Jennifer Rosenbluth, MD, PhD

Assistant Professor

Jennifer Rosenbluth, MD, PhD, is a medical oncologist who specializes in breast cancer, an Assistant Professor in the Department of Medicine, and a member of the Breast Oncology Program in the Helen Diller Family Comprehensive Cancer Center. The research in her laboratory utilizes three-dimensional organoid cultures of premalignant and tumorigenic breast tissues to identify heterogeneous populations of cells that promote cancer development and progression.

Education
- Medical Oncology, Dana-Farber Cancer Institute
- Internal Medicine, Massachusetts General Hospital
AB, - , Princeton University
MD, - , Vanderbilt University School of Medicine
PhD, - , Vanderbilt University School of Medicine
Honors and Awards
  • Investigator Award, Chan Zuckerberg Biohub, 2022
  • Young Investigator Grant, Breast Cancer Alliance, 2021
  • Clinical Scientist Development Award, Doris Duke Charitable Foundation, 2021
  • Fellowship Award, Terri Brodeur Breast Cancer Foundation, 2021
  • Sulochana Pradhan, MD Endowed Professorship in Breast Cancer, UCSF, 2021
  • Sidney Farber Scholar, Dana-Farber Cancer Institute, 2020-2021
  • Eleanor and Miles Shore Award, Dana-Farber Cancer Institute, 2019-2020
  • Career Catalyst Research Grant, Susan G. Komen Foundation, 2019
  • Postdoctoral Fellowship, American Cancer Society, 2017-2019
  • Young Investigator Award, American Society of Clinical Oncology, 2017-2018
  • Leadership Council Fellow, Dana-Farber Cancer Institute, 2014
  • Dean's Award for Research, Vanderbilt University, 2011
  • John G. Coniglio Prize for Excellence in Biochemistry, Vanderbilt University, 2011
Websites
Publications

  1. Cho NW, Guldberg SM, Nabet BY, Yu JZ, Kim EJ, Hiam-Galvez KJ, Yee JL, DeBarge R, Tenvooren I, Ashitey NA, Lynce F, Dillon DA, Rosenbluth JM, Spitzer MH. T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFα Inflammation. Cancer immunology research 2024. PMID: 39404741


  2. Graham AJ, Khoo MWL, Srivastava V, Viragova S, Kim H, Parekh K, Hennick KM, Bird M, Goldhammer N, Yu JZ, Morley CD, Lebel P, Kumar S, Rosenbluth JM, Nowakowski TJ, Klein O, Gómez-Sjöberg R, Gartner ZJ. MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis. bioRxiv : the preprint server for biology 2024. PMID: 38370663


  3. Greenwood HI, Maldonado Rodas CK, Freimanis RI, Glencer AC, Miller PN, Mukhtar RA, Brabham C, Yau C, Rosenbluth JM, Hirst GL, Campbell MJ, Borowsky A, Hylton N, Esserman LJ, Basu A. Magnetic resonance imaging insights from active surveillance of women with ductal carcinoma in situ. NPJ breast cancer 2024. PMID: 39098868


  4. Garrido-Castro AC, Regan MM, Niman SM, Nakhlis F, Remolano C, Rosenbluth JM, Block C, Warren LE, Bellon JR, Yeh E, Harrison BT, Troll E, Lin NU, Tolaney SM, Overmoyer B, Lynce F. Clinical outcomes of de novo metastatic HER2-positive inflammatory breast cancer. NPJ breast cancer 2023. PMID: 37268625


  5. Nguyen HP, Sheng R, Murray E, Ito Y, Bruck M, Biellak C, An K, Lynce F, Dillon DA, Magbanua MJM, Huppert LA, Hammerlindl H, Esserman L, Rosenbluth JM, Ahituv N. Implantation of engineered adipocytes that outcompete tumors for resources suppresses cancer progression. bioRxiv : the preprint server for biology 2023. PMID: 37034710


  6. Glencer AC, Miller PN, Greenwood H, Maldonado Rodas CK, Freimanis R, Basu A, Mukhtar RA, Brabham C, Kim P, Hwang ES, Rosenbluth JM, Hirst GL, Campbell MJ, Borowsky AD, Esserman LJ. Identifying Good Candidates for Active Surveillance of Ductal Carcinoma In Situ: Insights from a Large Neoadjuvant Endocrine Therapy Cohort. Cancer Research Communications 2022. PMID: 36970720


