Neil Trivedi, MD

ASSOC PROF OF CLIN-FY

Dr. Matthay's overall focus is on improving clinical care of patients with acute respiratory failure from the acute respiratory distress syndrome and from sepsis. His research and clinical trials groups are very well funded by grants from the National Institute of Health. He also spends considerable time mentoring physicians and young faculty in career development and academic medicine.

Education
2018 - Diversity, Equity, and Inclusion Champion Training, UCSF
Fellowship, 2007 - Pulmonary/Critical Care, UCSF
Residency, 2004 - Internal Medicine, UCSF
MD, 2001 - Medical School, UCLA
BA, 1996 - Biology and Psychology, University of Pennsylvania
Publications

  1. Chovanec J, Tunc I, Hughes J, Halstead J, Mateja A, Liu Y, O'Connell MP, Kim J, Park YH, Wang Q, Le Q, Pirooznia M, Trivedi NN, Bai Y, Yin Y, Hsu AP, McElwee J, Lassiter S, Nelson C, Bandoh J, DiMaggio T, ?elb J, Rijavec M, Carter MC, Komarow HD, Sabato V, Steinberg J, Hafer KM, Feuille E, Hourigan CS, Lack J, Khoury P, Maric I, Zanotti R, Bonadonna P, Schwartz LB, Milner JD, Glover SC, Ebo DG, Koro?ec P, Caughey GH, Brittain EH, Busby B, Metcalfe DD, Lyons JJ. Genetically defined individual reference ranges for tryptase limit unnecessary procedures and unmask myeloid neoplasms. Blood advances 2023. PMID: 36170795


  2. Berchuck JE, Meyer CS, Zhang N, Berchuck CM, Trivedi NN, Cohen B, Wang S. Association of Mental Health Treatment With Outcomes for US Veterans Diagnosed With Non-Small Cell Lung Cancer. JAMA oncology 2020. PMID: 32496507


  3. Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, Orozco LD, Christensen E, Wong M, Corpuz R, Hang JQ, Lutman J, Sukumaran S, Wu Y, Ubhayakar S, Liang X, Schwartz LB, Babina M, Woodruff PG, Fahy JV, Ahuja R, Caughey GH, Kusi A, Dennis MS, Eigenbrot C, Kirchhofer D, Austin CD, Wu LC, Koerber JT, Lee WP, Yaspan BL, Alatsis KR, Arron JR, Lazarus RA, Yi T. An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell 2020. PMID: 31978350


  4. Maun HR, Jackman JK, Choy DF, Loyet KM, Staton TL, Jia G, Dressen A, Hackney JA, Bremer M, Walters BT, Vij R, Chen X, Trivedi NN, Morando A, Lipari MT, Franke Y, Wu X, Zhang J, Liu J, Wu P, Chang D, Orozco LD, Christensen E, Wong M, Corpuz R, Hang JQ, Lutman J, Sukumaran S, Wu Y, Ubhayakar S, Liang X, Schwartz LB, Babina M, Woodruff PG, Fahy JV, Ahuja R, Caughey GH, Kusi A, Dennis MS, Eigenbrot C, Kirchhofer D, Austin CD, Wu LC, Koerber JT, Lee WP, Yaspan BL, Alatsis KR, Arron JR, Lazarus RA, Yi T. An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma. Cell 2019. PMID: 31585081


  5. Bolognini N, Trivedi NN, Au AS, Vora N. Fibrodysplasia Ossificans Progressiva and Its Implications in Podiatric Medicine: A Case Report. Journal of the American Podiatric Medical Association 2019. PMID: 31762308


  6. Jacob E Berchuck, Craig Meyer, Ning Zhang, Neil Trivedi, Beth Cohen, Sunny Wang. Disparities in lung cancer outcomes for veterans with comorbid mental disorders. Journal of Clinical Oncology 2019. PMID:


  7. Greenland JR, Wang P, Brotman JJ, Ahuja R, Chong TA, Kleinhenz ME, Leard LE, Golden JA, Hays SR, Kukreja J, Singer JP, Rajalingam R, Jones K, Laszik ZG, Trivedi NN, Greenland NY, Blanc PD. Gene signatures common to allograft rejection are associated with lymphocytic bronchitis. Clinical transplantation 2019. PMID: 30849195


  8. Trivedi NN, Brown JK, Rubenstein T, Rostykus AD, Fish AL, Yu H, Carbonell L, Juang A, Kamer S, Patel B, Sidhu M, Vuong D, Wang S, Beggs M, Wu AH, Arjomandi M. Analytical validation of a novel multi-analyte plasma test for lung nodule characterization. Biomedical research and reviews 2018. PMID: 32923944


  9. Trivedi NN, Arjomandi M, Brown JK, Rubenstein T, Rostykus AD, Esposito S, Axler E, Beggs M, Yu H, Carbonell L, Juang A, Kamer S, Patel B, Wang S, Fish AL, Haddad Z, Wu AH. Risk assessment for indeterminate pulmonary nodules using a novel, plasma-protein based biomarker assay. Biomedical research and clinical practice 2018. PMID: 32913898


