Marc Simon, MD, MS

McCormick A, Krishnan A, Badesch D, Benza RL, Bull TM, De Marco T, Feldman J, Hemnes AR, Hirsch R, Horn E, Kennedy J, Mathai SC, McConnell W, Pugliese SC, Sager JS, Shlobin OA, Simon MA, Lammi MR. Pulmonary artery compliance in different forms of pulmonary hypertension. Heart (British Cardiac Society) 2023. PMID: 36787969

Cormack JM, Simon MA, Kim K. Backscatter tensor imaging and 3D speckle tracking for simultaneous ex vivo structure and deformation measurement of myocardium. Ultrasound in medicine & biology 2023. PMID: 36858914

Simon MA, Cormack JM, Sharifi Kia D. Knowing All the Angles (on Right Ventricular Myocardial Remodeling). Circulation. Heart failure 2023. PMID: 36748500

Kolaitis NA, Chen H, Calabrese DR, Kumar K, Obata J, Bach C, Golden JA, Simon MA, Kukreja J, Hays SR, Leard LE, Singer JP, De Marco T. The Lung Allocation Score Remains Inequitable for Patients with PAH, Even After the 2015 Revision. American journal of respiratory and critical care medicine 2022. PMID: 36094471

DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani G, Thenappan T, Ford HJ, Al-Naamani N, Simon MA, Mazimba S, Runo JR, Chakinala M, Horn EM, Ryan JJ, Frantz RP, Krowka MJ, PHAR Investigators. Erratum: Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: An analysis of the Pulmonary Hypertension Association Registry. Pulmonary circulation 2022. PMID: 36540874

Cormack JM, Simon MA, Kim K. Refraction-corrected backscatter tensor imaging of excised porcine ventricular myocardium. JASA express letters 2022. PMID: 36182344

Garry JD, Kolaitis NA, Kronmal R, Thenappan T, Hemnes A, Grinnan D, Bull T, Chakinala MM, Horn E, Simon MA, De Marco T, Pulmonary Hypertension Association Registry Investigators. Anticoagulation in pulmonary arterial hypertension - association with mortality, healthcare utilization, and quality of life: The Pulmonary Hypertension Association Registry (PHAR). The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2022. PMID: 36150996

Kolaitis NA, Lammi M, Mazimba S, Feldman J, McConnell W, Sager JS, Raval AA, Simon MA, De Marco T, PHAR investigators. Human Immune Deficiency Virus-Associated Pulmonary Arterial Hypertension: A Report from the Pulmonary Hypertension Association Registry. TO REMOVE 2022. PMID: 35180043

Vizza CD, Lang IM, Badagliacca R, Benza RL, Rosenkranz S, White RJ, Adir Y, Andreassen AK, Balasubramanian V, Bartolome S, Blanco I, Bourge RC, Carlsen J, Camacho REC, D'Alto M, Farber HW, Frantz RP, Ford HJ, Ghio S, Gomberg-Maitland M, Humbert M, Naeije R, Orfanos SE, Oudiz RJ, Perrone SV, Shlobin OA, Simon MA, Sitbon O, Torres F, Luc Vachiery J, Wang KY, Yacoub MH, Liu Y, Golden G, Matsubara H. Aggressive Afterload Lowering to Improve the Right Ventricle: A New Target for Medical Therapy in Pulmonary Arterial Hypertension? American journal of respiratory and critical care medicine 2022. PMID: 34905704

Xu J, Desmond EL, Wong TC, Neill CG, Simon MA, Brigham JC. Right Ventricular Shape Feature Quantification for Evaluation of Pulmonary Hypertension: Feasibility and Preliminary Associations With Clinical Outcome Submitted for Publication. Journal of biomechanical engineering 2022. PMID: 34549255

Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW, Chen P-S, Clancy CE, Delisle BP, Gold MR, Goldberger JJ, Goldstein DS, Habecker BA, Handoko ML, Harvey R, Hummel JP, Hund T, Meyer C, Redline S, Ripplinger CM, Simon MA, Somers VK, Stavrakis S, Taylor-Clark T, Undem BJ, Verrier RL, Zucker IH, Sopko G, Shivkumar K.. Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation JACC: Basic to Translational Science 2022. PMID:

Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW, Chen PS, Clancy CE, Delisle BP, Gold MR, Goldberger JJ, Goldstein DS, Habecker BA, Handoko ML, Harvey R, Hummel JP, Hund T, Meyer C, Redline S, Ripplinger CM, Simon MA, Somers VK, Stavrakis S, Taylor-Clark T, Undem BJ, Verrier RL, Zucker IH, Sopko G, Shivkumar K. Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop. JACC. Basic to translational science 2022. PMID: 35411324

Simon MA, Hanrott K, Budd DC, Torres F, Grünig E, Escribano-Subias P, Meseguer ML, Halank M, Opitz C, Hall DA, Hewens D, Powley WM, Siederer S, Bayliffe A, Lazaar AL, Cahn A, Rosenkranz S. An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension. Pulmonary circulation 2022. PMID: 35506108

Sharifi Kia D, Shen Y, Bachman TN, Goncharova EA, Kim K, Simon MA. The Effects of Healthy Aging on Right Ventricular Structure and Biomechanical Properties: A Pilot Study. Frontiers in medicine 2022. PMID: 35083230

Simon MA, Hanrott K, Budd DC, Torres F, Grünig E, Escribano-Subias P, Meseguer ML, Halank M, Opitz C, Hall DA, Hewens D, Powley WM, Siederer S, Bayliffe A, Lazaar AL, Cahn A, Rosenkranz S. An open-label, dose-escalation study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of GSK2586881 in participants with pulmonary arterial hypertension Pulmonary circulation 2021. PMID:

Xu J, Wong TC, Simon MA, Brigham JC. A clinically applicable strategy to estimate the in vivo distribution of mechanical material properties of the right ventricular wall. International journal for numerical methods in biomedical engineering 2021. PMID: 34724355

Xu J, Desmond EL, Wong T C, Neill CG, Simon MA, Brigham JC. Right Ventricular Shape Feature Quantification for Evaluation of Pulmonary Hypertension: Feasibility and Preliminary Associations with Clinical Outcome Submitted for Publication J Biomech Eng 2021. PMID:

Xu J, Wong T C, Simon MA, Brigham JC. A Clinically Applicable Strategy to Estimate the In Vivo Distribution of Mechanical Material Properties of the Right Ventricular Wall Int J Numer Meth Biomed Engng 2021. PMID:

Pandey A, Shah SJ, Butler J, Kellogg DL, Lewis GD, Forman DE, Mentz RJ, Borlaug BA, Simon MA, Chirinos JA, Fielding RA, Volpi E, Molina AJA, Haykowsky MJ, Sam F, Goodpaster BH, Bertoni AG, Justice JN, White JP, Ding J, Hummel SL, LeBrasseur NK, Taffet GE, Pipinos II, Kitzman D. Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review. Journal of the American College of Cardiology 2021. PMID: 34503685

Chaudhary R, Sukhi A, Simon MA, Villanueva FS, Pacella JJ. Role of Internal Jugular Venous Ultrasound in suspected or confirmed Heart Failure: A Systematic Review. Journal of cardiac failure 2021. PMID: 34419599

Inampudi C, Silverman D, Simon MA, Leary PJ, Sharma K, Houston BA, Vachiéry JL, Haddad F, Tedford RJ. Pulmonary Hypertension in the Context of Heart Failure With Preserved Ejection Fraction. Chest 2021. PMID: 34391755

Nayak A, Hu Y, Ko YA, Mehta A, Liu C, Pennington J, Xie R, Cowger J, Kirklin JK, Kormos RL, Simon MA, Morris AA. Gender Differences in Mortality After Left Ventricular Assist Device Implant: A Causal Mediation Analysis Approach. ASAIO journal (American Society for Artificial Internal Organs : 1992) 2020. PMID: 33060408

Kong K, Koontz D, Morse C, Roth E, Domsic RT, Simon MA, Stratton E, Buchholz C, Tobin-Finch K, Simms R, George MP, Hassoun PM, Farber H, Lafyatis R. A Pilot Study of Dimethyl Fumarate in Pulmonary Arterial Hypertension Associated with Systemic Sclerosis. Journal of scleroderma and related disorders 2021. PMID: 35005243

Sharifi Kia D, Kim K, Simon MA. Current Understanding of the Right Ventricle Structure and Function in Pulmonary Arterial Hypertension. Frontiers in physiology 2021. PMID: 34122125

DuBrock HM, Burger CD, Bartolome SD, Feldman JP, Ivy DD, Rosenzweig EB, Sager JS, Presberg KW, Mathai SC, Lammi MR, Klinger JR, Eggert M, De Marco T, Elwing JM, Badesch D, Bull TM, Cadaret LM, Ramani G, Thenappan T, Ford HJ, Al-Naamani N, Simon MA, Mazimba S, Runo JR, Chakinala M, Horn EM, Ryan JJ, Frantz RP, Krowka MJ. Health disparities and treatment approaches in portopulmonary hypertension and idiopathic pulmonary arterial hypertension: an analysis of the Pulmonary Hypertension Association Registry. Pulmonary circulation 2021. PMID: 34158918

Zhu N, Swietlik EM, Welch CL, Pauciulo MW, Hagen JJ, Zhou X, Guo Y, Karten J, Pandya D, Tilly T, Lutz KA, Martin JM, Treacy CM, Rosenzweig EB, Krishnan U, Coleman AW, Gonzaga-Jauregui C, Lawrie A, Trembath RC, Wilkins MR, Regeneron Genetics Center, PAH Biobank Enrolling Centers’ Investigators, NIHR BioResource for Translational Research - Rare Diseases, National Cohort Study of Idiopathic and Heritable PAH, Morrell NW, Shen Y, Gräf S, Nichols WC, Chung WK. Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Genome medicine 2021. PMID: 33971972

Bachman TN, Kim K, Simon MA. Semi-Automated Graphical System for Calculating Pulmonary Vascular Impedances in a Clinical Setting IEEE open journal of engineering in medicine and biology 2021. PMID:

Burkhoff D, Borlaug BA, Shah SJ, Zolty R, Tedford RJ, Thenappan T, Zamanian RT, Mazurek JA, Rich JD, Simon MA, Chung ES, Raza F, Majure DT, Lewis GD, Preston IR, Rich S. Levosimendan Improves Hemodynamics and Exercise Tolerance in PH-HFpEF: Results of the Randomized Placebo-Controlled HELP Trial. JACC. Heart failure 2021. PMID: 33839076

Kolaitis NA, Zamanian RT, de Jesus Perez VA, Badesch DB, Benza RL, Burger CD, Chakinala MM, Elwing JM, Feldman J, Lammi MR, Mathai SC, McConnell JW, Presberg KW, Robinson JC, Sager J, Shlobin OA, Simon MA, Kawut SM, Glidden DV, Singer JP, De Marco T. Clinical Differences and Outcomes between Methamphetamine-Associated and Idiopathic Pulmonary Arterial Hypertension in the PHAR. Annals of the American Thoracic Society 2020. PMID: 33064950

