Joel Ernst, MD

Professor and Chief

The goal of my research is to provide the mechanistic basis for development of effective vaccines against tuberculosis.

Education
2018 - Diversity, Equity, and Inclusion Champion Training, University of California
06/1986 - Leukocyte cell biology, University of California, San Francisco
06/1984 - Hematology and Oncology, University of California, San Francisco
06/1982 - Infectious Diseases, University of California, San Francisco
06/1981 - Internal Medicine, University of California, San Francisco
M.D., 05/1978 - Medicine, University of Nebraska
Honors and Awards
  • McFadden Memorial Lecturer, University of Nebraska, 2016
  • Dean's Honors Lecturer, New York University School of Medicine, 2015
  • Honorary Doctorate (M.D., honoris causa), Linköping University, Sweden, 2013
  • Elected Fellow, American Academy of Microbiologists, 2010
  • Thaler Lecturer, Aeras Global TB Vaccine Foundation, 2009
  • Elected Member, Association of American Physicians, 2009
  • Kirby Lecturer, University of Washington, 2009
Publications

  1. Grace PS, Peters JM, Sixsmith J, Lu R, Luedeman C, Fenderson BA, Vickers A, Slein MD, Irvine EB, McKitrick T, Wei MH, Cummings RD, Wallace A, Cavacini LA, Choudhary A, Proulx MK, Sundling C, Källenius G, Reljic R, Ernst JD, Casadevall A, Locht C, Pinter A, Sasseti CM, Bryson BD, Fortune SM, Alter G. Antibody-Fab and -Fc features promote Mycobacterium tuberculosis restriction. bioRxiv : the preprint server for biology 2024. PMID: 39416184


  2. Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Chen L, Ernst JD. Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection. PLoS pathogens 2024. PMID: 38701094


  3. Ogongo P, Tran A, Marzan F, Gingrich D, Krone M, Aweeka F, Lindestam Arlehamn CS, Martin JN, Deeks SG, Hunt PW, Ernst JD. High-parameter phenotypic characterization reveals a subset of human Th17 cells that preferentially produce IL-17 against M. tuberculosis antigen. Frontiers in immunology 2024. PMID: 38698866


  4. Ogongo P, Tran A, Marzan F, Gingrich D, Krone M, Aweeka F, Lindestam Arlehamn CS, Martin JN, Deeks SG, Hunt PW, Ernst JD. M. tuberculosis antigen-responsive IL17 + CD4 T cells are disproportionately spared in ART-suppressed HIV. bioRxiv : the preprint server for biology 2023. PMID: 36711855


  5. Ogongo P, Wassie L, Tran A, Columbus D, Sharling L, Ouma G, Ouma SG, Bobosha K, Lindestam Arlehamn CS, Gandhi NR, Auld SC, Rengarajan J, Day CL, Altman JD, Blumberg HM, Ernst JD, TBRU ASTRa Study Group. Rare Variable M. tuberculosis Antigens induce predominant Th17 responses in human infection. bioRxiv : the preprint server for biology 2024. PMID: 38496518


  6. Miyakawa R, Louie J, Keh C, Chen L, Javid B, Ernst JD, Goswami N, Chow FC. A teenage girl with altered mental status and paraparesis. Journal of clinical tuberculosis and other mycobacterial diseases 2024. PMID: 38468819


  7. Limberis JD, Nalyvayko A, Ernst JD, Metcalfe JZ. selSeq: A method for the enrichment of non-polyadenylated RNAs including enhancer and long non-coding RNAs for sequencing. PloS one 2023. PMID: 38015898


  8. Limberis JD, Nalyvayko A, Ernst JD, Metcalfe JZ. A simple, single-tube overlapping amplicon-targeted Illumina sequencing assay. PloS one 2023. PMID: 37708184


  9. Zheng W, Chang IC, Limberis J, Budzik J, Zha BS, Howard Z, Chen L, Ernst J. Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during chronic infection. Research square 2023. PMID: 37398178


  10. Zheng W, Chang IC, Limberis J, Budzik JM, Zha BS, Howard Z, Ernst JD. Mycobacterium tuberculosis resides in lysosome-poor monocyte-derived lung cells during persistent infection. bioRxiv : the preprint server for biology 2023. PMID: 36711606


