Monika Sarkar, MD, MAS
Associate Professor
My clinical focus is on women with liver disease, including pregnancy-related liver conditions and reproductive health. My research program is focused on the role of sex hormones in modulating liver disease in women. I have a specific research interest in young women with the hyperandrogenic condition known as Polycystic Ovarian Syndrome given their high risk for developing Non Alcoholic Fatty Liver Disease (NAFLD) and early onset liver scarring. Within the transplant setting my focus is reproductive health, including pregnancy and contraceptive management in transplant recipients.
Education
Honors and Awards
- R03, NIDDK, 2022-2024
- K23, NIDDK, 2017-2023
- K Scholars Team Science Award, UCSF, 2017-2018
- UCSF Hellman Research Award, UCSF, 2016-2018
- RAP Pilot Award for Junior Investigators, UCSF, 2016-2017
- Liver Center Flex Funds, UCSF, 2015-2016
- Liver Center Pilot/Feasibility Research Award, UCSF Liver Center, 2014-2015
- Sheila Sherlock Career Development Research Award, AASLD, 2013-2015
- Advanced Hepatology Fellowship Award, AASLD, 2012-2013
Publications
Walia A, Yin O, Coscia L, Afshar Y, Irani R, Constantinescu S, Moritz M, Sarkar M. Clinical outcomes in patients with unintended pregnancy after liver transplantation: A multicenter registry cohort study. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2024. PMID: 39451110
Garriga M, Zhang G, Sarkar M. Contraception in patients with liver disease and liver transplant. Clinical liver disease 2024. PMID: 38379765
Wang M, Cedars MI, Mehta N, Sarkar M. How I Approach Hepatocellular Adenomas in Hormonally Distinct Populations: Time to Think Outside the (Contraceptive Pill) Box. The American journal of gastroenterology 2023. PMID: 37552072
Monika Sarkar. Introduction: Pregnancy and liver disease. Clinical liver disease 2023. PMID:
Maldonado SS, Cedars MI, Yates KP, Wilson LA, Gill R, Terrault NA, Suzuki A, Sarkar MA. Anti-Mullerian Hormone, a Marker of Ovarian Reserve, Is Protective Against Presence and Severity of NASH in Premenopausal Women. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2023. PMID: 37678489
Feld LD, Sarkar M, Au JS, Flemming JA, Gripshover J, Kardashian A, Muir AJ, Nephew L, Orloff SL, Terrault N, Rabinowitz L, Volerman A, Arora V, Farnan J, Villa E. Parental leave, childcare policies, and workplace bias for hepatology professionals: A national survey. Hepatology communications 2023. PMID: 37639705
Sarkar M, Irani RA. Family planning and donor type: Unrecognized benefits of living donor liver transplantation? Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2023. PMID: 37548545
Cooper KM, Delk M, Devuni D, Sarkar M. Sex differences in chronic liver disease and benign liver lesions. JHEP reports : innovation in hepatology 2023. PMID: 37791378
Meera Garriga, Marcelle I. Cedars, Monika Sarkar. Mo1530 OUTCOMES IN WOMEN WITH CHRONIC LIVER DISEASE UNDERGOING INFERTILITY TREATMENT. Gastroenterology 2023. PMID:
Grace Zhang, Marcelle I. Cedars, Heather Huddleston, Sy Han Chiou, Yanin T. Srisengfa, Monika Sarkar. Sa1609 POLYCYSTIC OVARY SYNDROME INCREASES FIBROSIS SEVERITY IN YOUNG WOMEN WITH NAFLD. Gastroenterology 2023. PMID:
