Tien Peng, MD

Associate Professor

The Peng Lab is interested in how fibroblasts integrate extracellular cues to modify the tissue niche, with a particular focus on fibroblasts that support tissue-resident stem cells and immune cells. We utilize complex murine genetic models and human specimen to interrogate how fibroblasts maintain organ homeostasis, initiate disease, and drive tissue aging. Tien is a pulmonologist by training and the lab utilizes the lung as a model organ due to its immense cellular diversity and architectural complexity.

Education
Clinical/Postdoctoral Fellowship, 2015 - Pulmonary Medicine/Cell and Developmental Biology, University of Pennsylvania
Internal Medicine Residency, 2009 - , Columbia University Medical Center
M.D., 2006 - School of Medicine, Johns Hopkins University
B.A., 2000 - , University of Virginia
Honors and Awards
  • NIH New Innovator Award, National Institutes of Health, 2016-2021
  • Young Physician Scientist Award, American Society for Clinical Investigation, 2016
  • Jo Rae Wright Award, Federation of American Societies for Experimental Biology, 2014
Websites
Publications

  1. Lee JY, Peng T. Convergent evolution of senescent fibroblasts in fibrosis and cancer with aging. Seminars in cancer biology 2024. PMID: 39433114


  2. Zhu X, Xu M, Portal C, Lin Y, Ferdinand A, Peng T, Morrisey EE, Dlugosz AA, Castellano JM, Lee V, Seykora JT, Iomini C, Millar SE. Identification of Meibomian gland stem cell populations and mechanisms of aging. bioRxiv : the preprint server for biology 2024. PMID: 39149265


  3. Lee JY, Reyes N, Woo SH, Goel S, Stratton F, Kuang C, Mansfield AS, LaFave LM, Peng T. Senescent fibroblasts in the tumor stroma rewire lung cancer metabolism and plasticity. bioRxiv : the preprint server for biology 2024. PMID: 39131266


  4. Lee JY, Reyes NS, Ravishankar S, Zhou M, Krasilnikov M, Ringler C, Pohan G, Wilson C, Ang KK, Wolters PJ, Tsukui T, Sheppard D, Arkin MR, Peng T. An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis. The Journal of clinical investigation 2024. PMID: 38451724


  5. Chen X, Haribowo AG, Baik AH, Fossati A, Stevenson E, Chen YR, Reyes NS, Peng T, Matthay MA, Traglia M, Pico AR, Jarosz DF, Buchwalter A, Ghaemmaghami S, Swaney DL, Jain IH. In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response. Science advances 2023. PMID: 38064566


  6. Peng T. Bad Neighbors or Bad Neighborhoods: Pathogenic Residency of T Cells in COPD. American journal of respiratory and critical care medicine 2023. PMID: 37855741


  7. COVID Tissue Atlas Consortium, Granados AA, Bucher S, Song H, Agrawal A, Chen AT, Peng T, Neff N, Pisco AO, Huang F, Wang B. Single-nuclei characterization of pervasive transcriptional signatures across organs in response to COVID-19. eLife 2023. PMID: 37830426


  8. Sbierski-Kind J, Cautivo KM, Wagner JC, Dahlgren MW, Nilsson J, Krasilnikov M, Mroz NM, Lizama CO, Gan AL, Matatia PR, Taruselli MT, Chang AA, Caryotakis S, O'Leary CE, Kotas M, Mattis AN, Peng T, Locksley RM, Molofsky AB. Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis. bioRxiv : the preprint server for biology 2023. PMID: 37163060


  9. Wang C, Hyams B, Allen NC, Cautivo K, Monahan K, Zhou M, Dahlgren MW, Lizama CO, Matthay M, Wolters P, Molofsky AB, Peng T. Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir. Immunity 2023. PMID: 36822205


  10. Reyes NS, Krasilnikov M, Allen NC, Lee JY, Hyams B, Zhou M, Ravishankar S, Cassandras M, Wang C, Khan I, Matatia P, Johmura Y, Molofsky A, Matthay M, Nakanishi M, Sheppard D, Campisi J, Peng T. Sentinel p16INK4a+ cells in the basement membrane form a reparative niche in the lung. Science (New York, N.Y.) 2022. PMID: 36227993


  11. Allen NC, Reyes NS, Lee JY, Peng T. Intersection of Inflammation and Senescence in the Aging Lung Stem Cell Niche. Frontiers in cell and developmental biology 2022. PMID: 35912114


