John Imboden, MD

Professor of Medicine

Division of Rheumatology

Publications
  1. Shimizu T, Cruz A, Tanaka M, Mamoto K, Pedoia V, Burghardt AJ, Heilmeier U, Link TM, Graf J, Imboden JB, Li X. Structural Changes over a Short Period Are Associated with Functional Assessments in Rheumatoid Arthritis. The Journal of rheumatology 2019. PMID: 30770506


  2. Graf J, Imboden J. Vasculitis and peripheral neuropathy. Current opinion in rheumatology 2019. PMID: 30461543


  3. Gianfrancesco MA, Trupin L, Shiboski S, van der Laan M, Graf J, Imboden J, Yazdany J, Schmajuk G. Smoking Is Associated with Higher Disease Activity in Rheumatoid Arthritis: A Longitudinal Study Controlling for Time-varying Covariates. The Journal of rheumatology 2018. PMID: 30504507


  4. Mok A, Rhead B, Holingue C, Shao X, Quach HL, Quach D, Sinclair E, Graf J, Imboden J, Link T, Harrison R, Chernitskiy V, Barcellos LF, Criswell LA. Hypomethylation of CYP2E1 and DUSP22 Promoters Associated With Disease Activity and Erosive Disease Among Rheumatoid Arthritis Patients. Volume 70 of Issue 4. Arthritis & rheumatology (Hoboken, N.J.) 2018. PMID: 29287311


  5. Goglin SE, Imboden JB. Neurologic Manifestations of Rheumatic Diseases. Rheumatic diseases clinics of North America 2017. PMID: 29061250


  6. Sarah E. Goglin,John B. Imboden. Neurologic Manifestations of Rheumatic Diseases. Rheumatic Disease Clinics of North America 2017. PMID:


  7. Shimizu T, Choi HJ, Heilmeier U, Tanaka M, Burghardt AJ, Gong J, Chanchek N, Link TM, Graf J, Imboden JB, Li X. Assessment of 3-month changes in bone microstructure under anti-TNFa therapy in patients with rheumatoid arthritis using high-resolution peripheral quantitative computed tomography (HR-pQCT). Volume 19 of Issue 1. Arthritis research & therapy 2017. PMID: 28978352


  8. DeQuattro K, Imboden JB. Neurologic Manifestations of Rheumatoid Arthritis. Rheumatic diseases clinics of North America 2017. PMID: 29061242


  9. Malmstroem S, Rejnmark L, Imboden JB, Shoback DM, Bikle DD. Current Assays to Determine Free 25-Hydroxyvitamin D in Serum. Volume 100 of Issue 5. Journal of AOAC International 2017. PMID: 28492133


  10. Ku E, Pedoia V, Tanaka M, Heilmeier U, Imboden J, Graf J, Link T, Li X. Evaluating radiocarpal cartilage matrix changes 3-months after anti-TNF treatment for rheumatoid arthritis using MR T1? imaging. Volume 45 of Issue 5. Journal of magnetic resonance imaging : JMRI 2016. PMID: 27661002


  11. Barton JL, Trupin L, Schillinger D, Evans-Young G, Imboden J, Montori VM, Yelin E. Use of Low-Literacy Decision Aid to Enhance Knowledge and Reduce Decisional Conflict Among a Diverse Population of Adults With Rheumatoid Arthritis: Results of a Pilot Study. Arthritis care & research 2016. PMID: 26605752


  12. H. Choi, U. Heilmeier, M. Tanaka, A.J. Burghardt, N. Chanchek, T.M. Link, J. Graft, J.B. Imboden, X. Li. SAT0545 The Effect of anti-TNF Alpha Treatment on Erosion Progression in Rheumatoid Arthritis by High-Resolution Peripheral Quantitative Computed Tomography: Three-Month Data. Annals of the rheumatic diseases 2016. PMID:


  13. Liu J, Pedoia V, Heilmeier U, Ku E, Su F, Khanna S, Imboden J, Graf J, Link T, Li X. High-temporospatial-resolution dynamic contrast-enhanced (DCE) wrist MRI with variable-density pseudo-random circular Cartesian undersampling (CIRCUS) acquisition: evaluation of perfusion in rheumatoid arthritis patients. Volume 29 of Issue 1. NMR in biomedicine 2015. PMID: 26608949


  14. Scheibe MM, Imboden JB, Schmajuk G, Margaretten M, Graf JD, Chen AH, Yelin EH, Yazdany J. Efficiency Gains for Rheumatology Consultation Using a Novel Electronic Referral System in a Safety-Net Health Setting. Volume 67 of Issue 8. Arthritis care & research 2015. PMID: 25623810