  11. Zwyer M, Rutaihwa LK, Windels E, Hella J, Menardo F, Sasamalo M, Sommer G, Schm?lling L, Borrell S, Reinhard M, D?tsch A, Hiza H, Stritt C, Sikalengo G, Fenner L, De Jong BC, Kato-Maeda M, Jugheli L, Ernst JD, Niemann S, Jeljeli L, Ballif M, Egger M, Rakotosamimanana N, Yeboah-Manu D, Asare P, Malla B, Dou HY, Zetola N, Wilkinson RJ, Cox H, Carter EJ, Gnokoro J, Yotebieng M, Gotuzzo E, Abimiku A, Avihingsanon A, Xu ZM, Fellay J, Portevin D, Reither K, Stadler T, Gagneux S, Brites D. Back-to-Africa introductions of Mycobacterium tuberculosis as the main cause of tuberculosis in Dar es Salaam, Tanzania. PLoS pathogens 2023. PMID: 37014917


  12. Sawyer AJ, Patrick E, Edwards J, Wilmott JS, Fielder T, Yang Q, Barber DL, Ernst JD, Britton WJ, Palendira U, Chen X, Feng CG. Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis. The Journal of experimental medicine 2023. PMID: 36920308


  13. Limberis JD, Nalyvayko A, Ernst JD, Metcalfe JZ. Circularization of rv0678 for Genotypic Bedaquiline Resistance Testing of Mycobacterium tuberculosis. Microbiology spectrum 2023. PMID: 36877083


  14. Ogongo P, Ernst JD. Finding antigens for TB vaccines: the good, the bad and the useless. Nature medicine 2023. PMID: 36604539


  15. Seth A, Mittal E, Luan J, Kolla S, Mazer MB, Joshi H, Gupta R, Rathi P, Wang Z, Morrissey JJ, Ernst JD, Portal-Celhay C, Morley SC, Philips JA, Singamaneni S. High-resolution imaging of protein secretion at the single-cell level using plasmon-enhanced FluoroDOT assay. Cell reports methods 2022. PMID: 36046626


  16. Zha BS, Desvignes L, Fergus TJ, Cornelius A, Cheng TY, Moody DB, Ernst JD. Bacterial Strain-Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection. 2022. PMID: 35695454


  17. von Borstel A, Chevour P, Arsovski D, Krol JMM, Howson LJ, Berry AA, Day CL, Ogongo P, Ernst JD, Nomicos EYH, Boddey JA, Giles EM, Rossjohn J, Traore B, Lyke KE, Williamson KC, Crompton PD, Davey MS. Repeated Plasmodium falciparum infection in humans drives the clonal expansion of an adaptive γδ T cell repertoire. 2021. PMID: 34851691


  18. Ceglia V, Kelley EJ, Boyle AS, Zurawski S, Mead HL, Harms CE, Blanck JP, Flamar AL, Kirschman JH, Ogongo P, Ernst JD, Levy Y, Zurawski G, Altin JA. A Framework to Identify Antigen-Expanded T Cell Receptor Clusters Within Complex Repertoires. 2021. PMID: 34917073


  19. Xiao Y, Lidsky PV, Shirogane Y, Aviner R, Wu CT, Li W, Zheng W, Talbot D, Catching A, Doitsh G, Su W, Gekko CE, Nayak A, Ernst JD, Brodsky L, Brodsky E, Rousseau E, Capponi S, Bianco S, Nakamura R, Jackson PK, Frydman J, Andino R. A defective viral genome strategy elicits broad protective immunity against respiratory viruses. 2021. PMID: 34852237


  20. Fossati A, Richards AL, Chen KH, Jaganath D, Cattamanchi A, Ernst JD, Swaney DL. Toward Comprehensive Plasma Proteomics by Orthogonal Protease Digestion. Journal of proteome research 2021. PMID: 34319755


  21. Nathan A, Beynor JI, Baglaenko Y, Suliman S, Ishigaki K, Asgari S, Huang CC, Luo Y, Zhang Z, Lopez K, Lindestam Arlehamn CS, Ernst JD, Jimenez J, Calderón RI, Lecca L, Van Rhijn I, Moody DB, Murray MB, Raychaudhuri S. Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease. Nature immunology 2021. PMID: 34031617


  22. Hiatt J, Cavero DA, McGregor MJ, Zheng W, Budzik JM, Roth TL, Haas KM, Wu D, Rathore U, Meyer-Franke A, Bouzidi MS, Shifrut E, Lee Y, Kumar VE, Dang EV, Gordon DE, Wojcechowskyj JA, Hultquist JF, Fontaine KA, Pillai SK, Cox JS, Ernst JD, Krogan NJ, Marson A. Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins. Cell reports 2021. PMID: 33979618


  23. McLaughlin TA, Nizam A, Hayara FO, Ouma GS, Campbell A, Khayumbi J, Ongalo J, Ouma SG, Shah NS, Altman JD, Kaushal D, Rengarajan J, Ernst JD, Blumberg HM, Waller LA, Gandhi NR, Day CL, Benkeser D. Schistosoma mansoni Infection Is Associated With a Higher Probability of Tuberculosis Disease in HIV-Infected Adults in Kenya. Journal of acquired immune deficiency syndromes (1999) 2021. PMID: 33074856