Nayak A, Hu Y, Ko YA, Steinberg R, Das S, Mehta A, Liu C, Pennington J, Xie R, Kirklin JK, Kormos RL, Cowger J, Simon MA, Morris AA. Creation and Validation of a Novel Sex-Specific Mortality Risk Score in LVAD Recipients. Journal of the American Heart Association 2021. PMID: 33764158

Hasselberg NE, Kagiyama N, Soyama Y, Sugahara M, Goda A, Ryo-Koriyama K, Batel O, Chakinala M, Simon MA, Gorcsan J. The Prognostic Value of Right Atrial Strain Imaging in Patients with Precapillary Pulmonary Hypertension. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2021. PMID: 33774108

Min J, Badesch D, Chakinala M, Elwing J, Frantz R, Horn E, Klinger J, Lammi M, Mazimba S, Sager J, Shlobin O, Simon M, Thenappan T, Grinnan D, Ventetuolo C, Al-Naamani N, PHAR Investigators. Prediction of Health-related Quality of Life and Hospitalization in Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry. American journal of respiratory and critical care medicine 2021. PMID: 33211974

Contijoch F, Wong D, Igata S, McDivit Mizzell A, Auger W, DeMaria AN, Blanchard D, Waheed A, Bachman TN, Simon MA, Pinsky MR, Madani M. Association between Pre-operative Dynamic Measures of Vascular Load and Post-operative Hemodynamics in Patients with Chronic Thromboembolic Pulmonary Hypertension after Pulmonary Thromboendarterectomy. Annals of the American Thoracic Society 2020. PMID: 33141597

Dew MA, Hollenberger JC, Obregon LL, Hickey GW, Sciortino CM, Lockard KL, Kunz NM, Mathier MA, Ramani RN, Kilic A, McNamara DM, Simon MA, Keebler ME, Kormos RL. The Preimplantation Psychosocial Evaluation and Prediction of Clinical Outcomes During Mechanical Circulatory Support: What Information Is Most Prognostic? Volume 105 of Issue 3. Transplantation 2020. PMID: 32345866

Rajaratnam A, Rehman S, Sharma P, Singh VK, Saul M, Vanderpool RR, Gladwin MT, Simon MA, Morris A. Right ventricular load and contractility in HIV-associated pulmonary hypertension. PloS one 2021. PMID: 33621231

Sharifi Kia D, Fortunato R, Maiti S, Simon MA, Kim K. An exploratory assessment of stretch-induced transmural myocardial fiber kinematics in right ventricular pressure overload. Scientific Reports 2021. PMID: 33574400

Coons JC, Crisamore K, Adams S, Modany A, Simon MA, Zhao W, Shaik IH, Venkataramanan R, Empey PE. A pilot study of oral treprostinil pharmacogenomics and treatment persistence in patients with pulmonary arterial hypertension. Therapeutic advances in respiratory disease 2021. PMID: 33929912

Xu J, Zupan R, Simon M, Wong T, Brigham JC. Shape-based strategy for inverse estimation of soft tissue mechanical material properties from untagged medical imaging data J Eng Mech 2021. PMID:

So S, Khalaf A, Yi X, Herring C, Zhang Y, Simon MA, Akcakaya M, Lee S, Yun M. Induced bioresistance via BNP detection for machine learning-based risk assessment. Biosensors & bioelectronics 2020. PMID: 33370705

Sun W, Tang Y, Tai YY, Handen A, Zhao J, Speyer G, Al Aaraj Y, Watson A, Romanelli ME, Sembrat J, Rojas M, Simon MA, Zhang Y, Lee J, Xiong Z, Dutta P, Vasamsetti SB, McNamara D, McVerry B, McTiernan CF, Sciurba FC, Kim S, Smith KA, Mazurek JA, Han Y, Vaidya A, Nouraie SM, Kelly NJ, Chan SY. SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension. Volume 5 of Issue 11. JACC. Basic to translational science 2020. PMID: 33294740

Min J, Feng R, Badesch D, Berman-Rosenzweig E, Burger C, Chakinala M, De Marco T, Feldman J, Hemnes A, Horn EM, Lammi MR, Mathai S, McConnell JW, Presberg K, Robinson J, Sager J, Shlobin OA, Simon M, Thenappan T, Ventetuolo C, Al-Naamani N, PHAR Investigators. Obesity in Pulmonary Arterial Hypertension (PAH): The Pulmonary Hypertension Association Registry (PHAR). Annals of the American Thoracic Society 2020. PMID: 33085915

Diaz-Castrillon CE, Seese L, Mathier MA, Keebler ME, Hickey GW, McNamara D, Simon MA, Horn E, Kilic A. Nationwide variability in the use of induction immunosuppression for adult heart transplantation. Volume 35 of Issue 11. Journal of cardiac surgery 2020. PMID: 33016378

Mentz RJ, Xu H, O'Brien EC, Thomas L, Alexy T, Gupta B, Vilaro J, Lala A, DeVore AD, Dhingra R, Briasoulis A, Simon MA, Stehlik J, Rodgers JE, Dunlay SM, Abshire M, Wells QS, Barringhaus KG, Eckman PM, Lowes BD, Espinoza J, Blanco R, Shen X, Duffy CI, Hernandez AF. PROVIDE-HF primary results: Patient-Reported Outcomes inVestigation following Initiation of Drug therapy with Entresto (sacubitril/valsartan) in heart failure. American heart journal 2020. PMID: 32980364