  15. Hellmann DB, Imboden JB. Update in rheumatology: evidence published in 2014. Annals of internal medicine 2015. PMID: 25927977


  16. Yang H, Yu A, Burghardt AJ, Virayavanich W, Link TM, Imboden JB, Li X. Quantitative characterization of metacarpal and radial bone in rheumatoid arthritis using high resolution- peripheral quantitative computed tomography. International journal of rheumatic diseases 2015. PMID: 25865349


  17. Yang H, Rivoire J, Hoppe M, Srikhum W, Imboden J, Link TM, Li X. Computer-aided and manual quantifications of MRI synovitis, bone marrow edema-like lesions, erosion and cartilage loss in rheumatoid arthritis of the wrist. Skeletal radiology 2014. PMID: 25488101


  18. Hsue PY, Scherzer R, Grunfeld C, Imboden J, Wu Y, Del Puerto G, Nitta E, Shigenaga J, Schnell Heringer A, Ganz P, Graf J. Depletion of B-cells with rituximab improves endothelial function and reduces inflammation among individuals with rheumatoid arthritis. Volume 3 of Issue 5. Journal of the American Heart Association 2014. PMID: 25336464


  19. Carlson AQ, Tuot DS, Jen KY, Butcher B, Graf J, Sam R, Imboden JB. Pauci-immune glomerulonephritis in individuals with disease associated with levamisole-adulterated cocaine: a series of 4 cases. Volume 93 of Issue 17. Medicine 2014. PMID: 25398064


  20. Teruel JR, Burghardt AJ, Rivoire J, Srikhum W, Noworolski SM, Link TM, Imboden JB, Li X. Bone structure and perfusion quantification of bone marrow edema pattern in the wrist of patients with rheumatoid arthritis: a multimodality study. The Journal of rheumatology 2014. PMID: 25086074


  21. Barton JL, Trupin L, Tonner C, Imboden J, Katz P, Schillinger D, Yelin E. English language proficiency, health literacy, and trust in physician are associated with shared decision making in rheumatoid arthritis. The Journal of rheumatology 2014. PMID: 24931952


  22. Coffey G, Betz A, Graf J, Stephens G, Hua Lin P, Imboden J, Sinha U. Methotrexate and a spleen tyrosine kinase inhibitor cooperate to inhibit responses to peripheral blood B cells in rheumatoid arthritis. Volume 1 of Issue 2. Pharmacology research & perspectives 2013. PMID: 25505569


  23. Burghardt AJ, Lee CH, Kuo D, Majumdar S, Imboden JB, Link TM, Li X. Quantitative in vivo HR-pQCT imaging of 3D wrist and metacarpophalangeal joint space width in rheumatoid arthritis. Annals of biomedical engineering 2013. PMID: 23887879


  24. Richman NC, Yazdany J, Graf J, Chernitskiy V, Imboden JB. Extraarticular manifestations of rheumatoid arthritis in a multiethnic cohort of predominantly Hispanic and Asian patients. Volume 92 of Issue 2. Medicine 2013. PMID: 23429352


  25. Srikhum W, Virayavanich W, Burghardt AJ, Yu A, Link TM, Imboden JB, Li X. Quantitative and semiquantitative bone erosion assessment on high-resolution peripheral quantitative computed tomography in rheumatoid arthritis. The Journal of rheumatology 2013. PMID: 23418386


  26. Barton JL, Schmajuk G, Trupin L, Graf J, Imboden J, Yelin EH, Schillinger D. Poor knowledge of methotrexate associated with older age and limited English-language proficiency in a diverse rheumatoid arthritis cohort. Volume 15 of Issue 5. Arthritis research & therapy 2013. PMID: 24432366


  27. Bajpai UD, Swainson LA, Mold JE, Graf JD, Imboden JB, McCune JM. A functional variant in FCRL3 is associated with higher Fc receptor-like 3 expression on T cell subsets and rheumatoid arthritis disease activity. Volume 64 of Issue 8. Arthritis and rheumatism 2012. PMID: 22392608


  28. Graf J, Lynch K, Yeh CL, Tarter L, Richman N, Nguyen T, Kral A, Dominy S, Imboden J. Purpura, cutaneous necrosis, and antineutrophil cytoplasmic antibodies associated with levamisole-adulterated cocaine. Volume 63 of Issue 12. Arthritis and rheumatism 2011. PMID: 22127712


