Leslie Benet, PhD

Professor

Clinical Pharmacology

Dr. Benet, Professor and former Chairman (1978-1998), Department of Bioengineering and Therapeutic Sciences, Schools of Pharmacy and Medicine, University of California, San Francisco, received his A.B. (English), B.S. (Pharmacy), M.S. from the University of Michigan and Ph.D. from the University of California. He has received nine honorary doctorates: Uppsala University, Sweden (Pharm.D., 1987), Leiden University, The Netherlands (Ph.D., 1995), University of Illinois at Chicago (D.Sc., 1997), Philadelphia College of Pharmacy and Science (D.Sc., 1997), Long Island University (D.Sc., 1999), University of Athens, Greece (Ph.D., 2005), Catholic University of Leuven, Belgium (Ph.D., 2010), University of Michigan (D.Sc., 2011) and University of Lisbon, Portugal (Ph.D., 2016). His research interests, more than 620 publications, 7 books and 12 patents are in the areas of pharmacokinetics, biopharmaceutics, drug delivery and pharmacodynamics. Dr. Benet is listed by Clarivate Analytics as one of the most highly cited pharmacologists worldwide with his published peer-reviewed papers cited over 33,000 times, while Google Scholar credits him with over 50,000 citations. His most recent work has addressed the deficiencies of in vitro-in vivo extrapolation (IVIVE) and different approaches to advancing our understanding and prediction of clearance processes. Dr. Benet was a Founder/Editor of the JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS (1973-98) and Associate Editor of PHARMACOLOGY AND THERAPEUTICS (1995-2000). He presently serves a member of the Editorial boards of PHARMACOLOGY and AAPS JOURNAL. He is a Fellow of the American Association for the Advancement of Science (AAAS), the American Association of Pharmaceutical Scientists (AAPS), the American College of Clinical Pharmacology (ACCP) and the Controlled Release Society (CRS). In 1982, Dr. Benet received the APhA Academy of Pharmaceutical Sciences (APS) Research Achievement Award in Pharmaceutics and the University of Michigan, College of Pharmacy, Distinguished Alumnus Award. In 1985, he served as President of APS. During 1986, Dr. Benet was a Founder and first President of the AAPS. In 1987, Dr. Benet was elected to membership in the National Academy of Medicine (NAM) of the U.S. National Academy of Sciences. In 1988, he received the ACCP Distinguished Service Award and in 1989, the AAPS Distinguished Pharmaceutical Scientist Award. In 1990, he was the recipient of the Rho Chi Lecture Award, and the UCSF Long Teaching Award, while in 1991, he received the Volwiler Research Achievement Award of the American Association of Colleges of Pharmacy (AACP). In 1993-94, he served as AACP President. In 1995, he received the Rawls-Palmer Progress in Medicine Award of the American Society for Clinical Pharmacology and Therapeutics (ASCPT); in 1996, the AAPS Distinguished Service Award; and in 2000 the APhA Takeru Higuchi Research Prize and the AAPS Wurster Research Award in Pharmaceutics. In 2001 he was awarded the Høst-Madsen Medal of the International Pharmaceutical Federation (FIP) and the UCSF Outstanding Faculty Mentorship Award (repeated in 2016). In 2004, he was awarded the Pharmaceutical Sciences World Congress Research Achievement Award and the CRS Career Achievement in Oral Drug Delivery Award. In 2007 he was selected as the UCSF Distinguished Clinical Research Lecturer; in 2010, the ASCPT Hunter Memorial Award in Therapeutics; and in 2011 the ACCP Distinguished Investigator award. In 2012, the September issue of PHARMACEUTICAL RESEARCH was dedicated in his honor and he was made an honorary member of FIP. In 2013, he was awarded the APhA Ebert Prize, the AAPS Journal Outstanding Manuscript award and the September issue of JOURNAL OF PHARMACEUTICAL SCIENCES was dedicated in his honor. In 2015 he received the ISSX North American Scientific Achievement award; in 2016 the Remington Honor Medal from the APhA, the highest honor in American Pharmacy; and in 2017 a full day symposium in his honor entitled “The Cutting Edge in Pharmaceutical Sciences—50 Years of Progress Celebrating Les Benet’s 80th Birthday” was held in conjunction with the Pharmaceutical Sciences World Congress in Stockholm, Sweden. In 2023 he received the Lifetime Achievement Award of the Frankfurt Foundation for the Quality of Medicines. Dr. Benet formerly served as Chair of the Pharmacology Study Section and the Pharmacological Sciences Review Committee for the NIH, the FDA CBER Peer Review Committee, the FDA Expert Panel on Individual Bioequivalence, the Board of Pharmaceutical Sciences of the FIP, the Organizing Committee for the FIP Millennial World Congress of Pharmaceutical Sciences, the Congressionally mandated NAM/National Research Council (NRC) Committee on Accelerating the Research, Development and Acquisition of Medical Countermeasures Against Biological Warfare Agents and the FIP Foundation for Education and Research and as a member of the FDA Science Board, the FDA Generic Drugs Advisory Committee and the NRC Biodefense Standing Committee. He presently serves as Chair of the Board of Directors of Medicines360, a nonprofit pharmaceutical company, emphasizing products for women’s health. July 2023