Patel-Sanchez N, Perito E, Tsai P, Raymond-Flesch M, Lodish M, Sarkar M. Prevalence of nonalcoholic fatty liver disease increased with type 2 diabetes mellitus in overweight/obese youth with polycystic ovary syndrome. Journal of pediatric endocrinology & metabolism : JPEM 2023. PMID: 37060356
Levy C, Brady CW, Terrault N, Stotts MJ, Sarkar M. Reproductive health and liver disease: a patient-friendly summary of the 2021 AASLD guidance. Clinical liver disease 2023. PMID: 36937776
Sarkar M, Flemming JA. Letter to Editor: Influence of maternal NAFLD on infant weight-the real precursor to NAFLD in offspring? Hepatology (Baltimore, Md.) 2023. PMID: 36930760
Kardashian A, Kushner T, Au JS, Flemming JA, Gripshover J, Muir AJ, Orloff SL, Villa E, Sarkar M, AASLD Women’s Initiative Committee. The key role of hepatology providers in optimizing reproductive care in patients with liver disease: a call to action. Hepatology (Baltimore, Md.) 2023. PMID: 37142412
Qureshy Z, Lokken RP, Kakar S, Grab J, Mehta N, Sarkar M. Influence of progestin-only hormonal use on hepatocellular adenomas: A retrospective cohort study. Contraception 2022. PMID: 36476331
Wang M, Sarkar M, Mehta N. Now you see it, now you don't: Estrogen exposure and obesity effects on HCA development and regression. Hepatology (Baltimore, Md.) 2022. PMID: 36176041
Bernards S, Lee E, Leung N, Akan M, Gan K, Zhao H, Sarkar M, Tayur S, Mehta N. Awarding additional MELD points to the shortest waitlist candidates improves sex disparity in access to liver transplant in the United States. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2022. PMID: 35871752
Maldonado SS, Grab J, Wang CW, Huddleston H, Cedars M, Sarkar M. Polycystic ovary syndrome is associated with nonalcoholic steatohepatitis in women of reproductive age. Hepatology communications 2022. PMID: 35861548
Sarkar M, Irani RA. Reply to HEP-22-0894. Hepatology (Baltimore, Md.) 2022. PMID: 35686940
Shingina A, Sarkar M, Feld L. On the Importance of Safe Access to Reproductive Options for Adolescents and Women with Liver Disease. Gastroenterology 2022. PMID: 35752297
Stephanie Maldonado, Joshua Grab, Connie W. Wang, Heather Huddleston, Marcelle I. Cedars, Monika Sarkar. Su1406: POLCYSTIC OVARY SYNDROME (PCOS) INCREASES RISK OF NASH AMONG REPRODUCTIVE-AGED WOMEN WITH NAFLD: A US POPULATION-BASED STUDY. Gastroenterology 2022. PMID:
Gadgil MD, Sarkar M, Sands C, Lewis MR, Herrington DM, Kanaya AM. Associations of NAFLD with circulating ceramides and impaired glycemia. 2022. PMID: 35292328
Sadaf Dabeer, Katherine H Ingram, Duke Appiah, Melissa Wellons, Catherine Kim, Dhananjay Vaidya, David S Siscovick, Cora E Lewis, Charles Quesenberry, Pamela Schreiner, Ronit Calderon-Margalit, Monika Sarkar, Erica P Gunderson. Abstract P139: Changes In Sex Hormones In Premenopausal Black And White Women Associated With Childbearing: The Cardia Women’s Study. Circulation 2022. PMID:
Huang AC, Grab J, Flemming JA, Dodge JL, Irani RA, Sarkar M. Pregnancies With Cirrhosis Are Rising and Associated With Adverse Maternal and Perinatal Outcomes. 2021. PMID: 34928866
Wang CW, Grab J, Tana MM, Irani RA, Sarkar M. Outcomes of Pregnancy in Autoimmune Hepatitis: A Population-Based Study. Hepatology (Baltimore, Md.) 2021. PMID: 34455632
Sarkar M, Cedars M. Untangling the Influence of Sex Hormones on Nonalcoholic Fatty Liver Disease in Women. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2021. PMID: 34509644
