Lisa Winston, MD

Professor

HIV, Infectious Disease, and Global Medicine, Infectious Diseases

Lisa Winston received her MD from Johns Hopkins University School of Medicine in 1994. She completed her residency in Internal Medicine at UCSF and was Chief Resident at San Francisco General Hospital. Dr. Winston then completed fellowships in Infectious Diseases and Clinical Pharmacology at UCSF.

She is the Chief of the Medical Staff and Hospital Epidemiologist at Zuckerberg San Francisco General Hospital and Trauma Center. Her research interests are infection control and prevention and antimicrobial resistant bacterial pathogens.

Education:
• AB, Harvard University, 1990
• MD, Johns Hopkins University School of Medicine, 1994

Training:
• Internal Medicine Residency, University of California, San Francisco, 1994-1997
• Chief Resident, University of California, San Francisco, 1997-1998
• Infectious Diseases Fellowship, University of California, San Francisco, 1998 – 2001
• Clinical Pharmacology Fellowship, University of California, San Francisco, 1999-2001

Certification:
• American Board of Internal Medicine, certified 1997, recertified 2007 and 2017
• American Board of Internal Medicine, subspecialty Infectious Diseases, certified 2000, recertified 2010 and 2020

Memberships & Affiliations:
• Infectious Diseases Society of America, fellow
• Society for Healthcare Epidemiology of America

Education
2017 - Diversity, Equity, and Inclusion Champion Training, University of California, San Francisco
Residency, 1997 - Internal Medicine, University of California, San Francisco
Publications
  1. Guh AY, Fridkin S, Goodenough D, Winston LG, Johnston H, Basiliere E, Olson D, Wilson CD, Watkins JJ, Korhonen L, Gerding DN. Potential underreporting of treated patients using a Clostridioides difficile testing algorithm that screens with a nucleic acid amplification test. Infection control and hospital epidemiology 2024. PMID: 38268440


  2. Alice Guh, Rongxia Li, Lauren C Korhonen, Lisa Gail Winston, Erin Parker, Christopher A Czaja, Helen Johnston, Elizabeth Basiliere, James Meek, Danyel M Olson, Scott Fridkin, Lucy E Wilson, Rebecca Perlmutter, Stacy Holzbauer, Paige D’Heilly, Erin Phipps, Kristina Flores, Ghinwa Dumyati, Rebecca Pierce, Valerie Ocampo, Christopher Wilson, Jasmine Watkins, Dale Gerding, L Clifford McDonald. 684. Characteristics of Patients with Initial Clostridioides difficile Infection (CDI) That Are Associated With Increased Risk of Multiple CDI Recurrences. Open forum infectious diseases 2023. PMID:


  3. Alice Guh, Lisa Gail Winston, Helen Johnston, Elizabeth Basiliere, Danyel M Olson, Scott Fridkin, Dana Goodenough, Christopher Wilson, Jasmine Watkins, Lauren C Korhonen, Dale N Gerding. 1665. Potential underreporting of treated patients using a Clostridioides difficile testing algorithm that screens with a nucleic acid amplification test. Open forum infectious diseases 2022. PMID:


  4. Guh AY, Yi SH, Baggs J, Winston L, Parker E, Johnston H, Basiliere E, Olson D, Fridkin SK, Mehta N, Wilson L, Perlmutter R, Holzbauer SM, D'Heilly P, Phipps EC, Flores KG, Dumyati GK, Hatwar T, Pierce R, Ocampo VLS, Wilson CD, Watkins JJ, Korhonen L, Paulick A, Adamczyk M, Gerding DN, Reddy SC. Comparison of the Risk of Recurrent Clostridioides Difficile Infections Among Patients in 2018 Versus 2013. Open forum infectious diseases 2022. PMID: 36072699


  5. Appa A, Adamo M, Le S, Davis J, Winston L, Doernberg SB, Chambers H, Martin M, Hills NK, Coffin PO, Jain V. Comparative one-year outcomes of invasive Staphylococcus aureus infections among persons with and without drug use: an observational cohort study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2021. PMID: 33904900


  6. Dana Freiser, Merjo Roca, Tony Chung, Tanvi Bhakta, Lisa G. Winston, Gabriel M. Ortiz. The Evolution of a Hospital-Based Covid-19 Vaccination Program for Inpatients. NEJM Catalyst 2022. PMID:


  7. Winston LG, Winkler ML, Kheterpal A, Villalba JA. Case 36-2021: A 22-Year-Old Man with Pain and Erythema of the Left Hand. 2021. PMID: 34818483


  8. Dietz BW, Winston LG, Koehler JE, Margaretten M. Copycat. 2021. PMID: 34731540


  9. Appa A, Adamo M, Le S, Davis J, Winston L, Doernberg SB, Chambers H, Martin M, Hills NK, Coffin P, Jain V. Patient-Directed Discharges Among Persons Who Use Drugs Hospitalized with Invasive S. aureus Infections: Opportunities for Improvement. The American journal of medicine 2021. PMID: 34508704


  10. Skrobarcek KA, Mu Y, Ahern J, Basiliere E, Beldavs ZG, Brousseau G, Dumyati G, Fridkin S, Holzbauer SM, Johnston H, Kainer MA, Meek J, Ocampo VLS, Parker E, Perlmutter R, Phipps EC, Winston L, Guh A. Association between Socioeconomic Status and Incidence of Community-Associated Clostridioides difficile Infection - United States, 2014-2015. 2021. PMID: 33462596


  11. Whitman JD, Pham P, Bern C, Dekker EM, Haller BL, Jain V, Winston LG. Significant and sustained decrease in non-SARS-CoV-2 respiratory viral infections during COVID-19 public health interventions. medRxiv : the preprint server for health sciences 2021. PMID: 34013283


  12. Ayesha Ashley Appa, Meredith Adamo, Stephenie Le, Jennifer Davis, Lisa Gail Winston, Sarah B Doernberg, Henry Chambers, Marlene Martin, Phillip Coffin, Vivek Jain. 39. Comparative One-year Outcomes of Invasive staphylococcus Aureus infections Among Persons with and Without Drug Use in an Urban West Coast Cohort. Open forum infectious diseases 2020. PMID:


  13. Vivek Jain, Lillian B Brown, Carina Marquez, Luis Rubio, Natasha Spottiswoode, Bethlehem Churnet, Katherine Brooks, Mengyu Zhou, Timothy Muldoon, Carolyn Hendrickson, Adithya Cattamanchi, Antonio Gomez, Brian Haas, Edwin Charlebois, Annie Luetkemeyer, Annie Luetkemeyer, Monica Gandhi, Diane Havlir, Sumant Ranji, Lisa Gail Winston. 448. Disproportionate Burden of COVID-19 on Latinx Residents among Hospitalized Patients at San Francisco’s Public Health Hospital. Open forum infectious diseases 2020. PMID:


  14. Lillian B Brown, Lisa Gail Winston, Barbara Haller, Phong Pham, Beatrice Marcelo, Wendy Cheung, Kara Lynch, Vivek Jain. 496. Higher SARS-CoV-2 RT-PCR Cycle Threshold (Ct) Values Associated with Longer Symptom Duration Among Patients Hospitalized with COVID-19. Open forum infectious diseases 2020. PMID:


  15. Alice Guh, Lauren C Korhonen, Lisa Gail Winston, Brittany Martin, Helen Johnston, Geoffrey Brousseau, Elizabeth Basiliere, Danyel M Olson, Scott Fridkin, Lucy E Wilson, Rebecca Perlmutter, Stacy Holzbauer, Maria Bye, Erin C Phipps, Kristina Flores, Ghinwa Dumyati, Deborah Nelson, Trupti Hatwar, Valerie Ocampo, Marion Kainer, Clifford McDonald. 780. How Much Does Prior Hospitalization Contribute to Readmission with Community-onset Clostridioides difficile Infection?. 2020. PMID:


  16. Guh AY, Mu Y, Winston LG, Johnston H, Olson D, Farley MM, Wilson LE, Holzbauer SM, Phipps EC, Dumyati GK, Beldavs ZG, Kainer MA, Karlsson M, Gerding DN, McDonald LC. Trends in U.S. Burden of Clostridioides difficile Infection and Outcomes. The New England journal of medicine 2020. PMID: 32242357