Education
Ph.D., 1965 - Graduate Division (Pharmaceutical Chemistry), University of California, San Francisco
Honors and Awards
  • Remington Honor Medal, American Pharmacists Association, 2016
  • Doctor of Philosophy, honoris causa, University of Lisbon, Portugal, 2016
  • William B. Abrams Lectureship, FDA/CDER and ASCPT, 2015
  • William B. Abrams Lectureship, FDA/CDER and American Society for Clinical Pharmacology and Therapeutics, 2015
  • North American Scientific Achievement Award, International Society for the Study of Xenobiotics, 2015
  • "25 Top Pharmacy Professors" in USA, Medical Technology Schools, 2015
  • Listed among "25 Top Pharmacy Professors" in the U.S.A., Medical Technology Schools, 2015
  • Guest Professorship, Sichuan University, Sichuan Province, China, 2014-2019
  • 1 of 16 pharmacologists worldwide to be listed in both 2001 and 2014 compilations, Thompson Reuters Highly Cited Researcher, 2014
  • Highly cited Researcher-Pharmacology, Thomson Reuters, 2014
  • AAPS Journal Manuscript Award for the Most Outstanding Manuscript, American Association of Pharmaceutical Scientists, 2013
  • 2013 APhA-APRS Ebert Prize, American Pharmacists Association Academy of Pharmaceutical Research and Science (APhA-APRS),, 2013
  • Busse Lecture, University of Wisconsin, 2013
  • Invited Plenary Lecture, CPSA Shanghai 2012: From Bench to Decision Making – From Basics to Applications, Shanghai, China, 2012
  • Honorary Member, Chinese Society of Clinical Pharmacy, Zhengzhou, China, 2012
  • Honorary Member, International Pharmaceutical Federation, The Netherlands, 2012
  • Invited Plenary Lecture, International Symposium on Past, Present and Future Molecular Pharmacokinetics, Tokyo, Japan, 2012
  • Invited Keynote Lecture, NRPB – AAPS Workshop on Clinical and Diagnostic Biomarkers, Taipei, Taiwan, 2012
  • Invited Keynote Lecture, Texas Tech University Health Science Center School of Pharmacy Research Days, Texas Tech University, 2012
  • Visiting Professor of the First Clinical Medical College of Zhengzhou University, and the Institute, Zhengzhou University, Henan Province, China, 2012
  • Distinguished Investigator Award, American College of Clinical Pharmacology, 40th Annual Meeting, Chicago, IL, 2011
  • The AstraZeneca Drug Hunting Lecture, AstraZeneca Research & Development Mölndal, Sweden, 2011
  • Invited Plenary Lecture, Symposium, Biomedical Centre, Uppsala University, Uppsala, Sweden, 2011
  • Inaugural Albert B. Prescott Distinguished Lecture, Horace Rackham School of Graduate Studies, University of Michigan, 2011
  • Named “National Associate”, National Research Council, 2011
  • Gerhard Levy Distinguished Lectureship in Pharmaceutical Sciences, State University of New York at Buffalo, 2011
  • Doctor of Science, honoris causa, University of Michigan, 2011
  • Invited Plenary Lecture, 18th International Symposium on Microsomes and Drug Oxidations, Beijing, China, 2010
  • Invited Plenary Lecture, 2010 Pharmaceutical Sciences World Congress and the AAPS Annual Meeting and Exposition, New Orleans,, 2010
  • Oscar B. Hunter Memorial Award in Therapeutics, American Society for Clinical Pharmacology and Therapeutics 111th Annual Meeting, Atlanta, Georgia, 2010
  • Doctor of Philosophy, honoris causa, Catholic University of Leuven, Leuven, Belgium, 2010
  • Elected Fellow, Controlled Release Society, 2010
  • Invited Keynote Lecture, The 42nd Annual Pharmaceutics Graduate Student Research Meeting (PGSRM), The Ohio State University, 2010
  • Invited Plenary Lecture, 129th Annual Meeting of the Pharmaceutical Society of Japan, Kyoto, Japan, 2009
  • Invited Plenary Lecture, 9th International Symposium of the Controlled Release Society Indian Chapter, Mumbai, India, 2009
  • Nagai Foundation Tokyo Distinguished Lectureship 2008, 2008
  • National Defense Medical Center, Taipei, 2008
  • Invited Keynote Speaker, 100th Anniversary of School of Pharmacy, NDMC; 2008 PST & TSHP Joint International Conference, 2008
  • Paul Ehrlich Magic-Bullet Award 2008 Lifetime Achievement, 100th Anniversary of the Nobel Prize Awarded to Paul Ehrlich, Nürnberg, Germany, 2008
  • Invited Featured Speaker, 109th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, 2008
  • Invited Plenary Lecture, 28th Annual Meeting of the Japanese Society for Drug Delivery Systems, Tokyo, Japan, 2008
  • Keynote Lecture, 8th International Symposium on Advances in Technology & Business Potential of New Drug Delivery Syst, 2008
  • Invited Plenary Lecture, Modified Release Forum, West Point, PA, 2008
  • Chair, Scientific Advisory Board, iMED.UL (Research Institute for Medicines and Pharmaceutical Sciences) University of Lisbon, Portuga, 2008
  • Plenary Lecture, 7th International Symposium on Advances in Technology and Business Potential of New Drug Delivery Sy, 2007
  • Keynote Lecture, Biocomputing Day, Division of Biocomputing, School of Medicine, University of New Mexico, 2007
  • International Honorary Member, Japan Society for the Study of Xenobiotics, Sendai, Japan, 2007
  • Keynote Lecture, Meeting of the European Drug Absorption Network, Leuven, Belgium, 2007
  • UCSF 7th Distinguished Clinical Research Lecturer, University of California San Francisco, 2007
  • Graduation Speaker, University of Michigan College of Pharmacy, Ann Arbor, MI, 2007
  • Plenary Lecture, 16th International Symposium on Microsomes and Drug Oxidation, Budapest, 2006
  • Plenary Lecture, 4th International COE Symposium, Target Validation, Lead Optimization & Clinical Development, Tokyo, 2006
  • Plenary Lecture, Analytica Conference 2006, Munich, Germany, 2006
  • Plenary Lecture, Canadian Society for Pharmaceutical Sciences 9th Annual International Symposium on Pharmaceutical Sc, 2006
  • Chair, Gordon Research Conference on Drug Metabolism, Plymouth, NH, 2006
  • Keynote Address, Great Lakes Symposium 2006, Buffalo, NY, 2006
  • Plenary Lecture, Journees Galeniques de Saint-Remy de Provence, Saint-Remy, France, 2006
  • Plenary Lecture, 2nd International Symposium on Scientific & Regulatory Aspects of Dissolution & Bioequivalence, 2005
  • Plenary Lecture, 9th International Congress of Therapeutic Drug Monitoring & Clinical Toxicology, 2005
  • Keynote Address, British Pharmaceutical Conference, Manchester, UK, 2005
  • Doctor of Philosophy, honoris causa, University of Athens, Greece, 2005
  • Career Achievement Award in Oral Drug Delivery, Controlled Release Society 2004 Annual Meeting & Exposition, 2004
  • Research Achievement Award in Pharmaceutical Sciences, Pharmaceutical Sciences World Congress 2004, Kyoto, 2004
  • Opening Plenary Lecture, First Congress of the Portuguese Society for Pharmaceutical Sciences, 2003
  • ISI Highly Cited Researcher, Institute for Scientific Information, 2003
  • Invested as a “Member of Honour”, Romanian Academy of Medical Sciences, 2003
  • Chair, IOM/NRC Committee on Accelerating the Research, Development and Acquisition, of Medical Countermeasures Against Biological Warfare Agents, 2002-2004
  • Plenary Lecture, 10th International Conference on Pharmaceutical Technology, Florence, Italy, 2002
  • Invested as a “Miembro Honorario”, Academia de Ciencias Farmacéuticas de Chile, Santiago, Chile, 2002
  • Plenary Lecture, International Pharmaceutical Technology Symposium 2002, Istanbul, Turkey, 2002
  • Elected Fellow, American Association of Indian Pharmaceutical Scientists, 2001
  • Høst-Madsen Medal, International Pharmaceutical Federation, 2001
Websites
Publications

  1. Benet LZ, Sodhi JK. Are all measures of liver Kpuu a function of FH, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance? European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2024. PMID: 38522769


  2. Wakuda H, Xiang Y, Sodhi JK, Uemura N, Benet LZ. An Explanation of Why Dose-Corrected Area Under the Curve for Alternate Administration Routes Can Be Greater than for Intravenous Dosing. The AAPS journal 2024. PMID: 38291293


  3. Benet LZ. Solubility-Permeability Interplay in Facilitating the Prediction of Drug Disposition Routes, Extent of Absorption, Food Effects, Brain Penetration and Drug Induced Liver Injury Potential. Journal of pharmaceutical sciences 2023. PMID: 37429358


  4. Benet LZ, Sodhi JK. The Uses and Advantages of Kirchhoff's Laws vs. Differential Equations in Pharmacology, Pharmacokinetics, and (Even) Chemistry. The AAPS journal 2023. PMID: 37038013


  5. Liu W, Yu Z, Wang Z, Waubant EL, Zhai S, Benet LZ. Using an animal model to predict the effective human dose for oral multiple sclerosis drugs. Clinical and translational science 2022. PMID: 36419359


  6. Pachter JA, Dill KA, Sodhi JK, Benet LZ. Review of the application of Kirchhoff's Laws of series and parallel flows to pharmacology: Defining organ clearance. Pharmacology & therapeutics 2022. PMID: 36075300


  7. Bocci G, Oprea TI, Benet LZ. State of the Art and Uses for the Biopharmaceutics Drug Disposition Classification System (BDDCS): New Additions, Revisions, and Citation References. TO REMOVE 2022. PMID: 35199251


  8. Kameyama T, Sodhi J, Benet LZ. Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide A Useful Improvement in In Vitro-In Vivo Extrapolation (IVIVE) Predictability? TO REMOVE 2022. PMID: 35086847


  9. Benet LZ, Sodhi JK. Can In Vitro In Vivo Extrapolation (IVIVE) Be Successful? Recognizing the Incorrect Clearance Assumptions. TO REMOVE 2021. PMID: 34731496


  10. Liu S, Sodhi JK, Benet LZ. Analyzing Potential Intestinal Transporter Drug-Drug Interactions: Reevaluating Ticagrelor Interaction Studies. TO REMOVE 2021. PMID: 34729703


  11. Burmeister Getz E, Carroll KJ, Mielke J, Jones B, Benet LZ. Batch Selection via In Vitro/In Vivo Correlation in Pharmacokinetic Bioequivalence Testing. TO REMOVE 2021. PMID: 34410534


  12. Bamfo NO, Hosey-Cojocari C, Benet LZ, Remsberg CM. Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans. TO REMOVE 2021. PMID: 34254223


  13. Xiang Y, Okochi H, Kozachenko I, Sodhi JK, Frassetto LA, Benet LZ. Effects of Single Dose Rifampin on the Pharmacokinetics of Fluvastatin in Healthy Volunteers. Clinical pharmacology and therapeutics 2021. PMID: 33880760


  14. Benet LZ, Sodhi JK, Makrygiorgos G, Mesbah A. There is Only One Valid Definition of Clearance: Critical Examination of Clearance Concepts Reveals the Potential for Errors in Clinical Drug Dosing Decisions. TO REMOVE 2021. PMID: 33973074


  15. Kou W, Sodhi JK, Wu X, Benet LZ. Investigating Intestinal Transporter Involvement in Rivaroxaban Disposition through Examination of Changes in Absorption. TO REMOVE 2021. PMID: 33847849


  16. Okochi H, Louie A, Phung N, Zhang K, Tallerico RM, Kuncze K, Spinelli MA, Koss CA, Benet LZ, Gandhi M. Tenofovir and emtricitabine concentrations in hair are comparable between individuals on tenofovir disoproxil fumarate versus tenofovir alafenamide-based ART. Drug testing and analysis 2021. PMID: 33742745