Sonnenberg EM, Lee-Riddle GS, Walls DO, Caicedo JC, Jackson WE, Hughes L, Ladner DP, Liapakis A, Pomfret EA, Sarkar M, Selzner N, Torres AM, Abt PL, Olthoff KM. Pregnancy Outcomes After Living Liver Donation: A Multi-Institutional Study. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2021. PMID: 33993632
Yanin T. Srisengfa, Srilakshmi Seetharaman, Monika Sarkar. Sa362 REPRODUCTIVE HEALTH CHARACTERISTICS IN PRE-MENOPAUSAL WOMEN WITH NAFLD. Gastroenterology 2021. PMID:
Kushner T, Kaplowitz E, Mei R, Xu C, Acker A, Rosenbluth E, Oredein I, Sarkar M, Terrault N, Bansal M, Forde KA. Adherence to pregnancy hepatitis B care guidelines in women and infants in the United States and evaluation of two interventions to improve care: A multicentre hospital-based study. Journal of viral hepatitis 2021. PMID: 33372359
Sarkar M, Djerboua M, Flemming JA. NAFLD Cirrhosis Is Rising Among Childbearing Women and Is the Most Common Cause of Cirrhosis in Pregnancy. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2021. PMID: 33465483
Sarkar M, Brady CW, Fleckenstein J, Forde KA, Khungar V, Molleston JP, Afshar Y, Terrault NA. Reproductive Health and Liver Disease: Practice Guidance by the American Association for the Study of Liver Diseases. Hepatology (Baltimore, Md.) 2020. PMID: 32946672
Sarkar M, Grab J, Irani RA. Reply to: "Intrahepatic cholestasis of pregnancy: An under recognised complication of maternal NAFLD?" Journal of hepatology 2020. PMID: 33339610
Sarkar M, Suzuki A, Abdelmalek M, Yates K, Wilson L, Bass NM, Gill R, Cedars M, Terrault N. Testosterone is Associated With Nonalcoholic Steatohepatitis (NASH) and Fibrosis in Pre-Menopausal Women With NAFLD. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020. PMID: 33010412
Ritchie J, Seidman D, Srisengfa Y, Jacoby V, Perito ER, Sarkar M. Family Planning in Liver Transplant: Patient and Provider Knowledge and Practices. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2020. PMID: 32583555
Flemming JA, Mullin M, Lu J, Sarkar MA, Djerboua M, Velez MP, Brogly S, Terrault NA. Outcomes of Pregnant Women With Cirrhosis and Their Infants in a Population-Based Study. Gastroenterology 2020. PMID: 32781083
Jacquie Lu, Monika Mullin, Maya Djerboua, Monika Sarkar, Susan Brogly, Maria Velez, Norah Terrault, Jennifer Flemming. SAT147 Increased risk of perinatal complications in women with cirrhosis: a population-based matched cohort study. Journal of hepatology 2020. PMID:
Sarkar M, Suzuki A. Reproductive Health and Nonalcoholic Fatty Liver Disease in Women: Considerations Across the Reproductive Lifespan. Clinical liver disease 2020. PMID: 32617153
Sarkar M, Grab J, Dodge JL, Gunderson EP, Rubin J, Irani RA, Cedars M, Terrault N. Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes. Journal of hepatology 2020. PMID: 32531415
Sarkar M, Sawinski D, Coscia L. IUD Safety and Efficacy in Transplant: Getting Our Message Right. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2020. PMID: 32170779
Annsa C. Huang, Joshua Grab, Jennifer A. Flemming, Jennifer L. Dodge, Monika Sarkar. 1004 PREGNANCIES WITH CIRRHOSIS ARE RISING AND ASSOCIATED WITH ADVERSE MATERNAL AND FETAL OUTCOMES. Gastroenterology 2020. PMID:
Lee E, Sarkar M, Dodge J, Kohi M, Mehta N. Shorter Height is Associated with Lower Probability of Liver Transplantation in Patients with Hepatocellular Carcinoma. Transplantation 2019. PMID: 31577670