London B, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Simon MA, Sullivan LM, Weinberg JM. Diversity, Equity, and Inclusiveness in Medicine and Cardiology: Next Steps for JAHA. Volume 9 of Issue 20. Journal of the American Heart Association 2020. PMID: 32941090

Simon MA, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Sullivan LM, Weinberg JM. Equity, Diversity, and Inclusiveness in Cardiovascular Medicine and Health Care. Journal of the American Heart Association 2020. PMID: 32941102

Simon MA, Ahmad F, Eitzman DT, Gupta AK, Jneid H, Peterson P, Remme CA, Rice K, Schelbert EB, Sullivan LM, Weinberg JM. J Am Heart Assoc Equity, Diversity, and Inclusiveness in Cardiovascular Medicine and Health Care 2020. PMID:

Badlam JB, Badesch DB, Austin ED, Benza RL, Chung WK, Farber HW, Feldkircher K, Frost AE, Poms AD, Lutz KA, Pauciulo MW, Yu C, Nichols WC, Elliott CG, USPHSR Investigators. United States Pulmonary Hypertension Scientific Registry: Baseline Characteristics. Chest 2020. PMID: 32858008

Mulkareddy V, Simon MA. Metformin in Pulmonary Hypertension in Left Heart Disease. Frontiers in medicine 2020. PMID: 32974359

Simon MA, Vachiéry JL. Clearing Our Vision for Discerning Precapillary From Postcapillary Pulmonary Hypertension With the OPTICS Risk Score. Journal of the American Heart Association 2020. PMID: 32750289

Sharifi Kia D, Benza E, Bachman TN, Tushak C, Kim K, Simon MA. Angiotensin Receptor-Neprilysin Inhibition Attenuates Right Ventricular Remodeling in Pulmonary Hypertension. Journal of the American Heart Association 2020. PMID: 32552157

Bashline MJ, Bachman TN, Helbling NL, Nouraie M, Gladwin MT, Simon MA. The Effects of Inhaled Sodium Nitrite on Pulmonary Vascular Impedance in Patients With Pulmonary Hypertension Associated with Heart Failure With Preserved Ejection Fraction. Volume 26 of Issue 8. Journal of cardiac failure 2020. PMID: 32446946

Goncharova EA, Simon MA, Yuan JX. mTORC1 in Pulmonary Arterial Hypertension. At the Crossroads between Vasoconstriction and Vascular Remodeling? Volume 201 of Issue 10. American journal of respiratory and critical care medicine 2020. PMID: 31968178

Pi H, Kosanovich CM, Handen A, Tao M, Visina J, Vanspeybroeck G, Simon MA, Risbano MG, Desai A, Mathier MA, Rivera-Lebron BN, Nguyen Q, Kliner J, Nouraie M, Chan SY. Outcomes of Pulmonary Arterial Hypertension Are Improved in a Specialty Care Center. Volume 158 of Issue 1. Chest 2020. PMID: 32109446

Bellavia D, Iacovoni A, Agnese V, Falletta C, Coronnello C, Pasta S, Novo G, di Gesaro G, Senni M, Maalouf J, Sciacca S, Pilato M, Simon M, Clemenza F, Gorcsan SJ. Usefulness of regional right ventricular and right atrial strain for prediction of early and late right ventricular failure following a left ventricular assist device implant: A machine learning approach. The International journal of artificial organs 2019. PMID: 31830841

Zhu N, Pauciulo MW, Welch CL, Lutz KA, Coleman AW, Gonzaga-Jauregui C, Wang J, Grimes JM, Martin LJ, He H, PAH Biobank Enrolling Centers’ Investigators, Shen Y, Chung WK, Nichols WC. Novel risk genes and mechanisms implicated by exome sequencing of 2572 individuals with pulmonary arterial hypertension. Genome medicine 2019. PMID: 31727138

Bashline MJ, Simon MA. Use of Tricuspid Annular Plane Systolic Excursion/Pulmonary Artery Systolic Pressure As a Non-Invasive Method to Assess Right Ventricular-PA Coupling in Patients With Pulmonary Hypertension. Circulation. Cardiovascular imaging 2019. PMID: 31500450

Simon MA, Maron BA. Pulmonary Hypertension in Patients with Heart Failure with Preserved Ejection Fraction. Where to Draw the Line. American journal of respiratory and critical care medicine 2019. PMID: 31038986

Nguyen QL, Wang Y, Helbling N, Simon MA, Shiva S. Alterations in platelet bioenergetics in Group 2 PH-HFpEF patients. PloS one 2019. PMID: 31365585

Simon MA, Bachman TN, Watson J, Baldwin JT, Wagner WR, Borovetz HS. Current and Future Considerations in the Use of Mechanical Circulatory Support Devices: An Update, 2008-2018. Annual review of biomedical engineering 2019. PMID: 31167107

Estephan LE, Genuardi MV, Kosanovich CM, Risbano MG, Zhang Y, Petro N, Watson A, Al Aaraj Y, Sembrat JC, Rojas M, Goncharov DA, Simon MA, Goncharova EA, Vaidya A, Smith A, Mazurek J, Han Y, Chan SY. Distinct plasma gradients of microRNA-204 in the pulmonary circulation of patients suffering from WHO Groups I and II pulmonary hypertension. Pulmonary circulation 2019. PMID: 30854934

Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, MacKenzie Ross RV, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Vonk Noordegraaf A, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR, UK NIHR BioResource Rare Diseases Consortium, UK PAH Cohort Study Consortium, US PAH Biobank Consortium. Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis. The Lancet. Respiratory medicine 2018. PMID: 30527956

Tarantelli RA, Schweitzer F, Simon MA, Vanderpool RR, Christman I, Rayens E, Kling HM, Zullo T, Carney JP, Lopresti BJ, Bertero T, Chan SY, Norris KA. Longitudinal Evaluation of Pulmonary Arterial Hypertension in a Rhesus Macaque (Macaca mulatta) Model of HIV Infection. Comparative medicine 2018. PMID: 30541636

Simon MA, Nouraie M, Gladwin MT. Left Ventricular Ejection Fraction Cut Point of 50% for Heart Failure With Preserved Ejection Fraction-Reply. Volume 3 of Issue 10. JAMA cardiology 2018. PMID: 30027277

Rafikova O, Williams ER, McBride ML, Zemskova M, Srivastava A, Nair V, Desai AA, Langlais PR, Zemskov E, Simon M, Mandarino LJ, Rafikov R. Hemolysis-induced Lung Vascular Leakage Contributes to the Development of Pulmonary Hypertension. American journal of respiratory cell and molecular biology 2018. PMID: 29652520

Levine AR, Simon MA, Gladwin MT. Pulmonary vascular disease in the setting of heart failure with preserved ejection fraction. Trends in cardiovascular medicine 2018. PMID: 30177249

Sultan I, Cardounel A, Abdelkarim I, Kilic A, Althouse AD, Sharbaugh MS, Gupta A, Xu J, Fukui M, Simon MA, Schindler JT, Lee JS, Gleason TG, Cavalcante JL. Right ventricle to pulmonary artery coupling in patients undergoing transcatheter aortic valve implantation. Heart (British Cardiac Society) 2018. PMID: 30093545

Simon MA, Schnatz RG, Romeo JD, Pacella JJ. Bedside Ultrasound Assessment of Jugular Venous Compliance as a Potential Point-of-Care Method to Predict Acute Decompensated Heart Failure 30-Day Readmission. Journal of the American Heart Association 2018. PMID: 30371245

Vanderpool RR, Saul M, Nouraie M, Gladwin MT, Simon MA. Association Between Hemodynamic Markers of Pulmonary Hypertension and Outcomes in Heart Failure With Preserved Ejection Fraction. Volume 3 of Issue 4. JAMA cardiology 2018. PMID: 29541759

Coons JC, Bunner C, Ishizawar DC, Risbano MG, Rivera-Lebron B, Mathier MA, Chan SY, Simon MA. Impact of four times daily dosing of oral treprostinil on tolerability and daily dose achieved in pulmonary hypertension. Pulmonary circulation 2018. PMID: 29199910

Avazmohammadi R, Hill M, Simon M, Sacks M. Transmural remodeling of right ventricular myocardium in response to pulmonary arterial hypertension. APL bioengineering 2017. PMID: 30417163

Benza RL, Raina A, Gupta H, Murali S, Burden A, Zastrow MS, Park MH, Simon MA. Bosentan-based, treat-to-target therapy in patients with pulmonary arterial hypertension: results from the COMPASS-3 study. Volume 8 of Issue 1. Pulmonary circulation 2017. PMID: 29064349

Jang S, Vanderpool RR, Avazmohammadi R, Lapshin E, Bachman TN, Sacks M, Simon MA. Biomechanical and Hemodynamic Measures of Right Ventricular Diastolic Function: Translating Tissue Biomechanics to Clinical Relevance. Journal of the American Heart Association 2017. PMID: 28899895

Schelbert EB, Fridman Y, Wong TC, Abu Daya H, Piehler KM, Kadakkal A, Miller CA, Ugander M, Maanja M, Kellman P, Shah DJ, Abebe KZ, Simon MA, Quarta G, Senni M, Butler J, Diez J, Redfield MM, Gheorghiade M. Temporal Relation Between Myocardial Fibrosis and Heart Failure With Preserved Ejection Fraction: Association With Baseline Disease Severity and Subsequent Outcome. JAMA cardiology 2017. PMID: 28768311

Vanderpool RR, Desai AA, Knapp SM, Simon MA, Abidov A, Yuan JX, Garcia JGN, Hansen LM, Knoper SR, Naeije R, Rischard FP. How prostacyclin therapy improves right ventricular function in pulmonary arterial hypertension. The European respiratory journal 2017. PMID: 28838981

Nguyen QL, Corey C, White P, Watson A, Gladwin MT, Simon MA, Shiva S. Platelets from pulmonary hypertension patients show increased mitochondrial reserve capacity. JCI insight 2017. PMID: 28289721

Cavalcante JL, Simon MA, Chan SY. Comprehensive Right-Sided Assessment for Transcatheter Aortic Valve Replacement Risk Stratification: Time for a Change. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2017. PMID: 28063482

Nayak A, Neill C, Kormos RL, Lagazzi L, Halder I, McTiernan C, Larsen J, Inashvili A, Teuteberg J, Bachman TN, Hanley-Yanez K, McNamara DM, Simon MA. Chemokine receptor patterns and right heart failure in mechanical circulatory support. Volume 36 of Issue 6. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2016. PMID: 28209402

Simon MA, Vanderpool RR, Nouraie M, Bachman TN, White PM, Sugahara M, Gorcsan J, Parsley EL, Gladwin MT. Acute hemodynamic effects of inhaled sodium nitrite in pulmonary hypertension associated with heart failure with preserved ejection fraction. JCI insight 2016. PMID: 27812547

