Jan Christoph, PhD, MSc

Asst Professor In Residence

Jan Christoph studies the heart from a complex and dynamical systems perspective. He is interested in arrhythmia mechanisms and the coupling between electrophysiology and tissue mechanics, as well as electromechanical feedback. He uses computational methods, artificial intelligence and high-resolution imaging to study the heart.

Publications

  1. Hua Z, Patlatzoglou K, Kappadan V, Sun X, Lebert J, Efstathiou P, Tonko JB, Lee IE, Sohi A, Agha-Jaffar D, Mohamed N, Abdelghani Y, Onslow O, Baranwal T, Pyman E, Guichard JB, Ripplinger CM, Luther S, Peters NS, Christoph J, Ng FS. AI-enabled motion artifact correction to replace emission- and excitation-ratiometry in cardiac optical mapping: A proof-of-concept study. Cardiovascular research 2026. PMID: 42082431


  2. Kappadan V, Hua Z, Tonko JB, Mohamed N, Lebert J, Efstathiou P, Abdelghani Y, Agha-Jaffar D, Sohi A, Sun X, Guichard JB, Christoph J, Peters NS, Ng FS. Combined emission ratiometry and motion tracking for optical mapping of contracting hearts: Validation with monophasic action potentials. The Journal of physiology 2026. PMID: 42303282


  3. Schnell A, Wei X, Bossenz J, Manuilova I, Christoph J, Allabauer I, Classen M, Regensburger AP, Woelfle J, Erber R, Hoerning A. Inflammation significantly alters mucosal transcriptomic signatures in pediatric inflammatory bowel disease. Crohn's & colitis 360 2026. PMID: 42027409


  4. Chowdhary S, Lebert J, Dickman S, Manetta M, Gordon C, Christoph J. Panoramic voltage-sensitive optical mapping of contracting hearts using cooperative multiview motion tracking with 12 cameras. The Journal of physiology 2026. PMID: 41804229


  5. Nimani S, Bains S, Alerni N, Ördög B, Horváth A, Matas L, Louradour J, Giammarino L, Tester DJ, Beslac O, Lopez R, Meier S, Egle M, Christoforou N, Barbieri M, Vashanthakumar V, Perez-Feliz S, Parodi C, Garcia Casalta LG, Kim CSJ, Zhou W, Ye D, Jurgensen J, Barry MA, Bego M, Keyes L, Owens J, Pinkstaff J, Christoph J, Zehender M, Brunner M, Heijman J, Casoni D, Praz F, Haeberlin A, Brooks G, Ackerman MJ, Odening KE. AAV9-mediated KCNH2 suppression-replacement gene therapy in a transgenic rabbit model of type 1 short QT syndrome. European heart journal 2025. PMID: 40884219


  6. Kappadan V, Hua Z, Efstathiou P, Lebert J, Sohi A, Agha-Jaffar D, Tonko JB, Sun X, Mohamed N, Abdelghani Y, Peters NS, Christoph J, Ng FS. Differential response to acute ischemia between isolated contracting hearts and hearts perfused with excitation-contraction uncouplers. American journal of physiology. Heart and circulatory physiology 2025. PMID: 41212552


  7. Negash S, Papon H, Apfelbacher T, Koçman SE, Gundlack J, Manuilova I, Christoph J, Schildmann J, Kantelhardt EJ, Jahn P, Knöchelmann A, Mikolajczyk R. Perceptions of the German General Population Towards Implementing Artificial Intelligence in Medical Care: A Population-Based Survey. Studies in health technology and informatics 2025. PMID: 40380671


  8. Baranwal T, Lebert J, Christoph J. Dreaming of electrical waves: Generative modeling of cardiac excitation waves using diffusion models. APL machine learning 2024. PMID: 39364376


  9. Christoph J, Ripplinger CM. Paralysis by analysis: Overcoming cardiac contraction with computer vision. Proceedings of the National Academy of Sciences of the United States of America 2023. PMID: 37792520


  10. Kappadan V, Sohi A, Parlitz U, Luther S, Uzelac I, Fenton F, Peters NS, Christoph J, Ng FS. Optical mapping of contracting hearts. The Journal of physiology 2023. PMID: 36866700