Sarkar M, Yates K, Suzuki A, Lavine J, Gill R, Ziegler T, Terrault N, Dhindsa S. Low Testosterone Is Associated With Nonalcoholic Steatohepatitis (NASH) and Severity of NASH Fibrosis in Men With NAFLD. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2019. PMID: 31812658
Yuan L, Kardashian A, Sarkar M. NAFLD in women: Unique pathways, biomarkers and therapeutic opportunities. Current hepatology reports 2019. PMID: 32523869
Sarkar M, Terrault N, Chan W, Cedars M, Huddleston H, Duwaerts CC, Balitzer D, Gill RM. Polycystic Ovary Syndrome (PCOS) Is Associated With NASH Severity and Advanced Fibrosis. Liver international : official journal of the International Association for the Study of the Liver 2019. PMID: 31627243
Julia Ritchie, Dominika Seidman, Yanin Srisengfa, Vanessa L. Jacoby, Emily Perito, Monika Sarkar. Deficiencies in Reproductive Health Counseling in Liver Transplant Patients [2H]. Obstetrics and gynecology 2019. PMID:
Monika Sarkar, Katherine P. Yates, Ayako Suzuki, Joel E. Lavine, Ryan M. Gill, Norah Terrault, Sandeep Dhindsa. Sa1623 – Low Testosterone is Associated with Nash and Fibrosis Severity in Men with Nafld. Gastroenterology 2019. PMID:
Sarkar M, VanWagner LB, Terry JG, Carr JJ, Rinella M, Schreiner PJ, Lewis CE, Terrault N. Sex Hormone-Binding Globulin Levels in Young Men Are Associated With Nonalcoholic Fatty Liver Disease in Midlife. The American journal of gastroenterology 2019. PMID: 30730350
Sarkar M. Testosterone Levels in Women: Implications for Fatty Liver and Beyond. Journal of women's health (2002) 2019. PMID: 30789289
Kushner T, Sarkar M, Tran T. Noninvasive Tests for Prognosticating Outcomes in Patients With Chronic Liver Disease in Pregnancy: Ready for Prime Time? The American journal of gastroenterology 2019. PMID: 30730857
Sarkar M, Lai JC, Sawinski D, Zeigler TE, Cedars M, Forde KA. Sex hormone levels by presence and severity of cirrhosis in women with chronic hepatitis C virus infection. Journal of viral hepatitis 2018. PMID: 30339729
Ajmera VH, Terrault NA, VanWagner LB, Sarkar M, Lewis CE, Carr JJ, Gunderson EP. Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women. Journal of hepatology 2018. PMID: 30392752
Kushner T, Sarkar M. Chronic Hepatitis B in Pregnancy. Clinical liver disease 2018. PMID: 30988905
Dave S, Dodge JL, Terrault NA, Sarkar M. Racial and Ethnic Differences in Graft Loss Among Female Liver Transplant Recipients. Transplantation proceedings 2018. PMID: 29880364
Sarkar M, Bramham K, Moritz MJ, Coscia L. Reproductive health in women following abdominal organ transplant. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018. PMID: 29446243
Sarkar M, Terrault N, Duwaerts CC, Tien P, Cedars MI, Huddleston H. The Association of Hispanic Ethnicity with Nonalcoholic Fatty Liver Disease in Polycystic Ovary Syndrome. Current opinion in gynecology and obstetrics 2018. PMID: 30112518
Campos-Varela I, Agudelo EZ, Sarkar M, Roberts JP, Terrault NA. Use of a hepatitis C virus (HCV) RNA-positive donor in a treated HCV RNA-negative liver transplant recipient. Transplant infectious disease : an official journal of the Transplantation Society 2018. PMID: 29125670
Cullaro G, Sarkar M, Lai JC. Sex-based disparities in delisting for being "too sick" for liver transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2017. PMID: 29194969