  24. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk RP, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. Evaluation of SARS-CoV-2 serology assays reveals a range of test performance. Nature biotechnology 2020. PMID: 32855547


  25. Collins JM, Siddiqa A, Jones DP, Liu K, Kempker RR, Nizam A, Shah NS, Ismail N, Ouma SG, Tukvadze N, Li S, Day CL, Rengarajan J, Brust JCM, Gandhi NR, Ernst JD, Blumberg HM, Ziegler TR. Tryptophan catabolism reflects disease activity in human tuberculosis. JCI insight 2020. PMID: 32369456


  26. Whitman JD, Hiatt J, Mowery CT, Shy BR, Yu R, Yamamoto TN, Rathore U, Goldgof GM, Whitty C, Woo JM, Gallman AE, Miller TE, Levine AG, Nguyen DN, Bapat SP, Balcerek J, Bylsma SA, Lyons AM, Li S, Wong AW, Gillis-Buck EM, Steinhart ZB, Lee Y, Apathy R, Lipke MJ, Smith JA, Zheng T, Boothby IC, Isaza E, Chan J, Acenas DD, Lee J, Macrae TA, Kyaw TS, Wu D, Ng DL, Gu W, York VA, Eskandarian HA, Callaway PC, Warrier L, Moreno ME, Levan J, Torres L, Farrington LA, Loudermilk R, Koshal K, Zorn KC, Garcia-Beltran WF, Yang D, Astudillo MG, Bernstein BE, Gelfand JA, Ryan ET, Charles RC, Iafrate AJ, Lennerz JK, Miller S, Chiu CY, Stramer SL, Wilson MR, Manglik A, Ye CJ, Krogan NJ, Anderson MS, Cyster JG, Ernst JD, Wu AHB, Lynch KL, Bern C, Hsu PD, Marson A. Test performance evaluation of SARS-CoV-2 serological assays. medRxiv : the preprint server for health sciences 2020. PMID: 32511497


  27. Rivera-Correa J, de Siqueira IC, Mota S, do Rosário MS, Pereira de Jesus PA, Alcantara LCJ, Ernst JD, Rodriguez A. Anti-ganglioside antibodies in patients with Zika virus infection-associated Guillain-Barré Syndrome in Brazil. PLoS neglected tropical diseases 2019. PMID: 31527907


  28. Ernst JD, Cornelius A, Bolz M. Dynamics of Mycobacterium tuberculosis Ag85B Revealed by a Sensitive Enzyme-Linked Immunosorbent Assay. mBio 2019. PMID: 31015327


  29. Norris BA, Ernst JD. Mononuclear cell dynamics in M. tuberculosis infection provide opportunities for therapeutic intervention. PLoS pathogens 2018. PMID: 30365557


  30. Ernst JD, Cornelius A, Desvignes L, Tavs J, Norris BA. Limited antimycobacterial efficacy of epitope peptide administration despite enhanced antigen-specific CD4 T cell activation. The Journal of infectious diseases 2018. PMID: 29548008


  31. Ernst JD. Mechanisms of M. tuberculosis Immune Evasion as Challenges to TB Vaccine Design. Cell host & microbe 2018. PMID: 30001523


  32. Ernst JD. Float Like Bacilli, STING Like a B: Type I Interferons in Tuberculosis. Volume 197 of Issue 6. American journal of respiratory and critical care medicine 2018. PMID: 29262261


  33. Whatney WE, Gandhi NR, Lindestam Arlehamn CS, Nizam A, Wu H, Quezada MJ, Campbell A, Allana S, Kabongo MM, Khayumbi J, Muchiri B, Ongalo J, Tonui J, Sasser LE, Fergus TJ, Ouma GS, Ouma SG, Beck AA, Mulligan MJ, Oladele A, Kaushal D, Cain KP, Waller L, Blumberg HM, Altman JD, Ernst JD, Rengarajan J, Day CL. A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection. Volume 200 of Issue 8. Journal of immunology (Baltimore, Md. : 1950) 2018. PMID: 29540577


  34. Bolz M, Ernst JD. Fishing for Answers in Human Mycobacterial Infections. Volume 47 of Issue 3. Immunity 2017. PMID: 28930653


  35. Boggiano C, Eichelberg K, Ramachandra L, Shea J, Ramakrishnan L, Behar S, Ernst JD, Porcelli SA, Maeurer M, Kornfeld H. "The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design" - Meeting report. Volume 35 of Issue 27. Vaccine 2017. PMID: 28476627