  17. Benet LZ. Using Individualized Patient Data for Prediction of Population Dosing Recommendations Versus Predictions of Individualized Patient Dosing. TO REMOVE 2021. PMID: 33742720


  18. Sodhi JK, Benet LZ. Successful and Unsuccessful Prediction of Human Hepatic Clearance for Lead Optimization. TO REMOVE 2021. PMID: 33765384


  19. Sodhi JK, Huang CH, Benet LZ. Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions. Clinical pharmacokinetics 2020. PMID: 32725383


  20. Sodhi JK, Liu S, Benet LZ. Intestinal Efflux Transporters P-gp and BCRP Are Not Clinically Relevant in Apixaban Disposition. TO REMOVE 2020. PMID: 32996065


  21. Benet LZ, Sodhi JK. Investigating the Theoretical Basis for In Vitro-In Vivo Extrapolation (IVIVE) in Predicting Drug Metabolic Clearance and Proposing Future Experimental Pathways. The AAPS journal 2020. PMID: 32914238


  22. Di L, Artursson P, Avdeef A, Benet L, Houston B, Kansy M, Kerns E, Lennernäs H, Smith D, Sugano K. The Critical Role of Passive Permeability in Designing Successful Drugs. ChemMedChem 2020. PMID: 32743945


  23. Sodhi JK, Benet LZ. The Necessity of Using Changes in Absorption Time to Implicate Intestinal Transporter Involvement in Oral Drug-Drug Interactions. The AAPS journal 2020. PMID: 32808084


  24. Sodhi JK, Benet LZ. A Simple Methodology to Differentiate Changes in Bioavailability from Changes in Clearance Following Oral Dosing of Metabolized Drugs. Clinical pharmacology and therapeutics 2020. PMID: 32150643


  25. Sodhi JK, Wang HJ, Benet LZ. Are there any experimental perfusion data that preferentially support the dispersion and parallel tube models over the well-stirred model of organ elimination? Drug metabolism and disposition: the biological fate of chemicals 2020. PMID: 32305951


  26. Liu W, Yan T, Chen K, Yang L, Benet L, Zhai S. Predicting Interactions between Rifampin and Antihypertensive Drugs Using the Biopharmaceutics Drug Disposition Classification System (BDDCS). Pharmacotherapy 2020. PMID: 32100890


  27. Sodhi JK, Liu S, Benet LZ. Challenging the Relevance of Unbound Tissue-to-Blood Partition Coefficient (Kpuu) on Prediction of Drug-Drug Interactions. Pharmaceutical research 2020. PMID: 32215750


  28. Sun A, Benet LZ. Late-Stage Failures of Monoclonal Antibody Drugs: A Retrospective Case Study Analysis. Pharmacology 2020. PMID: 31910414


  29. Bocci G, Benet LZ, Oprea TI. Can BDDCS illuminate targets in drug design? Drug discovery today 2019. PMID: 31585170


  30. Wang HJ, Benet LZ. Protein binding and hepatic clearance: Re-examining the discrimination between models of hepatic clearance with diazepam in the isolated perfused rat liver preparation. Drug metabolism and disposition: the biological fate of chemicals 2019. PMID: 31563869


  31. Bowman CM, Benet LZ. In Vitro - In Vivo Accuracy: The CYP3A4 Anomaly. Drug metabolism and disposition: the biological fate of chemicals 2019. PMID: 31551322


  32. Surofchy DD, Frassetto LA, Benet LZ. Food, Acid Supplementation and Drug Absorption - a Complicated Gastric Mix: a Randomized Control Trial. Pharmaceutical research 2019. PMID: 31485804


  33. Benet LZ, Bowman CM, Sodhi JK. How Transporters Have Changed Basic Pharmacokinetic Understanding. The AAPS journal 2019. PMID: 31482335


  34. Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ. The enhancement of subcutaneous first-pass metabolism causes non-linear pharmacokinetics of TAK-448 after a single subcutaneous administration to rats. Drug metabolism and disposition: the biological fate of chemicals 2019. PMID: 31201213


  35. Bowman CM, Benet LZ. Interlaboratory Variability in Human Hepatocyte Intrinsic Clearance Values and Trends with Physicochemical Properties. Pharmaceutical research 2019. PMID: 31152241


  36. Benet LZ, Bowman CM, Koleske ML, Rinaldi CL, Sodhi JK. Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs. Journal of pharmacokinetics and pharmacodynamics 2019. PMID: 30911879


  37. Bowman CM, Benet LZ. In vitro-in vivo extrapolation and hepatic clearance dependent underprediction. Journal of pharmaceutical sciences 2019. PMID: 30817922


  38. Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ. Characterization of fasiglifam-related liver toxicity in dogs. Drug metabolism and disposition: the biological fate of chemicals 2019. PMID: 30765394


  39. Bowman CM, Okochi H, Benet LZ. The Presence of a Transporter-Induced Protein Binding Shift: A new Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation. Drug metabolism and disposition: the biological fate of chemicals 2019. PMID: 30674616


  40. Benet LZ, Jayachandran P, Carroll KJ, Burmeister Getz E. Batch-to-Batch and Within-Subject Variability: What Do We Know and How Do These Variabilities Affect Clinical Pharmacology and Bioequivalence? Clinical pharmacology and therapeutics 2019. PMID: 30652313


  41. Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ. Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs. Clinical pharmacology and therapeutics 2019. PMID: 30652304


  42. Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR. TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling. International journal for parasitology. Drugs and drug resistance 2018. PMID: 30503203


  43. Benet LZ, Bowman CM, Liu S, Sodhi JK. The Extended Clearance Concept Following Oral and Intravenous Dosing: Theory and Critical Analyses. Pharmaceutical research 2018. PMID: 30349948


  44. Hysi PG, Khawaja AP, Menni C, Tamraz B, Wareham N, Khaw KT, Foster PJ, Benet LZ, Spector TD, Hammond CJ. Ascorbic acid metabolites are involved in intraocular pressure control in the general population. Redox biology 2018. PMID: 30391827


  45. Gandhi M, Bacchetti P, Rodrigues WC, Spinelli M, Koss CA, Drain PK, Baeten JM, Mugo NR, Ngure K, Benet LZ, Okochi H, Wang G, Vincent M. Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence. EClinicalMedicine 2018. PMID: 30906930


  46. Bowman CM, Benet LZ. An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2018. PMID: 30098391


  47. Chan R, Benet LZ. Evaluation of the Relevance of DILI Predictive Hypotheses in Early Drug Development: Review of In Vitro Methodologies vs BDDCS Classification. Toxicology research 2018. PMID: 29785262


  48. Benet LZ. Predicting Pharmacokinetics/Pharmacodynamics in the Individual Patient: Separating Reality From Hype. Journal of clinical pharmacology 2018. PMID: 29663413


  49. Chan R, Benet LZ. Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI. Volume 162 of Issue 2. Toxicological sciences : an official journal of the Society of Toxicology 2018. PMID: 29272540


  50. Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S. A Drug-drug Interaction Between Cyclosporine and Nystatin. Clinical therapeutics 2018. PMID: 29551534


  51. Phung N, Kuncze K, Okochi H, Louie A, Benet LZ, Ofokotun I, Haas DW, Currier JS, Chawana TD, Sheth AN, Bacchetti P, Gandhi M, Horng H. Development and validation of an assay to analyze atazanavir in human hair via liquid chromatography/tandem mass spectrometry. Volume 32 of Issue 5. Rapid communications in mass spectrometry : RCM 2018. PMID: 29315954


  52. Parasrampuria DA, Benet LZ, Sharma A. Why Drugs Fail in Late Stages of Development: Case Study Analyses from the Last Decade and Recommendations. The AAPS journal 2018. PMID: 29536211


  53. Park J, Thomas S, Zhong AY, Wolfe AR, Krings G, Terranova-Barberio M, Pawlowska N, Benet LZ, Munster PN. Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer. Volume 8 of Issue 1. Scientific Reports 2018. PMID: 29311658


  54. Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, Benet LZ, Kuncze K, Louie A, Saberi P, Wilson CM, Gandhi M. Comparison of Measures of Adherence to HIV Preexposure Prophylaxis among Adolescent and Young Men Who Have Sex with Men in the United States. Volume 66 of Issue 2. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017. PMID: 29020194


  55. Benet LZ, Liu S, Wolfe AR. The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio. Clinical pharmacology and therapeutics 2017. PMID: 28762489


  56. Morrissey KM, Benet LZ, Ware JA. Commentary on: "Influence of OATP1B1 Function on the Disposition of Sorafenib-ß-D-Glucuronide". Clinical and translational science 2017. PMID: 28664655


