and systolic performance in hypertrophic cardiomyopathy after nifedipine. The New England journal of medicine 1980. PMID: 7191052


  143. Benotti JR, Grossman W, Braunwald E, Carabello BA. Effects of amrinone on myocardial energy metabolism and hemodynamics in patients with severe congestive heart failure due to coronary artery disease. Circulation 1980. PMID: 7379283


  144. Carabello BA, Green LH, Grossman W, Cohn LH, Koster JK, Collins JJ. Hemodynamic determinants of prognosis of aortic valve replacement in critical aortic stenosis and advanced congestive heart failure. Circulation 1980. PMID: 7379284


  145. Benotti JR, Grossman W, Cohn PF. Clinical profile of restrictive cardiomyopathy. Circulation 1980. PMID: 6445242


  146. Wynne J, Malacoff RF, Benotti JR, Curfman GD, Grossman W, Holman BL, Smith TW, Braunwald E. Oral amrinone in refractory congestive heart failure. The American journal of cardiology 1980. PMID: 7377123


  147. Borow KM, Green LH, Mann T, Sloss LJ, Braunwald E, Collins JJ, Cohn L, Grossman W. End-systolic volume as a predictor of postoperative left ventricular performance in volume overload from valvular regurgitation. The American journal of medicine 1980. PMID: 7377221


  148. Wynne J, Mann T, Alpert JS, Green LH, Grossman W. Hemodynamic effects of nitrous oxide administered during cardiac catheterization. JAMA 1980. PMID: 7359715


  149. Serizawa T, Carabello BA, Grossman W. Effect of pacing-induced ischemia on left ventricular diastolic pressure-volume relations in dogs with coronary stenoses. Circulation research 1980. PMID: 7357697


  150. Grossman W, Barry WH. Diastolic pressure-volume relations in the diseased heart. Federation proceedings 1980. PMID: 6444388


  151. Grossman W, Serizawa T, Carabello BA. Studies on the mechanism of altered left ventricular diastolic pressure-volume relations during ischaemia. European heart journal 1980. PMID: 7274224


  152. Alpert JS, Sloss LJ, Cohn PF, Grossman W. The diagnostic accuracy of combined clinical and noninvasive cardiac evaluation: comparison with findings at cardiac catheterization. Catheterization and cardiovascular diagnosis 1980. PMID: 7471199


  153. Marsh JD, Green LH, Wynne J, Cohn PF, Grossman W. Left ventricular end-systolic pressure-dimension and stress-length relations in normal human subjects. The American journal of cardiology 1979. PMID: 506934


  154. Gunther S, Green L, Muller JE, Mudge GH, Grossman W. Inappropriate coronary vasoconstriction in patients with coronary artery disease: a role for nifedipine? The American journal of cardiology 1979. PMID: 386763


  155. Carabello BA, Barry WH, Grossman W. Changes in arterial pressure during left heart pullback in patients with aortic stenosis: a sign of severe aortic stenosis. The American journal of cardiology 1979. PMID: 474420


  156. Grossman W. Diastolic properties of the heart. Circulation 1979. PMID: 376178


  157. Antman EM, Green LH, Grossman W. Physiologic determinants of the electrocardiographic diagnosis of left ventricular hypertrophy. Circulation 1979. PMID: 156094


  158. Gunther S, Grossman W. Determinants of ventricular function in pressure-overload hypertrophy in man. Circulation 1979. PMID: 154367


  159. Mudge GH, Goldberg S, Gunther S, Mann T, Grossman W. Comparison of metabolic and vasoconstrictor stimuli on coronary vascular resistance in man. Circulation 1979. PMID: 761335


  160. Mann T, Goldberg S, Mudge GH, Grossman W. Factors contributing to altered left ventricular diastolic properties during angina pectoris. Circulation 1979. PMID: 758105


  161. Goldberg S, Mann T, Grossman W. Nitrate therapy of heart failure in valvular heart disease. Importance of resting level of peripheral vascular resistance in determining cardiac output response. The American journal of medicine 1978. PMID: 685988


  162. Goldberg S, Grossman W, Markis JE, Cohen MV, Baltaxe HA, Levin DC. Total occlusion of the left main coronary artery. A clinical, hemodynamic and angiographic profile. The American journal of medicine 1978. PMID: 623135


  163. Grossman W, Braunwald E, Mann T, McLaurin LP, Green LH. Contractile state of the left ventricle in man as evaluated from end-systolic pressure-volume relations. Circulation 1977. PMID: 71960