  36. Arlehamn CS, Copin R, Leary S, Mack SJ, Phillips E, Mallal S, Sette A, Blatner G, Siefers H, Ernst JD. Sequence-based HLA-A, B, C, DP, DQ, and DR typing of 100 Luo infants from the Boro area of Nyanza Province, Kenya. Volume 78 of Issue 4. Human immunology 2017. PMID: 28315719


  37. Ernst JD. Antigenic Variation and Immune Escape in the MTBC. Volume 1019. Advances in experimental medicine and biology 2017. PMID: 29116635


  38. Copin R, Wang X, Louie E, Escuyer V, Coscolla M, Gagneux S, Palmer GH, Ernst JD. Within Host Evolution Selects for a Dominant Genotype of Mycobacterium tuberculosis while T Cells Increase Pathogen Genetic Diversity. Volume 12 of Issue 12. PLoS pathogens 2016. PMID: 27973588


  39. Portal-Celhay C, Tufariello JM, Srivastava S, Zahra A, Klevorn T, Grace PS, Mehra A, Park HS, Ernst JD, Jacobs WR, Philips JA. Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4+ T-cell activation. Volume 2. Nature microbiology 2016. PMID: 27918526


  40. Wiens KE, Ernst JD. Type I Interferon is Pathogenic During Chronic Mycobacterium africanum Infection. Volume 214 of Issue 12. The Journal of infectious diseases 2016. PMID: 27803172


  41. Blumberg HM, Ernst JD. The Challenge of Latent TB Infection. Volume 316 of Issue 9. JAMA 2016. PMID: 27599327


  42. Wiens KE, Ernst JD. The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent. Volume 12 of Issue 8. PLoS pathogens 2016. PMID: 27500737


  43. Lindestam Arlehamn CS, McKinney DM, Carpenter C, Paul S, Rozot V, Makgotlho E, Gregg Y, van Rooyen M, Ernst JD, Hatherill M, Hanekom WA, Peters B, Scriba TJ, Sette A. A Quantitative Analysis of Complexity of Human Pathogen-Specific CD4 T Cell Responses in Healthy M. tuberculosis Infected South Africans. Volume 12 of Issue 7. PLoS pathogens 2016. PMID: 27409590


  44. Srivastava S, Grace PS, Ernst JD. Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis. Volume 19 of Issue 1. Cell host & microbe 2016. PMID: 26764596


  45. Gaur RL, Ren K, Blumenthal A, Bhamidi S, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N. Correction: LprG-Mediated Surface Expression of Lipoarabinomannan Is Essential for Virulence of Mycobacterium tuberculosis. Volume 11 of Issue 12. PLoS pathogens 2015. PMID: 26650245


  46. Grace PS, Ernst JD. Suboptimal Antigen Presentation Contributes to Virulence of Mycobacterium tuberculosis In Vivo. Volume 196 of Issue 1. Journal of immunology (Baltimore, Md. : 1950) 2015. PMID: 26573837


  47. Coscolla M, Copin R, Sutherland J, Gehre F, de Jong B, Owolabi O, Mbayo G, Giardina F, Ernst JD, Gagneux S. M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens. Volume 18 of Issue 5. Cell host & microbe 2015. PMID: 26607161


  48. Desvignes L, Weidinger C, Shaw P, Vaeth M, Ribierre T, Liu M, Fergus T, Kozhaya L, McVoy L, Unutmaz D, Ernst JD, Feske S. STIM1 controls T cell-mediated immune regulation and inflammation in chronic infection. Volume 125 of Issue 6. The Journal of clinical investigation 2015. PMID: 25938788


  49. Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB, Moody DB. In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection. Volume 22 of Issue 4. Chemistry & biology 2015. PMID: 25910243


  50. Srivastava S, Ernst JD, Desvignes L. Beyond macrophages: the diversity of mononuclear cells in tuberculosis. Volume 262 of Issue 1. Immunological reviews 2014. PMID: 25319335


  51. Gaur RL, Ren K, Blumenthal A, Bhamidi S, González-Nilo FD, Gibbs S, Jackson M, Zare RN, Ehrt S, Ernst JD, Banaei N. LprG-mediated surface expression of lipoarabinomannan is essential for virulence of Mycobacterium tuberculosis. Volume 10 of Issue 9. PLoS pathogens 2014. PMID: 25232742


  52. Copin R, Coscollá M, Efstathiadis E, Gagneux S, Ernst JD. Impact of in vitro evolution on antigenic diversity of Mycobacterium bovis bacillus Calmette-Guerin (BCG). Volume 32 of Issue 45. Vaccine 2014. PMID: 25211768


  53. Srivastava S, Ernst JD. Cell-to-cell transfer of M. tuberculosis antigens optimizes CD4 T cell priming. Volume 15 of Issue 6. Cell host & microbe 2014. PMID: 24922576