  29. Li X, Yu A, Virayavanich W, Noworolski SM, Link TM, Imboden J. Quantitative characterization of bone marrow edema pattern in rheumatoid arthritis using 3 Tesla MRI. Journal of magnetic resonance imaging : JMRI 2011. PMID: 21987483


  30. Barton JL, Trupin L, Schillinger D, Gansky SA, Tonner C, Margaretten M, Chernitskiy V, Graf J, Imboden J, Yelin E. Racial and ethnic disparities in disease activity and function among persons with rheumatoid arthritis from university-affiliated clinics. Arthritis care & research 2011. PMID: 21671414


  31. Rooney T, Scherzer R, Shigenaga JK, Graf J, Imboden JB, Grunfeld C. Levels of plasma fibrinogen are elevated in well-controlled rheumatoid arthritis. Volume 50 of Issue 8. Rheumatology (Oxford, England) 2011. PMID: 21441551


  32. Margaretten M, Barton J, Julian L, Katz P, Trupin L, Tonner C, Graf J, Imboden J, Yelin E. Socioeconomic determinants of disability and depression in patients with rheumatoid arthritis. Arthritis care & research 2011. PMID: 20824800


  33. Gratton SB, Imboden JB. A 23-year-old woman with fever, rash, and arthritis. Arthritis care & research 2010. PMID: 20506489


  34. Barton JL, Imboden J, Graf J, Glidden D, Yelin EH, Schillinger D. Patient-physician discordance in assessments of global disease severity in rheumatoid arthritis. Volume 62 of Issue 6. Arthritis care & research 2010. PMID: 20535797


  35. Margaretten M, Yelin E, Imboden J, Graf J, Barton J, Katz P, Julian L. Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis. Arthritis and rheumatism 2009. PMID: 19877099


  36. Graf J, Scherzer R, Grunfeld C, Imboden J. Levels of C-reactive protein associated with high and very high cardiovascular risk are prevalent in patients with rheumatoid arthritis. Volume 4 of Issue 7. PloS one 2009. PMID: 19606218


  37. Ku IA, Imboden JB, Hsue PY, Ganz P. Rheumatoid arthritis: model of systemic inflammation driving atherosclerosis. Circulation journal : official journal of the Japanese Circulation Society 2009. PMID: 19430165


  38. Imboden JB. The immunopathogenesis of rheumatoid arthritis. Annual review of pathology 2009. PMID: 18954286


  39. Hellmann DB, Imboden JB. Update in rheumatology. Annals of internal medicine 2006. PMID: 17146068


  40. Sadra A, Cinek T, Imboden JB. Translocation of CD28 to lipid rafts and costimulation of IL-2. Proceedings of the National Academy of Sciences of the United States of America 2004. PMID: 15280538


  41. Andres PG, Howland KC, Nirula A, Kane LP, Barron L, Dresnek D, Sadra A, Imboden J, Weiss A, Abbas AK. Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation. Nature immunology 2004. PMID: 15004555


  42. Chikuma S, Imboden JB, Bluestone JA. Negative regulation of T cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. The Journal of experimental medicine 2003. PMID: 12515820


  43. Imboden JB, Shoback DM, Inokuchi S. Analysis of inositol phospholipid turnover during lymphocyte activation. Current protocols in immunology 2001. PMID: 18432702


  44. Sadra A, Cinek T, Imboden JB. Multiple probing of an immunoblot membrane using a non-block technique: advantages in speed and sensitivity. Analytical biochemistry 2000. PMID: 10660470


  45. Cinek T, Sadra A, Imboden JB. Cutting edge: tyrosine-independent transmission of inhibitory signals by CTLA-4. Journal of immunology (Baltimore, Md. : 1950) 2000. PMID: 10604984


  46. Sadra A, Cinek T, Arellano JL, Shi J, Truitt KE, Imboden JB. Identification of tyrosine phosphorylation sites in the CD28 cytoplasmic domain and their role in the costimulation of Jurkat T cells. Journal of immunology (Baltimore, Md. : 1950) 1999. PMID: 9973466


  47. Barz C, Nagel T, Truitt KE, Imboden JB. Mutational analysis of CD28-mediated costimulation of Jun-N-terminal kinase and IL-2 production. Journal of immunology (Baltimore, Md. : 1950) 1998. PMID: 9820510