  164. Mann T, Brodie BR, Grossman W, McLaurin LP. Effect of angina on the left ventricular diastolic pressure-volume relationship. Circulation 1977. PMID: 849634


  165. Brodie BR, Grossman W, Mann T, McLaurin LP. Effects of sodium nitroprusside on left ventricular diastolic pressure-volume relations. The Journal of clinical investigation 1977. PMID: 830666


  166. Mudge GH, Grossman W, Mills RM, Lesch M, Braunwald E. Reflex increase in coronary vascular resistance in patients with ischemic heart disease. The New England journal of medicine 1976. PMID: 10527


  167. Brodie BR, Cuck L, Klausner S, Grossman W, Parmley W. Effects of sodium nitroprusside and nitroglycerin on tension prolongation of cat papillary muscle during recovery from hypoxia. Circulation research 1976. PMID: 822961


  168. Brodie BR, Grossman W, McLaurin L, Starek PJ, Craige E. Diagnosis of prosthetic mitral valve malfunction with combined echo-phonocardiography. Circulation 1976. PMID: 1244259


  169. Mudge GH, Grossman W, Mills RM, Lesch M, Braunwald E. Evidence for reflex coronary artery spasm in patients with ischemic heart disease. Transactions of the Association of American Physicians 1976. PMID: 1020121


  170. Mann T, McLaurin L, Grossman W, Craige E. Assessing the hemodynamic severity of acute aortic regurgitation due to infective endocarditis. The New England journal of medicine 1975. PMID: 1134517


  171. Grossman W, Jones D, McLaurin LP. Wall stress and patterns of hypertrophy in the human left ventricle. The Journal of clinical investigation 1975. PMID: 124746


  172. Rankin LS, Moos S, Grossman W. Alterations in preload and ejection phase indices of left ventricular performance,. Circulation 1975. PMID: 1122594


  173. Grossman W, McLaurin LP, Stefadouros MA. Left ventricular stiffness associated with chronic pressure and volume overloads in man. Circulation research 1974. PMID: 4278409


  174. Stefadouros MA, Grossman W, el-Shahawy M, Witham C. The effect of isometric exercise on the left ventricular volume in normal man. Circulation 1974. PMID: 4598634


  175. Gibson TC, Madry R, Grossman W, McLaurin LP, Craige E. The A wave of the apexcardiogram and left ventricular diastolic stiffness. Circulation 1974. PMID: 4813178


  176. Grossman W, McLaurin LP, Moos SP, Stefadouros M, Young DT. Wall thickness and diastolic properties of the left ventricle. Circulation 1974. PMID: 4271709


  177. McLaurin LP, Rolett EL, Grossman W. Impaired left ventricular relaxation during pacing-induced ischemia. The American journal of cardiology 1973. PMID: 4744260


  178. McLaurin LP, Gibson TC, Waider W, Grossman W, Craige E. An appraisal of mitral valve echocardiograms mimicking mitral stenosis in conditions with right ventricular pressure overload. Circulation 1973. PMID: 4744786


  179. McLaurin LP, Grossman W, Stefadouros MA, Rolett EL, Young DT. A new technique for the study of left ventricular pressure-volume relations in man. Circulation 1973. PMID: 4781248


  180. Grossman W, McLaurin LP, Saltz SB, Paraskos JA, Dalen JE, Dexter L. Changes in the inotropic state of the left ventricle during isometric exercise. British heart journal 1973. PMID: 4718821


  181. Grossman W, Stefadouros MA, McLaurin LP, Rolett EL, Young DT. Quantitative assessment of left ventricular diastolic stiffness in man. Circulation 1973. PMID: 4266321


  182. Stefadouros MA, Dougherty MJ, Grossman W, Craige E. Determination of systemic vascular resistance by a noninvasive technic. Circulation 1973. PMID: 4686587


  183. Johnson LW, Grossman W, Dalen JE, Dexter L. Pulmonic stenosis in the adult. Long-term follow-up results. The New England journal of medicine 1972. PMID: 5082217


  184. Meister SG, Grossman W, Dexter L, Dalen JE. Paradoxical embolism. Diagnosis during life. The American journal of medicine 1972. PMID: 4559985


  185. Smith R, Grossman W, Johnson L, Segal H, Collins J, Dalen J. Arrhythmias following cardiac valve replacement. Circulation 1972. PMID: 5020795