  57. Benet LZ, Wu HF. Understanding the Potential Interethnic Difference in Rosuvastatin Pharmacokinetics. Volume 106 of Issue 9. Journal of pharmaceutical sciences 2017. PMID: 28502797


  58. Noguchi S, Nishimura T, Mukaida S, Benet LZ, Nakashima E, Tomi M. Cellular Uptake of Levocetirizine by Organic Anion Transporter 4. Volume 106 of Issue 9. Journal of pharmaceutical sciences 2017. PMID: 28385546


  59. Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ. Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions. Volume 106 of Issue 9. Journal of pharmaceutical sciences 2017. PMID: 28385543


  60. Chan R, Benet LZ. Evaluation of DILI Predictive Hypotheses in Early Drug Development. Volume 30 of Issue 4. Chemical research in toxicology 2017. PMID: 28257576


  61. Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, Chirenje ZM, Marrazzo JM, Gandhi M. Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations. AIDS research and human retroviruses 2017. PMID: 28253024


  62. Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ. Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption. Volume 34 of Issue 3. Pharmaceutical research 2016. PMID: 28028768


  63. Li J, Larregieu CA, Benet LZ. Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system (BDDCS). Volume 14 of Issue 12. Chinese journal of natural medicines 2016. PMID: 28262115


  64. Burmeister Getz E, Carroll KJ, Mielke J, Benet LZ, Jones B. Between-Batch Pharmacokinetic Variability Inflates Type I Error Rate in Conventional Bioequivalence Trials: A Randomized Advair Diskus Clinical Trial. Volume 101 of Issue 3. Clinical pharmacology and therapeutics 2016. PMID: 27727445


  65. Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM. Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study. Volume 3 of Issue 11. The lancet. HIV 2016. PMID: 27658870


  66. Bowman CM, Benet LZ. Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System. Volume 44 of Issue 11. Drug metabolism and disposition: the biological fate of chemicals 2016. PMID: 27519549


  67. Benet LZ. 2016 Remington Honor Medal Address: Science for the profession. Volume 56 of Issue 4. Journal of the American Pharmacists Association : JAPhA 2016. PMID: 27450136


  68. Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M. Isoniazid hair concentrations in children with tuberculosis: a proof of concept study. Volume 20 of Issue 6. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 2016. PMID: 27155191


  69. Benet LZ, Hosey CM, Ursu O, Oprea TI. BDDCS, the Rule of 5 and drugability. Volume 101. Advanced drug delivery reviews 2016. PMID: 27182629


  70. Burmeister Getz E, Carroll KJ, Jones B, Benet LZ. Batch-to-batch pharmacokinetic variability confounds current bioequivalence regulations: A dry powder inhaler randomized clinical trial. Volume 100 of Issue 3. Clinical pharmacology and therapeutics 2016. PMID: 27037630


  71. Chan R, Wei CY, Chen YT, Benet LZ. Use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to Help Predict the Occurrence of Idiosyncratic Cutaneous Adverse Drug Reactions Associated with Antiepileptic Drug Usage. Volume 18 of Issue 3. The AAPS journal 2016. PMID: 26951484


  72. Zheng Y, Chen X, Benet LZ. Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain. Volume 55 of Issue 2. Clinical pharmacokinetics 2016. PMID: 26293617


  73. Hosey CM, Chan R, Benet LZ. BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs. Volume 18 of Issue 1. The AAPS journal 2015. PMID: 26589308


  74. Garrison KL, Sahin S, Benet LZ. Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS. Volume 104 of Issue 9. Journal of pharmaceutical sciences 2015. PMID: 26010239


  75. Hosey CM, Benet LZ. Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions. Volume 12 of Issue 5. Molecular pharmaceutics 2015. PMID: 25816851


  76. Zheng Y, Benet LZ, Okochi H, Chen X. pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion. Volume 32 of Issue 8. Pharmaceutical research 2015. PMID: 25690341


  77. Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG. A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia. Volume 15 of Issue 6. Clinical lymphoma, myeloma & leukemia 2015. PMID: 25776193


  78. Parasrampuria DA, Benet LZ. Inclusion of placebos and blinding for ascending dose first-in-human studies and other underpowered phase 1 studies has not been justified and on balance is not useful. Volume 117 of Issue 1. Basic & clinical pharmacology & toxicology 2014. PMID: 25406995


  79. Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA. The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria. Volume 16 of Issue 6. The AAPS journal 2014. PMID: 25274610


  80. Hosey CM, Broccatelli F, Benet LZ. Predicting when biliary excretion of parent drug is a major route of elimination in humans. Volume 16 of Issue 5. The AAPS journal 2014. PMID: 25004821


  81. Larregieu CA, Benet LZ. Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery. Volume 11 of Issue 4. Molecular pharmaceutics 2014. PMID: 24628254


  82. Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ. Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients. Volume 97 of Issue 6. Transplantation 2014. PMID: 24389906


  83. Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S. Mouse liver repopulation with hepatocytes generated from human fibroblasts. Volume 508 of Issue 7494. Nature 2014. PMID: 24572354


  84. Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA. Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development. Volume 10 of Issue 11. Molecular pharmaceutics 2013. PMID: 24044612


  85. Estudante M, Maya M, Morais JG, Soveral G, Benet LZ. Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil. Volume 10 of Issue 11. Molecular pharmaceutics 2013. PMID: 24044638


  86. Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L. Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients. Volume 34 of Issue 8. Biopharmaceutics & drug disposition 2013. PMID: 24030928


  87. Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ. Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Volume 10 of Issue 11. Molecular pharmaceutics 2013. PMID: 23980906


  88. Horng H, Benet LZ. The nonenzymatic reactivity of the acyl-linked metabolites of mefenamic acid toward amino and thiol functional group bionucleophiles. Volume 41 of Issue 11. Drug metabolism and disposition: the biological fate of chemicals 2013. PMID: 23975029


  89. Horng H, Benet LZ. Characterization of the acyl-adenylate linked metabolite of mefenamic Acid. Volume 26 of Issue 3. Chemical research in toxicology 2013. PMID: 23402341


  90. Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB. Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice. Volume 30 of Issue 4. Pharmaceutical research 2013. PMID: 23417511


  91. Larregieu CA, Benet LZ. Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements. Volume 15 of Issue 2. The AAPS journal 2013. PMID: 23344793


  92. Benet LZ. The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development. Volume 102 of Issue 1. Journal of pharmaceutical sciences 2012. PMID: 23147500


  93. Benet LZ. A step closer to personalized chemotherapy: consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates. Volume 92 of Issue 5. Clinical pharmacology and therapeutics 2012. PMID: 23085879


  94. Estudante M, Morais JG, Soveral G, Benet LZ. Intestinal drug transporters: an overview. Volume 65 of Issue 10. Advanced drug delivery reviews 2012. PMID: 23041352


  95. Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA. Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy? Volume 92 of Issue 2. Clinical pharmacology and therapeutics 2012. PMID: 22739140


  96. Benet LZ. Benet L Z and Galeazzi R L: noncompartmental determination of the steady-state volume of distribution, J Pharm Sci 68, 1071-1074, 1979--the backstory. Volume 14 of Issue 2. The AAPS journal 2012. PMID: 22302585


  97. Liu W, Okochi H, Benet LZ, Zhai SD. Sotalol permeability in cultured-cell, rat intestine, and PAMPA system. Volume 29 of Issue 7. Pharmaceutical research 2012. PMID: 22350803


  98. Broccatelli F, Cruciani G, Benet LZ, Oprea TI. BDDCS class prediction for new molecular entities. Volume 9 of Issue 3. Molecular pharmaceutics 2012. PMID: 22224483


  99. Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ. Improving the prediction of the brain disposition for orally administered drugs using BDDCS. Volume 64 of Issue 1. Advanced drug delivery reviews 2011. PMID: 22261306


  100. Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL. Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations. Volume 31 of Issue 9. Pharmacotherapy 2011. PMID: 21923588


  101. Grover A, Frassetto LA, Benet LZ, Chakkera HA. Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients. Volume 39 of Issue 11. Drug metabolism and disposition: the biological fate of chemicals 2011. PMID: 21849516


  102. Benet LZ, Broccatelli F, Oprea TI. BDDCS applied to over 900 drugs. Volume 13 of Issue 4. The AAPS journal 2011. PMID: 21818695


  103. Rowland M, Benet LZ. Lead PK commentary: predicting human pharmacokinetics. Volume 100 of Issue 10. Journal of pharmaceutical sciences 2011. PMID: 21630278