Park DW, Sebastiani A, Yap CH, Simon MA, Kim K. Quantification of Coupled Stiffness and Fiber Orientation Remodeling in Hypertensive Rat Right-Ventricular Myocardium Using 3D Ultrasound Speckle Tracking with Biaxial Testing. PloS one 2016. PMID: 27780271

Avazmohammadi R, Hill MR, Simon MA, Zhang W, Sacks MS. A novel constitutive model for passive right ventricular myocardium: evidence for myofiber-collagen fiber mechanical coupling. Biomechanics and modeling in mechanobiology 2016. PMID: 27696332

Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY. Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension. Volume 126 of Issue 9. The Journal of clinical investigation 2016. PMID: 27548520

Vanderpool RR, Rischard F, Naeije R, Hunter K, Simon MA. Simple functional imaging of the right ventricle in pulmonary hypertension: Can right ventricular ejection fraction be improved? International journal of cardiology 2016. PMID: 27532240

Maron BA, Gladwin MT, Simon MA. Update in Pulmonary Vascular Disease 2015. American journal of respiratory and critical care medicine 2016. PMID: 27304242

Sista AK, Goldhaber SZ, Vedantham S, Kline JA, Kuo WT, Kahn SR, Kabrhel C, McLaughlin VV, White SB, Kim NH, Gray M, Simon MA, Benenati JF, Misra S, Sterling KM, Kee ST, Konstantinides SV, Jaff MR, Kearon C. Research Priorities in Submassive Pulmonary Embolism: Proceedings from a Multidisciplinary Research Consensus Panel. Journal of vascular and interventional radiology : JVIR 2016. PMID: 27287967

Goda A, Ryo K, Delgado-Montero A, Tayal B, Handa R, Simon MA, Gorcsan J. The Prognostic Utility of a Simplified Biventricular Echocardiographic Index of Cardiac Remodeling in Patients with Pulmonary Hypertension. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography 2016. PMID: 27049663

Coons JC, Miller T, Simon MA, Ishizawar DC, Mathier MA. Oral treprostinil for the treatment of pulmonary arterial hypertension in patients transitioned from parenteral or inhaled prostacyclins: case series and treatment protocol. Pulmonary circulation 2016. PMID: 27162621

Ryo K, Goda A, Onishi T, Delgado-Montero A, Tayal B, Champion HC, Simon MA, Mathier MA, Gladwin MT, Gorcsan J. Characterization of right ventricular remodeling in pulmonary hypertension associated with patient outcomes by 3-dimensional wall motion tracking echocardiography. Circulation. Cardiovascular imaging 2015. PMID: 26038432

Simon MA. MY APPROACH to the patient with right ventricular failure. Trends in cardiovascular medicine 2015. PMID: 25983075

Yap CH, Park DW, Dutta D, Simon M, Kim K. Methods for using 3-D ultrasound speckle tracking in biaxial mechanical testing of biological tissue samples. Ultrasound in medicine & biology 2015. PMID: 25616585

Novelli EM, Hildesheim M, Rosano C, Vanderpool R, Simon M, Kato GJ, Gladwin MT. Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease. PloS one 2014. PMID: 25478953

Teuteberg JJ, Simon MA. Non-invasive screening for cardiac allograft vasculopathy: go small or go home? Volume 34 of Issue 2. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2014. PMID: 25511745

Vanderpool RR, Pinsky MR, Naeije R, Deible C, Kosaraju V, Bunner C, Mathier MA, Lacomis J, Champion HC, Simon MA. RV-pulmonary arterial coupling predicts outcome in patients referred for pulmonary hypertension. Heart (British Cardiac Society) 2014. PMID: 25214501

Gomez-Arroyo J, Sandoval J, Simon MA, Dominguez-Cano E, Voelkel NF, Bogaard HJ. Treatment for pulmonary arterial hypertension-associated right ventricular dysfunction. Volume 11 of Issue 7. Annals of the American Thoracic Society 2014. PMID: 25079379

Hill MR, Simon MA, Valdez-Jasso D, Zhang W, Champion HC, Sacks MS. Structural and mechanical adaptations of right ventricle free wall myocardium to pressure overload. Annals of biomedical engineering 2014. PMID: 25164124

Wu J, Simon MA, Brigham JC. A comparative analysis of global shape analysis methods for the assessment of the human right ventricle Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization 2014. PMID:

Wu J, Brigham KG, Simon M, Brigham JC. An implementation of independent component analysis for 3D statistical shape analysis Biomedical Signal Processing and Control 2014. PMID:

Shankarraman V, Kocyildirim E, Olia SE, Kameneva MV, Dzadony RJ, Maul TM, Simon MA, Champion HC, Wagner WR, Bermudez CA. Biocompatibility Assessment of the CentriMag-Novalung Adult ECMO Circuit in a Model of Acute Pulmonary Hypertension. ASAIO journal (American Society for Artificial Internal Organs : 1992) 2014. PMID: 24658516

Simon MA, Lacomis CD, George MP, Kessinger C, Weinman R, McMahon D, Gladwin MT, Champion HC, Morris A. Isolated right ventricular dysfunction in patients with human immunodeficiency virus. Volume 20 of Issue 6. Journal of cardiac failure 2014. PMID: 24726418

Simon MA. Advances in Pulmonary Hypertension Nitric Oxide Therapeutics in Pulmonary Vascular Disease 2014. PMID:

George MP, Novelli EM, Shigemura N, Simon MA, Feingold B, Krishnamurti L, Morrell MR, Gries CG, Haider S, Johnson BA, Crespo MM, Bhama JK, Bermudez C, Yousem SA, Toyoda Y, Champion HC, Pilewski JM, Gladwin MT. First successful lung transplantation for sickle cell disease with severe pulmonary arterial hypertension and pulmonary veno-occlusive disease. Pulmonary circulation 2013. PMID: 25006411

Simon MA. Matrix metalloproteinases in right ventricular failure. Nature reviews. Cardiology 2013. PMID: 23959227

Wong TC, Piehler KM, Kang IA, Kadakkal A, Kellman P, Schwartzman DS, Mulukutla SR, Simon MA, Shroff SG, Kuller LH, Schelbert EB. Myocardial extracellular volume fraction quantified by cardiovascular magnetic resonance is increased in diabetes and associated with mortality and incident heart failure admission. European heart journal 2013. PMID: 23756336

Bachman TN, Bursic JJ, Simon MA, Champion HC. A Novel Acquisition Technique to Utilize Swan-Ganz Catheter data as a Surrogate for High-fidelity Micromanometry within the Right Ventricle and Pulmonary Circuit. Cardiovascular engineering and technology 2013. PMID: 25484997

Simon M, Soran O. Standing the test of time: exercise testing for heart failure prognosis in the beta-blocker era. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 2013. PMID: 23666297

Wu J, Wang Y, Simon MA, Sacks MS, Brigham JC. A new computational framework for anatomically consistent 3D statistical shape analysis with clinical imaging applications Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization 2013. PMID:

Simon MA. Assessment and treatment of right ventricular failure. Volume 10 of Issue 4. Nature reviews. Cardiology 2013. PMID: 23399974

Wong TC, Piehler K, Puntil KS, Moguillansky D, Meier CG, Lacomis JM, Kellman P, Cook SC, Schwartzman DS, Simon MA, Mulukutla SR, Schelbert EB. Effectiveness of late gadolinium enhancement to improve outcomes prediction in patients referred for cardiovascular magnetic resonance after echocardiography. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 2013. PMID: 23324403

George MP, Champion HC, Simon M, Guyach S, Tarantelli R, Kling HM, Brower A, Janssen C, Murphy J, Carney JP, Morris A, Gladwin MT, Norris KA. Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension. American journal of respiratory cell and molecular biology 2012. PMID: 23239493

Wu J, Wang Y, Simon MA, Brigham JC. A new approach to kinematic feature extraction from the human right ventricle for classification of hypertension: a feasibility study. Physics in medicine and biology 2012. PMID: 23154583

Wong TC, Piehler K, Meier CG, Testa SM, Klock AM, Aneizi AA, Shakesprere J, Kellman P, Shroff SG, Schwartzman DS, Mulukutla SR, Simon MA, Schelbert EB. Association between extracellular matrix expansion quantified by cardiovascular magnetic resonance and short-term mortality. Circulation 2012. PMID: 22851543

Valdez-Jasso D, Simon MA, Champion HC, Sacks MS. A murine experimental model for the mechanical behaviour of viable right-ventricular myocardium. The Journal of physiology 2012. PMID: 22848044

Adelstein E, Bhattacharya S, Simon MA, Gorcsan J, Saba S. Comparison of outcomes for patients with nonischemic cardiomyopathy taking intravenous inotropes versus those weaned from or never taking inotropes at cardiac resynchronization therapy. Volume 110 of Issue 6. The American journal of cardiology 2012. PMID: 22681865

Wang Y, Simon M, Bonde P, Harris BU, Teuteberg JJ, Kormos RL, Antaki JF. Prognosis of right ventricular failure in patients with left ventricular assist device based on decision tree with SMOTE. IEEE transactions on information technology in biomedicine : a publication of the IEEE Engineering in Medicine and Biology Society 2012. PMID: 22334033

Refaat MM, Tanaka T, Kormos RL, McNamara D, Teuteberg J, Winowich S, London B, Simon MA. Survival benefit of implantable cardioverter-defibrillators in left ventricular assist device-supported heart failure patients. Volume 18 of Issue 2. Journal of cardiac failure 2011. PMID: 22300782

Wang Y, Simon MA, Bonde P, Harris BU, Teuteberg JJ, Kormos RL, Antaki JF. Decision tree for adjuvant right ventricular support in patients receiving a left ventricular assist device. Volume 31 of Issue 2. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2011. PMID: 22168963

Singh M, Shullo M, Kormos RL, Lockard K, Zomak R, Simon MA, Bermudez C, Bhama J, McNamara D, Toyoda Y, Teuteberg JJ. Impact of renal function before mechanical circulatory support on posttransplant renal outcomes. Volume 91 of Issue 5. The Annals of thoracic surgery 2011. PMID: 21524442

Tanaka H, Tanabe M, Simon MA, Starling RC, Markham D, Thohan V, Mather P, McNamara DM, Gorcsan J. Left ventricular mechanical dyssynchrony in acute onset cardiomyopathy: association of its resolution with improvements in ventricular function. Volume 4 of Issue 5. JACC. Cardiovascular imaging 2011. PMID: 21565730

Simon MA, Pinsky MR. Right ventricular dysfunction and failure in chronic pressure overload. Cardiology research and practice 2011. PMID: 21559218

Bhattacharya S, Abebe K, Simon M, Saba S, Adelstein E. Role of cardiac resynchronization in end-stage heart failure patients requiring inotrope therapy. Journal of cardiac failure 2010. PMID: 21111981