  54. Copin R, Coscollá M, Seiffert SN, Bothamley G, Sutherland J, Mbayo G, Gagneux S, Ernst JD. Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition. Volume 5 of Issue 1. mBio 2014. PMID: 24425732


  55. Wiens KE, Swaminathan H, Copin R, Lun DS, Ernst JD. Equivalent T cell epitope promiscuity in ecologically diverse human pathogens. Volume 8 of Issue 8. PloS one 2013. PMID: 23951341


  56. Srivastava S, Ernst JD. Cutting edge: Direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo. Volume 191 of Issue 3. Journal of immunology (Baltimore, Md. : 1950) 2013. PMID: 23817429


  57. Desvignes LP, Ernst JD. Taking sides: interferons in leprosy. Volume 13 of Issue 4. Cell host & microbe 2013. PMID: 23601100


  58. Fan L, Xiao HP, Hu ZY, Ernst JD. Variation of Mycobacterium tuberculosis antigen-specific IFN-γ and IL-17 responses in healthy tuberculin skin test (TST)-positive human subjects. Volume 7 of Issue 8. PloS one 2012. PMID: 22880090


  59. Bold TD, Ernst JD. CD4+ T cell-dependent IFN-γ production by CD8+ effector T cells in Mycobacterium tuberculosis infection. Volume 189 of Issue 5. Journal of immunology (Baltimore, Md. : 1950) 2012. PMID: 22837486


  60. Ernst JD. The immunological life cycle of tuberculosis. Volume 12 of Issue 8. Nature reviews. Immunology 2012. PMID: 22790178


  61. Ernst JD, Hanekom W, Hawn T, Kampmann B, Rengarajan J. Meeting report: The International Conference on Human Immunity to Tuberculosis. Volume 92 of Issue 5. Tuberculosis (Edinburgh, Scotland) 2012. PMID: 22658910


  62. Desvignes L, Wolf AJ, Ernst JD. Dynamic roles of type I and type II IFNs in early infection with Mycobacterium tuberculosis. Volume 188 of Issue 12. Journal of immunology (Baltimore, Md. : 1950) 2012. PMID: 22566567


  63. Bold TD, Davis DC, Penberthy KK, Cox LM, Ernst JD, de Jong BC. Impaired fitness of Mycobacterium africanum despite secretion of ESAT-6. Volume 205 of Issue 6. The Journal of infectious diseases 2012. PMID: 22301632


  64. Blomgran R, Desvignes L, Briken V, Ernst JD. Mycobacterium tuberculosis inhibits neutrophil apoptosis, leading to delayed activation of naive CD4 T cells. Volume 11 of Issue 1. Cell host & microbe 2012. PMID: 22264515


  65. Philips JA, Ernst JD. Tuberculosis pathogenesis and immunity. Volume 7. Annual review of pathology 2011. PMID: 22054143


  66. Bold TD, Banaei N, Wolf AJ, Ernst JD. Suboptimal activation of antigen-specific CD4+ effector cells enables persistence of M. tuberculosis in vivo. Volume 7 of Issue 5. PLoS pathogens 2011. PMID: 21637811


  67. Blomgran R, Ernst JD. Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection. Volume 186 of Issue 12. Journal of immunology (Baltimore, Md. : 1950) 2011. PMID: 21555529


  68. Philips JA, Ernst JD. Directly observing therapy: a new view of drug tolerance in tuberculosis. Volume 145 of Issue 1. Cell 2011. PMID: 21458661


  69. Kwan CK, Ernst JD. HIV and tuberculosis: a deadly human syndemic. Volume 24 of Issue 2. Clinical microbiology reviews 2011. PMID: 21482729


  70. Urdahl KB, Shafiani S, Ernst JD. Initiation and regulation of T-cell responses in tuberculosis. 2011. PMID: 21451503


  71. Comas I, Chakravartti J, Small PM, Galagan J, Niemann S, Kremer K, Ernst JD, Gagneux S. Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconserved. Volume 42 of Issue 6. Nature genetics 2010. PMID: 20495566


  72. Desvignes L, Ernst JD. Interferon-gamma-responsive nonhematopoietic cells regulate the immune response to Mycobacterium tuberculosis. Volume 31 of Issue 6. Immunity 2009. PMID: 20064452


  73. Olmos S, Stukes S, Ernst JD. Ectopic activation of Mycobacterium tuberculosis-specific CD4+ T cells in lungs of CCR7-/- mice. Volume 184 of Issue 2. Journal of immunology (Baltimore, Md. : 1950) 2009. PMID: 20007536


  74. Benson SA, Ernst JD. TLR2-dependent inhibition of macrophage responses to IFN-gamma is mediated by distinct, gene-specific mechanisms. Volume 4 of Issue 7. PloS one 2009. PMID: 19629181