  11. M?nkler P, Klatt N, Scherschel K, Kuklik P, Jungen C, Cavus E, Eickholt C, Christoph J, Lemoine MD, Christ T, Willems S, Riedel R, Kirchhof P, Meyer C. Repolarization indicates electrical instability in ventricular arrhythmia originating from papillary muscle. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2023. PMID: 35989424


  12. Lebert J, Mittal M, Christoph J. Reconstruction of three-dimensional scroll waves in excitable media from two-dimensional observations using deep neural networks. Physical review. E 2023. PMID: 36797900


  13. Lebert J, Ravi N, Kensah G, Christoph J. Real-Time Optical Mapping of Contracting Cardiac Tissues With GPU-Accelerated Numerical Motion Tracking. Volume 9. Frontiers in cardiovascular medicine 2022. PMID: 35686036


  14. Lebert J, Ravi N, Fenton FH, Christoph J. Rotor Localization and Phase Mapping of Cardiac Excitation Waves Using Deep Neural Networks. Volume 12. Frontiers in physiology 2021. PMID: 34975536


  15. Vogt M, Schulz B, Wagdi A, Lebert J, van Belle GJ, Christoph J, Bruegmann T, Patejdl R. Direct optogenetic stimulation of smooth muscle cells to control gastric contractility. Volume 11 of Issue 11. Theranostics 2021. PMID: 33859764


  16. Christoph J, Lebert J. Inverse mechano-electrical reconstruction of cardiac excitation wave patterns from mechanical deformation using deep learning. Volume 30 of Issue 12. Chaos (Woodbury, N.Y.) 2020. PMID: 33380038


  17. Kunz M, Wolf B, Fuchs M, Christoph J, Xiao K, Thum T, Atlan D, Prokosch HU, Dandekar T. A comprehensive method protocol for annotation and integrated functional understanding of lncRNAs. Briefings in Bioinformatics 2020. PMID: 31578571


  18. Kappadan V, Telele S, Uzelac I, Fenton F, Parlitz U, Luther S, Christoph J. High-Resolution Optical Measurement of Cardiac Restitution, Contraction, and Fibrillation Dynamics in Beating vs. Blebbistatin-Uncoupled Isolated Rabbit Hearts. Volume 11. Frontiers in physiology 2020. PMID: 32528304


  19. Lebert J, Christoph J. Synchronization-based reconstruction of electromechanical wave dynamics in elastic excitable media. Volume 29 of Issue 9. Chaos (Woodbury, N.Y.) 2019. PMID: 31575136


  20. Christoph J, Luther S. Marker-Free Tracking for Motion Artifact Compensation and Deformation Measurements in Optical Mapping Videos of Contracting Hearts. Volume 9. Frontiers in physiology 2018. PMID: 30450053


  21. Christoph J, Chebbok M, Richter C, Schröder-Schetelig J, Bittihn P, Stein S, Uzelac I, Fenton FH, Hasenfuß G, Gilmour RF, Luther S. Electromechanical vortex filaments during cardiac fibrillation. Volume 555 of Issue 7698. Nature 2018. PMID: 29466325


  22. Christoph J, Schröder-Schetelig J, Luther S. Electromechanical optical mapping. Volume 130 of Issue Pt B. Progress in biophysics and molecular biology 2017. PMID: 28947080


  23. Lilienkamp T, Christoph J, Parlitz U. Features of Chaotic Transients in Excitable Media Governed by Spiral and Scroll Waves. Volume 119 of Issue 5. Physical review letters 2017. PMID: 28949756


  24. Christoph J, Knell C, Naschberger E, Stürzl M, Maier C, Prokosch HU, Sedlmayr M. Two Years of tranSMART in a University Hospital for Translational Research and Education. Studies in health technology and informatics 2017. PMID: 28508781


  25. Richter C, Christoph J, Lehnart SE, Luther S. Optogenetic Light Crafting Tools for the Control of Cardiac Arrhythmias. Volume 1408. Methods in molecular biology (Clifton, N.J.) 2016. PMID: 26965131