Genovese EA, Dew MA, Teuteberg JJ, Simon MA, Bhama JK, Bermudez CA, Lockard KL, Winowich S, Kormos RL. Early adverse events as predictors of 1-year mortality during mechanical circulatory support. Volume 29 of Issue 9. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010. PMID: 20580265

Simon MA. Right ventricular adaptation to pressure overload. Current opinion in critical care 2010. PMID: 20179591

Simon MA, Kliner DE, Girod JP, Moguillansky D, Villanueva FS, Pacella JJ. Detection of elevated right atrial pressure using a simple bedside ultrasound measure. American heart journal 2010. PMID: 20211304

Nair PK, Kormos RL, Teuteberg JJ, Mathier MA, Bermudez CA, Toyoda Y, Dew MA, Simon MA. Pulsatile left ventricular assist device support as a bridge to decision in patients with end-stage heart failure complicated by pulmonary hypertension. Volume 29 of Issue 2. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2010. PMID: 20113910

Simon MA, Primack BA, Teuteberg J, Kormos RL, Bermudez C, Toyoda Y, Shah H, Gorcsan J, McNamara DM. Left ventricular remodeling and myocardial recovery on mechanical circulatory support. Volume 16 of Issue 2. Journal of cardiac failure 2009. PMID: 20142020

Simon MA, Rajagopalan N, Mathier MA, Shroff SG, Pinsky MR, López-Candales A. Tissue Doppler imaging of right ventricular decompensation in pulmonary hypertension. Congestive heart failure (Greenwich, Conn.) 2009. PMID: 19925505

Genovese EA, Dew MA, Teuteberg JJ, Simon MA, Kay J, Siegenthaler MP, Bhama JK, Bermudez CA, Lockard KL, Winowich S, Kormos RL. Incidence and patterns of adverse event onset during the first 60 days after ventricular assist device implantation. Volume 88 of Issue 4. The Annals of thoracic surgery 2009. PMID: 19766801

Rajagopalan N, Simon MA, Edelman K, Mathier MA, López-Candales A. Identifying left ventricular dysfunction in pulmonary hypertension. Congestive heart failure (Greenwich, Conn.) 2009. PMID: 19751422

Simon MA, Deible C, Mathier MA, Lacomis J, Goitein O, Shroff SG, Pinsky MR. Phenotyping the right ventricle in patients with pulmonary hypertension. Clinical and translational science 2009. PMID: 20443908

Johnson L, Simon MA, Pinsky MR, Shroff SG. Insights into the effects of contraction dyssynchrony on global left ventricular mechano-energetic function. Pacing and clinical electrophysiology : PACE 2009. PMID: 19170912

Rajagopalan N, Simon MA, Suffoletto MS, Shah H, Edelman K, Mathier MA, López-Candales A. Noninvasive estimation of pulmonary vascular resistance in pulmonary hypertension. Echocardiography (Mount Kisco, N.Y.) 2008. PMID: 19054039

Rajagopalan N, Simon MA, Shah H, Mathier MA, López-Candales A. Utility of right ventricular tissue Doppler imaging: correlation with right heart catheterization. Echocardiography (Mount Kisco, N.Y.) 2008. PMID: 18445057

Hung TK, Balasubramanian SR, Simon MA, Suffoletto M, Borovetz HS, Gorcsan J. Hemodynamic information and analysis of cardiac pumping Journal of Mechanics in Medicine and Biology 2008. PMID:

Simon MA, Watson J, Baldwin JT, Wagner WR, Borovetz HS. Current and future considerations in the use of mechanical circulatory support devices. Annual review of biomedical engineering 2008. PMID: 18647112

Rajagopalan N, Simon MA, Mathier MA, López-Candales A. Identifying right ventricular dysfunction with tissue Doppler imaging in pulmonary hypertension. International journal of cardiology 2007. PMID: 17714807

Rajagopalan N, Suffoletto MS, Tanabe M, Miske G, Thomas NC, Simon MA, Bazaz R, Gorcsan J, López-Candales A. Right ventricular function following cardiac resynchronization therapy. The American journal of cardiology 2007. PMID: 17950803

Rajagopalan N, Saxena N, Simon MA, Edelman K, Mathier MA, López-Candales A. Correlation of tricuspid annular velocities with invasive hemodynamics in pulmonary hypertension. Congestive heart failure (Greenwich, Conn.) 2007. PMID: 17673871

Rajagopalan N, Dohi K, Simon MA, Suffoletto M, Edelman K, Murali S, López-Candales A. Right ventricular dyssynchrony in heart failure: a tissue Doppler imaging study. Volume 12 of Issue 4. Journal of cardiac failure 2006. PMID: 16679258

Simon MA, Kormos RL, Gorcsan J, Dohi K, Winowich S, Stanford E, Carozza L, Murali S. Differential exercise performance on ventricular assist device support. Volume 24 of Issue 10. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2005. PMID: 16210122

Simon MA, Kormos RL, Murali S, Nair P, Heffernan M, Gorcsan J, Winowich S, McNamara DM. Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes. Volume 112 of Issue 9 Suppl. Circulation 2005. PMID: 16159839

Shakar SF, Lowes BD, Lindenfeld J, Zolty R, Simon M, Robertson AD, Bristow MR, Wolfel EE. Peak oxygen consumption and outcome in heart failure patients chronically treated with beta-blockers. Journal of cardiac failure 2004. PMID: 14966770

Lowes BD, Simon MA, Tsvetkova TO, Bristow MR. Inotropes in the beta-blocker era. Clinical cardiology 2000. PMID: 10754776