  7. Gray GK, Li CM, Rosenbluth JM, Selfors LM, Girnius N, Lin JR, Schackmann RCJ, Goh WL, Moore K, Shapiro HK, Mei S, D'Andrea K, Nathanson KL, Sorger PK, Santagata S, Regev A, Garber JE, Dillon DA, Brugge JS. A human breast atlas integrating single-cell proteomics and transcriptomics. Volume 57 of Issue 11. Developmental cell 2022. PMID: 35617956


  8. Hirko KA, Regan MM, Remolano MC, Schlossman J, Harrison B, Yeh E, Jacene H, Nakhlis F, Block C, Rosenbluth JM, Garrido-Castro AC, Overmoyer BA. Dermal Lymphatic Invasion, Survival, and Time to Recurrence or Progression in Inflammatory Breast Cancer. Volume 44 of Issue 9. American journal of clinical oncology 2021. PMID: 34149037


  9. Dekkers JF, van Vliet EJ, Sachs N, Rosenbluth JM, Kopper O, Rebel HG, Wehrens EJ, Piani C, Visvader JE, Verissimo CS, Boj SF, Brugge JS, Clevers H, Rios AC. Long-term culture, genetic manipulation and xenotransplantation of human normal and breast cancer organoids. Volume 16 of Issue 4. Nature protocols 2021. PMID: 33692550


  10. Li CM, Shapiro H, Tsiobikas C, Selfors LM, Chen H, Rosenbluth J, Moore K, Gupta KP, Gray GK, Oren Y, Steinbaugh MJ, Guerriero JL, Pinello L, Regev A, Brugge JS. Aging-Associated Alterations in Mammary Epithelia and Stroma Revealed by Single-Cell RNA Sequencing. Volume 33 of Issue 13. Cell reports 2020. PMID: 33378681


  11. White RE, Warren L, Nakhlis F, Rosenbluth J, Bellon J, Block C, Overmoyer B. Characteristics associated with inflammatory breast cancer (IBC): An epidemiologic study from a dedicated IBC program. Volume 26 of Issue 9. The breast journal 2020. PMID: 32875655


  12. Jacene HA, DiPiro PJ, Bellon J, Hu J, Cheng SC, Warren L, Schlosnagle E, Nakhlis F, Rosenbluth JM, Yeh E, Overmoyer B. Discrepancy between FDG-PET/CT and contrast-enhanced CT in the staging of patients with inflammatory breast cancer: implications for treatment planning. Volume 181 of Issue 2. Breast cancer research and treatment 2020. PMID: 32318957


  13. Rosenbluth JM, Schackmann RCJ, Gray GK, Selfors LM, Li CM, Boedicker M, Kuiken HJ, Richardson A, Brock J, Garber J, Dillon D, Sachs N, Clevers H, Brugge JS. Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages. Volume 11 of Issue 1. Nature communications 2020. PMID: 32249764


  14. Sarkizova S, Klaeger S, Le PM, Li LW, Oliveira G, Keshishian H, Hartigan CR, Zhang W, Braun DA, Ligon KL, Bachireddy P, Zervantonakis IK, Rosenbluth JM, Ouspenskaia T, Law T, Justesen S, Stevens J, Lane WJ, Eisenhaure T, Lan Zhang G, Clauser KR, Hacohen N, Carr SA, Wu CJ, Keskin DB. A large peptidome dataset improves HLA class I epitope prediction across most of the human population. Volume 38 of Issue 2. Nature biotechnology 2019. PMID: 31844290


  15. Rosenbluth JM, Overmoyer BA. Inflammatory Breast Cancer: a Separate Entity. Volume 21 of Issue 10. Current oncology reports 2019. PMID: 31414257


  16. Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG, Brugge JS. Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion. Volume 29 of Issue 5. Cell metabolism 2019. PMID: 30799286