  104. Terasaki T, Sugiyama Y, Benet LZ. Professor Akira Tsuji: scientist, educator, and leader. Volume 100 of Issue 9. Journal of pharmaceutical sciences 2011. PMID: 21630279


  105. Reyes M, Benet LZ. Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics. Volume 100 of Issue 9. Journal of pharmaceutical sciences 2011. PMID: 21618544


  106. Grover A, Benet LZ. Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation. Volume 38 of Issue 3. Journal of pharmacokinetics and pharmacodynamics 2011. PMID: 21499748


  107. Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX. The BCS, BDDCS, and regulatory guidances. Volume 28 of Issue 7. Pharmaceutical research 2011. PMID: 21491148


  108. Park MS, Okochi H, Benet LZ. Is Ciprofloxacin a Substrate of P-glycoprotein? Volume 4 of Issue 1. Archives of drug information 2011. PMID: 21572514


  109. Aarons L, Benet LZ. Founding figures of pharmacokinetics: tribute to Malcolm Rowland. Volume 37 of Issue 6. Journal of pharmacokinetics and pharmacodynamics 2010. PMID: 21069561


  110. Benet LZ. Clearance (née Rowland) concepts: a downdate and an update. Volume 37 of Issue 6. Journal of pharmacokinetics and pharmacodynamics 2010. PMID: 21113650


  111. Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ. Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism. Volume 32 of Issue 1. Neurotoxicology 2010. PMID: 21075140


  112. Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ. Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers. Volume 88 of Issue 4. Clinical pharmacology and therapeutics 2010. PMID: 20703222


  113. Benet LZ, Larregieu CA. The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted. Volume 88 of Issue 3. Clinical pharmacology and therapeutics 2010. PMID: 20668447


  114. . Membrane transporters in drug development. Volume 9 of Issue 3. Nature reviews. Drug discovery 2010. PMID: 20190787


  115. Frymoyer A, Hersh AL, Coralic Z, Benet LZ, Joseph Guglielmo B. Prediction of vancomycin pharmacodynamics in children with invasive methicillin-resistant Staphylococcus aureus infections: a Monte Carlo simulation. Volume 32 of Issue 3. Clinical therapeutics 2010. PMID: 20399990


  116. Sun H, Frassetto LA, Huang Y, Benet LZ. Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease. Volume 87 of Issue 4. Clinical pharmacology and therapeutics 2010. PMID: 20090676


  117. Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ. Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes. Volume 38 of Issue 1. Drug metabolism and disposition: the biological fate of chemicals 2010. PMID: 19786506


  118. Benet LZ. Predicting drug disposition via application of a Biopharmaceutics Drug Disposition Classification System. Volume 106 of Issue 3. Basic & clinical pharmacology & toxicology 2009. PMID: 20002064


  119. de Souza J, Benet LZ, Huang Y, Storpirtis S. Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers. Volume 98 of Issue 11. Journal of pharmaceutical sciences 2009. PMID: 19472342


  120. Benet LZ. The drug transporter-metabolism alliance: uncovering and defining the interplay. Volume 6 of Issue 6. Molecular pharmaceutics 2009. PMID: 19874004


  121. Benet LZ. A Holy Grail of clinical pharmacology: prediction of drug pharmacokinetics and pharmacodynamics in the individual patient. Volume 86 of Issue 2. Clinical pharmacology and therapeutics 2009. PMID: 19621007


  122. Shugarts S, Benet LZ. The role of transporters in the pharmacokinetics of orally administered drugs. Volume 26 of Issue 9. Pharmaceutical research 2009. PMID: 19568696


  123. Frymoyer A, Hersh AL, Benet LZ, Guglielmo BJ. Current recommended dosing of vancomycin for children with invasive methicillin-resistant Staphylococcus aureus infections is inadequate. Volume 28 of Issue 5. The Pediatric infectious disease journal 2009. PMID: 19295465


  124. Grover A, Benet LZ. Effects of drug transporters on volume of distribution. Volume 11 of Issue 2. The AAPS journal 2009. PMID: 19399628


  125. Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM. Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women. Volume 50 of Issue 5. Journal of acquired immune deficiency syndromes (1999) 2009. PMID: 19408353


  126. Sahin S, Benet LZ. The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms. Volume 25 of Issue 12. Pharmaceutical research 2008. PMID: 19015955


  127. Zheng HX, Huang Y, Frassetto LA, Benet LZ. Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite. Volume 85 of Issue 1. Clinical pharmacology and therapeutics 2008. PMID: 18843263


  128. Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J. Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4. Volume 2 of Issue 5. Journal of infection in developing countries 2008. PMID: 19745507


  129. Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA. Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat. Volume 21 of Issue 10. Chemical research in toxicology 2008. PMID: 18693772


  130. Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX. The use of BDDCS in classifying the permeability of marketed drugs. Volume 25 of Issue 3. Pharmaceutical research 2008. PMID: 18236138


  131. Li C, Grillo MP, Badagnani I, Fife KL, Benet LZ. Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats. Volume 36 of Issue 4. Drug metabolism and disposition: the biological fate of chemicals 2008. PMID: 18187563


  132. Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG. HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes. Volume 8 of Issue 2. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007. PMID: 18093266


  133. Custodio JM, Wu CY, Benet LZ. Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption. Volume 60 of Issue 6. Advanced drug delivery reviews 2007. PMID: 18199522


  134. Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ. Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients. Volume 7 of Issue 12. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2007. PMID: 17949460


  135. Boernsen KO, Egge-Jacobsen W, Inverardi B, Strom T, Streit F, Schiebel HM, Benet LZ, Christians U. Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus. Volume 42 of Issue 6. Journal of mass spectrometry : JMS 2007. PMID: 17511017


  136. Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ. Effects of uptake and efflux transporter inhibition on erythromycin breath test results. Volume 81 of Issue 6. Clinical pharmacology and therapeutics 2007. PMID: 17361125


  137. Olsen J, Li C, Skonberg C, Bjørnsdottir I, Sidenius U, Benet LZ, Hansen SH. Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats. Volume 35 of Issue 5. Drug metabolism and disposition: the biological fate of chemicals 2007. PMID: 17303625


  138. Lau YY, Huang Y, Frassetto L, Benet LZ. effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers. Volume 81 of Issue 2. Clinical pharmacology and therapeutics 2006. PMID: 17192770


  139. Lam JL, Shugarts SB, Okochi H, Benet LZ. Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism. Volume 319 of Issue 2. The Journal of pharmacology and experimental therapeutics 2006. PMID: 16905688


  140. Lam JL, Okochi H, Huang Y, Benet LZ. In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay. Volume 34 of Issue 8. Drug metabolism and disposition: the biological fate of chemicals 2006. PMID: 16698890


  141. Lau YY, Okochi H, Huang Y, Benet LZ. Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism. Volume 34 of Issue 7. Drug metabolism and disposition: the biological fate of chemicals 2006. PMID: 16624870


  142. Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Volume 34 of Issue 7. Drug metabolism and disposition: the biological fate of chemicals 2006. PMID: 16581945


  143. Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET. Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma. Volume 20 of Issue 10. Rapid communications in mass spectrometry : RCM 2006. PMID: 16628600


  144. Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH. A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi. Volume 49 of Issue 12. Antimicrobial agents and chemotherapy 2005. PMID: 16304193


  145. Olsen J, Li C, Bjørnsdottir I, Sidenius U, Hansen SH, Benet LZ. In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats. Volume 18 of Issue 11. Chemical research in toxicology 2005. PMID: 16300382


  146. Lau YY, Okochi H, Huang Y, Benet LZ. Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems. Volume 316 of Issue 2. The Journal of pharmacology and experimental therapeutics 2005. PMID: 16258024


  147. Chang JH, Benet LZ. Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells. Volume 2 of Issue 5. Molecular pharmaceutics 2005. PMID: 16196496


  148. Sun H, Frassetto L, Benet LZ. Effects of renal failure on drug transport and metabolism. Volume 109 of Issue 1-2. Pharmacology & therapeutics 2005. PMID: 16085315


  149. Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L. Effects of short-term alendronate on bone mineral density in haemodialysis patients. Volume 10 of Issue 4. Nephrology (Carlton, Vic.) 2005. PMID: 16109088


  150. Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ. Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients. Volume 80 of Issue 1. Transplantation 2005. PMID: 16003227


  151. Putnam WS, Woo JM, Huang Y, Benet LZ. Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics. Volume 45 of Issue 4. Journal of clinical pharmacology 2005. PMID: 15778422


  152. Benet LZ. There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found. Volume 5 of Issue 2. Molecular interventions 2005. PMID: 15821156