  48. Lu Y, Cuevas B, Gibson S, Khan H, LaPushin R, Imboden J, Mills GB. Phosphatidylinositol 3-kinase is required for CD28 but not CD3 regulation of the TEC family tyrosine kinase EMT/ITK/TSK: functional and physical interaction of EMT with phosphatidylinositol 3-kinase. Journal of immunology (Baltimore, Md. : 1950) 1998. PMID: 9820515


  49. Weber JR, Orstavik S, Torgersen KM, Danbolt NC, Berg SF, Ryan JC, Taskén K, Imboden JB, Vaage JT. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. The Journal of experimental medicine 1998. PMID: 9529333


  50. Gibson S, Truitt K, Lu Y, Lapushin R, Khan H, Imboden JB, Mills GB. Efficient CD28 signalling leads to increases in the kinase activities of the TEC family tyrosine kinase EMT/ITK/TSK and the SRC family tyrosine kinase LCK. The Biochemical journal 1998. PMID: 9494076


  51. Daikh D, Wofsy D, Imboden JB. The CD28-B7 costimulatory pathway and its role in autoimmune disease. Volume 62 of Issue 2. Journal of leukocyte biology 1997. PMID: 9261329


  52. Shi J, Cinek T, Truitt KE, Imboden JB. Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells. Journal of immunology (Baltimore, Md. : 1950) 1997. PMID: 9144481


  53. Imboden J. Turning off natural killers. Innate immunity. Current biology : CB 1996. PMID: 8805356


  54. Truitt KE, Nagel T, Suen LF, Imboden JB. Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells. Journal of immunology (Baltimore, Md. : 1950) 1996. PMID: 8648094


  55. Bell GM, Fargnoli J, Bolen JB, Kish L, Imboden JB. The SH3 domain of p56lck binds to proline-rich sequences in the cytoplasmic domain of CD2. The Journal of experimental medicine 1996. PMID: 8551220


  56. Truitt KE, Shi J, Gibson S, Segal LG, Mills GB, Imboden JB. CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase. Journal of immunology (Baltimore, Md. : 1950) 1995. PMID: 7594470


  57. Imboden JB, Koretsky GA. Intracellular signalling. Switching off signals. Current biology : CB 1995. PMID: 7583115


  58. Sánchez-Margalet V, Goldfine ID, Truitt K, Imboden J, Sung CK. Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1. Molecular endocrinology (Baltimore, Md.) 1995. PMID: 7659087


  59. Truitt KE, Hicks CM, Imboden JB. Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells. The Journal of experimental medicine 1994. PMID: 7509360


  60. Bell GM, Dethloff GM, Imboden JB. CD45-negative mutants of a rat natural killer cell line fail to lyse tumor target cells. Journal of immunology (Baltimore, Md. : 1950) 1993. PMID: 8104222


  61. Gregory M. Bell, Joseph B. Bolen, John B. Imboden. Association of Src-Like Protein Tyrosine Kinases with the CD2 Cell Surface Molecule in Rat T Lymphocytes and Natural Killer Cells. Molecular and cellular biology 1992. PMID:


  62. Weber JR, Bell GM, Han MY, Pawson T, Imboden JB. Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor. The Journal of experimental medicine 1992. PMID: 1500851


  63. Bell GM, Seaman WE, Niemi EC, Imboden JB. The OX-44 molecule couples to signaling pathways and is associated with CD2 on rat T lymphocytes and a natural killer cell line. The Journal of experimental medicine 1992. PMID: 1346273


  64. Goldfien RD, Seaman WE, Hempel WM, Imboden JB. Divergent regulation of phospholipase C-alpha and phospholipase C-gamma transcripts during activation of a human T cell line. Journal of immunology (Baltimore, Md. : 1950) 1991. PMID: 2033247


  65. Ledbetter JA, Schieven GL, Uckun FM, Imboden JB. CD45 cross-linking regulates phospholipase C activation and tyrosine phosphorylation of specific substrates in CD3/Ti-stimulated T cells. Journal of immunology (Baltimore, Md. : 1950) 1991. PMID: 1847166


  66. Budd RC, Winslow G, Inokuchi S, Imboden JB. Intact antigen receptor-mediated generation of inositol phosphates and increased intracellular calcium in CD4 CD8 T lymphocytes from MRL lpr mice. Journal of immunology (Baltimore, Md. : 1950) 1990. PMID: 1976707


  67. JA Ledbetter, JB Imboden, GL Schieven, LS Grosmaire, PS Rabinovitch, T Lindsten, CB Thompson, CH June. CD28 ligation in T-cell activation: evidence for two signal transduction pathways. Blood 1990. PMID:


  68. Ledbetter JA, Imboden JB, Schieven GL, Grosmaire LS, Rabinovitch PS, Lindsten T, Thompson CB, June CH. CD28 ligation in T-cell activation: evidence for two signal transduction pathways. Blood 1990. PMID: 2156582


  69. Imboden JB, June CH, McCutcheon MA, Ledbetter JA. Stimulation of CD5 enhances signal transduction by the T cell antigen receptor. The Journal of clinical investigation 1990. PMID: 1688565


  70. John B. Imboden, Arthur Weiss. The Initiation of Human T Lymphocyte Activation (Part 1 of 2). TO REMOVE 1988. PMID:


  71. John B. Imboden, Arthur Weiss. The Initiation of Human T Lymphocyte Activation (Part 2 of 2). TO REMOVE 1988. PMID:


  72. Ledbetter JA, June CH, Rabinovitch PS, Grossmann A, Tsu TT, Imboden JB. Signal transduction through CD4 receptors: stimulatory vs. inhibitory activity is regulated by CD4 proximity to the CD3/T cell receptor. European journal of immunology 1988. PMID: 2966739


  73. John B. Imboden,Arthur Weiss. CHAPTER 4 REGULATION OF INTERLEUKIN 2 PRODUCTION BY THE T CELL ANTIGEN RECEPTOR. TO REMOVE 1988. PMID:


  74. Bernard Manger, John Imboden, Arthur Weiss. Role of the T3/T-Cell Antigen Receptor Complex in T-Cell Activation. TO REMOVE 1988. PMID:


  75. Imboden JB, Weiss A. The initiation of human T lymphocyte activation. Progress in allergy 1988. PMID: 2845427


  76. Manger B, Weiss A, Imboden J, Laing T, Stobo JD. The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies. Journal of immunology (Baltimore, Md. : 1950) 1987. PMID: 3116093


  77. Imboden JB, Pattison G. Regulation of inositol 1,4,5-trisphosphate kinase activity after stimulation of human T cell antigen receptor. The Journal of clinical investigation 1987. PMID: 3494750


  78. Weiss A, Shields R, Newton M, Manger B, Imboden J. Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene. Journal of immunology (Baltimore, Md. : 1950) 1987. PMID: 3104454


  79. Weiss A, Imboden JB. Cell surface molecules and early events involved in human T lymphocyte activation. Advances in immunology 1987. PMID: 2961214


  80. Weiss A, Imboden J, Hardy K, Stobo J. The role of the antigen receptor/T3 complex in T-cell activation. Advances in experimental medicine and biology 1987. PMID: 2957896


  81. Imboden JB, Shoback DM, Pattison G, Stobo JD. Cholera toxin inhibits the T-cell antigen receptor-mediated increases in inositol trisphosphate and cytoplasmic free calcium. Proceedings of the National Academy of Sciences of the United States of America 1986. PMID: 3016713


  82. Weiss A, Manger B, Imboden J. Synergy between the T3/antigen receptor complex and Tp44 in the activation of human T cells. Journal of immunology (Baltimore, Md. : 1950) 1986. PMID: 3088111


  83. Weiss A, Imboden J, Hardy K, Manger B, Terhorst C, Stobo J. The role of the T3/antigen receptor complex in T-cell activation. Annual review of immunology 1986. PMID: 2939858


  84. Imboden JB, Weiss A, Stobo JD. Transmembrane signalling by the T3-antigen receptor complex. Immunology today 1985. PMID: 25291003


  85. Wiskocil R, Weiss A, Imboden J, Kamin-Lewis R, Stobo J. Activation of a human T cell line: a two-stimulus requirement in the pretranslational events involved in the coordinate expression of interleukin 2 and gamma-interferon genes. Journal of immunology (Baltimore, Md. : 1950) 1985. PMID: 3918105


  86. Imboden JB, Weiss A, Stobo JD. The antigen receptor on a human T cell line initiates activation by increasing cytoplasmic free calcium. Journal of immunology (Baltimore, Md. : 1950) 1985. PMID: 3871211


  87. Weiss A, Imboden J, Shoback D, Stobo J. Role of T3 surface molecules in human T-cell activation: T3-dependent activation results in an increase in cytoplasmic free calcium. Proceedings of the National Academy of Sciences of the United States of America 1984. PMID: 6234599


  88. Weiss A, Imboden J, Wiskocil R, Stobo J. The role of T3 in the activation of human T cells. Journal of clinical immunology 1984. PMID: 6203926