  17. Jacene HA, Youn T, DiPiro PJ, Hu J, Cheng SC, Franchetti Y, Shah H, Bellon JR, Warren L, Schlosnagle E, Nakhlis F, Rosenbluth J, Yeh E, Overmoyer B, Dana-Farber Cancer Institute Inflammatory Breast Cancer Program. Metabolic Characterization of Inflammatory Breast Cancer With Baseline FDG-PET/CT: Relationship With Pathologic Response After Neoadjuvant Chemotherapy, Receptor Status, and Tumor Grade. Volume 19 of Issue 2. Clinical breast cancer 2018. PMID: 30584057


  18. Jovanovic B, Mayer IA, Mayer EL, Abramson VG, Bardia A, Sanders ME, Kuba MG, Estrada MV, Beeler JS, Shaver TM, Johnson KC, Sanchez V, Rosenbluth JM, Dillon PM, Forero-Torres A, Chang JC, Meszoely IM, Grau AM, Lehmann BD, Shyr Y, Sheng Q, Chen SC, Arteaga CL, Pietenpol JA. A Randomized Phase II Neoadjuvant Study of Cisplatin, Paclitaxel With or Without Everolimus in Patients with Stage II/III Triple-Negative Breast Cancer (TNBC): Responses and Long-term Outcome Correlated with Increased Frequency of DNA Damage Response Gene Volume 23 of Issue 15. Clinical cancer research : an official journal of the American Association for Cancer Research 2017. PMID: 28270498


  19. Marshall CB, Mays DJ, Beeler JS, Rosenbluth JM, Boyd KL, Santos Guasch GL, Shaver TM, Tang LJ, Liu Q, Shyr Y, Venters BJ, Magnuson MA, Pietenpol JA. p73 Is Required for Multiciliogenesis and Regulates the Foxj1-Associated Gene Network. Volume 14 of Issue 10. Cell reports 2016. PMID: 26947080


  20. Rosenbluth JM, Mays DJ, Jiang A, Shyr Y, Pietenpol JA. Differential regulation of the p73 cistrome by mammalian target of rapamycin reveals transcriptional programs of mesenchymal differentiation and tumorigenesis. Volume 108 of Issue 5. Proceedings of the National Academy of Sciences of the United States of America 2011. PMID: 21245298


  21. Eby KG, Rosenbluth JM, Mays DJ, Marshall CB, Barton CE, Sinha S, Johnson KN, Tang L, Pietenpol JA. ISG20L1 is a p53 family target gene that modulates genotoxic stress-induced autophagy. Volume 9. Molecular cancer 2010. PMID: 20429933


  22. Bauer JA, Chakravarthy AB, Rosenbluth JM, Mi D, Seeley EH, De Matos Granja-Ingram N, Olivares MG, Kelley MC, Mayer IA, Meszoely IM, Means-Powell JA, Johnson KN, Tsai CJ, Ayers GD, Sanders ME, Schneider RJ, Formenti SC, Caprioli RM, Pietenpol JA. Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation. Volume 16 of Issue 2. Clinical cancer research : an official journal of the American Association for Cancer Research 2010. PMID: 20068102


  23. Rosenbluth JM, Johnson K, Tang L, Triplett T, Pietenpol JA. Evaluation of p63 and p73 antibodies for cross-reactivity. Volume 8 of Issue 22. Cell cycle (Georgetown, Tex.) 2009. PMID: 19855172


  24. Rosenbluth JM, Pietenpol JA. mTOR regulates autophagy-associated genes downstream of p73. Volume 5 of Issue 1. Autophagy 2009. PMID: 19001857


  25. Rosenbluth JM, Pietenpol JA. The jury is in: p73 is a tumor suppressor after all. Volume 22 of Issue 19. Genes & development 2008. PMID: 18832062


  26. Rosenbluth JM, Mays DJ, Pino MF, Tang LJ, Pietenpol JA. A gene signature-based approach identifies mTOR as a regulator of p73. Volume 28 of Issue 19. Molecular and cellular biology 2008. PMID: 18678646


  27. Rosenbluth J, Schiff R, Liang WL, Menna G, Young W. Xenotransplantation of transgenic oligodendrocyte-lineage cells into spinal cord-injured adult rats. Experimental neurology 1997. PMID: 9294414


  28. Young W, Rosenbluth J, Wojak JC, Sakatani K, Kim H. Extracellular potassium activity and axonal conduction in spinal cord of the myelin-deficient mutant rat. Experimental neurology 1989. PMID: 2551718