  75. Banaei N, Kincaid EZ, Lin SY, Desmond E, Jacobs WR, Ernst JD. Lipoprotein processing is essential for resistance of Mycobacterium tuberculosis to malachite green. Volume 53 of Issue 9. Antimicrobial agents and chemotherapy 2009. PMID: 19596883


  76. Miller EA, Ernst JD. Anti-TNF immunotherapy and tuberculosis reactivation: another mechanism revealed. Volume 119 of Issue 5. The Journal of clinical investigation 2009. PMID: 19422095


  77. Blumenthal A, Kobayashi T, Pierini LM, Banaei N, Ernst JD, Miyake K, Ehrt S. RP105 facilitates macrophage activation by Mycobacterium tuberculosis lipoproteins. Volume 5 of Issue 1. Cell host & microbe 2009. PMID: 19154986


  78. Bold TD, Ernst JD. Who benefits from granulomas, mycobacteria or host? Volume 136 of Issue 1. Cell 2009. PMID: 19135882


  79. Miller EA, Ernst JD. Illuminating the black box of TNF action in tuberculous granulomas. Volume 29 of Issue 2. Immunity 2008. PMID: 18701080


  80. Sinnis P, Ernst JD. CO-opting the host HO-1 pathway in tuberculosis and malaria. Volume 3 of Issue 5. Cell host & microbe 2008. PMID: 18474353


  81. Wolf AJ, Desvignes L, Linas B, Banaiee N, Tamura T, Takatsu K, Ernst JD. Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs. Volume 205 of Issue 1. The Journal of experimental medicine 2007. PMID: 18158321


  82. Ernst JD, Lewinsohn DM, Behar S, Blythe M, Schlesinger LS, Kornfeld H, Sette A. Meeting Report: NIH Workshop on the Tuberculosis Immune Epitope Database. Volume 88 of Issue 4. Tuberculosis (Edinburgh, Scotland) 2007. PMID: 18068490


  83. Blythe MJ, Zhang Q, Vaughan K, de Castro R, Salimi N, Bui HH, Lewinsohn DM, Ernst JD, Peters B, Sette A. An analysis of the epitope knowledge related to Mycobacteria. Volume 3. Immunome research 2007. PMID: 18081934


  84. Kincaid EZ, Wolf AJ, Desvignes L, Mahapatra S, Crick DC, Brennan PJ, Pavelka MS, Ernst JD. Codominance of TLR2-dependent and TLR2-independent modulation of MHC class II in Mycobacterium tuberculosis infection in vivo. Volume 179 of Issue 5. Journal of immunology (Baltimore, Md. : 1950) 2007. PMID: 17709534


  85. Wolf AJ, Linas B, Trevejo-Nuñez GJ, Kincaid E, Tamura T, Takatsu K, Ernst JD. Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo. Volume 179 of Issue 4. Journal of immunology (Baltimore, Md. : 1950) 2007. PMID: 17675513


  86. Ernst JD, Trevejo-Nuñez G, Banaiee N. Genomics and the evolution, pathogenesis, and diagnosis of tuberculosis. Volume 117 of Issue 7. The Journal of clinical investigation 2007. PMID: 17607348


  87. Banaiee N, Jacobs WR, Ernst JD. LspA-independent action of globomycin on Mycobacterium tuberculosis. Volume 60 of Issue 2. The Journal of antimicrobial chemotherapy 2007. PMID: 17579235


  88. Banaiee N, Jacobs WR, Ernst JD. Regulation of Mycobacterium tuberculosis whiB3 in the mouse lung and macrophages. 2006. PMID: 16923787


  89. Banaiee N, Kincaid EZ, Buchwald U, Jacobs WR, Ernst JD. Potent inhibition of macrophage responses to IFN-gamma by live virulent Mycobacterium tuberculosis is independent of mature mycobacterial lipoproteins but dependent on TLR2. Volume 176 of Issue 5. Journal of immunology (Baltimore, Md. : 1950) 2006. PMID: 16493060


  90. Rosales JL, Ernst JD, Hallows J, Lee KY. GTP-dependent secretion from neutrophils is regulated by Cdk5. Volume 279 of Issue 52. The Journal of biological chemistry 2004. PMID: 15492003


  91. Peters W, Cyster JG, Mack M, Schlöndorff D, Wolf AJ, Ernst JD, Charo IF. CCR2-dependent trafficking of F4/80dim macrophages and CD11cdim/intermediate dendritic cells is crucial for T cell recruitment to lungs infected with Mycobacterium tuberculosis. Volume 172 of Issue 12. Journal of immunology (Baltimore, Md. : 1950) 2004. PMID: 15187146