  10. A. Fish, A. Vachani, M. Beggs, L. Carbonell, Z. Haddad, A. Juang, S. Kamer, B. Patel, H. Yu, A. Wu, P. Massion, M. Arjomandi, J. Brown, N. Trivedi, T. Rubenstein. MA23.03 Risk Assessment for Indeterminate Pulmonary Nodules Using a Novel, Plasma-Protein Based Biomarker Assay. Journal of Thoracic Oncology 2018. PMID:


  11. Lyons JJ, Yu X, Hughes JD, Le QT, Jamil A, Bai Y, Ho N, Zhao M, Liu Y, O'Connell MP, Trivedi NN, Nelson C, DiMaggio T, Jones N, Matthews H, Lewis KL, Oler AJ, Carlson RJ, Arkwright PD, Hong C, Agama S, Wilson TM, Tucker S, Zhang Y, McElwee JJ, Pao M, Glover SC, Rothenberg ME, Hohman RJ, Stone KD, Caughey GH, Heller T, Metcalfe DD, Biesecker LG, Schwartz LB, Milner JD. Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number. Volume 48 of Issue 12. Nature genetics 2016. PMID: 27749843


  12. Babina M, Guhl S, Artuc M, Trivedi NN, Zuberbier T. Phenotypic variability in human skin mast cells. Experimental dermatology 2016. PMID: 26706922


  13. J.R. Greenland, C.M. Wong, R. Ahuja, M. Gottschall, N.N. Trivedi, J. Kukreja, S.R. Hays, J.P. Singer, J.A. Golden, Q. Tang, G.H. Caughey. (828) CD25+ Regulatory T Cells in Bronchoalveolar Lavage Fluid Are Associated with Lung Allograft Rejection. The Journal of Heart and Lung Transplantation 2014. PMID:


  14. Greenland JR, Jewell NP, Gottschall M, Trivedi NN, Kukreja J, Hays SR, Singer JP, Golden JA, Caughey GH. Bronchoalveolar lavage cell immunophenotyping facilitates diagnosis of lung allograft rejection. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2014. PMID: 24512389


  15. J.R. Greenland, K.D. Jones, S.R. Hays, J.A. Golden, A. Urisman, N.P. Jewell, G.H. Caughey, N.N. Trivedi. Large-Airway Lymphocytic Bronchitis Predicts Bronchiolitis Obliterans Syndrome. The Journal of Heart and Lung Transplantation 2013. PMID:


  16. Raman K, Trivedi NN, Raymond WW, Ganesan R, Kirchhofer D, Verghese GM, Craik CS, Schneider EL, Nimishakavi S, Caughey GH. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. Volume 288 of Issue 15. The Journal of biological chemistry 2013. PMID: 23447538


  17. Neil N. Trivedi, George H. Caughey. Chapter 591 Human a-, ß- and d-Tryptases. Handbook of Proteolytic Enzymes 2013. PMID:


  18. Neil N. Trivedi, George H. Caughey. Chapter 592 ?-Tryptase. Handbook of Proteolytic Enzymes 2013. PMID:


  19. Greenland JR, Jones KD, Hays SR, Golden JA, Urisman A, Jewell NP, Caughey GH, Trivedi NN. Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome. Volume 187 of Issue 4. American journal of respiratory and critical care medicine 2012. PMID: 23239157


  20. Raymond WW, Trivedi NN, Makarova A, Ray M, Craik CS, Caughey GH. How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution. Volume 185 of Issue 9. Journal of immunology (Baltimore, Md. : 1950) 2010. PMID: 20889553


  21. Trivedi NN, Caughey GH. Mast cell peptidases: chameleons of innate immunity and host defense. Volume 42 of Issue 3. American journal of respiratory cell and molecular biology 2009. PMID: 19933375


  22. Trivedi NN, Tamraz B, Chu C, Kwok PY, Caughey GH. Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations. Volume 124 of Issue 5. The Journal of allergy and clinical immunology 2009. PMID: 19748655


  23. N. Trivedi, B. Tamraz, P.Y. Kwok, G.H. Caughey. An Inactivating, Frame-shifted Mutation of ,III Tryptase is Common in People of Northern and Western European Ancestory. Journal of Allergy and Clinical Immunology 2009. PMID:


  24. Caughey GH, Beauchamp J, Schlatter D, Raymond WW, Trivedi NN, Banner D, Mauser H, Fingerle J. Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases. Volume 283 of Issue 20. The Journal of biological chemistry 2008. PMID: 18353771


  25. Trivedi NN, Raymond WW, Caughey GH. Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution. Volume 121 of Issue 5. The Journal of allergy and clinical immunology 2008. PMID: 18325577


  26. Trivedi NN, Tong Q, Raman K, Bhagwandin VJ, Caughey GH. Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates. Volume 179 of Issue 9. Journal of immunology (Baltimore, Md. : 1950) 2007. PMID: 17947681


  27. Haberer J, Trivedi NN, Kohlwes J, Tierney L. Clinical problem-solving. A gut feeling. The New England journal of medicine 2003. PMID: 12840095