  17. Novosad SA, Mu Y, Winston LG, Johnston H, Basiliere E, Olson DM, Farley MM, Revis A, Wilson L, Perlmutter R, Holzbauer SM, Whitten T, Phipps EC, Dumyati GK, Beldavs ZG, Ocampo VLS, Davis CM, Kainer M, Gerding DN, Guh AY. Treatment of Clostridioides difficile Infection and Non-compliance with Treatment Guidelines in Adults in 10 US Geographical Locations, 2013-2015. Journal of general internal medicine 2019. PMID: 31768906


  18. Guh AY, Hatfield KM, Winston LG, Martin B, Johnston H, Brousseau G, Farley MM, Wilson L, Perlmutter R, Phipps EC, Dumyati GK, Nelson D, Hatwar T, Kainer MA, Paulick AL, Karlsson M, Gerding DN, McDonald LC. Toxin Enzyme Immunoassays Detect Clostridioides difficile Infection with Greater Severity and Higher Recurrence Rates. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2019. PMID: 30615074


  19. Kelly M Hatfield, James Baggs, Lisa Gail Winston, Erin Parker, Helen Johnston, Geoff Brousseau, Danyel M Olson, Scott Fridkin, Lucy Wilson, Rebecca Perlmuter, Stacy Holzbauer, Erin C Phipps, Emily B Hancock, Ghinwa Dumyati, Valerie Ocampo, Marion A Kainer, Lauren C Korhonen, John A Jernigan, L Clifford McDonald, Alice Guh. 837. Prior Hospitalizations Among Cases of Community-Associated Clostridioides difficile Infection—10 US States, 2014–2015. Open forum infectious diseases 2019. PMID:


  20. Aronowitz PB, Williams DM, Henderson MC, Winston LG. Mind the Base Rate: an Exercise in Clinical Reasoning. Journal of general internal medicine 2019. PMID: 31270792


  21. Geha RM, Dhaliwal G, Winston LG, Kickler TS, Manesh R. Overcoming the Barrier. The New England journal of medicine 2018. PMID: 30575451


  22. Kimberly Skrobarcek, Yi Mu, Jennifer Ahern, Zintars Beldavs, Geoff Brousseau, Ghinwa Dumyati, Monica M Farley, Stacy Holzbauer, Marion A Kainer, James I Meek, Rebecca Perlmutter, Erin C Phipps, Lisa G Winston, Alice Y Guh. 482. Association between Socioeconomic Status Factors and Incidence of Community-Associated Clostridium difficile Infection Utilizing Factor Analysis—United States, 2014–2015. Open forum infectious diseases 2018. PMID:


  23. Alice Guh, Kelly Hatfield, Lisa G Winston, Brittany Martin, Helen Johnston, Geoff Brousseau, Monica M Farley, Lucy E Wilson, Rebecca Perlmutter, Erin C Phipps, Ghinwa Dumyati, Deborah Nelson, Trupti Hatwar, Marion A Kainer, L Clifford McDonald. 490. Comparison of Clostridium difficile Infection Outcomes by Diagnostic Testing Method. Open forum infectious diseases 2018. PMID:


  24. Kelly M Hatfield, James Baggs, Lisa G Winston, Erin Parker, Brittany Martin, James I Meek, Danyel Olson, Monica M Farley, Andrew Revis, Stacy Holzbauer, Maria Bye, Lucy Wilson, Rebecca Perlmutter, Erin C Phipps, Rebecca Pierce, Valerie L S Ocampo, Marion A Kainer, Miranda Smith, L Clifford McDonald, John A Jernigan, Alice Guh. 492. Long-Term Outcomes of Clostridium difficile Infection Among Medicare Beneficiaries. Open forum infectious diseases 2018. PMID:


  25. Chaisson LH, Duong D, Cattamanchi A, Roemer M, Handley MA, Schillinger D, Sur M, Pham P, Lin MA, Goldman LE, Quan J, Perez S, Healy M, Higashi J, Winston L, Haller B, Luetkemeyer AF, Davis JL. Association of Rapid Molecular Testing With Duration of Respiratory Isolation for Patients With Possible Tuberculosis in a US Hospital. JAMA internal medicine 2018. PMID: 30178007