  92. Fortune SM, Solache A, Jaeger A, Hill PJ, Belisle JT, Bloom BR, Rubin EJ, Ernst JD. Mycobacterium tuberculosis inhibits macrophage responses to IFN-gamma through myeloid differentiation factor 88-dependent and -independent mechanisms. Volume 172 of Issue 10. Journal of immunology (Baltimore, Md. : 1950) 2004. PMID: 15128816


  93. Nagabhushanam V, Solache A, Ting LM, Escaron CJ, Zhang JY, Ernst JD. Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma. Volume 171 of Issue 9. Journal of immunology (Baltimore, Md. : 1950) 2003. PMID: 14568951


  94. Kincaid EZ, Ernst JD. Mycobacterium tuberculosis exerts gene-selective inhibition of transcriptional responses to IFN-gamma without inhibiting STAT1 function. Volume 171 of Issue 4. Journal of immunology (Baltimore, Md. : 1950) 2003. PMID: 12902509


  95. Peters W, Ernst JD. Mechanisms of cell recruitment in the immune response to Mycobacterium tuberculosis. Volume 5 of Issue 2. Microbes and infection 2003. PMID: 12650773


  96. Sonda S, Ting LM, Novak S, Kim K, Maher JJ, Farese RV, Ernst JD. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii. Volume 276 of Issue 37. The Journal of biological chemistry 2001. PMID: 11457847


  97. Peters W, Scott HM, Chambers HF, Flynn JL, Charo IF, Ernst JD. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. 2001. PMID: 11438742


  98. Ernst JD. Bacterial inhibition of phagocytosis. 2000. PMID: 11207593


  99. Rosales JL, Ernst JD. GTP-dependent permeabilized neutrophil secretion requires a freely diffusible cytosolic protein. 2000. PMID: 11029752


  100. Liu W, Ernst JD, Broaddus VC. Phagocytosis of crocidolite asbestos induces oxidative stress, DNA damage, and apoptosis in mesothelial cells. American journal of respiratory cell and molecular biology 2000. PMID: 10970829


  101. Flynn JL, Ernst JD. Immune responses in tuberculosis. 2000. PMID: 10899019


  102. Ernst JD. Toward the development of antibacterial vaccines: report of a symposium and workshop. Organizing Committee. 1999. PMID: 10524978


  103. Ting LM, Kim AC, Cattamanchi A, Ernst JD. Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1. 1999. PMID: 10490990


  104. Ernst JD. Editorial response: variation in clinical and immune responses to bacille Calmette-Guérin--implications for an improved tuberculosis vaccine. 1999. PMID: 10825040


  105. Ernst JD, Yang L, Rosales JL, Broaddus VC. Preparation and characterization of an endogenously fluorescent annexin for detection of apoptotic cells. Analytical biochemistry 1998. PMID: 9648647


  106. Majeed M, Perskvist N, Ernst JD, Orselius K, Stendahl O. Roles of calcium and annexins in phagocytosis and elimination of an attenuated strain of Mycobacterium tuberculosis in human neutrophils. 1998. PMID: 9600863


  107. Ernst JD. Macrophage receptors for Mycobacterium tuberculosis. 1998. PMID: 9529042


  108. Rosales JL, Ernst JD. Calcium-dependent neutrophil secretion: characterization and regulation by annexins. 1997. PMID: 9550422


  109. Larsson M, Majeed M, Ernst JD, Magnusson KE, Stendahl O, Forsum U. Role of annexins in endocytosis of antigens in immature human dendritic cells. 1997. PMID: 9497492


  110. Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Crocidolite asbestos induces apoptosis of pleural mesothelial cells: role of reactive oxygen species and poly(ADP-ribosyl) polymerase. Environmental health perspectives 1997. PMID: 9400715


  111. Collins HL, Schaible UE, Ernst JD, Russell DG. Transfer of phagocytosed particles to the parasitophorous vacuole of Leishmania mexicana is a transient phenomenon preceding the acquisition of annexin I by the phagosome. 1997. PMID: 9044049


  112. Zimmerli S, Edwards S, Ernst JD. Selective receptor blockade during phagocytosis does not alter the survival and growth of Mycobacterium tuberculosis in human macrophages. 1996. PMID: 8969271


  113. Broaddus VC, Yang L, Scavo LM, Ernst JD, Boylan AM. Asbestos induces apoptosis of human and rabbit pleural mesothelial cells via reactive oxygen species. The Journal of clinical investigation 1996. PMID: 8903324


  114. Read RC, Zimmerli S, Broaddus C, Sanan DA, Stephens DS, Ernst JD. The (alpha2-->8)-linked polysialic acid capsule of group B Neisseria meningitidis modifies multiple steps during interaction with human macrophages. 1996. PMID: 8757855