Rubin JB, Hameed B, Gottfried M, Lee WM, Sarkar M. Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2017. PMID: 29199145
Kelly EM, Dodge JL, Bacchetti P, Sarkar M, French AL, Tien PC, Glesby MJ, Golub ET, Augenbraun M, Plankey M, Peters MG. Moderate Alcohol Use Is Not Associated With Fibrosis Progression in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Women: A Prospective Cohort Study. Volume 65 of Issue 12. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017. PMID: 29020382
Sarkar M, Baffy G. Perinatal programming of adolescent nonalcoholic fatty liver disease: A case for gender inequality? Hepatology (Baltimore, Md.) 2017. PMID: 28771759
Sarkar M, Dodge JL, Greenblatt RM, Kuniholm MH, DeHovitz J, Plankey M, Kovacs A, French AL, Seaberg EC, Ofotokun I, Fischl M, Overton E, Kelly E, Bacchetti P, Peters MG. Reproductive Aging and Hepatic Fibrosis Progression in Human Immunodeficiency Virus/Hepatitis C Virus-Coinfected Women. Volume 65 of Issue 10. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017. PMID: 29020239
Sarkar M, Wellons M, Cedars MI, VanWagner L, Gunderson EP, Ajmera V, Torchen L, Siscovick D, Carr JJ, Terry JG, Rinella M, Lewis CE, Terrault N. Testosterone Levels in Pre-Menopausal Women are Associated With Nonalcoholic Fatty Liver Disease in Midlife. The American journal of gastroenterology 2017. PMID: 28291240
Tsai JH, Ferrell LD, Tan V, Yeh MM, Sarkar M, Gill RM. Aggressive non-alcoholic steatohepatitis following rapid weight loss and/or malnutrition. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2017. PMID: 28256569
Kardashian A, Ma Y, Scherzer R, Price JC, Sarkar M, Korn N, Tillinghast K, Peters MG, Noworolski SM, Tien PC. Sex differences in the association of HIV infection with hepatic steatosis. Volume 31 of Issue 3. AIDS (London, England) 2017. PMID: 27831949
Sarkar M, Dodge JL, Roberts JP, Terrault N, Yao F, Mehta N. Increased hepatocellular carcinoma recurrence in women compared to men with high alpha fetoprotein at liver transplant. Annals of hepatology 2016. PMID: 27236153
Kuniholm MH, O'Brien TR, Prokunina-Olsson L, Augenbraun M, Plankey M, Karim R, Sarkar M, French AL, Pierce C, Strickler HD, Anastos K. Association of Hepatitis C Virus Infection With CD4/CD8 Ratio in HIV-Positive Women. Journal of acquired immune deficiency syndromes (1999) 2016. PMID: 27183178
Kelly EM, Dodge JL, Sarkar M, French AL, Tien PC, Glesby MJ, Golub ET, Augenbraun M, Plankey M, Peters MG. Marijuana Use Is Not Associated With Progression to Advanced Liver Fibrosis in HIV/Hepatitis C Virus-coinfected Women. Volume 63 of Issue 4. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2016. PMID: 27225241
Jessica Rubin, Bilal Hameed, Michelle Gottfried, William M. Lee, Monika Sarkar. 352 Sex Differences in Acetaminophen-Induced Acute Liver Injury and Acute Liver Failure. Gastroenterology 2016. PMID:
Asima K. Ahmad, Chia-Ning Kao, Monika Sarkar, Marcelle I. Cedars, Heather Huddleston. Association between markers of non-alcoholic fatty liver disease and glucose tolerance in polycystic ovarian syndrome population. Fertility and sterility 2016. PMID:
Mehta N, Sarkar M, Dodge JL, Fidelman N, Roberts JP, Yao FY. Intention to treat outcome of T1 hepatocellular carcinoma with the "wait and not ablate" approach until meeting T2 criteria for liver transplant listing. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 2016. PMID: 26479422