  26. Vaisman A, Jula M, Wagner J, Winston LG. Examining the association between hospital-onset Clostridium difficile infection and multiple-bed room exposure: a case-control study. Infection control and hospital epidemiology 2018. PMID: 30060776


  27. Guh AY, Mu Y, Baggs J, Winston LG, Bamberg W, Lyons C, Farley MM, Wilson LE, Holzbauer SM, Phipps EC, Beldavs ZG, Kainer MA, Karlsson M, Gerding DN, Dumyati G. Trends in incidence of long-term-care facility onset Clostridium difficile infections in 10 US geographic locations during 2011-2015. American journal of infection control 2018. PMID: 29329918


  28. Guh AY, Adkins SH, Li Q, Bulens SN, Farley MM, Smith Z, Holzbauer SM, Whitten T, Phipps EC, Hancock EB, Dumyati G, Concannon C, Kainer MA, Rue B, Lyons C, Olson DM, Wilson L, Perlmutter R, Winston LG, Parker E, Bamberg W, Beldavs ZG, Ocampo V, Karlsson M, Gerding DN, McDonald LC. Risk Factors for Community-Associated Clostridium difficile Infection in Adults: A Case-Control Study. Open forum infectious diseases 2017. PMID: 29732377


  29. Alon Vaisman, Michael Jula, Jessica Wagner, Lisa G Winston. Association Between Hospital-Onset Clostridium difficile infection and Admission to a Multi-Bed Room: A Case–control Study. Open forum infectious diseases 2017. PMID:


  30. Kimberly Skrobarcek, Yi Mu, Lisa G Winston, Geoff Brousseau, Carol Lyons, Monica Farley, Rebecca Perlmutter, Stacy Holzbauer, Erin C Phipps, Ghinwa Dumyati, Zintars G Beldavs, Marion Kainer, Alice Guh. Socioeconomic Status Factors Associated with Increased Incidence of Community-Associated Clostridium difficile Infection. Open forum infectious diseases 2017. PMID:


  31. Shannon Novosad, Lisa G. Winston, Helen Johnston, Elizabeth Badolato, Carol Lyons, Monica Farley, Andrew Revis, Lucy Wilson, Rebecca Perlmutter, Stacy M. Holzbauer, Tory Whitten, Erin C. Phipps, Ghinwa Dumyati, Zintars G. Beldaversus, Valerie L.S. Ocampo, Marion Kainer, Corinne M. Davis, Jamie Barnes, Dale Gerding, Alice Guh. Treatment of Clostridium difficile Infection in 10 US Geographical Locations, 2013–2014. Open forum infectious diseases 2016. PMID:


  32. Hunter JC, Mu Y, Dumyati GK, Farley MM, Winston LG, Johnston HL, Meek JI, Perlmutter R, Holzbauer SM, Beldavs ZG, Phipps EC, Dunn JR, Cohen JA, Avillan J, Stone ND, Gerding DN, McDonald LC, Lessa FC. Burden of Nursing Home-Onset Clostridium difficile Infection in the United States: Estimates of Incidence and Patient Outcomes. Open forum infectious diseases 2016. PMID: 26798767


  33. Sujan C. Reddy, Alice Guh, Fernanda C. Lessa, Yi Mu, Zintars G. Beldavs, Corinne M. Davis, Ghinwa Dumyati, Stacy M. Holzbauer, Helen L. Johnston, Carol Lyons, Erin C. Phipps, Lucy E. Wilson, Lisa G. Winston, Dale N. Gerding, L. Clifford McDonald, Monica M. Farley. Risk Factors for Clostridium difficile Infection Recurrence. Open forum infectious diseases 2015. PMID:


  34. Dantes R, Mu Y, Hicks LA, Cohen J, Bamberg W, Beldavs ZG, Dumyati G, Farley MM, Holzbauer S, Meek J, Phipps E, Wilson L, Winston LG, McDonald LC, Lessa FC. Association Between Outpatient Antibiotic Prescribing Practices and Community-Associated Clostridium difficile Infection. Open forum infectious diseases 2015. PMID: 26509182


  35. Lessa FC, Winston LG, McDonald LC. Burden of Clostridium difficile infection in the United States. The New England journal of medicine 2015. PMID: 26061850