  153. Benet L. Basic pharmacological interactions and how they may impact on one another. Volume 38 Suppl 1. Journal of acquired immune deficiency syndromes (1999) 2005. PMID: 15867606


  154. Wu CY, Benet LZ. Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Volume 22 of Issue 1. Pharmaceutical research 2005. PMID: 15771225


  155. Mohri K, Okada K, Benet LZ. Stereoselective taurine conjugation of (R)-benoxaprofen enantiomer in rats: in vivo and in vitro studies using rat hepatic mitochondria and microsomes. Volume 22 of Issue 1. Pharmaceutical research 2005. PMID: 15771233


  156. Lam JL, Benet LZ. Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes. Volume 32 of Issue 11. Drug metabolism and disposition: the biological fate of chemicals 2004. PMID: 15483198


  157. Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U. Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors. Volume 26 of Issue 5. Therapeutic drug monitoring 2004. PMID: 15385839


  158. Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M. Novel percutaneous adventitial drug delivery system for regional vascular treatment. Volume 63 of Issue 2. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 2004. PMID: 15390346


  159. Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N. Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors. Volume 143 of Issue 3. British journal of pharmacology 2004. PMID: 15339861


  160. Sun H, Huang Y, Frassetto L, Benet LZ. Effects of uremic toxins on hepatic uptake and metabolism of erythromycin. Volume 32 of Issue 11. Drug metabolism and disposition: the biological fate of chemicals 2004. PMID: 15286055


  161. Kim WY, Benet LZ. P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Volume 21 of Issue 7. Pharmaceutical research 2004. PMID: 15290871


  162. Benet LZ, Cummins CL, Wu CY. Unmasking the dynamic interplay between efflux transporters and metabolic enzymes. International journal of pharmaceutics 2004. PMID: 15158963


  163. Frassetto LA, Benet LZ. Pharmacogenomics and transplantation: where are we? Volume 4 of Issue 6. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2004. PMID: 15147415


  164. Serkova NJ, Christians U, Benet LZ. Biochemical mechanisms of cyclosporine neurotoxicity. Volume 4 of Issue 2. Molecular interventions 2004. PMID: 15087483


  165. Lau YY, Wu CY, Okochi H, Benet LZ. Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay. Volume 308 of Issue 3. The Journal of pharmacology and experimental therapeutics 2003. PMID: 14634033


  166. Wu CY, Benet LZ. Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918. Volume 31 of Issue 11. Drug metabolism and disposition: the biological fate of chemicals 2003. PMID: 14570757


  167. Cummins CL, Jacobsen W, Christians U, Benet LZ. CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam. Volume 308 of Issue 1. The Journal of pharmacology and experimental therapeutics 2003. PMID: 14569063


  168. Benet LZ, Cummins CL, Wu CY. Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data. Current drug metabolism 2003. PMID: 14529371


  169. Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ. Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro. Volume 31 of Issue 6. Drug metabolism and disposition: the biological fate of chemicals 2003. PMID: 12756204


  170. Li C, Grillo MP, Benet LZ. In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat. Volume 305 of Issue 1. The Journal of pharmacology and experimental therapeutics 2003. PMID: 12649376


  171. Cummins CL, Salphati L, Reid MJ, Benet LZ. In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model. Volume 305 of Issue 1. The Journal of pharmacology and experimental therapeutics 2003. PMID: 12649383


  172. Li C, Grillo MP, Benet LZ. In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester. Volume 187 of Issue 2. Toxicology and applied pharmacology 2003. PMID: 12649042


  173. Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC. Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects. Volume 18 of Issue 2. Drug metabolism and pharmacokinetics 2003. PMID: 15618725


  174. Hebert MF, Wacher VJ, Roberts JP, Benet LZ. Pharmacokinetics of cyclosporine pre- and post-liver transplantation. Volume 43 of Issue 1. Journal of clinical pharmacology 2003. PMID: 12520626


  175. Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ. Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). Volume 68 of Issue 12. Planta medica 2002. PMID: 12494328


  176. Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N. Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine. Volume 302 of Issue 3. The Journal of pharmacology and experimental therapeutics 2002. PMID: 12183671


  177. Susanto M, Benet LZ. Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport? Volume 19 of Issue 4. Pharmaceutical research 2002. PMID: 12033380


  178. Benet LZ, Hoener BA. Changes in plasma protein binding have little clinical relevance. Volume 71 of Issue 3. Clinical pharmacology and therapeutics 2002. PMID: 11907485


  179. Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U. Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia. Volume 22 of Issue 3. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2002. PMID: 11891440


  180. Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ. Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation. Volume 42 of Issue 3. Journal of clinical pharmacology 2002. PMID: 11865967


  181. Cummins CL, Jacobsen W, Benet LZ. Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4. Volume 300 of Issue 3. The Journal of pharmacology and experimental therapeutics 2002. PMID: 11861813


  182. Unger M, Jacobsen W, Holzgrabe U, Benet LZ. Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction. Volume 767 of Issue 2. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2002. PMID: 11885853


  183. Grillo MP, Benet LZ. Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro. Volume 30 of Issue 1. Drug metabolism and disposition: the biological fate of chemicals 2002. PMID: 11744612


  184. Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A. Red wine decreases cyclosporine bioavailability. Clinical pharmacology and therapeutics 2001. PMID: 11719733


  185. Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U. Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain. British journal of pharmacology 2001. PMID: 11454661


  186. Wacher VJ, Salphati L, Benet LZ. Active secretion and enterocytic drug metabolism barriers to drug absorption. Advanced drug delivery reviews 2001. PMID: 11259835


  187. Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U. Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD. Transplantation proceedings 2001. PMID: 11266932


  188. Sawamoto T, Van Gelder T, Christians U, Okamura N, Jacobsen W, Benet L. Membrane transport of mycophenolate mofetil and its active metabolite, mycophenolic acid in MDCK and MDR1-MDCK cell monolayers. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 2001. PMID: 11250452


  189. Parasrampuria DA, Lantz MV, Benet LZ. A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function. Pharmaceutical research 2001. PMID: 11336351


  190. Qiu Y, Benet LZ, Burlingame AL. Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry. Advances in experimental medicine and biology 2001. PMID: 11765013


  191. Zhang Y, Benet LZ. The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein. Clinical pharmacokinetics 2001. PMID: 11327196


  192. Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U. The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups. Clinical pharmacology and therapeutics 2001. PMID: 11180035


  193. Jacobsen W, Christians U, Benet LZ. In vitro evaluation of the disposition of A novel cysteine protease inhibitor. Drug metabolism and disposition: the biological fate of chemicals 2000. PMID: 11038163


  194. Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U. Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin. Drug metabolism and disposition: the biological fate of chemicals 2000. PMID: 11038166


  195. Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, Manns MP, Kirchner GI. Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants. Journal of chromatography. B, Biomedical sciences and applications 2000. PMID: 11092585


  196. Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, Christians U. Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine. The Journal of pharmacology and experimental therapeutics 2000. PMID: 10871329


  197. Christians U, First MR, Benet LZ. Recommendations for bioequivalence testing of cyclosporine generics revisited. Therapeutic drug monitoring 2000. PMID: 10850403


  198. Soldner A, Benet LZ, Mutschler E, Christians U. Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers. British journal of pharmacology 2000. PMID: 10725273


  199. Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U. The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates. British journal of pharmacology 2000. PMID: 10711346


  200. Hausen B, Ikonen T, Briffa N, Berry GJ, Christians U, Robbins RC, Hook L, Serkova N, Benet LZ, Schuler W, Morris RE. Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability. Transplantation 2000. PMID: 10653384


  201. Jäger W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, Benet LZ. Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism. Volume 27 of Issue 12. Drug metabolism and disposition: the biological fate of chemicals 1999. PMID: 10570034


  202. Benet LZ, Izumi T, Zhang Y, Silverman JA, Wacher VJ. Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery. Journal of controlled release : official journal of the Controlled Release Society 1999. PMID: 10518631


  203. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Baner K, Benet LZ, Sewing KF, Christians U. Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin. The Journal of pharmacology and experimental therapeutics 1999. PMID: 10490896


  204. Mizuma T, McDonagh AF, Lin ET, Benet LZ. Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin. British journal of clinical pharmacology 1999. PMID: 10383564


  205. Serkova N, Litt L, James TL, Sadée W, Leibfritz D, Benet LZ, Christians U. Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy. The Journal of pharmacology and experimental therapeutics 1999. PMID: 10215655


  206. Benet LZ. Relevance of pharmacokinetics in narrow therapeutic index drugs. Transplantation proceedings 1999. PMID: 10331032


  207. Benet LZ. Understanding bioequivalence testing. Transplantation proceedings 1999. PMID: 10330950


  208. Hausen B, Boeke K, Berry GJ, Segarra I, Benet LZ, Christians U, Morris RE. Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment. Transplantation 1999. PMID: 10221478