  12. Kathiriya JJ, Wang C, Zhou M, Brumwell A, Cassandras M, Le Saux CJ, Cohen M, Alysandratos KD, Wang B, Wolters P, Matthay M, Kotton DN, Chapman HA, Peng T. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. 2021. PMID: 34969962


  13. Kathiriya JJ, Peng T. An inflammatory switch for stem cell plasticity. Nature cell biology 2021. PMID: 34475536


  14. Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, Wolters P, Molofsky A, Sheppard D, Chapman H, Peng T. Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nature cell biology 2020. PMID: 33046884


  15. Wang C, Cassandras M, Peng T. The Role of Hedgehog Signaling in Adult Lung Regeneration and Maintenance. Journal of developmental biology 2019. PMID: 31323955


  16. Dahlgren MW, Jones SW, Cautivo KM, Dubinin A, Ortiz-Carpena JF, Farhat S, Yu KS, Lee K, Wang C, Molofsky AV, Tward AD, Krummel MF, Peng T, Molofsky AB. Adventitial Stromal Cells Define Group 2 Innate Lymphoid Cell Tissue Niches. Immunity 2019. PMID: 30824323


  17. Kim SJ, Shan P, Hwangbo C, Zhang Y, Min JN, Zhang X, Ardito T, Li A, Peng T, Sauler M, Lee PJ. Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. Aging cell 2019. PMID: 30790400


  18. Wang C, de Mochel NSR, Christenson SA, Cassandras M, Moon R, Brumwell AN, Byrnes LE, Li A, Yokosaki Y, Shan P, Sneddon JB, Jablons D, Lee PJ, Matthay MA, Chapman HA, Peng T. Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. The Journal of clinical investigation 2018. PMID: 29999500


  19. Frank DB, Peng T, Zepp JA, Snitow M, Vincent TL, Penkala IJ, Cui Z, Herriges MJ, Morley MP, Zhou S, Lu MM, Morrisey EE. Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell reports 2016. PMID: 27880906


  20. Peng T, Frank DB, Kadzik RS, Morley MP, Rathi KS, Wang T, Zhou S, Cheng L, Lu MM, Morrisey EE. Hedgehog actively maintains adult lung quiescence and regulates repair and regeneration. Nature 2015. PMID: 26436454


  21. Herriges MJ, Swarr DT, Morley MP, Rathi KS, Peng T, Stewart KM, Morrisey EE. Long noncoding RNAs are spatially correlated with transcription factors and regulate lung development. Genes & development 2014. PMID: 24939938


  22. Choi YS, Zhang Y, Xu M, Yang Y, Ito M, Peng T, Cui Z, Nagy A, Hadjantonakis AK, Lang RA, Cotsarelis G, Andl T, Morrisey EE, Millar SE. Distinct functions for Wnt/ß-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell stem cell 2013. PMID: 24315444


  23. Peng T, Tian Y, Boogerd CJ, Lu MM, Kadzik RS, Stewart KM, Evans SM, Morrisey EE. Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature 2013. PMID: 23873040


  24. Peng T, Morrisey EE. Development of the pulmonary vasculature: Current understanding and concepts for the future. Pulmonary circulation 2013. PMID: 23662197


  25. Peng T, Zamanian R, Krowka MJ, Benza RL, Roberts KE, Taichman DB, Rybak D, Trotter JF, Brown RS, Fallon MB, Kawut SM. Plasma levels of S100A4 in portopulmonary hypertension. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2009. PMID: 19399660


  26. Peng T, Blakeley J, Cingolani E, Griffiths E, Grossman SA. Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy. American journal of clinical oncology 2007. PMID: 18091066


  27. Ngo TT, Peng T, Liang XJ, Akeju O, Pastorino S, Zhang W, Kotliarov Y, Zenklusen JC, Fine HA, Maric D, Wen PY, De Girolami U, Black PM, Wu WW, Shen RF, Jeffries NO, Kang DW, Park JK. The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. Journal of the National Cancer Institute 2007. PMID: 17440165


  28. Akeju O, Peng T, Park JK. Short hairpin RNA loop design for the facilitation of sequence verification. BioTechniques 2006. PMID: 16526403


  29. Yu X, Zhan X, D'Costa J, Tanavde VM, Ye Z, Peng T, Malehorn MT, Yang X, Civin CI, Cheng L. Lentiviral vectors with two independent internal promoters transfer high-level expression of multiple transgenes to human hematopoietic stem-progenitor cells. Molecular therapy : the journal of the American Society of Gene Therapy 2003. PMID: 12788657