  36. Isaacson D, Haller B, Leslie H, Roemer M, Winston L. Novel handwashes are superior to soap and water in removal of Clostridium difficile spores from the hands. Volume 43 of Issue 5. American journal of infection control 2015. PMID: 25952050


  37. Lessa FC, Mu Y, Bamberg WM, Beldavs ZG, Dumyati GK, Dunn JR, Farley MM, Holzbauer SM, Meek JI, Phipps EC, Wilson LE, Winston LG, Cohen JA, Limbago BM, Fridkin SK, Gerding DN, McDonald LC. Burden of Clostridium difficile infection in the United States. The New England journal of medicine 2015. PMID: 25714160


  38. Rita P. Nguyen, Lisa G. Winston. A Critical Evaluation of Healthcare-Associated Pneumonia and the Need for Anti-pseudomonal Therapy, Including Double Coverage. Current Emergency and Hospital Medicine Reports 2014. PMID:


  39. Lessa FC, Mu Y, Winston LG, Dumyati GK, Farley MM, Beldavs ZG, Kast K, Holzbauer SM, Meek JI, Cohen J, McDonald LC, Fridkin SK. Determinants of Clostridium difficile Infection Incidence Across Diverse United States Geographic Locations. Open forum infectious diseases 2014. PMID: 25734120


  40. See I, Mu Y, Cohen J, Beldavs ZG, Winston LG, Dumyati G, Holzbauer S, Dunn J, Farley MM, Lyons C, Johnston H, Phipps E, Perlmutter R, Anderson L, Gerding DN, Lessa FC. NAP1 strain type predicts outcomes from Clostridium difficile infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014. PMID: 24604900


  41. Wendt JM, Cohen JA, Mu Y, Dumyati GK, Dunn JR, Holzbauer SM, Winston LG, Johnston HL, Meek JI, Farley MM, Wilson LE, Phipps EC, Beldavs ZG, Gerding DN, McDonald LC, Gould CV, Lessa FC. Clostridium difficile infection among children across diverse US geographic locations. Pediatrics 2014. PMID: 24590748


  42. Jennifer C. Hunter, Yi Mu, Ghinwa K. Dumyati, Monica M. Farley, Lisa G. Winston, Helen L. Johnston, James I. Meek, Lucy E. Wilson, M Stacy, Zintars G. Beldavs, Erin C. Phipps, John R. Dunn, Jessica a. Cohen, Nimalie D. Stone, L. Clifford Mcdonald, Fernanda C. Lessa. 524National estimates of incidence, recurrence, hospitalization, and death of nursing home-onset Clostridium difficile infections — United States, 2012. Open forum infectious diseases 2014. PMID:


  43. Gould CV, Edwards JR, Cohen J, Bamberg WM, Clark LA, Farley MM, Johnston H, Nadle J, Winston L, Gerding DN, McDonald LC, Lessa FC. Effect of nucleic acid amplification testing on population-based incidence rates of Clostridium difficile infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2013. PMID: 23899677


  44. Chitnis AS, Holzbauer SM, Belflower RM, Winston LG, Bamberg WM, Lyons C, Farley MM, Dumyati GK, Wilson LE, Beldavs ZG, Dunn JR, Gould LH, MacCannell DR, Gerding DN, McDonald LC, Lessa FC. Epidemiology of community-associated Clostridium difficile infection, 2009 through 2011. JAMA internal medicine 2013. PMID: 23780507


  45. Doernberg SB, Winston LG, Deck DH, Chambers HF. Does doxycycline protect against development of Clostridium difficile infection? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2012. PMID: 22563022


  46. Doernberg SB, Winston LG. Risk factors for acquisition of extended-spectrum ß-lactamase-producing Escherichia coli in an urban county hospital. American journal of infection control 2011. PMID: 21775020


  47. Chew KW, Yen IH, Li JZ, Winston LG. Predictors of pneumonia severity in HIV-infected adults admitted to an Urban public hospital. AIDS patient care and STDs 2011. PMID: 21488749


  48. Winston L, Chambers H. Coming home with MRSA. Archives of internal medicine 2009. PMID: 19667300


  49. Lisa G. Winston, Henry F. Chambers. Antimicrobial Resistance in Staphylococci: Mechanisms of Resistance and Clinical Implications. Antimicrobial Drug Resistance 2009. PMID:


  50. Lisa G. Winston, Daniel Deck, Ann F. Bolger. CHAPTER 81 ENDOCARDITIS. Pharmacology and Therapeutics 2009. PMID:


  51. Jain V, Yang MH, Kovacicova-Lezcano G, Juhle LS, Bolger AF, Winston LG. Infective endocarditis in an urban medical center: association of individual drugs with valvular involvement. The Journal of infection 2008. PMID: 18597851


  52. Dombrowski JC, Winston LG. Clinical failures of appropriately-treated methicillin-resistant Staphylococcus aureus infections. The Journal of infection 2008. PMID: 18533269


  53. Li JZ, Winston LG, Moore DH, Bent S. Efficacy of short-course antibiotic regimens for community-acquired pneumonia: a meta-analysis. The American journal of medicine 2007. PMID: 17765048


  54. Winston LG, Roemer M, Goodman C, Haller B. False-positive culture results from patient tissue specimens due to contamination of RPMI medium with Cryptococcus albidus. Volume 45 of Issue 5. Journal of clinical microbiology 2007. PMID: 17314221


  55. Weems JJ, Steinberg JP, Filler S, Baddley JW, Corey GR, Sampathkumar P, Winston L, John JF, Kubin CJ, Talwani R, Moore T, Patti JM, Hetherington S, Texter M, Wenzel E, Kelley VA, Fowler VG. Phase II, randomized, double-blind, multicenter study comparing the safety and pharmacokinetics of tefibazumab to placebo for treatment of Staphylococcus aureus bacteremia. Antimicrobial agents and chemotherapy 2006. PMID: 16870768


  56. Winston LG, Bolger AF. Modern epidemiology, prophylaxis, and diagnosis and therapy for infective endocarditis. Current cardiology reports 2006. PMID: 16524536


  57. Mendez MN, Gibbs L, Jacobs RA, McCulloch CE, Winston L, Guglielmo BJ. Impact of a piperacillin-tazobactam shortage on antimicrobial prescribing and the rate of vancomycin-resistant enterococci and Clostridium difficile infections. Pharmacotherapy 2006. PMID: 16509027


  58. Winston LG, Charlebois ED, Pang S, Bangsberg DR, Perdreau-Remington F, Chambers HF. Impact of a formulary switch from ticarcillin-clavulanate to piperacillin-tazobactam on colonization with vancomycin-resistant enterococci. American journal of infection control 2004. PMID: 15573053


  59. Winston LG, Felt SC, Huang WH, Chambers HF. Introduction of a waterless hand gel was associated with a reduced rate of ventilator-associated pneumonia in a surgical intensive care unit. Infection control and hospital epidemiology 2004. PMID: 15636285


  60. Young LS, Perdreau-Remington F, Winston LG. Clinical, epidemiologic, and molecular evaluation of a clonal outbreak of methicillin-resistant Staphylococcus aureus infection. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2004. PMID: 15095210


  61. Winston LG, Pang S, Haller BL, Wong M, Chambers HF, Perdreau-Remington F. API 20 strep identification system may incorrectly speciate enterococci with low level resistance to vancomycin. Volume 48 of Issue 4. Diagnostic microbiology and infectious disease 2004. PMID: 15062923


  62. Chambers HF, Winston LG. Mupirocin prophylaxis misses by a nose. Annals of internal medicine 2004. PMID: 15023716


  63. Winston L, Benowitz N. Once-daily dosing of aminoglycosides: how much monitoring is truly required? The American journal of medicine 2003. PMID: 12637142


  64. Winston LG, Bangsberg DR, Chambers HF, Felt SC, Rosen JI, Charlebois ED, Wong M, Steele L, Gerberding JL, Perdreau-Remington F. Epidemiology of vancomycin-resistant Enterococcus faecium under a selective isolation policy at an urban county hospital. American journal of infection control 2002. PMID: 12410216


  65. Winston LG, Perlman JL, Rose DA, Gerberding JL. Penicillin-nonsusceptible Streptococcus pneumoniae at San Francisco General Hospital. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 1999. PMID: 10530451