  209. Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ. Grapefruit juice activates P-glycoprotein-mediated drug transport. Pharmaceutical research 1999. PMID: 10227700


  210. Mizuma T, Benet LZ, Lin ET. Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding of a 1-O-acyl glucuronide metabolite. Biopharmaceutics & drug disposition 1999. PMID: 10211865


  211. Zhang Y, Guo X, Lin ET, Benet LZ. In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes. Pharmacology 1999. PMID: 9925971


  212. Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U. Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug metabolism and disposition: the biological fate of chemicals 1999. PMID: 9929499


  213. Salphati L, Benet LZ. Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A. Xenobiotica; the fate of foreign compounds in biological systems 1999. PMID: 10199593


  214. Hall SD, Thummel KE, Watkins PB, Lown KS, Benet LZ, Paine MF, Mayo RR, Turgeon DK, Bailey DG, Fontana RJ, Wrighton SA. Molecular and physical mechanisms of first-pass extraction. Drug metabolism and disposition: the biological fate of chemicals 1999. PMID: 9929497


  215. Flanagan SD, Benet LZ. Net secretion of furosemide is subject to indomethacin inhibition, as observed in Caco-2 monolayers and excised rat jejunum. Pharmaceutical research 1999. PMID: 10100306


  216. Segarra I, Brazelton TR, Guterman N, Hausen B, Jacobsen W, Morris RE, Benet LZ, Christians U. Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin. Journal of chromatography. B, Biomedical sciences and applications 1998. PMID: 9892080


  217. Tsunoda SM, Harris RZ, Mroczkowski PJ, Benet LZ. Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women. Journal of clinical pharmacology 1998. PMID: 11301566


  218. Wacher VJ, Silverman JA, Zhang Y, Benet LZ. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. Journal of pharmaceutical sciences 1998. PMID: 9811484


  219. Mizuma T, Benet LZ, Lin ET. High-performance liquid chromatographic determination and identification of acyl migration and photodegradation products of furosemide 1-O-acyl glucuronide. Journal of chromatography. B, Biomedical sciences and applications 1998. PMID: 9832372


  220. Zhang Y, Benet LZ. Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers. Pharmaceutical research 1998. PMID: 9794492


  221. Zhang Y, Hsieh Y, Izumi T, Lin ET, Benet LZ. Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats. The Journal of pharmacology and experimental therapeutics 1998. PMID: 9765344


  222. Benet LZ. Impact of intraindividual variability of drugs on therapeutic outcomes: lessons from outside transplantation. Transplantation proceedings 1998. PMID: 9723227


  223. Qiu Y, Benet LZ, Burlingame AL. Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry. The Journal of biological chemistry 1998. PMID: 9651401


  224. Salphati L, Benet LZ. Effects of ketoconazole on digoxin absorption and disposition in rat. Pharmacology 1998. PMID: 9654217


  225. Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. The Journal of pharmacology and experimental therapeutics 1998. PMID: 9618413


  226. Zhang Y, Guo X, Lin ET, Benet LZ. Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor. Drug metabolism and disposition: the biological fate of chemicals 1998. PMID: 9531525


  227. Mohri K, Okada K, Benet LZ. Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide. Drug metabolism and disposition: the biological fate of chemicals 1998. PMID: 9531520


  228. Jang GR, Benet LZ. Antiprogestin-mediated inactivation of cytochrome P450 3A4. Pharmacology 1998. PMID: 9532615


  229. Qiu Y, Burlingame AL, Benet LZ. Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals 1998. PMID: 9492388


  230. Salphati L, Benet LZ. Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers. Biochemical pharmacology 1998. PMID: 9514072


  231. Mizuma T, Benet LZ, Lin ET. Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberiite XAD-2 and its application to other 1-O-acyl-glucuronides. Preparative biochemistry & biotechnology 1998. PMID: 9516641


  232. Jang GR, Benet LZ. Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use. Journal of pharmacokinetics and biopharmaceutics 1997. PMID: 9697076


  233. Jang GR, Benet LZ. Cytochrome P4503A4-mediated N-demethylation of the antiprogestins lilopristone and onapristone. Drug metabolism and disposition: the biological fate of chemicals 1997. PMID: 9321513


  234. Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB. Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine. Clinical pharmacology and therapeutics 1997. PMID: 9333100


  235. Floren LC, Bekersky I, Benet LZ, Mekki Q, Dressler D, Lee JW, Roberts JP, Hebert MF. Tacrolimus oral bioavailability doubles with coadministration of ketoconazole. Clinical pharmacology and therapeutics 1997. PMID: 9246018


  236. Yuan R, Sumi M, Benet LZ. Investigation of aortic CYP3A bioactivation of nitroglycerin in vivo. The Journal of pharmacology and experimental therapeutics 1997. PMID: 9190888


  237. Wu ST, Benet LZ, Lin ET. Determination of amiprilose in human plasma by high-performance liquid chromatography with fluorimetric detection. Journal of chromatography. B, Biomedical sciences and applications 1997. PMID: 9187394


  238. Wu ST, Chang YP, Gee WL, Benet LZ, Lin ET. Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization. Journal of chromatography. B, Biomedical sciences and applications 1997. PMID: 9187392


  239. Shah VP, Yacobi A, Barr WH, Benet LZ, Breimer D, Dobrinska MR, Endrenyi L, Fairweather W, Gillespie W, Gonzalez MA, Hooper J, Jackson A, Lesko LJ, Midha KK, Noonan PK, Patnaik R, Williams RL. Evaluation of orally administered highly variable drugs and drug formulations. Pharmaceutical research 1996. PMID: 8956322


  240. Sambol NC, Chiang J, O'Conner M, Liu CY, Lin ET, Goodman AM, Benet LZ, Karam JH. Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus. Journal of clinical pharmacology 1996. PMID: 8973990


  241. Sambol NC, Brookes LG, Chiang J, Goodman AM, Lin ET, Liu CY, Benet LZ. Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man. British journal of clinical pharmacology 1996. PMID: 8904626


  242. Benet LZ. Morality play. Science (New York, N.Y.) 1996. PMID: 8815536


  243. Jang GR, Wrighton SA, Benet LZ. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes. Biochemical pharmacology 1996. PMID: 8765473


  244. Haj-Yehia AI, Benet LZ. In vivo depletion of free thiols does not account for nitroglycerin-induced tolerance: a thiol-nitrate interaction hypothesis as an alternative explanation for nitroglycerin activity and tolerance. The Journal of pharmacology and experimental therapeutics 1996. PMID: 8819515


  245. Iwaki M, Ogiso T, Hayashi H, Tanino T, Benet LZ. Acute dose-dependent disposition studies of nicotinic acid in rats. Drug metabolism and disposition: the biological fate of chemicals 1996. PMID: 8818575


  246. Kenkare SR, Benet LZ. Tolerance to nitroglycerin in rabbit aorta. Investigating the involvement of the mu isozyme of glutathione S-transferases. Biochemical pharmacology 1996. PMID: 8787552


  247. Berg-Candolfi M, Candolfi E, Benet LZ. Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression. Xenobiotica; the fate of foreign compounds in biological systems 1996. PMID: 9173679


  248. Harris RZ, Tsunoda SM, Mroczkowski P, Wong H, Benet LZ. The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics. Clinical pharmacology and therapeutics 1996. PMID: 8612388


  249. Jaeger W, Benet LZ, Bornheim LM. Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes. Xenobiotica; the fate of foreign compounds in biological systems 1996. PMID: 8730919


  250. Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clinical pharmacology and therapeutics 1996. PMID: 8653992


  251. Wu CY, Benet LZ, Hebert MF, Gupta SK, Rowland M, Gomez DY, Wacher VJ. Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine. Clinical pharmacology and therapeutics 1995. PMID: 7586942


  252. Sambol NC, Chiang J, Lin ET, Goodman AM, Liu CY, Benet LZ, Cogan MG. Kidney function and age are both predictors of pharmacokinetics of metformin. Journal of clinical pharmacology 1995. PMID: 8626883


  253. Zia-Amirhosseini P, Ding A, Burlingame AL, McDonagh AF, Benet LZ. Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac. The Biochemical journal 1995. PMID: 7487878


  254. d'Uscio CH, Aweeka FT, Prueksaritanont T, Tomlanovich SJ, Gupta SK, Lantz MV, Gambertoglio JG, Garovoy MR, Benet LZ. Immunopharmacodynamic studies of cyclosporine in patients awaiting renal transplantation. Journal of clinical pharmacology 1995. PMID: 8568014