E.M. Kelly, J. Dodge, P. Bacchetti, M. Sarkar, A. French, P. Tien, M. Glesby, E. Golub, M. Augenbraun, M. Plankey, M. Peters. PS073 Light to Moderate Alcohol Use is not Associated with Long-Term Progression of Liver Fibrosis in Hiv Hcv Coinfected Women. Journal of hepatology 2016. PMID:
J. Rubin, B. Hameed, M. Gottfried, W. Lee, M. Sarkar, the Acute Liver Failure Study Group. PS077 Sex Differences in Acetaminophen-Induced Acute Liver Injury and Acute Liver Failure. Journal of hepatology 2016. PMID:
Sarkar M, Aouzierat B, Bacchetti P, Prokunina-Olsson L, French A, Seaberg E, O'Brien TR, Kuniholm MH, Minkoff H, Plankey M, Strickler HD, Peters MG. Association of IFNL3 and IFNL4 polymorphisms with liver-related mortality in a multiracial cohort of HIV/HCV-coinfected women. Journal of viral hepatitis 2015. PMID: 26115445
Sarkar M, Watt KD, Terrault N, Berenguer M. Outcomes in liver transplantation: does sex matter? Journal of hepatology 2014. PMID: 25433162
Sarkar M, Terrault NA. Ending vertical transmission of hepatitis B: the third trimester intervention. Hepatology (Baltimore, Md.) 2014. PMID: 24668789
Sarkar M, Shvachko VA, Ready JB, Pauly MP, Terrault NA, Peters MG, Manos MM. Characteristics and management of patients with chronic hepatitis B in an integrated care setting. Volume 59 of Issue 9. Digestive diseases and sciences 2014. PMID: 24728968
Mehta N, Fidelman N, Sarkar M, Yao FY. Factors associated with outcomes and response to therapy in patients with infiltrative hepatocellular carcinoma. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2013. PMID: 23333661
Sarkar M, Bacchetti P, Tien P, Mileti E, French AL, Edlin BR, Keller M, Seaberg E, Nowicki MJ, Young M, Peters MG. Racial/ethnic differences in spontaneous HCV clearance in HIV infected and uninfected women. Volume 58 of Issue 5. Digestive diseases and sciences 2012. PMID: 23179159
Sarkar M, Bacchetti P, French AL, Tien P, Glesby MJ, Nowicki M, Plankey M, Gange S, Sharp G, Minkoff H, Peters MG. Lower liver-related death in African-American women with human immunodeficiency virus/hepatitis C virus coinfection, compared to Caucasian and Hispanic women. Volume 56 of Issue 5. Hepatology (Baltimore, Md.) 2012. PMID: 22618868
Monika Sarkar, Valentina Shvachko, Marion G. Peters, Michele Manos. 466 Hepatitis B Treatment in a California Managed Care Population: A Retrospective Analysis of Treatment and Monitoring Practices. Gastroenterology 2012. PMID:
Sarkar M, Stewart S, Yu A, Chen MS, Nguyen TT, Khalili M. Hepatocellular carcinoma screening practices and impact on survival among hepatitis B-infected Asian Americans. Journal of viral hepatitis 2012. PMID: 22762144
Marion G. Peters,Monika Sarkar. Chapter 32 Hepatitis virus infections. 2012. PMID:
Sarkar M, Hennessy S, Yang YX. Proton-pump inhibitor use and the risk for community-acquired pneumonia. Annals of internal medicine 2008. PMID: 18794558
Yang YX, Hennessy S, Propert K, Hwang WT, Sarkar M, Lewis JD. Chronic statin therapy and the risk of colorectal cancer. Pharmacoepidemiology and drug safety 2008. PMID: 18412290
Sarkar M, Wood R, Oh Y, Hecht TE, Kaiser L, Wasserstein A, Kochman ML. Presentation and management of acute fistulization of a foregut duplication cyst. Gastrointestinal endoscopy 2008. PMID: 18436220