  115. Kuypers FA, Lewis RA, Hua M, Schott MA, Discher D, Ernst JD, Lubin BH. Detection of altered membrane phospholipid asymmetry in subpopulations of human red blood cells using fluorescently labeled annexin V. 1996. PMID: 8562945


  116. Zimmerli S, Majeed M, Gustavsson M, Stendahl O, Sanan DA, Ernst JD. Phagosome-lysosome fusion is a calcium-independent event in macrophages. 1996. PMID: 8567729


  117. Larsson M, Majeed M, Stendahl O, Magnusson KE, Ernst JD, Forsum U. Mobilization of annexin V during the uptake of DNP-albumin by human dendritic cells. 1995. PMID: 8562025


  118. Schmidt DM, Ernst JD. A fluorometric assay for the quantification of RNA in solution with nanogram sensitivity. 1995. PMID: 8600826


  119. Ernst JD, Rosales JL, Zimmerli S. Calcium signalling initiated by CR1 (CD35) crosslinking is mediated by phagocyte Fc gamma receptors in cis. 1995. PMID: 7733955


  120. Larsson M, Majeed M, Stendahl O, Magnusson KE, Ernst JD, Forsum U. Annexin expression in human dendritic cells. 1995. PMID: 8526052


  121. Majeed M, Ernst JD, Magnusson KE, Kihlström E, Stendahl O. Selective translocation of annexins III, IV, and V during intracellular redistribution of Chlamydia trachomatis serovar L2 in HeLa and McCoy cells. 1994. PMID: 8080201


  122. Ernst JD, Mall A, Chew G. Annexins possess functionally distinguishable Ca2+ and phospholipid binding domains. 1994. PMID: 8179621


  123. Majeed M, Ernst JD, Magnusson KE, Kihlström E, Stendahl O. Selective translocation of annexins during intracellular redistribution of Chlamydia trachomatis in HeLa and McCoy cells. 1994. PMID: 8262618


  124. Ernst JD. Epitope mapping of annexin I: antibodies that compete with phospholipids and calcium recognize amino acids 42-99. 1993. PMID: 7678738


  125. Ernst JD. Annexin III translocates to the periphagosomal region when neutrophils ingest opsonized yeast. 1991. PMID: 1826705


  126. Ernst JD, Hoye E, Blackwood RA, Mok TL. Identification of a domain that mediates vesicle aggregation reveals functional diversity of annexin repeats. 1991. PMID: 1707872


  127. Ernst JD, Hoye E, Blackwood RA, Jaye D. Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules. 1990. PMID: 2138632


  128. Blackwood RA, Ernst JD. Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins. 1990. PMID: 2138016


  129. Ernst JD, Hoye E, Blackwood RA. Use of a novel strategy for the preparation and characterization of an antipeptide antibody capable of recognizing members of the annexin family. 1989. PMID: 2742594


  130. Meers P, Ernst JD, Düzgünes N, Hong KL, Fedor J, Goldstein IM, Papahadjopoulos D. Synexin-like proteins from human polymorphonuclear leukocytes. Identification and characterization of granule-aggregating and membrane-fusing activities. 1987. PMID: 2953727


  131. Ernst JD, Meers P, Hong K, Duzgunes N, Papahadjopoulos D, Goldstein IM. Human polymorphonuclear leukocytes contain synexin, a calcium-binding protein that mediates membrane fusion. 1986. PMID: 2955560


  132. Ernst JD, Hartiala KT, Goldstein IM, Sande MA. Complement (C5)-derived chemotactic activity accounts for accumulation of polymorphonuclear leukocytes in cerebrospinal fluid of rabbits with pneumococcal meningitis. 1984. PMID: 6480117


  133. Decazes JM, Ernst JD, Sande MA. Correlation of in vitro time-kill curves and kinetics of bacterial killing in cerebrospinal fluid during ceftriaxone therapy of experimental Escherichia coli meningitis. 1983. PMID: 6316841


  134. Ernst JD, Rusnak M, Sande MA. Combination antifungal chemotherapy for experimental disseminated candidiasis: lack of correlation between in vitro and in vivo observations with amphotericin B and rifampin. 1983. PMID: 6356285


  135. Ernst JD, Decazes JM, Sande MA. Experimental pneumococcal meningitis: role of leukocytes in pathogenesis. 1983. PMID: 6862627


  136. Hackbarth CJ, Ernst JD, Sande MA. Inhibition of isolation of Escherichia coli in blood cultures by trimethoprim-sulfamethoxazole. 1983. PMID: 6341486


  137. Ernst JD, Sande MA. Antibiotic combinations in experimental infections in animals. 1982. PMID: 7051233