  255. Iwaki M, Bischer A, Nguyen AC, McDonagh AF, Benet LZ. Stereoselective disposition of naproxen glucuronide in the rat. Drug metabolism and disposition: the biological fate of chemicals 1995. PMID: 8654198


  256. Bischer A, Iwaki M, Zia-Amirhosseini P, Benet LZ. Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin. Drug metabolism and disposition: the biological fate of chemicals 1995. PMID: 8565778


  257. Bornheim LM, Kim KY, Li J, Perotti BY, Benet LZ. Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain. Drug metabolism and disposition: the biological fate of chemicals 1995. PMID: 7493549


  258. Harris RZ, Benet LZ, Schwartz JB. Gender effects in pharmacokinetics and pharmacodynamics. Drugs 1995. PMID: 8521756


  259. Bischer A, Zia-Amirhosseini P, Iwaki M, McDonagh AF, Benet LZ. Stereoselective binding properties of naproxen glucuronide diastereomers to proteins. Journal of pharmacokinetics and biopharmaceutics 1995. PMID: 8882746


  260. Benet LZ, Goyan JE. Bioequivalence and narrow therapeutic index drugs. Pharmacotherapy 1995. PMID: 7479195


  261. Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Molecular carcinogenesis 1995. PMID: 7619215


  262. Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ. The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine. Clinical pharmacology and therapeutics 1995. PMID: 7628178


  263. Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ. Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals. Biopharmaceutics & drug disposition 1995. PMID: 7548779


  264. Haj-Yehia AI, Benet LZ. 2-(4-N-maleimidophenyl)-6-methoxybenzofuran: a superior derivatizing agent for fluorimetric determination of aliphatic thiols by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications 1995. PMID: 7655620


  265. Haj-Yehia AI, Benet LZ. Dissociation of tissue thiols content from nitroglycerin-induced cyclic-3',5'-guanosine monophosphate and the state of tolerance: in vivo experiments in rats. The Journal of pharmacology and experimental therapeutics 1995. PMID: 7714819


  266. Benet LZ, Zia-Amirhosseini P. Basic principles of pharmacokinetics. Toxicologic pathology 1995. PMID: 7569664


  267. Sekikawa H, Yagi N, Oda K, Kenmotsu H, Takada M, Chen HF, Lin ET, Benet LZ. Biliary excretion of furosemide glucuronide in rabbits. Biological & pharmaceutical bulletin 1995. PMID: 7550101


  268. Ding A, Zia-Amirhosseini P, McDonagh AF, Burlingame AL, Benet LZ. Reactivity of tolmetin glucuronide with human serum albumin. Identification of binding sites and mechanisms of reaction by tandem mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals 1995. PMID: 7628303


  269. Sekikawa H, Yagi N, Lin ET, Benet LZ. Apparent intramolecular acyl migration and hydrolysis of furosemide glucuronide in aqueous solution. Biological & pharmaceutical bulletin 1995. PMID: 7735228


  270. Haj-Yehia AI, Benet LZ. Determination of aliphatic thiols by fluorometric high-performance liquid chromatography after precolumn derivatization with 2-(4-N-maleimidophenyl)-6-methylbenzothiazole. Pharmaceutical research 1995. PMID: 7724479


  271. Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ. Hypersensitivity to nonsteroidal anti-inflammatory drugs. Nature medicine 1995. PMID: 7584944


  272. Kenkare SR, Han C, Benet LZ. Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase. Biochemical pharmacology 1994. PMID: 7811305


  273. Iwaki M, Ogiso T, Hayashi H, Lin ET, Benet LZ. Simultaneous measurement of nicotinic acid and its major metabolite, nicotinuric acid in urine using high-performance liquid chromatography: application of solid-liquid extraction. Journal of chromatography. B, Biomedical applications 1994. PMID: 7866544


  274. Perotti BY, Prueksaritanont T, Benet LZ. HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes. Pharmaceutical research 1994. PMID: 7524055


  275. Ojingwa JC, Spahn-Langguth H, Benet LZ. Irreversible binding of tolmetin to macromolecules via its glucuronide: binding to blood constituents, tissue homogenates and subcellular fractions in vitro. Xenobiotica; the fate of foreign compounds in biological systems 1994. PMID: 7975715


  276. Gustavson LE, Benet LZ. Menopause: pharmacodynamics and pharmacokinetics. Experimental gerontology 1994. PMID: 7925762


  277. Han C, Jung P, Sanders SW, Lin ET, Benet LZ. Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration. Biopharmaceutics & drug disposition 1994. PMID: 8011969


  278. Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH. Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Journal of clinical pharmacology 1994. PMID: 8163710


  279. Ojingwa JC, Spahn-Langguth H, Benet LZ. Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma. Journal of pharmacokinetics and biopharmaceutics 1994. PMID: 8027947


  280. Zia-Amirhosseini P, Spahn-Langguth H, Benet LZ. Bioactivation by glucuronide-conjugate formation. Advances in pharmacology (San Diego, Calif.) 1994. PMID: 8068561


  281. Zia-Amirhosseini P, Ojingwa JC, Spahn-Langguth H, McDonagh AF, Benet LZ. Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing. Clinical pharmacology and therapeutics 1994. PMID: 8299313


  282. Perotti BY, Okudaira N, Prueksaritanont T, Benet LZ. FK 506 metabolism in male and female rat liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 1994. PMID: 7512020


  283. Benet LZ. Pharmacokinetic profile of etodolac in special populations. European journal of rheumatology and inflammation 1994. PMID: 7744123


  284. Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ. Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients. Journal of clinical pharmacology 1994. PMID: 8132853


  285. Benet LZ, Zech K. Pharmacokinetics--a relevant factor for the choice of a drug? Alimentary pharmacology & therapeutics 1994. PMID: 8180291


  286. Munafo A, Hyneck ML, Benet LZ. Pharmacokinetics and irreversible binding of tolmetin and its glucuronic acid esters in the elderly. Pharmacology 1993. PMID: 8265721


  287. Lee FW, Salmonson T, Benet LZ. Pharmacokinetics and pharmacodynamics of nitroglycerin and its dinitrate metabolites in conscious dogs: intravenous infusion studies. Journal of pharmacokinetics and biopharmaceutics 1993. PMID: 8145130


  288. Gumbleton M, Benet LZ. Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers. Journal of pharmacokinetics and biopharmaceutics 1993. PMID: 8145129


  289. Kenkare SR, Benet LZ. Effect of ethacrynic acid, a glutathione-S-transferase inhibitor, on nitroglycerin-mediated cGMP elevation and vasorelaxation of rabbit aortic strips. Biochemical pharmacology 1993. PMID: 8394078


  290. Prueksaritanont T, Correia MA, Rettie AE, Swinney DC, Thomas PE, Benet LZ. Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A. Volume 21 of Issue 4. Drug metabolism and disposition: the biological fate of chemicals 1993. PMID: 8104135


  291. Gupta SK, Hwang SS, Benet LZ, Gumbleton M. Interpretation and utilization of effect and concentration data collected in an in vivo pharmacokinetic and in vitro pharmacodynamic study. Pharmaceutical research 1993. PMID: 8321858


  292. Ding A, Ojingwa JC, McDonagh AF, Burlingame AL, Benet LZ. Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America 1993. PMID: 8483897


  293. Spahn-Langguth H, Benet LZ. Microsomal acyl glucuronidation: enzyme-kinetic studies with labile glucuronides. Pharmacology 1993. PMID: 8488171


  294. Lee FW, Hu J, Metzler CH, Benet LZ. Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report. Journal of pharmacokinetics and biopharmaceutics 1993. PMID: 8229678


  295. Benet LZ. New techniques in drug metabolism and clinical pharmacology/pharmacokinetics. American biotechnology laboratory 1993. PMID: 7763426


  296. Mayer S, Mutschler E, Benet LZ, Sphahn-Langguth H. In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers. Chirality 1993. PMID: 8338721


  297. Benet LZ. Pharmacokinetics of sustained-release etodolac. Rheumatology international 1993. PMID: 8210922


  298. Benet LZ, Spahn-Langguth H, Iwakawa S, Volland C, Mizuma T, Mayer S, Mutschler E, Lin ET. Predictability of the covalent binding of acidic drugs in man. Life sciences 1993. PMID: 8350674


  299. Haefeli WE, Gumbleton M, Benet LZ, Hoffman BB, Blaschke TF. Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins. Clinical pharmacology and therapeutics 1992. PMID: 1458768


  300. Hebert MF, Roberts JP, Prueksaritanont T, Benet LZ. Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction. Clinical pharmacology and therapeutics 1992. PMID: 1424418


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